密闭舱内亚致死性爆炸伤大鼠脑组织及血浆内5-羟色胺的变化及对旷场行为的影响

目的:观察密闭舱内亚致死剂量爆炸伤大鼠血浆和额叶皮质内5-羟色胺(5-HT)的变化及其对大鼠旷场行为的影响。方法:采用在密闭舱内亚致死剂量爆炸伤的大鼠模型,高效液相色谱电化学法分析爆炸伤后不同时间点大鼠血浆和额叶皮质内5-HT浓度的变化,应用旷场行为观察箱观察大鼠旷场行为。结果:①舱内及舱外亚致死剂量爆炸伤大鼠血浆和脑组织内5-HT含量短暂升高后出现明显降低;②舱内爆炸伤后额叶皮质5-HT在48 h达峰值,随后下降,而舱外爆炸伤后在24 h即达峰值,随后下降;③亚致死剂量爆炸伤后大鼠旷场行为明显增加,且舱内明显高于舱外。结论:大鼠旷场行为变化与血浆5-HT浓度呈明显负相关。     

慢性应激模型大鼠脑内5-HT1A受体表达分析

目的 探讨慢性不可预见性轻度应激(CUMS)模型大鼠各脑区(海马、中缝核、前额叶及纹状体)5-HT1A受体表达及与旷场行为变化的关系;西酞普兰对5-HT1A受体表达的影响.方法 将24只雄性SD大鼠随机分为3组(n=8):A组为对照组;B组为CUMS应激组;C组为CUMS应激+西酞普兰用药组(每天腹腔注射西酞普兰水溶液2 ml,10mg/kg).实验为期6周,通过旷场试验评价大鼠行为,6周后处死大鼠获取脑组织,采用Real-Time PCR检测各脑区5-HT1A mRNA表达水平,并分析其与矿场行为的相关性.结果 B组海马5-HT1A mRNA表达较A组有增高趋势(P=0.05),其余各脑区5-HT1A mRNA表达均差异无统计学意义(P＞0.05).海马5-HT1AmRNA表达大鼠移动次数、转身次数呈正相关,与总不动时间呈负相关;中缝核、纹状体5-HT1A mR-NA表达与中心移动距离呈正相关,纹状体5-HT1A mRNA表达与中心停留时间呈正相关(P均＜0.05).结论 慢性应激可能会引起海马5-HT1A受体表达增高;抗抑郁剂西酞普兰对5-HT1A受体表达无影响.5-HT1A mRNA表达与旷场行为变化有相关性.     

帕罗西汀对束缚应激与额叶皮质相关性的影响研究

目的：观察束缚应激对大鼠额叶皮质的影响,探讨帕罗西汀在防治束缚应激引起焦虑的作用机制。方法：复制大鼠束缚应激模型,分为束缚应激组、治疗组和保护组,另设对照组（不束缚应激）,每组均n=10。观察大鼠行为学改变、额叶皮质c-fos基因表达、5-羟色胺（5-HT）和血浆皮质酮含量的变化,观察帕罗西汀干预的影响。结果：与对照组比较,束缚应激组大鼠额叶皮质的c-fos表达显著增加,5-HT表达明显减少,血浆皮质酮含量明显升高;与束缚应激组比较,治疗组和保护组血浆皮质酮含量和额叶皮质c-fos表达明显减少,5-HT表达明显增加。结论：额叶皮质参与了束缚应激反应;帕罗西汀抑制额叶皮质的c-fos基因表达、减少血浆皮质酮含量和增加额叶皮质5-HT含量可能是其抗焦虑作用机制之一。     

不同强度脑电场刺激对抑郁大鼠额叶单胺类递质含量的影响

目的:探讨不同强度脑电场刺激对抑郁大鼠额叶单胺类递质含量的影响。方法:建立Wistar大鼠抑郁症模型;分别在模型大鼠双侧颅骨大脑额叶区放置刺激电极(国家发明专利号ZL01103273.1)并固定,应用脑电场刺激仪给予不同强度脑电场刺激,刺激频率30Hz,刺激波形为正弦波,刺激持续时间1h。应用荧光分光光度法分别测定大鼠额叶脑组织内5羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)含量。结果:与正常对照组比,模型对照组大鼠5-HT及NE明显下降(分别P<0.001),治疗对照组单胺类递质无明显变化(分别P>0.05)。低强度治疗组治疗1h后,DA、5-HT及NE含量均无明显改变(分别P>0.05),中等强度治疗组及高强度模型治疗组大鼠额叶脑组织内5-HT及NE含量出现显著增高(分别P<0.05,P<0.01)。结论:一定强度的脑电场刺激可显著提高额叶内单胺类递质的含量,对抑郁症可能提示具有治疗作用。     

