胆固醇转移率影响因素的分析

本工作测定了正常人及与动脉粥样硬化(AS)有关疾病患者的胆固醇转移率(Rate of CholesterolTransfer, RCT)。证实患者的RCT均显著降低;高密度脂蛋白-胆固醇(HDL-ch)、季节、总胆固醇(TC)、甘油三酯(TG)、年龄、吸烟、遗传家族史、病种数对RCT有影响,无论正常人或病人HDL-ch与RCT呈正相关,支持HDL-ch与AS呈反相关的理论。     

慢性阻塞性肺部疾患缓解期患者血清氨基酸及微量元素分析

对２８例ＣＯＰＤ缓解期男性患者的血后分析发现，患者血清氨基酸含量与正常参考值比较无明显差别，支链氨基酸与芳香氨基酸比值也未见异常。血清微量元素含量，除锌、铬显著低于正常外（Ｐ＜０．０５），铁、铜、硒等元素的含量仍在正常范围内。     

正常人与高血脂,陈旧性心肌梗塞患者胆固醇转移率的比较

高密度脂蛋白(HDL)将胆固醇酯(CE)转运给极低密度脂蛋白(VLDL),是HDL处理CE的一个重要途经。Hsia等提出:胆固醇转移率(rate of cholesterol transfer)是在100ml血清中,每小时HDL将CE转移给VLDL的毫克数(mg)。本工作测定了正常人、高血脂和陈旧性心肌梗塞患者的RCT及其他血脂,     

己酮可可碱治疗尿毒症患者难治性贫血的研究

目的检验己酮可可碱可能改进肾衰竭患者对重组人促红素的反应。方法13例肾功能衰竭患者合并对重组人促红素抵抗性贫血入选。入选标准为治疗前每周注射促红素剂量≥12000IU/w满6个月而血红蛋白<10.7g/dl。患者服用己酮可可碱400mg,1次/d,连续使用12w。结果13例患者治疗前平均血红蛋白浓度为(8.6±1.2)g/dl,12w后己酮可可碱治疗后,平均血红蛋白浓度上升至(10.7±1.3)g/dl(=0.000)。结论己酮可可碱能显著地提高肾功能衰竭合并对重组人促红素抵抗性贫血患者的血红蛋白浓度。     

慢性阻塞性肺部疾患时组胺及溶酶体酶的变化

本文测定了慢性阻塞性肺部疾患(COPD)患者及动物组胺及溶酶体酶的变化。结果表明,COPD者痰液中组胺含量明显增高,并与病情间有一定关系;SO_2吸入所致大鼠慢性支气管炎时,肺组胺含量明显增高,哮喘患者在疾病的急性发作期,血浆中组胺含量及β-葡萄糖醛酸酶(β-g)活性均明显增高,肺气肿者血浆β-g仅有轻度增高,而血浆组胺无显明变化。讨论了组胺及溶酶体酶在COPD发病中的意义。     

高通量血液透析与常规血液透析治疗后 慢性尿毒症患者的指标分析

目的 探讨高通量血液透析与常规血液透析治疗慢性尿毒症患者的临床疗效。方法 选取2015年7月~2017年10月我院收治的慢性尿毒症患者55例为研究对象,按数字随机分为观察组27例和对照组28例,对照组给予常规血液透析,观察组给予高通量血液透析,对比两组治疗后β2-MG、Cer、Urea、KT/V各指标变化。结果 两组透析后β2-MG指标变化低于透析前,差异有统计学意义（P＜0.05）,观察组透析后β2-MG指标变化优于对照组,差异有统计学意义（P＜0.05）,两组透析前后各项指标均下降,差异有统计学意义（P＜0.05）,观察组透析后各项指标变化和对照组对比,差异无统计学意义（P＞0.05）,两组透析前后Cer、Urea等指标变化低于透析前,差异有统计学意义（P＜0.05）,观察组透析后Cer、Urea和KT/V等指标和对照组对比,差异无统计学意义（P＞0.05）。结论 将高通量透析用于慢性尿毒症患者的治疗中可以维持患者电解质平衡,促进患者身体恢复,改善患者症状。     

超氧化物歧化酶在某些慢性肾疾患时的变化

超氧化物歧化酶在某些慢性肾疾患时的变化解放军三Ｏ九医院（北京１０００９１）张林，齐子荣，孙玲，石海滨，周伟超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，ＳＯＤ）是人体内一种重要的氧自由基清除剂，它在人体防御机制中具有重要作用。在正常情况下，...     

