医学期刊编辑群体中成人心理弹性量表RSA的信效度分析

目的验证成人心理弹性量表(RSA)在医学期刊编辑群体中的信效度。方法采用成人心理弹性量表(RSA,resilience scale for adults)对中华预防医学会系列杂志200名医学期刊编辑进行测试。结果成人心理弹性量表在医学期刊编辑群体中施测具有良好的信效度。结论成人心理弹性量表可作为我国医学期刊编辑心理弹性情况的测量工具。     

医学期刊编辑人际关系的个性因素研究进展

人际关系是社会关系的一种。医学期刊编辑的工作不只是单纯地编辑稿件,在编辑的工作中有大量的事务工作和社会活动。很多时候他们需要与审稿者、编委、作者和读者联系,与他们保持良好的关系,医学期刊才能保持良好的循环。健康积极的人际关系对医学期刊编辑的主观幸福感有正向作用,人际     

家庭坚韧力在多发性骨髓瘤患者主观幸福感与疾病恐惧进展的中介效应分析

目的 分析家庭坚韧力在多发性骨髓瘤（MM）患者主观幸福感与疾病恐惧进展的中介效应。方法 采用便利样本抽样法纳入2020年12月至2022年9月阜阳市人民医院血液内科收治的80例MM患者进行研究。采用一般资料调查问卷、恐惧疾病进展简化量表（FoP-Q-SF）、家庭坚韧力量表（FHI）、纽芬兰主观幸福感量表（MUNSH）进行调查,方程模型、中介效应检验采用AMOS26.0软件构建。本研究共发放80份问卷,回收有效问卷80份,有效回收率为100%。结果 80例患者FoP-Q-SF评分为（35.56±7.38）分、FHI评分为（56.16±7.22）分、MUNSH评分为（11.00±3.58）分;80例患者中,FoP-Q-SF≥34分患者占35.0%;FoP-Q-SF评分与FHI评分、MUNSH评分呈负相关（P<0.05）;FHI评分与MUNSH评分呈正相关（P<0.05）。家庭坚韧力在主观幸福感和恐惧疾病进展间起部分中介作用,中介效应占总效应42.19%。结论 MM患者因恐惧疾病进展造成的心理功能失调发生率较高,可通过提高患者主观幸福感降低其恐惧疾病进展情绪水平,而患者的家庭坚韧...     

军医大学生学业倦怠与主观幸福感的关系及心理资本的中介作用

目的 探讨学业倦怠对军医大学生主观幸福感的影响及心理资本的中介作用。方法 采用学业倦怠问卷、幸福感量表、心理资本量表对某军医大学在校学员共796名进行调查,研究军医大学生主观幸福感、心理资本与学业倦怠的关系,并建立中介作用方程,检验心理资本的中介效应。结果 军医大学生主观幸福感平均分为4.42±0.77,心理资本平均分为4.48±0.67,学业倦怠平均分为2.45±0.69,主观幸福感、心理资本与学业倦怠的年级效应显著,大一学员的主观幸福感、心理资本得分高于大三学员（t_{主观幸福感}=12.45,P<0.01;t_心理资本=6.01,P<0.01）,大一学员的学业倦怠得分低于大三学员（t=－13.96,P<0.01）。学业倦怠与主观幸福感、心理资本均呈负相关（r=－0.539,P<0.01;r=－0.721,P<0.01）,心理资本与主观幸福感呈正相关（r=0.596,P<0.01）;心理资本在学业倦怠与主观幸福感之间起部分中介作用,中介效应占总效应的比例为57.90%。结论 主观幸福感可以预测军医大学生的学业倦怠,而且可以通过心理资本间接预测学业倦怠。提高军医大学生的主观幸福感有助于缓解学业倦怠,同时应注重心理资本的中介效应。     

主观幸福感在贫困大学生自杀态度与生命意义感中的中介作用

目的 了解贫困大学生自杀态度与生命意义感的关系,探讨主观幸福感在自杀态度形成中的中介作用。方法 采用随机分层的方法,对5所高校的1 100名在校大学生进行自杀态度与生命意义感的调查,分别采用自杀态度问卷（QSA）、生命意义感问卷（MLQ）、生活目的量表（PIL）和幸福感指数量表（IWB）为检测工具,分析贫困大学生自杀态度及其相关因素。构建结构方程模型分析主观幸福感在生命意义感对自杀态度影响中的中介作用。结果 共回收有效问卷1 038份,有效率94.4%;其中贫困生316名,非贫困生722名。贫困大学生的主观幸福感、对自杀者的态度和生活感受得分均显著低于非贫困大学生（P<0.05）。贫困大学生中,女生对自杀者家属态度的得分显著高于男生（P<0.05）;但男生寻求意义感、生活目标和自主感的得分显著高于女生（P<0.05）。贫困大学生自杀态度与生命意义感和主观幸福感密切相关（P<0.05,P<0.01）。主观幸福感在生命意义感对自杀态度的影响中发挥中介作用。 结论 生命意义感和主观幸福感是影响贫困大学生自杀态度的重要因素,高校应开展有针对性的生命教育进行引导。     