丹参多酚酸对慢性应激抑郁大鼠脑内细胞因子和糖皮质激素系统的影响

目的明确抑郁大鼠海马及前额叶皮质细胞因子和糖皮质激素系统的变化,探讨丹参多酚酸的干预作用及其机制。方法 38只雄性大鼠随机分为空白对照组(n=8)、应激对照组(n=7)、应激氟西汀组(n=8)、应激丹酚酸组(n=7)和应激联合组(n=8)等5组。除空白对照组外,其余4组采用慢性温和应激方法造模,持续6周,第4周起按照分组进行药物治疗,持续3周。第6周末时取大鼠前额叶皮质和海马,采用多因子检测方法检测细胞因子白介素1β(interleukin-1β,IL-1β)、白介素2(interleukin-2,IL-2)、干扰素γ(interferon-γ,IFN-γ)和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及皮质酮水平,采用RT-PCR和western blot方法检测糖皮质激素受体(glucocorticoid receptor,GR)基因核受体亚家族3C组成员1 (nuclear receptor subfamily 3, group C,member 1,Nr3c1)和FK506结合蛋白(FK506 binding protein, Fkbp5)mRNA及其蛋白表达水平。结果应激对照组前额叶皮质IL-1β和TNF-α、海马IFN-γ和TNF-α及前额叶皮质和海马皮质酮水平高于空白对照组、应激氟西汀组、应激丹酚酸组和应激联合组(P0.05)。所有大鼠前额叶皮质IL-1β与皮质酮水平呈正相关(r=0.34,P=0.04),海马TNF-α与皮质酮水平呈正相关(r=0.39,P=0.02)。应激对照组前额叶皮质Fkbp5 mRNA表达量较其他4组均升高(P0.01),海马Fkbp5 mRNA、前额叶皮质和海马FKBP5蛋白、前额叶皮质和海马Nr3c1 mRNA及GR蛋白表达水平的组间差异均无统计学意义(P0.05)。结论慢性应激大鼠前额叶皮质和海马促炎细胞因子和皮质酮水平、前额叶皮质Nr3c1和Fkbp5 mRNA表达水平增加,细胞因子与皮质酮水平呈正相关。丹参多酚酸和抗抑郁药物氟西汀可逆转这一变化。     

丹参多酚酸对慢性应激抑郁大鼠脑内细胞因子和糖皮质激素系统的影响北大核心CSCD

目的明确抑郁大鼠海马及前额叶皮质细胞因子和糖皮质激素系统的变化,探讨丹参多酚酸的干预作用及其机制。方法 38只雄性大鼠随机分为空白对照组(n=8)、应激对照组(n=7)、应激氟西汀组(n=8)、应激丹酚酸组(n=7)和应激联合组(n=8)等5组。除空白对照组外,其余4组采用慢性温和应激方法造模,持续6周,第4周起按照分组进行药物治疗,持续3周。第6周末时取大鼠前额叶皮质和海马,采用多因子检测方法检测细胞因子白介素1β(interleukin-1β,IL-1β)、白介素2(interleukin-2,IL-2)、干扰素γ(interferon-γ,IFN-γ)和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及皮质酮水平,采用RT-PCR和western blot方法检测糖皮质激素受体(glucocorticoid receptor,GR)基因核受体亚家族3C组成员1 (nuclear receptor subfamily 3, group C,member 1,Nr3c1)和FK506结合蛋白(FK506 binding protein, Fkbp5)mRNA及其蛋白表达水平。结果应激对照组前额叶皮质IL-1β和TNF-α、海马IFN-γ和TNF-α及前额叶皮质和海马皮质酮水平高于空白对照组、应激氟西汀组、应激丹酚酸组和应激联合组(P<0.05)。所有大鼠前额叶皮质IL-1β与皮质酮水平呈正相关(r=0.34,P=0.04),海马TNF-α与皮质酮水平呈正相关(r=0.39,P=0.02)。应激对照组前额叶皮质Fkbp5 mRNA表达量较其他4组均升高(P<0.01),海马Fkbp5 mRNA、前额叶皮质和海马FKBP5蛋白、前额叶皮质和海马Nr3c1 mRNA及GR蛋白表达水平的组间差异均无统计学意义(P>0.05)。结论慢性应激大鼠前额叶皮质和海马促炎细胞因子和皮质酮水平、前额叶皮质Nr3c1和Fkbp5 mRNA表达水平增加,细胞因子与皮质酮水平呈正相关。丹参多酚酸和抗抑郁药物氟西汀可逆转这一变化。     

