Effect of euphyllin on metabolic processes in blood and tissues during experimental pituitrin hypertension

A study was made of the effect of euphylline administration (25 mg/kg) for 20 days on some indicators of carbohydrate, energy, lipid and electrolyte metabolism in blood serum and tissues of the heart, aorta and liver during pituitrin hypertension in rabbits experiencing arterial pressure normalization. It was found that euphylline appreciably decreased hypercholesterolemia and hyperlipoproteinemia seen in hypertension. At the same tine the aortal wall showed a decrease in cholesterol content, in lactate dehydrogenase activity, and the normalization of transketolase activity and calcium concentration. In liver tissue, the activity of glycolytic enzymes was inhibited and cholesterol level declined. The heart muscle manifested a decrease in the activity of glycolytic and pentosephosphate pathway enzymes and in that of creatine kinase. The changes in electrolyte balance included sodium elevation in blood serum, heart and liver tissues.     

替硝唑注射液的细菌内毒素检查研究

目的 想建立替硝唑注射液的细菌内毒素检查法最佳方法,研究以细菌内毒素检查法代替家兔法对替硝唑注射液进行热原检查的可行性.方法 本实验根据鲎试剂在不产生干扰条件下能对样品进行细菌内毒素检查的原理,按照〈中国药典〉2005年版附录XIE细菌内毒素检查法要求进行实验,采用凝胶法鲎试验法,用两个厂家生产的鲎试剂,对连续生产的3批替硝唑注射液按有效浓度范围稀释后,进行干扰实验观察,然后进行细菌内毒素检查,所得结果与家兔法检查热原的结果进行对比.结果 使用灵敏度为0.25 EU/ml的鲎试剂,替硝唑注射液的2倍稀释液对两个厂家的鲎试剂均不产生干扰,3批替硝唑注射液的细菌内毒素检查结果与家兔法所得结果一致.结论 细菌内毒素检查法代替家兔法对替硝唑注射液进行热原检查是可行的.     

加替沙星注射液安全性随访研究

目的以左氧氟沙星注射液为对照,观察加替沙星注射液的安全性。方法对2007年5月至2007年10月期间来自北京市13所医院的1963例使用加替沙星的住院患者和1954例使用左氧氟沙星的住院患者进行随访研究,观察给药前、后肝功能(ALT,AST),肾功能(BUN,Cr)及血糖的变化。结果加替沙星与左氧氟沙星的不良反应发生率分别为1.07%和1.28%,P>0.05,无统计学差异。两药均对肝肾功能无明显影响;加替沙星组用药后高血糖的发生率(13.92%)高于左氧氟沙星组(6.53%),P<0.05,差异有统计学意义。结论加替沙星对肝肾功能的影响较小,对血糖代谢的影响相对较大,应用时,应密切监测血糖的变化。