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1.
Raj Kumar V. Kumar N. K. Das S. Behari A. K. Mahapatra 《Child's nervous system》2007,23(11):1295-1299
Background Lumbar disc herniation is mainly a disease of elderly people as degenerative changes progress with age.
Results and discussion Present retrospective analysis was performed on 742 patients of lumbar disc disease operated over 11 years. Of 742 cases aged
20 years or less, 25 has been evaluated to see the clinical features, radiological features, operative findings, and outcome
of lumbar disc surgery. The incidence of lumbar disc herniation in pediatric and adolescent populations was 3.5% (aged 20 years
or less). All patients presented with low back pain with or without radiculopathy (n = 25). Diagnosis was easily made on magnetic resonance imaging. Gross degenerative changes in disc and end plates were uncommon
(16%) in this population. The trauma may not be a predisposing factor in most of them. In 88% (n = 22) of the cases, only 1 level was affected; the commonest was L4–5 (n = 13). Disc herniation was centrolateral in 72% (n = 18) and central in 28% (n = 7). Disc was mostly soft, hydrated, and rubbery in 92% (n = 23). Disc herniation were subligamentous in 80% (n = 20) and extruded in 4% (n = 1). Sixteen percent (n = 4) of the patients had disc bulge with intact annulus.
Conclusions Operative intervention in the form of simple discectomy offers good result in 92% (n = 23) cases irrespective of approach and method. Longer follow-up is mandatory because the chances of recurrence or another
level involvement cannot be denied. 相似文献
2.
Sassan Keshavarzi Hal Meltzer Sharona Ben-Haim Charles Benjamin Newman Joshua D Lawson Michael L. Levy Kevin Murphy 《Child's nervous system》2009,25(7):837-844
Objective The objective of this study is to report our initial experience treating pediatric patients with central nervous system tumors
using a frameless, optically guided linear accelerator.
Materials and methods Pediatric patients were selected for treatment after evaluation by a multidisciplinary neuro-oncology team including neurosurgery,
neurology, pathology, oncology, and radiation oncology. Prior to treatment, all patients underwent treatment planning using
magnetic resonance imaging (MRI) and treatment simulation on a standard computed tomography scanner (CT). For CT simulation,
patients were fitted with a customized plastic face mask with a bite block attached to an optical array with four reflective
markers. After ensuring adequate reproducibility, these markers were tracked during treatment by an infra-red camera. All
treatments were delivered on a Varian Trilogy linear accelerator. The follow-up period ranges from 1–18 months, with a median
follow-up of 6 months.
Results Nine patients, ages ranging from 12 to 19 years old (median age 15 years old), with a variety of tumors have been treated.
Patients were treated for juvenile pilocytic astrocytoma (JPA; n = 2), pontine low-grade astrocytoma (n = 1), pituitary adenoma (n = 3), metastatic medulloblastoma (n = 1), acoustic neuroma (n = 1), and pineocytoma (n = 1). We followed patients for a median of 12 months (range 3–18 months) with no in-field failures and were able to obtain
encouraging toxicity profiles.
Conclusion Frameless stereotactic optically guided radiosurgery and radiotherapy provides a feasible and accurate tool to treat a number
of benign and malignant tumors in children with minimal treatment-related morbidity. 相似文献
3.
Aims and Objectives The significance of beaten copper appearance (BCA) on skull radiographs in children following surgery for isolated sagittal
craniosynostosis has not been studied. This study was designed to look for any correlation between BCA and symptoms suggestive
of intracranial hypertension in this group of patients.
Materials and Methods Forty-eight consecutive children, who were operated for isolated sagittal synostosis from1987 to 2000 and had postoperative
skull radiographs, were included. Patients were divided into: (a) BCA group (n = 20), consisting of children who had beaten copper appearance on skull radiographs at last follow up, and (b) Non-BCA group
(n = 28), consisting of children who did not have this finding. Records were reviewed to look for symptoms suggestive of intracranial
hypertension, such as headache, head banging, and irritability.
