共查询到20条相似文献,搜索用时 15 毫秒
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Qi Yan Erick Forno Esther Herrera-Luis Maria Pino-Yanes Ge Yang Sam Oh Edna Acosta-Pérez Donglei Hu Celeste Eng Scott Huntsman José R. Rodriguez-Santana Michelle M. Cloutier Glorisa Canino Esteban G. Burchard Wei Chen Juan C. Celedón 《The Journal of allergy and clinical immunology》2021,147(3):933-940
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Paola Nicoletti Daniel F. Carr Sarah Barrett Laurence McEvoy Peter S. Friedmann Neil H. Shear Matthew R. Nelson Anca M. Chiriac Natalia Blanca-López José A. Cornejo-García Francesco Gaeta Alla Nakonechna Maria J. Torres Cristiano Caruso Rocco L. Valluzzi Aris Floratos Yufeng Shen Rebecca K. Pavlos Munir Pirmohamed 《The Journal of allergy and clinical immunology》2021,147(5):1830-1837.e15
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Kelly Bruton Paul Spill Shabana Vohra Owen Baribeau Saba Manzoor Siyon Gadkar Malcolm Davidson Tina D. Walker Joshua F.E. Koenig Yosef Ellenbogen Alexandra Florescu Jianping Wen Derek K. Chu Susan Waserman Rodrigo Jiménez-Saiz Slava Epelman Clinton Robbins Manel Jordana 《The Journal of allergy and clinical immunology》2021,147(4):1381-1392
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Protein degraders are emerging as potent therapeutic tools to address neurological disorders and many complex diseases. It offered several key advantages, including the doses, drug resistance, and side effects over traditional occupancy-based inhibitors. Translation of chemical degraders into a clinical therapy for neurodegenerative disorders has a well-documented knowledge and resource gap. Researchers strive to develop clinical candidates employing chemical degraders' technologies, including hydrophobic tagging, molecular glues, proteolysis targeting chimeras (PROTACs), specific and nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent protein erasers (SNIPERs), autophagy targeted chimeras, and autophagosome-tethered compounds for targeted degradation of pathological markers in neurodegenerative disease. Herein, we examined the present state of chemical-mediated targeted protein degradation in the quest for medications to treat neurodegenerative diseases. We further identified targeted degraders under clinical development for neurodegenerative diseases summarizing pertinent discoveries guiding the future of degradation therapeutics. We also addressed the necessary pharmacological interventions needed to achieve unprecedented therapeutic efficacy and its associated challenges. 相似文献
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ZhengWang Sun Ji Hye Kim Seo Hyeong Kim Hye Ran Kim KeLun Zhang Youdong Pan Min Kyung Ko Bo Mi Kim Howard Chu Hee Ra Lee Hye Li Kim Ji Hyung Kim Xiujun Fu Young-Min Hyun Ki Na Yun Jin Young Kim Dong Won Lee Seung Yong Song Chang Ook Park 《The Journal of allergy and clinical immunology》2021,147(5):1764-1777
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Theo Crosson Jo-Chiao Wang Benjamin Doyle Hannah Merrison Mohammad Balood Alexandre Parrin Maud Pascal Barbara C. Mindt Corey R. Seehus Alp Ozcan Xuan Huang Elise Semenara Nicole Y.Y. Lai Abdelilah Majdoubi Raja-Elie E. Abdulnour Trevor Rajchgot Moutih Rafei Simmie L. Foster Sebastien Talbot 《The Journal of allergy and clinical immunology》2021,147(6):2330-2342
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Briana N. James Clement Oyeniran Jamie L. Sturgill Jason Newton Rebecca K. Martin Erhard Bieberich Cynthia Weigel Melissa A. Maczis Elisa N.D. Palladino Joseph C. Lownik John B. Trudeau Joan M. Cook-Mills Sally Wenzel Sheldon Milstien Sarah Spiegel 《The Journal of allergy and clinical immunology》2021,147(5):1936-1948.e9
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Pelin Sahlén Rapolas Spalinskas Samina Asad Kunal Das Mahapatra Pontus Höjer Anandashankar Anil Jesper Eisfeldt Ankit Srivastava Pernilla Nikamo Anaya Mukherjee Kyu-Han Kim Otto Bergman Mona Ståhle Enikö Sonkoly Andor Pivarcsi Carl-Fredrik Wahlgren Magnus Nordenskjöld Fulya Taylan Isabel Tapia-Páez 《The Journal of allergy and clinical immunology》2021,147(5):1742-1752
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Xingnan Li Stephanie A. Christenson Brian Modena Huashi Li William W. Busse Mario Castro Loren C. Denlinger Serpil C. Erzurum John V. Fahy Benjamin Gaston Annette T. Hastie Elliot Israel Nizar N. Jarjour Bruce D. Levy Wendy C. Moore Prescott G. Woodruff Naftali Kaminski Sally E. Wenzel Deborah A. Meyers 《The Journal of allergy and clinical immunology》2021,147(3):894-909
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《Journal of microbiology, immunology, and infection》2023,56(4):747-756
BackgroundMore and more novel anticancer drugs have been approved for patients with hematological malignancies in recent years, but HBV reactivation (HBV-R) data in this population is very scarce. This study aimed to evaluated HBV-R risk in patients with hematological malignancies receiving novel anticancer drugs.MethodsHBV markers and serum HBV DNA levels of patients with hematological malignancies receiving novel anticancer drugs in a tertiary cancer hospital were retrospectively collected. HBV-R risk in the whole cohort and subgroups was described. The relevant literature was reviewed to make a pooled analysis.ResultsOf 845 patients receiving novel anticancer drugs, 258 (30.5%) were considered at risk for HBV-R. The median duration of exposure to novel drugs was 5.6 (0.1–67.6) months. The incidence of HBV-R was 2.1% in patients with past HBV infection without prophylactic antiviral treatment (PAT) and 1.2% in all patients at risk of HBV-R. In a pooled analysis of 11 studies with 464 patients, the incidence of HBV-R was 2.4% (95% CI: 1.3–4.2) in all at-risk patients receiving novel anticancer drugs and 0.6% (95% CI: 0.03–3.5) in patients with anticancer drugs plus PAT. The incidence of death due to HBV-R was 0.4% (95% CI: 0.1–1.6) in all at-risk patients and 18.2% (95% CI: 3.2–47.7) in patients with HBV-R.ConclusionMost episodes of HBV-R are preventable, and most cases with HBV-R are manageable. We recommend that novel anticancer drugs should not be intentionally avoided when treating cancer patients with HBV infection. 相似文献