Myocardial perfusion imaging after coronary revascularization: a clinical appraisal

Revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), are performed in many patients with coronary artery disease. Despite the effectiveness of these procedures, different follow-up strategies need to be considered for the management of patients after revascularization. Stress myocardial perfusion single-photon emission computed tomography (MPS) is a suitable imaging method for the evaluation of patients who have undergone PCI or CABG, and it has been used in the follow-up of such patients. Radionuclide imaging is included in the follow-up strategies after PCI and CABG in patients with symptoms, but guidelines warn against routine testing of all asymptomatic patients after revascularization. After PCI, in the absence of symptoms, radionuclide imaging is recommended and indicated as appropriate after incomplete or suboptimal revascularization and in specific asymptomatic patient subsets. On the other hand, the value of MPS late after CABG in risk stratification has been demonstrated even in the absence of symptoms. Thus, given the adverse outcome associated with silent ischaemia, it can be speculated that all patients regardless of clinical status should undergo stress testing late after revascularization. Larger prospective studies are needed to assess whether stress MPS will have an impact on the outcome in asymptomatic patients after revascularization.     

Rest perfusion defects in patients with no history of myocardial infarction predict the presence of a critical coronary artery stenosis

BACKGROUND: The rest/stress sequence in myocardial perfusion single photon emission computed tomography (SPECT) (MPS) permits evaluation of rest images before stress testing, allowing the identification of unexpected perfusion defects (PDs). We sought to study the angiographic correlates of these resting PDs. METHODS AND RESULTS: This study comprised 139 consecutive patients with no history of myocardial infarction referred for MPS whose stress test was canceled because of the observation of unexpected resting PDs (rest group). Of these, 60 patients (43.2%) were referred for angiography after MPS (6.0 +/- 11.5 days). Angiographic referral rates and results were compared with those of a diagnostic population (n = 3565) who demonstrated stress-induced PDs (stress group) on rest/stress MPS. The mean age in the rest group was 73 +/- 12.5 years, and 73% were men. The frequency of referral for angiography was higher in the rest group (43.2% vs 19.8%, P <.0001). In addition, the rest group more frequently had significant coronary artery disease (CAD) (>/=70%) (95% vs 80%, P =.008) and critical CAD (>/=90%) (80% vs 66%, P =.038). CONCLUSION: The rest/stress sequence for MPS enables the identification of patients with unexpected resting PD, usually resulting from critical CAD, in whom unnecessary stress testing can be avoided.     

Use of myocardial perfusion imaging and estimation of associated radiation doses in Germany from 2005 to 2012

Purpose

For several years the Working Group Cardiovascular Nuclear Medicine of the German Society of Nuclear Medicine has been performing a regular survey to obtain information on technique, utilization and development of myocardial perfusion scintigraphy (MPS). Currently, data of six surveys from 2005 to 2012 are available. The aim of this paper is to deliver a general and comprehensive overview of all surveys documenting the course of patient doses over time and the development of the method.

Methods

A one-page questionnaire with number of MPS patients, number of stress and rest MPS, referral structure and several technical issues was sent to all centres performing MPS in Germany and evaluated. With the data on protocol utilization, effective MPS patient doses were estimated.

Results

MPS per million population (pmp) varied between 2,380 and 2,770. In 2012, MPS pmp showed a slight increase for the first time. From 2005 to 2009 the angiography to MPS ratio increased from 3.4 to 4.4, and the revascularization to MPS ratio decreased from 0.66 to 0.53. In 2012, both indices demonstrated an opposite trend for the first time (4.1 and 0.55). A total of 108 centres participated in all surveys. They showed an increase in MPS patients of 4.0 % over the reporting period. In 2012, more than 50 % of the centres experienced no change or an increase in MPS numbers. The leading single competitor was MRI, followed by angiography and stress echocardiography. ²⁰¹Tl studies have decreased since 2005 from 20 to 5 %. ^99mTc MPS studies showed a mild increase in 2-day protocols. In 2012, the average effective dose per patient was estimated at 7.4 mSv. Due to the decreasing use of ²⁰¹Tl, a mild decline over the observation period can be documented. Dynamic exercise stress was the most common stress test and adenosine the leading pharmacological stress agent, with a growing percentage. In 2012, the regadenoson percentage was 9 %. Gated single photon emission computed tomography (SPECT) noted an increasing acceptance with >70 % in 2012. The segmental scoring of perfusion studies had a low acceptance. Ambulatory care cardiologists represented the major referral group.

