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1.
Pilot study of the optimal protocol of low dose step‐up follicle stimulating hormone therapy for infertile women
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Toshiya Matsuzaki Takeshi Iwasa Rie Yanagihara Mizuki Komasaka Kiyohito Yano Yiliyasi Mayila Ayaka Tachibana Yuri Yamamoto Takeshi Kato Akira Kuwahara Minoru Irahara 《Reproductive Medicine and Biology》2018,17(3):315-324
Purpose
To evaluate the optimized protocol of low dose follicle‐stimulating hormone (FSH) therapy that has a starting dose of 50 IU/62.5 IU with a small increment dose (12.5 IU) for women with World Health Organization (WHO) II ovulatory disorder and unexplained infertility.Methods
Anovulatory women with WHO group II ovulatory disorder (ovulation induction [OI] patients, n = 29), and with an unexplained infertility (ovarian stimulation [OS] patients, n = 21) were enrolled. The protocol of low dose step‐up FSH therapy was optimized for the starting dose as 50 IU (body mass index [BMI] < 20 group) and 62.5 IU (BMI ≥ 20 group) with the increment dose of 12.5 IU. Study outcomes were ovulation, monofollicular development and other variables.Results
In the OIpatients, the ovulation rate was 100% (BMI < 20 group) and 90.9% (BMI ≥ 20 group). Monofollicular development was 80.0% (BMI < 20) and 77.3% (BMI ≥ 20). The pregnancy rate was 60% (3/5 BMI < 20) and 18.2% (4/22 BMI ≥ 20). There was no multiple pregnancy. In the OSpatients, the ovulation rate was 100%. Monofollicular development was 85.7% (BMI < 20) and 76.6% (BMI ≥ 20). No pregnancy was achieved in the OSpatients.Conclusion
Optimized protocol of low dose FSH therapy setting a starting dose 50 IU/62.5 IU by BMI with an increment dose of 12.5 IU was safe and highly effective in WHO group II anovulatory patients. However, this protocol seemed uneffective for patients with unexplained infertility. 相似文献2.
Peter Takacs Mehdi Nassiri Keith Candiotti Jinfeng Yang Sujata Yavagal Carlos A. Medina 《Archives of gynecology and obstetrics》2010,282(4):389-394
Purpose
To compare fibulin-3 (FIB-3) and fibulin-5 (FIB-5) expressions in uterosacral ligaments (USL) of women with and without uterine prolapse. 相似文献3.
Yuji Taketani Eduardo Kelly Yasunori Yoshimura Hiroshi Hoshiai Minoru Irahara Hideki Mizunuma Hidekazu Saito Kazumichi Andoh Zourab Bebia Takumi Yanaihara 《Reproductive Medicine and Biology》2010,9(2):91-97
Purpose
To determine the optimal regimen of recombinant human follicle-stimulating hormone (r-hFSH) for ovulation induction (OI) in Japanese women with amenorrhea I or anovulatory infertility. 相似文献4.
Murat Ekin L. C. Kupelioglu L. Yasar K. Savan Z. Akcıg A. J. Ozcan 《Archives of gynecology and obstetrics》2009,280(6):971-974
Purpose
To investigate the coexistentence of anal incontinence (AI) in patients with urinary incontinence (UI). 相似文献5.
Birth plans—Impact on mode of delivery,obstetrical interventions,and birth experience satisfaction: A prospective cohort study
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Yalda Afshar MD PhD Jenny Y. Mei MD Kimberly D. Gregory MD MPH Sarah J. Kilpatrick MD PhD Tania F. Esakoff MD 《分娩》2018,45(1):43-49
Objective
To examine whether the presence of a birth plan was associated with mode of delivery, obstetrical interventions, and patient satisfaction.Methods
This was a prospective cohort study of singleton pregnancies greater than 34 weeks’ gestation powered to evaluate a difference in mode of delivery. Maternal characteristics, antenatal factors, neonatal characteristics, and patient satisfaction measures were compared between groups. Differences between groups were analyzed using chi‐squared for categorical variables, Fisher exact test for dichotomous variables, and Wilcoxon rank sum test for continuous or ordinal variables.Results
Three hundred women were recruited: 143 (48%) had a birth plan. There was no significant difference in the risk of cesarean delivery for women with a birth plan compared with those without a birth plan (21% vs 16%, adjusted odds ratio [adjOR] 1.11 [95% confidence interval (CI) 0.61‐2.04]). Women with a birth plan were 28% less likely to receive oxytocin (P < .01), 29% less likely to undergo artificial rupture of membranes (P < .01), and 31% less likely to have an epidural (P < .01). There was no difference in the length of labor (P = .12). Women with a birth plan were less satisfied (P < .01) and felt less in control (P < .01) of their birth experience than those without a birth plan.Conclusion
Women with and without a birth plan had similar odds of cesarean delivery. Though they had fewer obstetrical interventions, they were less satisfied with their birth experience, compared with women without birth plans. Further research is needed to understand how to improve childbirth‐related patient satisfaction. 相似文献6.