杏仁核亚核群毁损对PCP模型大鼠行为和递质的影响

目的探讨杏仁核亚核群毁损后五氯苯酚(pentachlorophenol,PCP)模型大鼠行为和前额叶单胺类递质含量的变化,为立体定向技术治疗精神病提供参考。方法经腹腔注射PCP制作精神分裂症动物模型,立体定向电极毁损大鼠杏仁核,对其刻板行为进行评分,应用高效液相色谱分析系统检测前额叶多巴胺(DA)、5-羟色胺(5-HT)和去甲肾上腺素(NE)的含量。结果杏仁核内侧核群毁损能减轻PCP模型大鼠的刻板行为和社会行为,与假毁损组之间具有非常显著性差别(P<0.001)。毁损组前额叶DA含量低于假毁损组(P <0.05),5-HT和NE含量均高于假毁损组(P<0.05)。结论PCP模型大鼠前额叶DA含量增高,5-HT和NE含量下降。立体定向毁损杏仁核内侧核群能够改变前额叶单胺类递质的水平,改善模型大鼠精神分裂症症状。     

杏仁核毁损对甲基苯丙胺大鼠脑内5-HT2A受体的影响

目的探讨杏仁核毁损对甲基苯丙胺（MAP）大鼠脑内5-HT2A受体表达的影响。方法24只SD大鼠分为对照组、模型组、假手术组和手术组，每组各6只；采用腹腔注射MAP制备精神分裂症模型，立体定向毁损杏仁核，采用Sams-Dodd法评定各组动物刻板行为的变化，以PCR技术测定脑组织中5-HT2A受体mRNA的表达。结果杏仁核毁损可明显降低MAP大鼠刻板行为评分（P〈0．05）。各组大鼠额叶、颞叶皮质和中脑均有5-HT2A受体mNRA（61lbp）的阳性表达，且均以额叶皮质表达最为强烈；模型组及假手术组大鼠中脑5-HT2A受体mRNA受体表达的水平明显低于对照组和手术组（P〈0．05）。结论杏仁核毁损可改善MAP大鼠的刻板行为，这可能是通过中脑5-HT2A受体mRNA表达的增高而起作用。     

天舒胶囊对偏头痛大鼠血浆β内啡肽、五羟色胺含量及其脑组织c-fos表达的影响

目的研究天舒胶囊对偏头痛大鼠血浆β内啡肽(β-EP)、五羟色胺(5-HT)含量及其脑组织c-fos表达的影响。方法皮下注射硝酸甘油建立偏头痛大鼠模型,给予天舒胶囊高、中、低剂量灌胃(剂量为7.5g/kg、3.75g/kg和1.88g/kg),按治疗和预防两种方式给药。空白对照组和模型组予以相应剂量的生理盐水灌胃。采用放免法和高效液相色谱法分别测定大鼠静脉血中β-EP、5-HT含量;免疫组化染色观察中脑导水管周围灰质β-EP、5-HT和c-fos阳性表达。结果与模型组比较,天舒胶囊高剂量治疗和预防组、中剂量预防组血浆β-EP水平明显升高(均P<0.05),天舒胶囊高、中、低剂量治疗和预防组血浆5-HT水平明显降低(均P<0.05);天舒胶囊中剂量治疗和预防组中脑导水管周围灰质c-fos表达明显降低(均P<0.05),而β-EP、5-HT表达增高(均P<0.05)。结论天舒胶囊可改善偏头痛发作时血管活性物质和神经递质水平失常,从而改善偏头痛症状。     