Conclusion

Germany has a moderate to moderate-high MPS utilization rate. Nevertheless, coronary artery disease (CAD) diagnosis and disease management are dominated by angiography. The survey data reveal a positive trend in MPS and a decrease in average patient dose reflecting good practice with guideline adherence, the implementation of technical improvements and success in training.     

2022年江苏省非医疗机构放射单位与人员辐射防护调查与分析

目的 了解江苏省非医疗机构职业放射性疾病的防治现状及发展趋势,掌握全省非医疗机构放射工作单位基本情况、放射性危害因素种类、放射工作人员职业卫生培训健康检查以及工作场所辐射水平等情况。方法 依据中国疾病预防控制中心辐射防护与核安全医学所制定的监测方案,对2022年度江苏省13个设区市和95个县(市、区)非医疗机构放射工作单位基本情况和职业健康管理等情况进行全覆盖的调查。调查主要通过发送调查表或根据其他监管部门相关信息进行交叉对比,同时与以往数据比对核实、现场检测、质量控制抽查等方式获得调查和监测结果,确认后在全国放射卫生信息平台进行数据填报。调查的主要内容包括放射工作人员数、个人剂量监测、培训情况、职业健康检查、个人防护用品等。结果 截至2022年底,江苏省非医疗机构放射工作单位共2 124家,非医疗机构放射工作人员26 478人,25 054人进行了个人剂量监测,监测率94.62%;24 305人近两年参加了放射防护培训,培训率91.79%;25 293人进行了放射工作人员职业健康检查,检查率95.52%;被检测的工作场所辐射水平均满足国家要求。结论 江苏省非医疗机构和放射工作人员数量较大且主要分布于苏南地区,对放射工作人员个人剂量监测、放射防护培训和职业健康检查覆盖率均超过90%,高于全国平均水平,但距离全覆盖仍有一定差距,后续应提高职业病防治监督和管理水平,无盲区监护非医疗机构放射工作人员的健康水平。     

Utility of stress myocardial perfusion imaging performed before electrophysiologic testing

BACKGROUND: Patients considered for electrophysiologic study (EPS) are often first referred for stress myocardial perfusion scintigraphy (MPS) to assess for inducible ischemia before testing. The purpose of this investigation was to determine the utility of this approach by examining the relationship between MPS and any interim cardiac catheterization and revascularization, as well as the results and safety of EPS. METHODS AND RESULTS: All patients undergoing EPS within 30 days after MPS at our institution between January 1997 and June 2000 were studied. Two hundred fifty-one patients met the inclusion criteria. The incidence of inducible sustained monomorphic ventricular tachycardia at EPS (IND) was 16%. One hundred twenty-nine patients had MPS ischemia (83 with high-risk features), but only twelve patients in all underwent revascularization between MPS and EPS. There were no ischemic complications during EPS. The presence of isolated ischemia on MPS was associated with a low rate of IND, not different from normal MPS findings (2%-3%). The combination of infarct and ischemia on MPS was associated with a high rate of IND that was similar to infarct alone (34% and 50%, respectively; P =.28). CONCLUSIONS: Patients with high-risk MPS results are more likely to undergo revascularization before EPS than patients with low-risk or normal MPS results. However, most patients with high-risk MPS results undergo EPS without interim revascularization, and no patient had an ischemia-related complication at EPS. Larger studies will be required to confirm this observation. MPS infarct, not ischemia, is associated with IND at EPS.     

Stressors and affective states among professional rugby union players

The purpose of the present study was to examine (a) the sources of sport and non-sport stress and their associated symptoms on rest days, training days, and match days and (b) the temporal aspects of sources and symptoms of stress and affective states. Professional male rugby union players ( n =16) completed the Daily Analysis of Life Demands in Athletes (DALDA) and the Activation Deactivation Adjective Check List (AD ACL) for 28 days. On match days players reported that few stressors were "worse than normal." Most stressors were "worse than normal" on training days followed by rest days and more stressors were "worse than normal" on the day after a match than on match days. Further, players reported an unpleasant, low activation state across the three analysis days, suggesting they were in an overtrained state. The findings of this study demonstrate that professional rugby players experience negative affect and a multitude of sport and non-sport stressors. Early detection of stressors and negative affective states could help prevent symptoms of overtraining and burnout and facilitate optimal training and sporting performance. Coaches and practitioners are encouraged to integrate the DALDA and AD ACL in their training and performance monitoring regimes.     

