色素性扁平苔藓

报告1例色素性扁平苔藓。患者男，20岁。躯干及四肢出现褐色斑疹半年余，无自觉症状。皮肤科检查见躯干及四肢散在大小不一、边界清楚的褐色斑疹和斑片，部分呈条索状，部分皮损肥厚、浸润。皮损组织病理改变符合色素性扁平苔藓。     

皮肤异色病样淀粉样变性1例

<正>患者女,24岁。患者8岁时无明显诱因颈部出现褐色斑,无瘙痒及疼痛等症状,未予治疗。近2年来,皮损逐渐加重,蔓延至四肢及胸背部皮肤。患者既往体健,否认慢性疾病、传染病病史,手术外伤史及食物和药物过敏史。双亲及一胞弟均体健,无类似疾病病史。体格检查:各系统检查无异常。皮肤科检查:颈部、躯干及四肢皮肤见褐色色素沉着斑,其间散在分布较多的绿豆至黄豆大、形状不规则的色素减退斑,颈部及双下肢有苔藓样丘疹,呈     

发疹性黑子病一例

<正>患儿男,13岁。面部及躯干四肢出现褐色斑4年。患儿足月顺产,父母非近亲结婚,出生时全身皮肤未见明显皮疹;4年前无明显诱因面部、躯干四肢逐渐出现棕褐色斑疹,粟粒至绿豆大小,对称分布,左前臂及右大腿内侧见黄褐色斑,表面散在分布斑点及丘疹。以面部皮损较多,密集分布,无自觉症状。皮疹逐年增多,泛发全身。皮疹的     

线状和漩涡状痣样过度黑素沉着病1例

患儿女,10岁。躯干及四肢色素沉着斑10年。皮肤科情况:躯干及四肢可见沿Blaschko线分布的线状、漩涡状褐色色素沉着斑片,边界清楚,表面无鳞屑和萎缩。皮损组织病理示:表皮轻度角化过度,基底层色素增加,灶性基底层液化变性,真皮浅中层小血管周围少量淋巴细胞、噬黑色素细胞浸润。诊断:线状和漩涡状痣样过度黑素沉着病。     

神经纤维瘤病1型合并贫血痣1例

正1临床资料患者女,28岁。多发褐色斑、淡白斑28年,皮肤结节10年。患者出生时便发现躯干、四肢散在椭圆形、大小不一褐色斑片,同时下肢有片状淡白斑,哭闹后明显,无自觉症状。随年龄增长,褐色斑数目逐渐增多,淡白斑面积增大。10年前躯干及四肢近端渐出现大小不等、质软、淡褐色结节,皮损妊娠期快速增多,且腋下出现雀斑样色素斑。患者智力正常,无癫痫发作史。其母亲有神经纤维瘤病。体检:     

结节性发热性非化脓性脂膜炎1例

<正> 1临床资料患者女,53岁。以躯干四肢皮下痛性结节3月就诊。3月前无明显诱因发热,躯干四肢对称出现暗红色斑丘疹,压痛。曾按“皮炎”诊治,疗效不佳且加重。遂来我科诊治。体检:一般情况良好,T38℃,系统检查未见异常。皮肤科情况:躯干四肢对称分布大片青褐色皮损,界清,儿掌至成人掌大小,表面萎缩凹陷,皮下触及结节斑块,部分融合成团块状与皮肤粘连。实验室检查:血尿粪常规、血沉正常。取左胸皮损行     

色素失禁症1例

患儿女,72d。躯干、四肢反复红斑、水疱伴色素沉着72d。皮肤科情况:躯干及四肢泼墨状和漩涡状褐色色素沉着斑,右手环指远节指骨和中指近节指骨及左手环指掌指关节伸侧、左足拇趾及中趾伸侧边界清楚深黄色疣状、突起较硬斑块。左手中指皮损组织病理示:表皮层局限性假上皮瘤样团块状增生,可见大量角化不良细胞;右小腿皮损组织病理示:表皮灶性基底层液化变性,色素失禁。诊断:色素失禁症。     

播散性浅表性汗孔角化症一例

患者,男,67岁。因躯干、四肢对称性褐色斑片3年,近1年加重伴瘙痒来我院就诊。患者3年前无明显诱因前胸后背、四肢出现褐色斑疹,除偶有瘙痒外无其他症状,未予重视及诊治。     

带状扁平苔薜1例北大核心CSCD

患者女,60岁。因躯干、四肢条带状褐色斑片、斑块10个月余就诊。患者10个月余前无明显诱因于右大腿外侧出现散在分布的褐色丘疹、斑疹,无瘙痒、疼痛等不适,未予治疗。后皮损范围逐渐扩大,累及躯干及其余肢体,逐渐融合为斑片、斑块,呈条带状分布,患者自行间断外用“复方醋酸地塞米松乳膏”,皮损范围未见缩小,颜色未见变淡。既往体健,否认高血压、糖尿病、肝炎、结核等病史,否认用药史,无多次妊娠史。家族成员中无类似病史。     

包素性玫瑰糠疹1例

临床资料 患者，女23岁。躯干，四肢泛发褐色色素斑半年余。患者约半年前无明显诱因于胸前，背部散发大小不一玫瑰红色斑块，无明显痒痛。皮损逐渐扩展至颈、四肢伸侧及整个躯干。数月后皮疹变成灰褐色，曾在外院以色素性荨麻疹诊治（）具体治疗不详，无明显改善。     

Macro‐micro dermatology: Erythematous papules and lentigo‐like macules – a new entity?

