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固定复方制剂文达敏在2型糖尿病治疗中的地位 总被引:1,自引:0,他引:1
随着人们生活方式的改变和肥胖发生率的上升,2型糖尿病(Type 2 diabetes mellitus,T2DM)发病率逐年增长,据2008年中国糖尿病流行病学调查,20~70岁以上人口T2DM发病率达10.5%,较1994年增加4倍[1].合理治疗T2DM并减少并发症,已成为21世纪初医疗卫生体系面临的重要挑战. 相似文献
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<正>2型糖尿病(Type 2 diabetes mellitus,T2DM)发病机理主要是各种因素导致的胰岛素抵抗和胰岛β细胞功能降低。早期主要表现为胰岛素分泌减少,血糖调节功能下降,胰岛β细胞功能减退速度影响糖尿病进展[1],故通过干预改善胰岛素第一分泌时相功能对T2DM治疗将有积极作用。研究表明T2DM早期胰岛β细胞功能损伤是可逆的[2],故β细胞功能的恢复成为可能。 相似文献
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目的 探讨2型糖尿病(Type 2 diabetes mellitus,T2DM)大鼠超声心动图的变化及胰岛素对其的影响.方法 高糖高脂饮食加小剂量链脲佐菌素腹腔注射(STZ,30 mg/kg)制备T2DM大鼠模型,随机临床对照试验(randomized controlled trials RCT)分为正常对照组、糖尿病(Diabetes mellitus,DM)组和胰岛素治疗组(每只3 U/d股内侧皮下注射),对照组和DM组注射等剂量的生理盐水(股内侧皮下注射),每天1次,持续喂养2个月.结果 与对照组组比较,糖尿病模型组大鼠LVEDV、LVESV和SV均明显降低;其他有所增加(P<0.05),胰岛素能显著降低LVFS、EF,对其他超声心动图指标无明显影响.结论 胰岛素能降低2型糖尿病大鼠的血糖,改善心功能,可不同程度下调SAN间质胶原的沉积. 相似文献
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胰岛素抵抗和2型糖尿病 总被引:3,自引:0,他引:3
全世界2型糖尿病(type 2 diabetes mellitus,T2DM)患病率较高,且在发展中国家有增长的趋势。胰岛素抵抗(insulin resistance,IR)是T2DM发病的重要原因。本文就IR及与T2DM的关系作一综述。 相似文献
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目的 探讨西格列汀二甲双胍片(Ⅱ)治疗老年2型糖尿病(Type 2 diabetes mellitus,T2DM)患者效果观察.方法 选择2019年1月至2020年12月本院收治的老年T2DM患者127例,分为对照组63例和观察组64例,对照组给予二甲双胍,观察组给予西格列汀二甲双胍片(Ⅱ),对比两组患者临床疗效,糖脂... 相似文献
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Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy 总被引:5,自引:0,他引:5
Fabris P Floreani A Tositti G Vergani D De Lalla F Betterle C 《Alimentary pharmacology & therapeutics》2003,18(6):549-558
Type 1 diabetes mellitus is the result of an autoimmune process characterized by pancreatic beta cell destruction. It has been reported that chronic hepatitis C infection is associated with type 2 diabetes mellitus, but not with type 1. Although the prevalence of markers of pancreatic autoimmunity in hepatitis C virus-positive patients is not significantly different to that reported in the general population, it increases during alpha-interferon therapy from 3 to 7%, probably due to the immunostimulatory effects of this cytokine. To date, 31 case reports of type 1 diabetes mellitus related to interferon treatment have been published. Type 1 diabetes mellitus occurs more frequently in patients treated for chronic hepatitis C than for other conditions and is irreversible in most cases. In 50% of these patients, markers of pancreatic autoimmunity predated treatment, the majority of cases having a genetic predisposition. Thus, in predisposed individuals, alpha-interferon can either induce or accelerate a diabetogenic process already underway. We suggest that islet cell autoantibodies and glutamic acid decarboxylase autoantibodies should be investigated before and during interferon treatment in order to identify subjects at high risk of developing type 1 diabetes mellitus. 相似文献
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Salvadó L Serrano-Marco L Barroso E Palomer X Vázquez-Carrera M 《Expert opinion on therapeutic targets》2012,16(2):209-223