Practicing safe SPECT: Caffeine abstinence in nuclear myocardial perfusion imaging

Conclusions  The studies available, however, do suggest that there should be concerns about patients arriving for nuclear stress testing with high caffeine levels. Because of the interindividual variation in caffeine metabolism and the varied caffeine content of products, health care professionals cannot use “cups of coffee” as a reliable measure of how much caffeine a patient has consumed to predict serum levels. For now, we believe that nuclear laboratories should have clear instructions to patients about caffeine abstinence and periodic confirmation via random monitoring. Further research should be carried out in this area, with a carefully selected patient population. There is no current evidence that 1 cup of coffee will not alter patient testing and the final diagnosis of coronary disease. Caffeine abstinence for at least 24 hours remains the safest approach for all patients scheduled for nuclear MPI with either dipyridamole or adenosine. It is possible that there is less of an influence of caffeine with adenosine stress and the abstinence period could be reduced to 12 hours.     

<Superscript>99m</Superscript>Tc sestamibi myocardial perfusion scintigraphy with the novel use of metamizol for the detection of perfusion reversibility

PURPOSE: This study aims to investigate whether induction with metamizol, an analgesic-antipyretic drug having spasmolitic activity, could be used to increase the detectability of ischemic/jeopardized myocardium during MPS (myocardial perfusion scintigraphy). MATERIALS AND METHODS: Metamizol-enhanced rest MPS (45 min after administration of 1 g metamizol orally, 740 MBq (99m)Tc sestamibi was injected, MPS was acquired 45 min later) was performed in 21 patients who had perfusion defects on their previous stress-rest (99m)Tc sestamibi MPS. Blood pressure was monitored at 15-min intervals. Stress, rest, metamizol-rest MPS images were interpreted on the model of 20 segments using a visual uptake score (VUS; 0 = normal, 1 = mild, 2 = moderate, 3 = significant decreases, 4 = no uptake). (99m)Tc sestamibi uptake ratios (MIBI-UR; mean counts in the region of the perfusion defect/mean counts in the region of the normal-perfused wall) were obtained on each MPS and compared with each other. Average MIBI-UR in each scintigraphic examination was calculated. MPS were compared with coronary angiography results. RESULTS: VUS and MIBI-UR results showed that metamizol-rest MPS displayed the defect reversibility better than rest MPS. Of the 14 segments with fixed perfusion defects on stress-rest MPS, 8 showed improvement of perfusion after metamizol induction. In 33 segments, lesion reversibility was better delineated on metamizol-rest MPS. Metamizol-induced sestamibi uptake was significantly higher (p < 0.001) than stress/baseline rest examinations as calculated by the MIBI-UR. Blood pressure remained unaltered. Coronary angiography results were in concordance with metamizol induced MPS. CONCLUSIONS: Metamizol-enhanced rest MPS increases detectability of ischemic/viable myocardium during MPS. Metamizol should be discontinued like nitrates before stress MPS since it may mask the visualization of ischemic perfusion defects.     

Comparative use of radionuclide stress testing, coronary artery calcium scanning, and noninvasive coronary angiography for diagnostic and prognostic cardiac assessment

Noninvasive cardiac imaging has undergone a recent resurgence with the development of new approaches for imaging coronary atherosclerosis. Non-contrast computed tomography (CT) for imaging the extent of coronary artery calcification (CAC) and contrast CT for noninvasive coronary angiography (CTA) are developments with a growing evidence base regarding risk assessment and the diagnosis of obstructive coronary disease. This review discusses the role of CAC for risk assessment of asymptomatic individuals and for the use of coronary CTA in symptomatic patients. By comparison, gated myocardial perfusion scintigraphy (MPS) is a well-established noninvasive imaging modality that is a core element in evaluation of patients with stable chest pain syndromes. Stress MPS is the most commonly used stress imaging technique for patients with suspected or known coronary disease. In contrast to the nascent evidence noted with coronary CTA, MPS has a robust evidence base, including the support of numerous clinical guidelines. We highlight the current evidence supporting the diagnostic accuracy and risk stratification data for MPS for symptomatic patients with known or suspected coronary artery disease. It is likely that assessing the extent of atherosclerosis using CAC or coronary CTA will become an increasing part of mainstream cardiovascular imaging practices. In some patients, further ischemia testing with MPS will be required. Similarly, in some patients referred for MPS, anatomic definition of atherosclerosis using CAC by CT may be appropriate. Thus, this review also provides a synopsis of the available literature on imaging that integrates both CT and MPS in combined strategies for the assessment of atherosclerotic and obstructive coronary disease burden. We also propose possible risk-based strategies through which imaging might be used to identifying candidates for more intensive prevention and risk factor modification strategies as well as those who would benefit from referral to coronary angiography and revascularization.     