大量饮酒及乙醇戒断后对大鼠脑内维生素C水平的影响

目的研究大量饮酒4 d及乙醇戒断后大鼠脑脊液中及各重要脑区内维生素C(VC)水平及钠依赖性VC转运体2(SVCT2)蛋白水平的变化。方法30只健康Wistar大鼠随机分为5组,对照组(A组)、大量饮酒4 d(B组)、大量饮酒4 d后戒断1 d(C组)、大量饮酒4 d后戒断2 d(D组)、大量饮酒4 d后戒断7 d(E组),每组6只。B、C、D、E组大鼠大量灌胃给予乙醇4 d,乙醇浓度为25%W/V,每8小时灌胃1次,连续4 d;A组给予等体积蒸馏水。采用Y迷宫实验评价大鼠的空间工作记忆能力;以高效液相-电化学法(HPLC-ECD)检测大鼠脑脊液及前额叶皮质、顶叶皮质、颞叶皮质、海马脑区内细胞内VC含量,免疫印迹法检测大鼠各脑区内SVCT2蛋白水平的变化。结果(1)Y迷宫实验:C、D组大鼠自发交替反应率分别为(24.64±15.11)%和(41.48±13.01)%,均显著低于A组[(75.47±8.61)%];E组大鼠的自发交替反应率恢复接近正常[(61.64±11.51)%],与A组差异无统计学意义(P>0.05)。(2)脑脊液内VC含量:B组大鼠脑脊液内VC含量为(204.54±25.51)μmol/L,显著高于A组[(145.57±18.98)μmol/L],而C、D组大鼠脑脊液内VC水平[分别为(90.24±15.45)、(86.93±14.53)μmol/L]明显低于A、B组,差异均有统计学意义(均P<0.001);E组大鼠脑脊液中VC含量[(135.80±17.16)μmol/L]与A组间差异无统计学意义(P>0.05)。(3)各脑区内VC水平:B组前额叶皮质、顶叶皮质、海马脑区脑组织匀浆(细胞内)VC水平变化趋势相同[分别为(1.18±0.13)、(1.14±0.12)、(1.20±0.20)μmol/g],均显著低于A组[分别为(1.64±0.11)、(1.62±0.13)、(2.06±0.27)μmol/g];C组在乙醇戒断后,前额叶皮质、顶叶皮质、海马脑区细胞内VC水平[分别为(1.20±0.29)、(1.05±0.06)、(1.21±0.15)μmol/g]有所恢复,但仍明显低于A组(均P<0.01);C组大鼠颞叶皮质细胞内VC水平[(1.37±0.04)μmol/g]显著高于顶叶皮质(P<0.05);D组各脑区细胞内VC水平均有回升趋势,前额叶皮质细胞内VC水平显著高于顶叶皮质[(1.63±0.24)μmol/g比(1.26±0.16)μmol/g,P<0.05];E组前额叶皮质、顶叶皮质、颞叶皮质、海马区细胞内VC水平[分别为(1.72±0.19)、(1.43±0.22)、(1.67±0.19)、(1.86±0.22)μmol/g]均较B组显著升高(均P<0.01),逐渐恢复至正常水平,海马区VC水平显著高于顶叶皮质(P<0.05)。(4)Western blot结果显示,与A组比较,B、C、D组大鼠前额叶皮质、顶叶皮质及C、D、E组大鼠海马区的SVCT2蛋白均显著升高(均P<0.05)。结论大量饮酒4 d可致大鼠脑损伤,乙醇干预后大鼠脑脊液中及各脑区脑组织匀浆中VC水平呈现负相关的变化过程,此过程中SVCT2蛋白表达上调,这将有助于脑脊液内的VC被转运至各脑区神经元内发挥抗氧化作用。     

The effect of age of onset of PD on risk of dementia

Background Dementia occurs in the majority of patients with Parkinson’s disease (PD). Late onset of PD has been reported to be associated with a higher risk for dementia. However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age. Methods Two community-based studies of PD in New York (n = 281) and Rogaland county, Norway (n = 227) and two population-based groups of healthy elderly from New York (n = 180) and Odense, Denmark (n = 2414) were followed prospectively for 3–4 years and assessed for dementia according to DSM-IIIR. All PD and control cases underwent neurological examination and were followed with neurological and neuropsychological assessments. We used Cox proportional hazards regression based on three different time scales to explore the effect of AAO of PD on risk of dementia, adjusting for age at baseline and other demographic and clinical variables. Findings In both PD groups and in the pooled analyses, there was a significant effect of age at baseline assessment on the time to develop dementia, but there was no effect of AAO independent of age itself. Consistent with these results, there was no increased relative effect of age on the time to develop dementia in PD cases compared with controls. Interpretation This study shows that it is the general effect of age, rather than AAO that is associated with incident dementia in subjects with PD. Received in revised form: 22 December 2005     

