频域干涉光断层扫描观察正常人眼脉络膜厚度的研究

目的 应用频域干涉光断层扫描仪(spectral-domain optical coherence tomography,SDOCT)观测正常人眼脉络膜厚度,并观察其与年龄、性别的关系.方法 临床观察研究.对2010年6～12月在沈阳军区总医院眼科,无视网膜或脉络膜疾病的109人(109只眼)应用Cirrus HD-OCT行黄斑部扫描,测量黄斑中心凹下及由中心凹向鼻侧及颞侧每隔500μm直至2500μm的脉络膜厚度.并评估脉络膜厚度与年龄、眼别及性别的关系.结果 黄斑中心凹下脉络膜平均厚度为(298.13 ±44.56)μm,明显厚于其鼻、颞两侧部位(P＜0.01).由中心凹向鼻、颞两侧脉络膜厚度逐渐变薄,且距中心凹同等距离颞侧脉络膜厚度明显大于鼻侧脉络膜厚度(P＜0.01).中心凹下平均脉络膜厚度与性别、眼别无关,与年龄呈负相关(r =-0.48,P＜0.01).结论 脉络膜厚度与所处位置有关,与年龄呈负相关.     

慢性中心性浆液性脉络膜视网膜病变患者双眼脉络膜厚度频域光相干断层扫描检查分析

[目的]观察慢性中心性浆液性脉络膜视网膜病变(CSC)患者患眼和对侧健眼的黄斑部脉络膜厚度.[方法]连续的慢性CSC患者45例纳入研究.其中,男性36例,女性9例;单眼39例,双眼6例.平均年龄(46.18±8.20)岁;平均病程(16.34±7.23)个月.散瞳后前置镜眼底检查,荧光素眼底血管造影和吲哚青绿血管造影检查确诊,分为CSC患眼组(A组)、单眼CSC患者对侧健眼组(B组),分别为51、39只眼.选择同期年龄、性别、屈光度匹配的正常人50名50只眼作为正常对照组(C组).采用海德堡Spectralis频域光相干断层扫描(OCT)对所有受检者行加强深度扫描,测定中心凹下脉络膜厚度(SFCT)和距中心凹3 mm处鼻侧(NCT3mm)、颞侧(TCT3mm)、上方(SCT3mm)和下方脉络膜厚度(ICT3mm).[结果]A、B、C组平均SFCT值分别为(436.76±87.01)、(394.71±61.63)、(294.86±75.30)μm.A、B组平均SFCT值均较C组平均SFCT值明显增加,三组间平均SFCT值比较,差异有统计学意义(F=44.791,P＜0.00l).三组间NCT3mm (F=15.816)、TCT3mm(F=22.823)、SCT3mm(F=15.147)和ICT3mm(F=11.527)平均脉络膜厚度值比较,差异均有统计学意义(P＜0.001).单眼者患眼平均SFCT值为(416.34±79.44) μm,较对侧健眼明显增厚,差异有统计学意义(t=2.897,P=0.007).[结论]CSC患眼脉络膜厚度明显增加,对侧健眼脉络膜厚度亦较正常对照者明显增厚.     

Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

Purpose:

To measure the choroidal thickness (CT) after dynamic exercise by using enhanced depth imaging optical coherence tomography (EDI-OCT).

Materials and Methods:

A total of 19 healthy participants performed 10 min of low-impact, moderate-intensity exercise (i.e., riding a bicycle ergometer) and were examined with EDI-OCT. Each participant was scanned before exercise and afterward at 5 min and 15 min. CT measurement was taken at the fovea and 1000 μ away from the fovea in the nasal, temporal, superior, and inferior regions. Retinal thickness, intraocular pressure, ocular perfusion pressure (OPP), heart rate, and mean blood pressure (mBP) were also measured.

Results:

A significant increase occurred in OPP and mBP at 5 min and 15 min following exercise (P ˂ 0.05). The mean subfoveal CT at baseline was 344.00 ± 64.71 μm compared to 370.63 ± 66.87 μm at 5 min and 345.31 ± 63.58 μm at 15 min after exercise. CT measurements at all locations significantly increased at 5 min following exercise compared to the baseline (P ˂ 0.001), while measurements at 15 min following exercise did not significant differ compared to the baseline (P ˃ 0.05). There was no significant difference in retinal thickness at any location before and at 5 min and 15 min following exercise (P ˃ 0.05).