Exercise, amino acids, and aging in the control of human muscle protein synthesis

In this review, we discuss recent research in the field of human skeletal muscle protein metabolism characterizing the acute regulation of mammalian target of rapamycin complex (mTORC) 1 signaling and muscle protein synthesis (MPS) by exercise, amino acid nutrition, and aging. Resistance exercise performed in the fasted state stimulates mixed MPS within 1 h after exercise, which can remain elevated for 48 h. We demonstrate that the activation of mTORC1 signaling (and subsequently enhanced translation initiation) is required for the contraction-induced increase in MPS. In comparison, low-intensity blood flow restriction (BFR) exercise stimulates MPS and mTORC1 signaling to an extent similar to traditional, high-intensity resistance exercise. We also show that mTORC1 signaling is required for the essential amino acid (EAA)-induced increase in MPS. Ingestion of EAAs (or protein) shortly after resistance exercise enhances MPS and mTORC1 signaling compared with resistance exercise or EAAs alone. In older adults, the ability of the skeletal muscle to respond to anabolic stimuli is impaired. For example, in response to an acute bout of resistance exercise, older adults are less able to activate mTORC1 or increase MPS during the first 24 h of postexercise recovery. However, BFR exercise can overcome this impairment. Aging is not associated with a reduced response to EAAs provided the EAA content is sufficient. Therefore, we propose that exercise combined with EAA should be effective not only in improving muscle repair and growth in response to training in athletes, but that strategies such as EAA combined with resistance exercise (or BFR exercise) may be very useful as a countermeasure for sarcopenia and other clinical conditions associated with muscle wasting.     

Myocardial perfusion scintigraphy in Europe 2005

Purpose  We have conducted a survey of myocardial perfusion scintigraphy (MPS) in 2005 in Europe with the intention of initiating a regular series of surveys to track usage of the technique. Methods  Information was obtained from 234 centres in 18 counties. The returning centres served 27% of the population of their countries, and estimates of the numbers of MPS per million of population (pmp) were made assuming that the population not reported either performed no studies (lower estimate) or the same number pmp as the reporting centres (upper estimate). Results  Estimates of MPS for the countries surveyed ranged from a lower limit of 373 pmp to an upper limit of 1,388 pmp. There were marked variations between countries with higher numbers (lower limit of estimate above the mid range of all countries combined) in Austria, Greece, Hungary, the Netherlands, Sweden and Slovenia, and lower numbers (upper limit of estimate below the mid range of all countries) in Finland, Germany and Poland. The ratio of MPS to coronary angiography to revascularisation procedures was 0.6 to 1.5 to 1. The median number of studies per centre was 496, with 32% of centres performing fewer than 250 studies in the year. The median waiting time for routine studies was 21 days and for urgent studies 3.4 days. Fifty-three percent of studies used pharmacological stress, with roughly equal numbers of adenosine and dipyridamole. Eighty-two percent of studies used ^99mTc-based tracers. Tomographic acquisition was almost universal with 65% of studies being ECG-gated and 20% attenuation-corrected. Eighteen percent of studies were reported from hard copy alone, and 60% of studies were reported without viewing the rotating planar data. Conclusion  We conclude that relatively low numbers of MPS studies are being performed in the surveyed centres, particularly when compared with coronary angiography and revascularisation. The use of ^99mTc-based tracers is high, but ECG-gated studies are less common. Some reporting practices are not ideal. These data will serve as a valuable baseline for future surveys, which are likely to be more complete.     

