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Josephine L.C. Anderson Stephan J.L. Bakker Uwe J.F. Tietge 《Journal of clinical lipidology》2021,15(2):301-310
BackgroundTransplant vasculopathy (TV) is a major contributing factor to chronic graft failure in renal transplant recipients (RTR). TV lesions resemble atherosclerosis in several ways, and it is plausible to believe that some risk factors influence both atherosclerotic plaque formation and formation of TV.ObjectiveThe objective of this prospective longitudinal study was to determine if dyslipidemia reflected by the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is prospectively associated with death censored chronic graft failure in RTR.Method454 prospectively included RTR with a functioning graft for at least one year, were followed for a median of 7 years. RTR were matched based on propensity scores to avoid potential confounding and subsequently the association of the TG/HDL-C ratio with the endpoint chronic graft failure, defined as return to dialysis or re-transplantation, was investigated.ResultsLinear regression analysis showed that concentration of insulin, male gender, BMI and number of antihypertensives predict the TG/HDL-C ratio. Cox regression showed that the TG/HDL-C ratio is associated with chronic graft failure (HR = 1.43, 95%CI = 1.12–1.84, p = 0.005) in competing risk analysis for mortality. Interaction testing indicated that the relationship of the TG/HDL-C ratio with graft failure is stronger in subjects with a higher insulin concentration.ConclusionOur results demonstrate that the TG/HDL-C ratio has the potential to act as a predictive clinical biomarker. Furthermore, there is a need for closer attention to lipid management in RTR in clinical practice with a focus on triglyceride metabolism. 相似文献
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Federica Bozzano Mariella Della Chiesa Andrea Pelosi Francesca Antonini Maria Libera Ascierto Genny Del Zotto Francesca Moretta Letizia Muccio Anna Luganini Giorgio Gribaudo Giovanni Cenderello Chiara Dentone Laura Nicolini Alessandro Moretta Lorenzo Moretta Andrea De Maria 《The Journal of allergy and clinical immunology》2021,147(6):2343-2357
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