Four new C19-diterpenoid alkaloids from the roots of Aconitum ouvrardianum

Four new C₁₉-diterpenoid alkaloids, 3-dehydroxyl-lipoindaconitine (1), 8-dehydroxyl-bikhaconine (2), 19R-acetonyl-talatisamine (3), and 16-hydroxyl-vilmorisine (4), were isolated from the roots of Aconitum ouvrardianum. Their structures were elucidated by spectral analyses, including ESI-MS, HR-ESI-MS, IR, UV, 1D and 2D NMR.     

Diterpenoid Alkaloids from Aconitum Racemulosum Franch Var. Pengzhouense

Abstract

A new diterpenoid alkaloid, racemulotine (1), was isolated from the whole plants of Aconitum racemulosum Franch var. pengzhouense, and its structure was elucidated by 1D-and 2D-NMR spectra.     

Two new C19-diterpenoid alkaloids from Aconitum tsaii

Two new C₁₉-diterpenoid alkaloids, 14-benzoylliljestrandisine (1) and 14-anisoylliljestrandisine (2), were isolated from the roots of Aconitum tsaii. Their structures were elucidated by different spectroscopic (IR, UV, 1D and 2D NMR) and mass-spectrometric techniques.     

New Norditerpenoid Alkaloids from the Roots of Aconitum Geniculatum

Four new norditerpenoid alkaloids, geniculatines A (1), B (4), C (7) and D (8), were isolated from the roots of Aconitum geniculatum Fletcher, and their structures were elucidated by spectral methods.     

New Norditerpenoid Alkaloids from the Roots of Aconitum Geniculatum

Abstract

Four new norditerpenoid alkaloids, geniculatines A (1), B (4), C (7) and D (8), were isolated from the roots of Aconitum geniculatum Fletcher, and their structures were elucidated by spectral methods.     

A new diterpenoid alkaloid from Aconitum jaluense

A new diterpenoid alkaloid, jaluenine (1), has been isolated from the roots of Aconitum jaluense. The structure of jaluenine was determined by spectroscopic methods including two dimensional NMR (¹H-¹H COSY, HMQC, HMBC, NOESY).     

A new diterpenoid alkaloid from Aconitum jaluense

A new diterpenoid alkaloid, jaluenine (1), has been isolated from the roots of Aconitum jaluense. The structure of jaluenine was determined by spectroscopic methods including two dimensional NMR (¹H-¹H COSY, HMQC, HMBC, NOESY).     

Two new C19-diterpenoid alkaloids from Aconitum straminiflorum

Two new C₁₉-diterpenoid alkaloids, straconitines A (1) and B (2), were isolated from the roots of Aconitum straminiflorum. Their structures were elucidated as 14-benzoylducloudine D (1) and 6-hydroxy-14-benzoylducloudine D (2) based on spectroscopic analysis, including IR, ESI-MS, HR-ESI-MS, 1D, and 2D NMR.     

Diterpenoid alkaloids from the roots of Aconitum brachypodum Diels

A new diterpenoid alkaloid, named bullatine H (1), along with 10 known diterpenoid alkaloids were isolated from the roots of Aconitum brachypodum Diels (Ranunculaceae). The structure of 1 was elucidated by analysis of its spectroscopic data. It should be noted that compound 1 is the first example with 11, 13-dioxygenated denudatine-type diterpenoid alkaloid isolated from Aconitum brachypodum.     

蒙药紫花高乌头根中二萜生物碱的分离与结构鉴定

目的进一步对蒙药紫花高乌头Aconitum excelsum Reichb．根的化学成分进行分离鉴定。方法通过硅胶柱层析分离，以IR，MS,^1H—NMR，^13C—NMR等光谱鉴定结构。结果从紫花高乌头根中分离得到6个化合物，经光谱分析和理化性质鉴定，确定其结构式分别是ranaconitine（Ⅰ），N—deacetyl lappaconitine（Ⅱ），1α，6，16，-三甲氧基-4，7，8，9，14α-五羟基-N-乙基乌头烷（Ⅲ），N—deacetylranaconitine（Ⅳ），β-谷甾醇（Ⅴ），豆甾醇（Ⅵ）。结论化合物Ⅱ，Ⅲ，Ⅳ，Ⅴ，Ⅵ为首次从该植物中得到，其中化合物Ⅲ为新二萜生物碱。     

Diterpenoid alkaloids from Aconitum racemulosum Franch var. pengzhouense

A new diterpenoid alkaloid, racemulotine (1), was isolated from the whole plants of Aconitum racemulosum Franch var. pengzhouense, and its structure was elucidated by 1D-and 2D-NMR spectra.     

New Norditerpenoid Alkaloids from Aconitum Hemsleyanum var. Pengzhouense

Abstract

Two new norditerpenoid alkaloids, 13-deoxyludaconitine (1) and 8-deacetylsungpaconitine (3), were isolated from the roots of Aconitum hemsleyanum Pritz var. pengzhouense and their structures were elucidated by spectral data.     