Conclusion:

Findings revealed that dynamic exercise causes a significant increase in CT for at least 5 min following exercise.     

频域相干光断层扫描对糖尿病黄斑区厚度的应用研究

目的 利用频域相干光断层扫描(OCT)测量并分析糖尿病( DM)患者的黄斑区视网膜厚度.方法 DM组90例(90只眼),并分为分无糖尿病视网膜病变(NDR) 、非增殖期(NPDR) 及增殖期(PDR) 病变3组,每组各30例(30只眼),正常对照组30例(30只眼).分别行最佳矫正视力(BCVA)、裂隙灯、眼底彩照、荧...     

Macular thickness measured by spectral-domain optical coherence tomography in healthy Thai eyes

Purpose

To describe the macular thickness measured by spectral-domain optical coherence tomography (SD-OCT) in healthy eyes of Thai people.

Design

Prospective cross-sectional study.

Methods

Three hundred sixty-eight healthy participants underwent a comprehensive ophthalmic examination, including Spectralis SD-OCT scanning, at Chiang Mai University Hospital. The images were obtained over maculae, using a high-speed volumetric raster scan pattern with lines 240?μm apart. Information was collected from both eyes of each person, with only the right one being used unless it was found to be ineligible (in which case the left eye was studied). A mean retinal thickness was calculated based on nine areas that corresponded to the Early Treatment Diabetic Retinopathy Study by OCT mapping software. The relationships between retinal thickness and sex, age, axial length, and spherical equivalence were analyzed.

Results

The mean age of the subjects was 49.17?±?17.24?years. The mean central retinal thickness was 259.18?±?19.08?μm, the mean foveal volume was 0.20?±?0.02, and the mean total macular volume was 8.59?±?0.37?mm³. Central subfield (CSF) thickness and foveal volume were significantly greater in men than in women (both P?<?0.001). When?analyzed for six?age groups by ANOVA, the CSF thickness showed no significant difference among the groups, with a P value of 0.280, and foveal volume showed no significant difference among the six groups, with a P value of 0.341. After age adjustment, axial length was correlated positively with the CSF thickness (P?<?0.001, Pearson correlation).

Conclusions

The normal macular thickness in Thais is thinner than those reported for other populations when measured using the Spectralis SD-OCT. Male gender and axial length were correlated positively with CSF thickness.     

Comparing central retinal thickness in diabetic macular edema measured by two different spectral-domain optical coherence tomography devices

Purpose

We evaluated central retinal thickness (CRT) in diabetic macular edema (DME) using two different spectral-domain (SD) optical coherence tomography (OCT) instruments: the Cirrus and Spectralis OCTs.

Methods

CRT was measured in 63 eyes of 32 patients with DME using both instruments on the same day.

Results

CRT measurements were significantly greater for the Spectralis than the Cirrus (p < 0.0003, n = 63, paired t test); mean CRT values were 382 ± 136 ??m with the Cirrus and 394 ± 139 ??m with the Spectralis. In eyes with poor best-corrected visual acuity (BCVA) (<20/40), mean CRT was 378 ± 130 ??m with the Cirrus and 395 ± 139 ??m with the Spectralis (p < 0.007, n = 29). In eyes with good acuity (equal to or better than 20/40), the mean CRT was 385 ± 142 ??m with the Cirrus and 393 ± 140 ??m with the Spectralis (p < 0.005, n = 34).

Conclusions

Foveal retinal thickness measurements may vary among SD-OCT devices. The differences between instruments could affect the results of a multicenter study.     