A study into commanders' understanding of, and attitudes to, stress and stress-related problems

OBJECTIVES: To undertake a tri-Service questionnaire survey to examine the commanders' understanding of, and attitudes to, stress and stress-related problems. METHODS: A questionnaire was designed to elicit information on: Personal experience of stress and stress-related problems; Stress education; Pre-deployments briefings; and Post-incident stress debriefing. A total of 9,020 questionnaires were distributed between the three Services based on their proportional manning contribution to the Armed Forces as a whole. The population sampled ranged in rank from Corporal/Leading Rate up to, and including, Colonel/Captain RN/Group Captain (ranks below Leading Rate/ Corporal were excluded because of their lack of command experience). The overall response rate was 55.8%. The study was carried out between September and December 2001 (i.e. pre-OP TELIC). RESULTS: Chronic work-based stressors were seen as most stressful when compared with family and health stressors. Most respondents accepted that stress and stress-related problems exist, but were reluctant to disclose their own stress-related problems or seek help for fear that it might be detrimental both personally and professionally. There was found to be little support from peers or commanders. Little stress training was provided during recruit training, there were gaps in pre-deployment briefings and little in the way of post-deployment stress support. CONCLUSIONS: Some of the more negative findings could have implications in terms of seeking help for stress-related problems at an early stage, which is counter-productive to the military's genuine attempts to foster the psychological welfare of its employees. Some concerns could be alleviated by better and more timely stress education, preferably early on in a commander's career, so that positive attitudes to stress and stress-related problems can be formed and any negative attitudes changed, thereby bringing about a change in organisational culture in relation to stress. Some of the study's concerns were addressed by the Operational Health Strategic Surveillance Committee which advised on operational health aspects of OP TELIC.     

Use of atropine in patients with submaximal heart rate during exercise myocardial perfusion SPECT

BACKGROUND: Failure to reach 85% of maximal predicted heart rate (MPHR) during exercise may render a myocardial perfusion single photon emission computed tomography (MPS) study nondiagnostic for ischemia detection. Although commonly used to increase heart rate (HR) during dobutamine stress, the administration of atropine for patients failing to achieve 85% of MPHR during exercise performed for MPS is still infrequent. METHODS AND RESULTS: Patients undergoing dual-isotope MPS were considered candidates for the study when, during exercise treadmill testing, they had less than 85% of MPHR and were unable to continue because of fatigue, without an ischemic response. Forty-seven patients (aged 65.3 +/- 12.5 years, 78.7% men) received atropine (0.6-1.2 mg). Maximal HR achieved before and after atropine was 118.0 +/- 14.8 beats/min (76.3% +/- 6.2% of MPHR) and 146.4 +/- 12.6 beats/min (94.4% +/- 8.1% of MPHR), respectively (P < .001). Of patients, 44 (93.6%) reached at least 85% of MPHR after atropine and had diagnostic MPS studies. After atropine, arrhythmias occurred in 14 patients (29.8%) and other minor side effects in 1 (2.1%). CONCLUSIONS: Atropine allows patients initially failing to achieve 85% of MPHR during exercise to increase HR and have a diagnostic MPS study, without major complications. It may provide an alternative to pharmacologic stress for patients with a blunted HR response to exercise.     

Behavioral correlates of sympathoadrenal reactivity: the toughness model

Research with humans is reviewed showing that increased levels of urinary epinephrine (EPI) and norepinephrine (NE) from samples taken following mental challenge/stress situations are associated with better performance in those situations and with emotional stability. Another research tradition with humans and animals shows that various training protocols lead to increased peripheral and central catecholamine capacities. Those training protocols include continuous exposure to cold, periodic exposure to some intermittent stressors such as foot or tail shock (with intervening rest periods), or programs of aerobic exercise. While increasing catecholamine capacities, those procedures also result in lower base rates of the catecholamines and with the delay of pituitary-adrenal-cortical responses in challenge/stress contexts. That physiological pattern of "toughness" leads to improved performance in challenge/stress situations, increased tolerance of stressors (i.e., reduced behavioral suppression or depression), emotional stability, and immune system enhancement. The special conditions are discussed that are required for demonstrating increased catecholamine capacities rather than the attenuation of arousal associated with increased muscular and neuroendocrine efficiency. Finally, the role played by toughness in reducing anxiety while increasing energy in challenge/stress situations is discussed.     