Alkaloids from Consolida olopetala.

Abstract

Three norditerpenoid alkaloids, delphatine (1), delcaroline (2), and browniine (3), and three diterpenoid alkaloids, hetisine (4), dehydronapelline (5), and 12-epidehydronapelline (6), have been isolated and identified from the aerial parts of Consolida olopetala. (Boiss.) Hayek (Ranunculaceae).     

New C20-diterpenoid alkaloids from Aconitum vilmorrianum and structural revision of 2-O-acetylorochrine and orochrine

Three new C₂₀-diterpenoid alkaloids vilmorrianines E (1), F (2), and G (3) were isolated from the whole plants of Aconitum vilmorrianum, along with one artifact N-chloromethyl vilmorrianine E hydrochloride (4), as well as two known alkaloids hemsleyaconitines F (5) and G (6). The structures of 1–4 were established by HR-ESI-MS, 1D-, 2D-NMR (HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. In addition, the structures of naturally occurring 2-O-acetylorochrine (7) and orochrine (8) were revised to be the known alkaloids heterophylloidine (9) and deacetyl heterophylloidine (10), respectively, on the basis of consideration of transannular effect and chemical correlations.     

Five New Norditerpenoid Alkaloids from Aconitum Sinomontanum

Abstract

From the roots of Aconitum sinomontanum, five new norditerpenoid alkaloids, sinomontanitines A (1) and B (2), sinomontanines A (3), B (4) and C (5), were isolated together with the known alkaloids lappaconitine (6) and ranaconitine (7), The structures of the new alkaloids were determined by spectral analysis.     

Diterpenoid alkaloids from Aconitum kirinense

A new C₁₈-diterpenoid alkaloid, kirinenine A (1), was isolated from the root of Aconitum kirinense, along with eight known diterpenoid alkaloids. The structures of all compounds were characterized on the basis of extensive NMR and MS analyses and by comparison with literature values, and the new one was further confirmed by X-ray crystallographic diffraction. All the compounds were isolated from the title plant for the first time.     

吉林乌头化学成分研究

从毛莨科乌头属植物吉林乌头（Acontum kirinine Nakai)中分得两个C20二萜生物碱lepenine(雷乌宁）和kirinine A(吉乌碱甲），用化学和波谱方法鉴定了它们的结构，其中后者为新化合物。     

Two new compounds from Aconitum tanguticum

A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl]-glucopyranoside (1) and 3,4-dimethoxy-trans-cinnamic acid-9-O-β-d-allopyranoside (2) on the basis of spectroscopic data (1D NMR, 2D NMR, and MS) and comparison with the literature data.     

Five new norditerpenoid alkaloids from Aconitum sinomontanum

From the roots of Aconitum sinomontanum, five new norditerpenoid alkaloids, sinomontanitines A (1) and B (2), sinomontanines A (3), B (4) and C (5), were isolated together with the known alkaloids lappaconitine (6) and ranaconitine (7), The structures of the new alkaloids were determined by spectral analysis.     

利用乌头类双酯型生物碱水解规律测定醇胺型乌头碱的含量

摘 要 目的：研究乌头类双酯型生物碱水解转化为醇胺型生物碱的转化率,水解乌头类双酯型生物碱对照品,利用水解转化率计算出水解原液中醇胺型生物碱的量,以此量作为醇胺型生物碱对照品的量,建立测定制川乌中乌头原碱、次乌头原碱、新乌头原碱含量的方法。方法: 通过控制乌头碱、次乌头碱、新乌头碱3种双酯型生物碱的水解条件,得到乌头原碱、次乌头原碱、新乌头原碱。采用高效液相色谱四级杆飞行时间串联质谱（HPLC-QTOF-MS）法,使用Agilent ZORBAX Extend C18 RRHT（2.1 mm×50 mm,1.8 μm）色谱柱,流速为0.21 ml·min^-1,柱温为30 ℃,流动相为甲醇 水（含0.1%甲酸和2.5 mmol·L^-1醋酸铵）系统梯度洗脱,采用电喷雾离子（ESI）源,正离子方式检测。结果: 在本文的水解条件下,乌头碱对于乌头原碱的转化率为99.64%;次乌头碱对于次乌头原碱的转化率为99.94%;新乌头碱对于新乌头原碱的转化率为99.57%。HPLC-QTOF-MS方法学表明,乌头原碱、次乌头原碱、新乌头原碱在一定范围内具有较好的线性关系,r值均大于0.999 1,精密度、重复性和稳定性的RSD都小于5%,加样回收率均在99.43%～100.10%之间。结论:本方法操作简便、专属性和重复性较好,在缺乏对照品的情况下,可以为乌头类中药材质量控制提供依据。