Roberto Matorras Jose Ignacio Pijoan Irantzu Perez-Ruiz Lucía Lainz Iker Malaina Sonia Borjaba 《Reproductive Medicine and Biology》2021,20(2):144-158
Background
The decision of whether frozen embryo transfer (FET) should be performed in the cycle immediately after OPU or at least one cycle later is controversial. FET could improve pregnancy rates in IVF; however, how much time is needed for the endometrium to return to optimal receptivity after ovarian stimulation is not known.Methods
Electronic search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials to identify studies providing data on the influence of the interval between embryo freezing (or OPU) and FET in FET cycles published between January 1, 2007, and February 1, 2020.Main findings
Data analyzed indicated that in the immediate FET cycles, there was a trend to an increased biochemical pregnancy rate (RR = 1.08; CI = 1.00-1.18), whereas the clinical pregnancy rate was somewhat higher, but without reaching statistical significance (RR = 1.07; CI = 0.99-1.15). The live birth rate was similar in the two groups (RR = 1.05; CI = 0.95-1.15), as was the implantation rate (RR = 0.98; CI = 0.83-1.16). Stratifying by embryo stage or FET type (freeze-all or FET after failed fresh transfer) showed no differences.Conclusion
Systematically delaying FET does not offer benefits to IVF outcomes. In addition, immediate transfer is associated with a nonsignificant trend to better clinical pregnancy rate and it also avoids the psychological effects of prolonging the stress on prospective parents.7.
Masako Kuroda Keiji Kuroda Ryohei Kuwatsuru Mari Kitade Iwaho Kikuchi Jun Kumakiri Shozo Matsuoka Satoru Takeda 《Reproductive Medicine and Biology》2012,11(2):95-100
Purpose
To evaluate preoperative magnetic resonance (MR) imaging features of bleeding and non-bleeding ectopic pregnancy (EP) by comparison with surgical findings. 相似文献8.
9.
Objective
To evaluate the association of periodontal disease (PD) in pregnancy with some adverse perinatal outcomes. 相似文献10.
Sharon Maslovitz Joseph B. Lessing Ariel Many 《Archives of gynecology and obstetrics》2010,281(3):473-477
Objective
To report complications associated with the use of trans-cervical Foley catheter with extra-amniotic saline infusion (EASI) for cervical ripening. 相似文献11.
David E. Reichman Joseph Politch Elizabeth S. Ginsburg Catherine Racowsky 《Journal of assisted reproduction and genetics》2010,27(7):347-356
Purpose
To investigate 24 h in vitro maturation (IVM) of cumulus-stripped immature oocytes from stimulated cycles. 相似文献12.