腺垂体功能减退症临床特征变化分析

目的探讨腺垂体功能减退症患者的病因结构变化及临床表现。方法回顾性分析我院2013-01—2016-12住院及门诊78例腺垂体功能减退症患者的临床资料。结果男32例(41.03%),女46例(58.97%);诊断时年龄11~89岁,平均62.5岁;鞍区占位(包括术前及术后)52例(66.67%),席汉综合征8例(10.26%),空泡蝶鞍9例(11.65%),病因不明8例(10.26%),垂体-下丘脑发育不良1例(1.28%)。首次就诊科室:纳差厌食、恶心呕吐就诊于消化内科36例(46.15%)最常见。ACTH+TSH+Gn+G激素缺乏为19例最多,占24.36%,ACTH+TSH+Gn缺乏15例,占19.23%。结论腺垂体功能减退症病因结构发生变化,发病人群、首发症状及受累激素也不同,患者女性多于男性,发病年龄偏高,症状不典型,分布于临床多个科室,其中以低钠血症为首发临床表现就诊消化内科最多。     

Standards of instrumentation of EMG

Standardization of Electromyography (EMG) instrumentation is of particular importance to ensure high quality recordings. This consensus report on “Standards of Instrumentation of EMG” is an update and extension of the earlier IFCN Guidelines published in 1999. First, a panel of experts in different fields from different geographical distributions was invited to submit a section on their particular interest and expertise. Then, the merged document was circulated for comments and edits until a consensus emerged.The first sections in this document cover technical aspects such as instrumentation, EMG hardware and software including amplifiers and filters, digital signal analysis and instrumentation settings. Other sections cover the topics such as temporary storage, trigger and delay line, averaging, electrode types, stimulation techniques for optimal and standardised EMG examinations, and the artefacts electromyographers may face and safety rules they should follow. Finally, storage of data and databases, report generators and external communication are summarized.     

Release of endogenous catecholamines from slices of hypothalamus of rats

The release of endogenous catecholamines from superfused slices of rat hypothalamus was studied under basal conditions and during release evoked by 40 mM K⁺. Catecholamines in superfusates, and in extracts of the tissue after stimulation, were isolated by column chromatography and quantitated by liquid chromatography with electrochemical detection. Norepinephrine (NE) was not consistently demonstrable in superfusate collected under basal conditions, but 40 mM K⁺ caused the release of from 2 to 4 ng/g of tissue per min. The addition of cocaine to the superfusate caused increases in basal and evoked release of NE. Epinephrine (E) could be measured in superfusates of slices from male but not female rats and then only when cocaine was added to the superfusate. Accordingly, the concentration of E in hypothalamus was greater in male rats than in female rats. Dopamine (DA) was not consistently measurable in the spontaneous overflow from slices either in the presence or absence of cocaine. K⁺-evoked release of DA could be demonstrated in slices from female rats. The addition of cocaine increased the evoked release of DA from slices from both sexes. Corticosterone, added to cocaine, had no effects on the efflux of any of the catecholamines. The experiments suggest that neuronal reuptake of all catecholamines is very efficient in the hypothalamus both under basal conditions and during evoked release.     