INTRODUCTION: The nuclear receptors Peroxisome Proliferator-Activated Receptors (PPAR)α and PPARγ are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively. Evidence is now emerging that the PPARβ/δ isotype is a potential pharmacological target for the treatment of insulin resistance and type 2 diabetes mellitus. AREAS COVERED: In this review, the capacity of PPARβ/δ to prevent the development of insulin resistance and type 2 diabetes mellitus is discussed. Special emphasis is placed on preclinical studies and the molecular mechanisms responsible for its actions in the main cell types involved in these pathologies: adipocytes, β-cells, skeletal muscle cells and hepatocytes. EXPERT OPINION: While several concerns remain for the development of PPARβ/δ agonists, these drugs have demonstrated their efficacy in the treatment of insulin resistance and type 2 diabetes mellitus in preclinical studies, as well as in a few short clinical studies in humans. Although this data is promising, additional studies must be performed to confirm the efficacy and safety of these drugs in the treatment of type 2 diabetes mellitus. 相似文献
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Kosiewicz MM Auci DL Fagone P Mangano K Caponnetto S Tucker CF Azeem N White SK Frincke JM Reading CL Nicoletti F 《European journal of pharmacology》2011,658(2-3):257-262
5-Androstene-3β,7β,17β-triol (AET) is a naturally occurring anti-inflammatory adrenal steroid that limits acute and chronic inflammation. HE3286 (17α-ethynyl-5-androstene-3β,7β,17β-triol) is a synthetic derivative of AET with improved pharmaceutical properties and efficacy in some animal models of autoimmunity. Here, daily oral doses of HE3286 led to a suppression of spontaneous autoimmune diabetes in the non-obese diabetic mouse model of type 1 diabetes mellitus when administered either shortly before or after the first incidence of disease onset. Efficacy was associated with reduced insulitis and a suppression of the pathogenic T helper cell type 1 and type 17 phenotypes in peripheral lymphoid organs. These results demonstrate that daily oral treatment with HE3286 administrated relatively late in the destructive autoimmune process led to a suppression of type 1 diabetes mellitus onset and of the pathological inflammatory status, supporting its clinical evaluation in type 1 diabetes mellitus subjects. 相似文献
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目的探讨2型糖尿病患者外周血白细胞计数与尿白蛋白相关性情况。方法选取笔者所在医院2型糖尿病患者90例作为观察组,同时选取同期健康体检者100例作为对照组。结果两组肝功、肾功能差异无统计学意义(P>0.05)。观察组血糖明显高于对照组,观察组白细胞总数、中性粒细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞和尿白蛋白均明显高于对照组,而淋巴细胞明显低于健康对照组,2型糖尿病患者尿白蛋白和白细胞总数、中性粒细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞呈明显正相关,而与淋巴细胞呈负相关,差异有统计学意义(P<0.05)。结论 2型糖尿病患者外周血白细胞计数和尿白蛋白具有明显的相关性,其可能和糖尿病的肾脏损伤密切相关。 相似文献
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目的评价硝苯地平联合厄贝沙坦治疗2型糖尿病合并高血压的临床疗效与安全性。方法 60例2型糖尿病合并高血压患者随机分为治疗组和对照组,2组同时给予糖尿病基础治疗,在此基础上,治疗组口服硝苯地平缓释片20mg,1~3次/天和厄贝沙坦片80 mg,1~3次/天,观察治疗前后血压的变化,并记录有无药物不良反应。结果治疗组有效率为90%,对照组为60%,治疗组明显优于对照组(P<0.05)。治疗组发生3例药物不良反应但较轻微。结论硝苯地平联合厄贝沙坦治疗糖尿病合并高血压的疗效肯定。 相似文献