Comparison of spectral-domain and time-domain optical coherence tomography in solar retinopathy

The purpose of this article is to compare spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) findings in patients with solar retinopathy. Complete ocular examinations and OCT were performed in two patients presenting with acute solar retinopathy soon after observation of an eclipse. Both patients were evaluated with SD-OCT and TD-OCT at the same time. SD-OCT demonstrated characteristic defects at the level of the inner and outer segment junction of the photoreceptors in all the affected eyes and decreased reflectiveness of the retinal pigment epithelium layer. TD-OCT images showed unremarkable findings in two eyes with deteriorated visual acuity. SD-OCT improves diagnosis and assessment of the degree and nature of foveal damage in patients with solar retinopathy and may be an important tool for use in identifying foveal damage not detected by TD-OCT. SD-OCT may be preferable to TD-OCT for confirmation or assessment of the degree of foveal damage in patients with solar retinopathy.     

Aspects of optical coherence tomography in diabetic retinopathy

Optical coherence tomography is a new and very useful technique for diabetic patients. It is used to determine the early changes in diabetic retinopathy and to help the ophthalmologist to choose the appropriate therapy.     

Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion

AIM: To evaluate central macular thickness (CMT) and mean choroidal thickness (MCT) in eyes with branch retinal vein occlusion (BRVO), before and after ranibizumab treatment using spectral domain-optical coherence tomography (SD-OCT). METHODS: Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 µm intervals up to 1500 µm temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab (0.5 mg/0.05 mL). Comparisons between the BRVO and fellow eyes were analyzed using Mann-Whitney U test. Pre-injection and post-injection measurements were analyzed using Wilcoxon test and repeated measure analysis. RESULTS: At baseline, there was a significant difference between the BRVO and fellow eyes in MCT [BRVO eyes 245 (165-330) µm, fellow eyes 229 (157-327) µm] and CMT [BRVO eyes 463 (266-899) µm, fellow eyes 235 (148-378) µm (P=0.041, 0.0001, respectively)]. Following treatment, CMT [295 (141-558) µm] and MCT [229 (157-329) µm] decreased significantly compared to the baseline measurements (P=0.001, 0.006, respectively). Also BCVA (logMAR) improved significantly (P=0.0001) in the BRVO eyes following treatment. After treatment CMT [BRVO eyes 295 (141-558) µm, fellow eyes 234 (157-351) µm] and MCT [BRVO eyes 229 (157-329) µm, fellow eyes 233 (162-286) µm] values did not reveal any significant difference in BRVO eyes and fellow eyes (P=0.051, 0.824, respectively). CONCLUSION: In eyes with BRVO, CMT and MCT values are greater than the fellow eyes, and decrease significantly following ranibizumab injection.     

Evaluation of morphological characteristics of diabetic macular edema in patients with non-proliferative versus proliferative diabetic retinopathy: a spectral-domain optical coherence tomography study

International Ophthalmology - To evaluate the morphological characteristics in patients with diabetic macular edema (DME), either with co-existent non-proliferative diabetic retinopathy (NPDR) or...     

Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome

Purpose

To investigate the choroidal thickness using optical coherence tomography in the eyes of patients with unilateral and bilateral pseudoexfoliation syndrome and to compare them with healthy controls.

Methods

We studied four groups: (1) affected eyes from 30 patients with unilateral PEX syndrome affecting the right eye of 17 patients and the left eye of 13 patients; (2) clinically unaffected eyes of 30 patients with unilateral PEX syndrome; (3) the eyes of 30 patients with bilateral PEX syndrome; and (4) the eyes of 30 normal healthy subjects. Choroidal thickness was evaluated using high-speed, high-resolution enhanced depth imaging by spectral-domain optical coherence tomography. Optical coherence tomography features were compared in all groups using the statistical package SPSS v 15.0.

Results

The mean subfoveal choroidal thicknesses were 237.35±58.01 μm in group 1; 330.75±47.84 μm in group 2; 206.3±86.75 μm in group 3; and 311.8±51.42 μm in group 4. Significant differences in the mean subfoveal choroidal thickness were found between groups 1 and 2 (P<0.001), groups 1 and 4 (P=0.004), groups 2 and 3 (P<0.001), and groups 3 and 4 (P<0.001).

Conclusion

In this study, it was observed that clinically affected eyes of patients with PEX syndrome have significantly thinner choroids compared with the clinically unaffected eyes of patients with unilateral PEX syndrome and eyes of healthy controls.