医学期刊编辑职业倦怠与应对方式研究现状

编辑职业是被誉为"为他人作嫁衣裳"的助人职业,而且,随着经济的高速发展,职业压力在编辑行业中也普遍存在。职业倦怠容易发生在助人行业和高压力群体,编辑职业具备产生职业倦怠的二大特征,是职业倦怠发生的高发人群。医学期刊编辑作为出版队伍中的特殊群体,其职业倦怠状态越来越受到学者们的关注。现将医学期刊编辑职业倦怠     

陆军新兵自尊与主观幸福感关系研究

目的了解陆军新兵自尊与主观幸福感水平并考察两者之间的关系。方法采用自尊量表和幸福感量表,统一指导语后对293名陆军某部新兵进行团体施测。结果 （1）自尊：（16.74±7.81）分,主观幸福感：幸福指数量表（5.43±2.56）分,人脸量表（5.26±1.37）分;除了＂非独生子＂新兵的幸福感（人脸量表）得分高于＂独生子＂新兵（P〈0.05）外,学历、家庭收入、生活区域、是否独子对新兵的自尊、主观幸福感水平无明显影响（P〉0.05）。（2）高自尊组新兵的主观幸福感高于低自尊组新兵的主观幸福感（P〈0.01）。（3）自尊与主观幸福感呈正相关（P〈0.01）,言语（量表）与非言语（人脸）幸福感之间一致性为0.57。结论自尊水平与主观幸福感密切相关,高自尊伴随高幸福感。     

临床药师心理压力对职业倦怠影响研究

目的：探讨药师心理压力与职业倦怠相关性,为药房管理提供干预依据。方法：采用中文版知觉心理压力量表（CPSS）和职业倦怠调查通用量表（MBI-GS）对100名临床药师进行测评,评定出重度心理压力者（研究组）和轻度心理压力者（对照组）,比较分析两组职业倦怠状况。结果：药师重度心理压力者（研究组）38名,轻度心理压力者（对照组）62名,重度心理压力检出率38.0%。研究组MBI-GS评分明显高于对照组（P〈0.01）,MBI-GS与CPSS存在高度相关性。结论：临床药师心理压力较大,是产生职业倦怠的重要因素,医院管理者应帮助临床药师减轻心理压力,以降低职业倦怠的发生,更好地优化药学服务。     

高校教师职业倦怠研究中量表选用现状分析

目的探讨高校教师职业倦怠研究中选用量表的情况,为规范倦怠的量化分析提供参考。方法采用文献计量法分析高校教师职业倦怠研究中以量表为研究工具的文献,探讨量表选用的分布及联用率。结果量表总数为219个。职业倦怠量表中Maslach倦怠量表系列的选用数居首位,教师职业倦怠量表居末位;社会心理量表中工作压力及专业态度类的选用数居首位,人格类居末位。社会心理量表与职业倦怠量表的联用率是人格类、生活质量及主观幸福感类并列首位,自我概念及效能感类居末位。结论需加强量表选择的针对性,注重自行设计量表的优势与不足;进一步探讨高校教师职业倦怠的社会、心理因素;需解决人格量表选用量及与职业倦怠量表联用率的偏差问题。     

医学院校研究生的知觉心理压力在其幸福感与导师指导风格倾向之间的中介作用

目的探究医学院校研究生的知觉心理压力在其导师指导风格倾向与研究生幸福感之间的中介作用。方法 2021年2月, 采用导师指导风格量表、知觉心理压力量表和总体幸福感量表对某医学院校208名研究生进行问卷调查, 采用Spearman相关分析和中介检验等方法分析相关数据。结果研究生的知觉心理压力评分为(25.69±5.92)分, 幸福感评分为(77.30±13.64)分, 其导师指导风格倾向的评分为(0.78±0.22)分。研究生的导师控制型指导风格倾向与知觉心理压力呈显著正相关(rs=0.16, P=0.026), 与幸福感呈显著负相关(rs=-0.27, P<0.001), 幸福感与知觉心理压力呈显著负相关(rs=-0.72, P<0.001);知觉心理压力在导师指导风格倾向和研究生幸福感之间的中介作用显著(95%CI=-13.40～-0.67), 且中介效应值(-6.64)占总效应值(-17.06)的38.9%。结论倾向于控制型指导风格的导师, 其研究生幸福感水平较低。研究生的知觉心理压力在其导师指导风格倾向与研究生幸福感之间具有中介作用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.