民航飞行学员飞行训练应激源研究

目的确定我国民航飞行学员飞行训练的应激源。方法采用德尔菲法形成量表初步维度并在此基础上编制初测量表,从不同训练分院及国外训练归校的学员中采取分层随机取样;选取524名飞行学员进行测试,对所得数据进行分析形成正式问卷。对所获数据进行探索性因素分析和验证性因素分析,并分别检验量表的内部一致性系数、重测信度、内容效度与结构效度。结果训练环境、职业前景、飞行教员、座舱环境4个维度共解释了总变异的57.154%。量表总体的Cronbach’sα系数为0.830,各因子的Cronbach’sα系数为0.751~0.782,重测的相关系数均在0.806(P<0.01)以上。维度间的相关系数为0.134~0.438(P<0.05),各维度与总体的相关系数在0.617~0.748(P<0.01)。一阶4因素模型(GFI=0.929、IFI=0.989、TLI=0.986、CFI=0.989、RMSEA=0.013)拟合效果较好。结论民航飞行学员飞行训练应激源量表符合心理测量学标准,具有良好信效度,民航飞行学员飞行训练应激源主要来源于训练环境、职业前景、飞行教员、座舱环境。     

Mucopolysaccharidosis IVA (Morquio A syndrome) and VI (Maroteaux–Lamy syndrome): under-recognized and challenging to diagnose

Objective

Mucopolysaccharidosis IVA (MPS IVA, or Morquio A syndrome) and VI (MPS VI, or Maroteaux–Lamy syndrome) are autosomal recessive lysosomal storage disorders. Skeletal abnormalities are common initial presenting symptoms and, when recognized early, may facilitate timely diagnosis and intervention, leading to improved patient outcomes. Patients with slowly progressing disease and nonclassic phenotypes can be particularly challenging to diagnose. The objective was to describe the radiographic features of patients with a delayed diagnosis of MPS IVA or VI.

Materials and Methods

This was a retrospective study. The records of 5 MPS IVA and 3 MPS VI patients with delayed diagnosis were reviewed. Radiographs were evaluated by a radiologist with special expertise in skeletal dysplasias.

Results

An important common theme in these cases was the appearance of multiple epiphyseal dysplasia (MED) with epiphyseal changes seemingly confined to the capital (proximal) femoral epiphyses. Very few patients had the skeletal features of classical dysostosis multiplex.

Conclusions

Radiologists should appreciate the wide phenotypic variability of MPS IVA and VI. The cases presented here illustrate the importance of considering MPS in the differential diagnosis of certain skeletal dysplasias/disorders, including MED, some forms of spondylo-epiphyseal dysplasia (SED), and bilateral Perthes-like disease. It is important to combine radiographic findings with clinical information to facilitate early testing and accurate diagnosis.     

Evaluation of cardiac functions in patients with thalassemia major

It is known that a blood transfusion is necessary for survival in patients with thalassemia, but it may cause myocardial dysfunction due to myocardial siderosis as in other organs. The aim of this study was to evaluate myocardial perfusion by means of stress thallium scanning (MPS) and left ventricular functions by rest radionuclide ventriculography (RNV). Twenty-one patients at ages 9-16 (mean 12.1 +/- 3.2) who have been diagnosed with thalassemia for 4-15 years (mean 12.7 +/- 4.8) were included in the study. They had blood transfusions 78-318 times (mean 162.1 +/- 71). MPS and RNV was performed within two days after the any transfusion. MPS showed ischemia in 3 patients and normal perfusion in 18 patients. RNV revealed normal systolic parameters (wall motion, EF, PER, TPE) but diminished diastolic parameters (TPF, PFR) compared with normal values (p < 0.05). We conclude that ischemia or fixed defects may be seen in stress MPS as a result of cardiac involvement in patients with thalassemia. But, RNV is an important and preferable test for the early detection of subclinic cardiomyopathy. RNV may therefore show diastolic abnormalities before the systolic abnormalities show up.     

天津市35家非医疗机构放射卫生管理的现状分析

目的:了解天津市非医疗机构放射卫生管理的现状,为卫生行政部门加强放射卫生管理提供科学依据。方法:依据《市卫生健康委关于印发2020年天津市职业病防治项目实施方案的通知》,2020年8至10月期间采用问卷调查的方法,从监测对象所属行业类别、辐射源项的基本情况、职业健康管理工作的开展情况、个人防护用品和辅助防护设施的配置情...     

ST-segment depression during vasodilator stress is of minor clinical importance in women with normal myocardial perfusion imaging and low or intermediate risk of coronary artery disease

Purpose  

The prognostic value of electrocardiographic (ECG) ST-segment depression during vasodilator stress testing in patients with normal myocardial perfusion scintigraphy (MPS) is based on retrospective studies with controversial results. Moreover, the true incidence of obstructive coronary artery disease (CAD) in these patients is unknown.