帕金森病运动症状进展分析

目的分析帕金森病(PD)患者运动症状进展特点。方法采用PD统一评分量表(UPDRS)Ⅲ对912例PD患者进行评估。结果与病程1年的患者比较,除病程1~2年的患者外,其他病程患者的UPDRSⅢ评分、强直分、姿势或步态异常分、轴性症状总分、言语分、步态分显著升高(均P0.05),病程5~6年及14年患者的震颤分,病程5~6年、7~8年、9~13年、14年患者的运动迟缓分、姿势分显著升高(P0.05~0.01)。轴性症状进展速度高于UPDRSⅢ评分。结论 PD患者病程早期UPDRSⅢ评分进展快,震颤症状进展独立于其他症状,轴性症状评分较UPDRSⅢ更敏感地反映疾病加重趋势。     

Effects of prevention of afferentation of the development of the chick optic lobe

BONDY, S. C., M. E. HARRINGTON AND C. L. ANDERSON. Effects of prevention of afferentation on the developmentof the chick optic lobe. BRAIN RES. BULL. 3(5) 411–413, 1978.—The effects of unilateral extirpation of the right optic cup of the three-day incubated chick embryo upon the rate of synthesis and the stability of DNA in the non-innervated optic lobe, have been studied. This surgical procedure prevents innervation of the optic lobe contralateral to the removed eye, while the other optic lobe is normally innervated by retinal ganglion cells of the remaining eye. At the 20th day of incubation, the DNA content of the non-innervated lobe was below that of the paired lobe receiving normal innervation. This deficiency of cell number was caused by two events; death of an excess number of neurons formed early in embryogenesis and a reduced rate of glial proliferation in the later stages of incubation.     

Frequency of accumulation of filaments in adaxonal cytoplasm of Schwann cells of myelinated fibers of rat spinal roots

Summary The frequency of accumulation of 6-nm filaments in the adaxonal cytoplasm of Schwann cells in the 6th lumbar dorsal and ventral roots was evaluated in 4-, 8-, 26- and 45-week-old Sprague-Dawley rats. The frequency was higher in 4- and 8-week-old (growing) rats than in 26- and 45-week old (mature) rats, and also higher in ventral than in dorsal roots in 4-, 8- and 26-week old rats. There were no clusters on certain groups of myelinated fibers according to the size of transverse axonal area, in both the ventral and dorsal roots. Therefore, this accumulation may reflect certain functions of the adaxonal cytoplasm of Schwann cell during natural growth and maturation of the axon and myelin sheath.     

《绵阳市社会心理服务工作管理办法》解读

2018年,国家卫生健康委员会等10部委联合发布《关于印发全国社会心理服务体系建设试点工作方案的通知》,四川省绵阳市被列为全国第一批试点地区。绵阳市人民政府依据《中华人民共和国精神卫生法》等相关法律法规和文件精神,结合前期调查研究和社会心理服务工作的试点实际,编制出台了《绵阳市社会心理服务工作管理办法》,并于2021年12月25日起施行。本文围绕社会心理服务的相关概念、办法总则、重点内容、保障措施等方面进行解读,以期为社会心理服务工作的规范、持续和有效开展提供参考。     

Function of circle of Willis

Nearly 400 years ago, Thomas Willis described the arterial ring at the base of the brain (the circle of Willis, CW) and recognized it as a compensatory system in the case of arterial occlusion. This theory is still accepted. We present several arguments that via negativa should discard the compensatory theory. (1) Current theory is anthropocentric; it ignores other species and their analog structures. (2) Arterial pathologies are diseases of old age, appearing after gene propagation. (3) According to the current theory, evolution has foresight. (4) Its commonness among animals indicates that it is probably a convergent evolutionary structure. (5) It was observed that communicating arteries are too small for effective blood flow, and (6) missing or hypoplastic in the majority of the population. We infer that CW, under physiologic conditions, serves as a passive pressure dissipating system; without considerable blood flow, pressure is transferred from the high to low pressure end, the latter being another arterial component of CW. Pressure gradient exists because pulse wave and blood flow arrive into the skull through different cerebral arteries asynchronously, due to arterial tree asymmetry. Therefore, CW and its communicating arteries protect cerebral artery and blood–brain barrier from hemodynamic stress.     

阿立哌唑对精神分裂症患者生活质量的影响

目的:比较阿立哌唑与利培酮对精神分裂症患者生活质量的影响。方法:60例精神分裂患者随机平分为两组各30例,分别给予阿立哌唑和利培酮治疗。疗程8周。用生活质量综合评定问卷-74(GQOLI-74)、阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效及不良反应。结果:阿立哌唑与利培酮均能显著提高精神分裂症患者生活质量,但阿立哌唑在改善GQOLI-74总分、躯体健康及社会功能维度优于利培酮。结论:阿立哌唑治疗有利于提高精神分裂症患者生活质量。