慢性肾功能衰竭尿毒症126例临床分析

目的：分析慢性肾功能衰竭尿毒症(CRF)患者的危险因素及治疗方案。方法选取我院2013年4月~2014年4月收治的126例CRF患者(观察组),同时选取同期的68例健康人群(对照组),对比两组患者年龄、性别、职业及高血压、糖尿病史情况,并总结观察组患者治疗方法。结果两组患者年龄、性别、受教育程度差异无统计学意义(P>0.05),但观察组患者职业以农民、工人、离休干部居多,且观察组患者糖尿病、泌尿系结石、高血压病史率高于对照组(P<0.05)。结论农民、工人、离休干部等职业以及糖尿病、泌尿系结石、高血压疾病是CRF的重要危险因素,而血液透析等治疗技术介入可显著延长CRF患者生存时间,改善患者生存质量。     

先天性肾发育不良、多囊肾—慢性肾功能衰竭1例报告

病例 :付某、男 ,6个月 ,咳嗽 2 0天 ,加剧伴气促 2天入院。 2 0天前受凉后咳嗽。流涕伴低热 ,自服阿莫西林等未见好转 ,近 2天咳嗽加剧。烦躁不安 ,气喘 ,有时有点头状呼吸。起病以来一直厌食 ,精神萎靡、但无呕吐、两便无殊。既往出生 2个月时因反复吐乳 ,住我院外科 ,排除幽门梗阻后给对症处理后好转出院。 5个月时因贫血 ,营养不良一直在当地县医院求诊 ,疗效不佳。体检 :Ｔ 36 .9℃ ,Ｐ130 /分 ,Ｒ5 6 /分。发育差 ,气促鼻扇。明显三凹征 ,心音尚强 ,律齐 ,双肺呼吸音粗 ,有少量湿性罗音及哮呜音 ,腹软 ,肝在季肋下 1.5ｃｍ ,质软边薄 …     

来适可对高脂血症患者小而密低密度脂蛋白胆固醇的影响

观察来适可对高脂血症患者血清小而密低密度脂蛋白胆固醇(small,dense low-density lipoprotein cholesterol,sdLDL-C)的影响.以40例高脂血症患者为治疗组,20名正常健康人为正常对照组.治疗组病人每日晚口服40mg来适可,共服4周.服药前后常规测定血脂和sdLDL-C的含...     

银杏叶片与达美康治疗2型糖尿病时血液流变性与血脂的变化

目的 :探讨银杏叶片 (GinkgobilobaL .ExtractsTablets ,GbE)对2型糖尿病患者血脂 (TC、TG)水平及血液流变性的影响及其机理。方法 :82例 2型糖尿病患者随机分为对照组 ( 4 0例 ) ,口服达美康 ,每次 80mg,2次 /天 ;治疗组 ( 4 2例 ) ,在对照组用药的基础上加用银杏叶片口服 ,2片 /次 ,3次 /天 ;两组均连续用药一月。分别观察各组治疗前后FBG、TC、TG、FIB、动脉舒张压 (DBP)以及血液流变性指标的变化。结果 :治疗结束时治疗组TC、TG、FBG、FIB、ηb、ηp、EAI、TK、ESR、DBP等指标有显著性改善 (P <0 .0 5～ 0 .0 1) ;而对照组只有全血粘度高切值、ESR、TG、FBG、DBP等有改善 (P <0 .0 5 ) ,两组比较除FBG、DBP外 ,其他指标均有显著性差异 (P <0 .0 5～ 0 .0 1)。结论 :达美康加用银杏叶片治疗 2型糖尿病能改善血液流变性和微循环 ,预防血管性并发症 ,比单用达美康效果要好     

血清小而密低密度脂蛋白胆固醇检测对预测脑梗死患者预后评估的价值

目的 探究血清小而密低密度脂蛋白胆固醇检测对预测脑梗死患者预后评估的价值。方法 将我院收治的30例脑梗死患者作为研究对象,分别对其进行血清小而密低密度脂蛋白胆固醇（sdLDL-C）、高密度脂蛋白胆固醇（HDL-C）以及低密度脂蛋白胆固醇（LDL-C）的检测,根据患者治疗后情况将其分为预后良好组（n=13）和预后不良组（n=17）,比较两组各血清指标,并使用Logistic多元回归分析脑梗死患者预后影响因素。结果 预后良好组sdLDL-C、LDL-C低于预后不良组,HDL-C高于预后不良组,差异均有统计学意义（P＜0.05）。Logistic多因素回归分析表明,sdLDL-C是脑梗死患者预后的高危因素。结论 脑梗死患者进行血清小而密低密度脂蛋白胆固醇的检测,有利于疾病的病因分析及预后评估。     

Serum Cholesterol Concentrations and Mood States in Violent Psychiatric Patients: An Experience Sampling Study

The well-documented negative association between serum cholesterol and aggressive behavior has led Kaplan to propose a cholesterol–serotonin hypothesis of aggression. According to this hypothesis, low dietary cholesterol intake leads to depressed central serotonergic activity, which itself has been reported in numerous studies of violent individuals. In the present study, 25 violent psychiatric patients participated in a microbehavioral experience sampling procedure to examine differences in self-reports of affective and cognitive experiences as a function of serum cholesterol concentrations. For 7 days, they wore signaling devices that emitted an average of seven signals a day. Following each signal, patients filled out a mood questionnaire. Total serum cholesterol (TSC) concentration was positively associated with measures of affect, cognitive efficiency, activation, and sociability, suggesting a link between low TSC and dysphoria. These findings are consistent with the cholesterol–serotonin hypothesis and with the substantive literature linking both aggression and depression to depressed central serotonergic activity.     

