Effect of injection ofCryptococcus heteropolysaccharide injection into bone marrow donors and recipients on structure of a heterotopic focus of hematopoiesis

Academician I. P. Pavlov First Leningrad Medical Institute. Leningrad Pharmaceutical Chemical Institute. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 105, No. 3, pp. 352–353, March, 1988.     

Effect of the thymus on precursor cells of the hematopoietic stroma

It was shown by transplantation of a fragment of bone marrow beneath the capsule of the kidney that thymectomy reduces the number of cells constructing the hematopoietic microenvironment. Transplantation of the thymus abolishes the effect of thymectomy.Laboratory of Bone Marrow Culture and Transplantation, Central Institute of Hematology and Blood Transfusion, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 585–586, June, 1979.     

Transfer of bone-marrow microenvironment by clones of stromal mechanocytes

Colonies consistign of clones of bone-marrow stromal fibroblasts, grown in monolayer cultures of mouse and guinea pig bone-marrow cells, transfer the hematopoietic microenvironment on retransplantation into the animal. Individual clones simultaneously form bone tissue and create a microenvironment for all three branches of medullary hematopoiesis: erythroid, myeloid, and megakaryocytio.Laboratory of Immunomorphology, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 12, pp. 705–707, December, 1978.     

Action of a polysaccharide fromThuja occidentale L. on stromal precursor cells of the hematopoietic microenvironment in mice

All-Union Hematologic Research Center, Ministry of Health of the USSR, Moscow. University Medical Clinic, Eppendorf, Hamburg, Germany. (Presented by Academician of the Academy of Medical Sciences of the USSR A. I. Vorob'ev) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 12, pp. 635–637, December, 1991.     

Role of the thymus in regulation of stromal cells transferring the hematopoiesis-inducing microenvironment in stress

Research Institute of Pharmacology, Tomsk Scientific Center, Academy of Medical Sciences of the USSR. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 108, No. 12, pp. 710–712, December, 1989.     

The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny

Fetal hematopoietic development occurs through the successive expansion and differentiation of hematopoietic stem cells in distinct anatomic sites. The temporal pattern of fetal hematopoietic ontogeny suggests a coordinated developmental sequence whereby the preceding organ sustains the basic, immediate hematopoietic needs of the embryo allowing time for the development of niches within the subsequent organ with more complex supportive functions. We examine the hypothesis that there is a period of stromal genesis and circulating mesenchymal precursor cells, which gives rise to specialized niches within each of the definitive fetal hematopoietic organs, and these niches regulate hematopoietic stem cells fate determination. This article reviews fetal hematopoietic and stromal development and the current understanding of the development, composition, and regulation of the fetal stem cell niche.     

Role of humoral factors in regulation of hematopoiesis during stress

Research Institute of Pharmacology, Tomsk Scientific Center, Academy of Medical Sciences of the USSR. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 7, pp. 15–18, July, 1991.     

Role of hematopoietic precursor cells in the restoration of hematopoiesis after treatment with cytostatics

Research Institute of Pharmacology, Tomsk Research Center, Academy of Medical Sciences of the USSR, Tomsk. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 1, pp. 50–51, January, 1992.     

肿瘤间质肌纤维母细胞的促血管形成作用

肌纤维母细胞是肿瘤性间质最主要成员之一，在肿瘤性血管形成中起重要作用。间质肌纤维母细胞通过旁分泌或自分泌的形式参与肿瘤间质重构和促血管形成因子的产生，直接或间接促使内皮细胞和血管周细胞的分化、增殖以及募集，促进肿瘤性血管形成。     

fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis.

Hematopoiesis in vertebrate development involves an embryonic, primitive wave and a later, definitive wave in which embryonic blood cells are replaced with adult blood cells. We here show that zebrafish fgf1 is involved in vivo in primitive hematopoiesis. Fibroblast growth factor-1 (FGF1) morpholino knockdown leads to abnormal accumulation of blood cells in the posterior intermediate cell mass at 32 hr postfertilization. Expression of the erythroid markers gata1 and ika, normally diminishing in differentiating erythrocytes at this stage, is maintained at abnormally high levels in primitive blood cells. The onset of erythrocyte differentiation as assessed by o-dianisidine staining is severely delayed. Most fgf1 morphants later recover to wild-type appearance, and primitive erythrocytes eventually differentiate. Zebrafish fgf1 is syntenic to human FGF1, which maps to a critically deleted region in human del(5q) syndrome posing an increased risk of leukemia to patients. As its knockdown in zebrafish changes expression of gata1, a gene involved in hematopoietic stem cell decisions, FGF1 should be considered to play a role in the pathogenesis of del(5q) syndrome.