Galli‐Galli disease is usually characterized by reticulate hyperpigmentation of the flexures. Rare patients may present without this finding, instead having only localized erythematous papules and brown, lentigo‐like macules on the trunk and extremities. Histological changes consist of elongated and in part hyperpigmented rete ridges and areas of acantholysis.     

A Case of Idiopathic Eruptive Macular Pigmentation Limited to Flexural Areas

Idiopathic eruptive macular pigmentation is a rare condition characterized by asymptomatic pigmented macules involving the neck, trunk, and proximal portions of the extremities. On histopathologic examination, there was increased pigmentation of the basal layer in otherwise normal epidermis and scattered melanophages in the papillary dermis. We report a case of a 26-year-old woman with idiopathic eruptive macular pigmentation involving only the flexural areas of the body. This condition should be considered in the differential diagnosis of flexural hyperpigmented skin lesions.     

线状和漩涡状痣样过度黑素沉着病一例

患者男,20岁.出生后全身开始出现色素斑,逐渐增多并排列成条纹状或漩涡状.无黏膜、眼睛、掌跖受累,损害至成年仍未消退.皮肤科检查:皮损分布广泛,躯干、四肢皆为淡褐色或深棕色条状或漩涡状排列的色素沉着斑纹,沿Blaschko线分布,斑纹较宽,在躯干部略呈漩涡状,弧形,四肢呈条状.组织病理检查:基底层色素增加,无色素失禁.诊断为线状和漩涡状痣样过度黑素沉着病.给予Q开关532 nm激光治疗1次,尚无明显效果,仍在随访中.本病需与色素失禁症和早期线状表皮痣相鉴别.     

伴中性粒细胞浸润的色素性荨麻疹

报告1例伴中性粒细胞浸润的色素性荨麻疹．患儿女,5岁。躯干、四肢色素沉着斑伴瘙痒1年余．体格检查示躯干、四肢广泛分布大量色素性斑片及少量红斑、抓痕．组织病理检查示真皮内大量中性粒细胞浸润及核尘,未见血管纤维素样坏死．高倍镜下见血管周围较多肥大细胞浸润．诊断为伴中性粒细胞浸润的色素性荨麻疹。     

Linear and whorled nevoid hypermelanosis

Linear and whorled nevoid hypermelanosis (LWNHM) is a reticulate pigmentary disorder with a sporadic occurrence, representing genetic mosaicism. It is characterised by hyperpigmented macules in a reticulate pattern along Blaschko's lines, sparing the mucous membranes and stabilising after one to two years. It may be associated with various neurological abnormalities. The disorder may resemble incontinentia pigmenti, epidermal nevus, or zebra-like hyperpigmentation clinically. We report LWMNHM in a 15-year-old girl with progressively increasing streaks of reticulate hyperpigmented macules arranged in a whorled pattern over the trunk and extremities, which appeared soon after birth. There was no history of any preceding eruption or any associated systemic abnormality. Histopathological examination revealed basal cell hyperpigmentation without any pigmentary incontinence. CT scan of the brain was normal.     

Idiopathic Eruptive Macular Pigmentation Involving the Distal Extremities: A Case Report

Idiopathic eruptive macular pigmentation is a disorder of pigmentation found in children and adolescents. It typically manifests as nonconfluent tan to brown macules involving the neck, trunk, and proximal extremities. We report the case of a 6‐year‐old girl with an atypical presentation involving the distal extremities. Histopathology confirmed the subtle increase in pigmentation of the basal layer of the epidermis. Treatments are largely ineffective. The condition is generally self‐limited over months to years, thus treatment is unnecessary.     

Erythema dyschromicum perstans and hepatitis C virus infection

A 48‐year‐old woman with a 10‐month history of widespread, hyperpigmented, slightly pruritic macules, with a red border, involving the trunk and the proximal limbs ( Fig. 1 ) was referred to our outpatient department. The oral mucosa, palms, soles, scalp, and nails were normal.

Figure 1 Open in figure viewer PowerPoint Multiple hyperpigmented macules with an active border on the trunk     

Mosaic neurofibromatosis type 1

A 24-year-old man presented with numerous lentigines and multiple cafe-au-lait macules on both sides of the face, neck, and trunk as well as on the proximal area of the upper extremities and in the axillae. The pigmented lesions had a Blaschko-linear distribution on the upper trunk and were limited to the left side of the abdomen, with a sharp demarcation at the midline. Multiple, cutaneous neurofibromas were found on the trunk, and ophthalmologic examination showed a Lisch nodule in the left iris. The clinical findings and their widespread but segmental distribution were consistent with a diagnosis of mosaic neurofibromatosis type 1.     

Disseminated superficial porokeratosis

A 65-year-old male diabetic presented with erythematous and hyperpigmented plaques with scaling and crusting involving the trunk and extensor surfaces of extremities of 10 years duration associated with mild itching. Cutaneous examination revealed large hyperpigmented and erythematous plaques with raised borders over the trunk and extremities. A small plaque on the (L) forearm showed a raised thread like margin with a furrow. A provisional diagnosis of disseminated superficial porokeratosis was made. Skin biopsy confirmed the diagnosis of disseminated superficial porokeratosis.     

Bilateral type of nevus of Ota presenting as agminated lentigines

We report a 30-year-old female patient with a history of hyperpigmented macules of the face since the age of 7 years. The clinical appearance, brown macules in multiple segmental or grouped patterns, was suggested to be agminated lentigines. However, histologic examination of the pigmented macule revealed scattered melanocytes within the dermis. We diagnosed this lesion as a bilateral type of nevus of Ota presenting as agminated lentigines. The differential diagnosis from acquired bilateral nevus of Ota-like macules was made.