冠心病患者血清小而密低密度脂蛋白胆固醇与同型半胱氨酸、D-二聚体含量分析

目的 研究冠心病(CHD)患者血清小而密低密度脂蛋白胆固醇(sdLDL-C)与同型半胱氨酸(Hcy)、D-二聚体(D-dimer)含量,探讨其在CHD中的应用价值.方法 CHD患者125例,其中稳定性心绞痛(SAP组)42例,不稳定性心绞痛(UAP组)45例,急性心肌梗死(AMI组)38例.同期体检健康人群(对照组)45例.平行检测各组及CHD组中不同分支病变病人血清sd LDL-C、Hcy、D-dimer含量.结果 对照组、SAP组、UAP组、AMI组血清sd LDL-C、Hcy、D-dimer含量依次增高,各组间差异具有统计学意义(P均＜0.01).CHD患者血清sd LDL-C、Hcy、D-dimer含量呈正相关(r=0.647,0.542,0.736,P均＜0.01).CHD患者冠状动脉3支病变与2支病变组血清sdLDL-C、Hcy、D-dimer含量均高于1支病变组(P均＜0.01).血清sd LDL-C、Hcy、D-dimer含量与CHD患者病变支数均呈正相关(r=0.547,0.631,0.482,P均＜0.01).结论 对CHD患者行血清sd LDL-C、Hcy、D-dimer含量检测有助于早期诊断、临床分型及临床合理用药.     

Cholesterol ester transfer protein,apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease in the Turkish population

The aim of this study was to compare patients with coronary artery disease (CAD) to healthy objects, in order to explore a possible association between CAD and the variants in the gene encoding cholesterol ester transfer protein (CETP), apolipoprotein E (Apo E) and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene polymorphisms and serum lipids were investigated in 173 patients with CAD and 111 healthy controls. The frequency of Apo epsilon4 (p < 0.05) and CETP M1 (p < 0.01) alleles were higher in the CAD group than in the control group. In the CAD group, those with the Msp M1 allele had higher levels of total cholesterol (TC) (p = 0026) and low-density lipoprotein cholesterol (LDL-C) than those with the Msp M2 allele. Subjects with an epsilon2 allele had the lowest levels of TC and LDL-C, while subjects with the epsilon4 allele had the highest. In the control group, CETP, the Msp M2 allele was associated with a higher level of high-density lipoprotein cholesterol (HDL-C) (p = 0.012) than the Msp M1 allele. The distributions of LPL genotype and allele did not differ between the CAD and control groups. The present study demonstrates that the CETP Msp1 and Apo E gene polymorphisms are associated with variations in lipids in patients with CAD and healthy controls in Turkish population.     

Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis

Blood of normal rabbits and of rabbits on an atherogenic high-cholesterol diet was incubated with sodium acetate-2-[¹⁴C]. After incubation, cholesterol and its precursors (squalene and lanosterol) were found and identified in the unsaponified fractions of leukocytes and platelets. Both in normal rabbits and in rabbits with atherosclerosis the highest specific activity in the leukocytes was found in cholesterol, followed by lanosterol and squalene; in the platelets the label accumulated mainly in lanosterol.A. V. Palladin Institute of Biochemistry, Academy of Sciences of the Ukrainian SSR. Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Gorev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 12, pp. 689–691, December, 1978.     

尿毒症患者血液透析前后的甲襞微循环

观察１８例慢性肾功能不全尿毒症终末期患者甲襞微循环的改变及其中１１例用血液透析治疗的患者第一次血透前与血透４～８次（平均５．９次）后甲襞微循环的变化，结果表明，尿毒症患者甲襞微循环加权积分综合判断，中度异常者占８３．３％，重度异常者占１６．７％。其中１１例作血透的患者在治疗前与治疗后总积分值分别为６．９０±０．７２与５．１０±０．７０，二者有非常显著差异。提示尿毒症患者甲襞微循环障碍经血透治疗后可有明显改善，但仍在中度异常范围。给尿毒症患者进行甲襞微循环检查，对其病情的估价有着一定的临床意义。