Byron Asimakopoulos Aggeliki Tiptiri-Kourpeti Chrysa Metallinou 《Reproductive Medicine and Biology》2021,20(3):361-367
Purpose
Progressive motility (PM) and vitality are positively associated with fertilization ability of spermatozoa. Here, the effects of IGF-I and NGFβ on PM and vitality of human spermatozoa were investigated.Methods
Forty-three volunteers gave semen samples after 2-3 days of sexual abstinence. Each sample was processed with density gradient centrifugation and sperm washing. The pellet was divided into 3 aliquots. An aliquot containing one million of progressively motile spermatozoa was incubated for an hour (37°C) in standard culture medium (control group), and two aliquots with the same number of progressively motile spermatozoa were incubated in medium supplemented with IGF-I or NGFβ. Two concentrations of IGF-I (100 ng/ml and 1000 ng/ml) and NGFβ (0,5 ng/ml and 5 ng/ml) were tested.Results
Both growth factors significantly increased PM and vitality in comparison with control either at the low or the high concentration. IGF-I seemed to be more effective than NGFβ. The effects did not seem to be dose dependent with the exception of the effect of IGF-I on vitality.Conclusions
The enhancement of PM and vitality of human spermatozoa by IGF-I and NGFβ opens new ways for the improvement of sperm processing. Further research is needed to determine the most effective concentrations.13.
Morphologically poor blastocysts could affect the implantation rate of a morphologically good blastocyst during a double‐blastocyst transfer for patients who have experienced repeated implantation failures
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Shirei Ohgi Yukino Taga Hisayo Anakubo Yuki Kurata Shota Hatakeyama Atsushi Yanaihara 《Reproductive Medicine and Biology》2018,17(3):249-254
Purpose
Increasing the number of transferred blastocysts sometimes is selected for patients with repeated implantation failure (RIF). To confirm this strategy, the pregnancy rates (PRs) were compared among the groups who had transferred either a single morphologically good blastocyst (MGB group), double blastocysts with both a MGB and a morphologically poor blastocyst (MGB + MPB group), or a double‐BT with 2 MGBs (two‐MGB group).Methods
This study was performed between April, 2009 and September, 2014, including 634 cycles for 354 patients with RIF. All the patients received cryopreserved blastocysts in either hormone replacement or natural ovulatory cycles. The included MGBs were at more than the Gardner grade 3BB stage. The PR and implantation rates (IRs) among the three groups were statistically evaluated by the chi‐square test. Statistical significance was set at P < .01.Results
Although the PRs were similar in these three groups, the IR in the MGB + MPB group was significantly lower than that of the MGB group. The rate in the two‐MGB group also was significantly lower than that of the MGB group.Conclusion
A double‐BT with a MGB and a MPB does not increase the pregnancy rate, compared with a single‐BT with a MGB among patients with RIF. 相似文献14.
Effect of inter‐twin delivery interval on umbilical artery pH and Apgar score in the second twin
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Alon Tal MD Hadar Peretz MD Gali Garmi MD Noah Zafran MD Shabtai Romano MD Raed Salim MD 《分娩》2018,45(1):37-42
Background
To examine the effect of inter‐twin delivery interval on umbilical artery pH and Apgar score of the second twin after vaginal delivery of the first twin.Methods
Retrospective study conducted at a single teaching hospital. All pregnant women with twin gestation who delivered the first twin vaginally at more than 24 weeks between 1995 and 2015 were included. Major malformations and intrauterine deaths of one or both twins were excluded. Women were divided into those who had an inter‐twin delivery interval of less than 30 minutes (group 1) or 30 minutes or more (group 2). Primary outcome was umbilical artery pH less than 7.1 and/or Apgar score less than 7 at 5 minutes of the second twin. Generalized linear regression with log was performed to evaluate the association with delivery interval.Results
Of 88 145 deliveries during this period, 1955 (2.2%) were twins. Overall, 713 twin pregnancies, 596 (83.6%) in group 1 and 117 (16.4%) in group 2, were eligible and included. Mean inter‐delivery interval was 11.0 ± 6.5 and 52.5 ± 31.5 minutes in groups 1 and 2, respectively. After adjusting for variables found significantly different between the groups in univariate analysis, inter‐delivery interval of less than 30 minutes or 30 minutes or more was not a significant risk factor for pH less than 7.1 and/or Apgar less than 7 (P = .91). The cesarean rate for delivery of the second twin after vaginal delivery of the first twin was 4.3% overall, with a higher rate among group 2 compared with group 1 (18.2% and 3.2%, respectively; P = .001).Conclusions
The second twin's Apgar score and cord artery pH are probably not affected when the inter‐twin delivery interval exceeds 30 minutes. 相似文献15.
Association of follicular fluid volume with membrane stretchability of human metaphase II oocytes following the gonadotropin‐releasing hormone agonist protocol during intracytoplasmic sperm injection
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Taketo Inoue Sayumi Taguchi Kayoko Hirao Yoshiko Tsujimoto Shuji Yamamoto Mikiko Uemura Kazunori Miyazaki Yoshiki Yamashita 《Reproductive Medicine and Biology》2018,17(3):283-288
Purpose
The authors previously revealed the association of the follicular fluid (FF) volume with oolemma stretchability following the gonadotropin‐releasing hormone (GnRH) antagonist protocol during intracytoplasmic sperm injection (ICSI). However, the impact of the GnRH agonist protocol on oolemma stretchability remains unclear.Methods
Data that were obtained from 74 ICSI cycles were reviewed retrospectively. Controlled ovarian stimulation was performed in accordance with the short GnRH agonist protocol. Each follicle was individually aspirated and assigned to one of six groups, according to the FF volume. The oolemma stretchability during ICSI was evaluated by using a mechanical stimulus for oolemma penetration; that is, oolemma penetration with or without aspiration (high vs low stretchability, respectively).Results
The incidence of low oolemma stretchability was significantly higher in the <1.0 mL group than that in the ≥1.0 mL group. The normal fertilization rate was significantly lower in the <1.0 mL group than that in the 2.0‐<3.0 mL group. The rate of blastocyst development was lower in the <1.0 mL group than that in the 3.0‐<4.0 mL group.Conclusion
The FF volume potentially was associated with metaphase II oolemma stretchability, fertilization, and blastocyst development. 相似文献16.
Jonah Musa Babafemi Taiwo Susan Goldsmith Sarah Sutton Baiba Berzins Robert L. Murphy 《Archives of gynecology and obstetrics》2011,283(2):343-348
Objective
To investigate epidemiological factors that predicts high-risk human papillomavirus (HR-HPV) types among women with atypical squamous cells of undetermined significance (ASCUS). 相似文献17.
Assisted reproductive technology in Japan: a summary report for 2015 by The Ethics Committee of The Japan Society of Obstetrics and Gynecology
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Hidekazu Saito Seung Chik Jwa Akira Kuwahara Kazuki Saito Tomonori Ishikawa Osamu Ishihara Koji Kugu Rintaro Sawa Kouji Banno Minoru Irahara 《Reproductive Medicine and Biology》2018,17(1):20-28
18.
Hiroyuki Tomari Ko Honjo Katsuko Kunitake Natsumi Aramaki Saori Kuhara Naomi Hidaka Kayoko Nishimura Yumi Nagata Toshitaka Horiuchi 《Reproductive Medicine and Biology》2018,17(3):268-274
Purpose
To investigate the relationship between the meiotic spindle size in human metaphase II oocytes and embryo developmental potential after intracytoplasmic sperm injection (ICSI).Methods
Analyzed were 1302 oocytes with a visible meiotic spindle from 281 patients aged under 40 years undergoing ICSI cycles. The meiotic spindle was imaged by using PolScope before ICSI. The oocytes were classified into three groups, according to spindle size: group A (<90 μm2), group B (90‐120 μm2), and group C (>120 μm2).Results
Overall, 389 (29.9%) oocytes were classified into group A, 662 (50.8%) into group B, and 251 (19.3%) into group C. The fertilization rate of the group B oocytes was significantly higher than for the A and C oocytes. The blastocyst formation rate in group B was significantly higher than in group A. In addition, the pregnancy rate in group B was significantly higher than in the other two groups.Conclusion
The oocytes with a spindle size of 90‐120 μm2 showed higher fertilization, blastocyst formation, and clinical pregnancy rates than those with larger or smaller spindles. The measurement of the meiotic spindle size thus has a positive predictive value for identifying human embryo developmental potential clinically. 相似文献19.
Liliam Cristine Rolo Luciano Marcondes Machado Nardozza Edward Araujo Júnior Paulo Martin Nowak Antonio Fernandes Moron 《Archives of gynecology and obstetrics》2010,281(2):235-240
Purpose
To establish normative data for amniotic fluid volume (AFV) between 7 and 10 + 6 weeks gestation using three-dimensional ultrasonography (3DUS). 相似文献20.