Results Median age at surgery was 4.8 months for BCA group and 4 months for the non-BCA group. Follow up ranged from 4 to 156 months
with a mean of 36.2 months. Total of 28.6% (n = 6) of the children with follow up radiographs done at ≤18 months of age had BCA. The incidence of BCA increased to 83.3%
in children with skull radiographs performed after 48 months of age. In 18 (90%) children, the BCA was ‘diffuse’ with 5 (25%)
children having the maximum possible score of 8. In the BCA group, 45% (n = 9) had symptoms compared to 10.7% (n = 3) in the control group (p = 0.0068).
Conclusions This study suggests a significant number of children with BCA on radiographs develop symptoms suggestive of raised ICP following
surgical treatment in infancy and prolonged follow up may be warranted in this group of patients. 相似文献
4.
Newsome MR Scheibel RS Seignourel PJ Steinberg JL Troyanskaya M Li X Levin HS 《Brain imaging and behavior》2009,3(3):298-305
As part of a preliminary investigation on the effects of methylphenidate on brain activation during a working memory (WM)
task in patients with traumatic brain injury (TBI), patients with TBI received 15 mg of methylphenidate (N = 4) or placebo (N = 5) twice a day for one month in a double-blind, placebo-controlled design. Brain activation was assessed at pre-treatment
and on the final treatment day using functional magnetic resonance imaging (fMRI) with an N-back task using faces as stimuli.
In a whole brain voxel-wise analysis, methylphenidate, compared to placebo, produced a decrease in brain activation for the
2-load minus 0-load contrast in the anterior cingulate, thalamus, cuneus and cerebellum, regions associated with WM performance.
Further, an a priori region of interest analysis with small volume correction found reduced activation in the anterior cingulate. Although based
on a small sample size, these preliminary findings suggest methylphenidate may increase processing efficiency associated with
cognitive control during WM tasks in patients with TBI. 相似文献
5.
6.
Aristotle N. Voineskos Donna J. Lang Gwyneth Zai Natalie Bulgin Sajid Shaikh Wayne Su Lili C. Kopala G. William MacEwan Allen E. Thornton Geoffrey N. Smith Jehannine C. Austin William G. Honer James L. Kennedy 《Brain imaging and behavior》2008,2(2):117-122
Evidence implicating myelin related genes in the pathophysiology of schizophrenia is accumulating. Abnormalities of brain
structure at the onset of psychosis may be related to variation in genes such as myelin associated glycoprotein (MAG). Subjects
with first episode schizophrenia (n = 30) or schizoaffective disorder (n = 11), and healthy comparison subjects (n = 43) participated in an MRI scan. Two single nucleotide polymorphisms (rs720309, rs720308) in the MAG gene were genotyped.
MAG genotype variation predicted cortical gray matter volume in first episode schizophrenia patients (p = 0.039), but not in controls (p = 0.827). Cortical gray matter, total gray matter, total white matter, and ventricular cerebrospinal fluid volumes did not
differ between groups. Genetic variation in the MAG gene may predict cortical gray matter volume differences in patients in
the first episode of schizophrenia or schizoaffective disorder. 相似文献
7.
M. Bakkers C. G. Faber M. Drent M. C. E. Hermans S. I. van Nes G. Lauria M. De Baets I. S. J. Merkies 《Journal of neurology》2010,257(12):2086-2090
Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and
autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using
the neuropathic pain scale (NPS) and the modified Composite Autonomic Symptoms Scale (mCOMPASS) was used in sarcoidosis patients
for this study. A total of 91 sarcoidosis patients (n = 23 without SFN symptoms, n = 43 with SFN symptoms but normal intraepidermal nerve fibre density (IENFD), n = 25 with SFN symptoms and reduced IENFD) were examined. NPS and mCOMPASS were assessed twice (reliability studies). Severity
of pain was compared between the subgroups. Correlation between NPS and a visual analogue pain scale (VAS) was assessed (validity
studies). Healthy controls (n = 105) completed the mCOMPASS for comparison with patients’ scores. Patients with sarcoidosis, SFN complaints, and reduced
IENFD demonstrated more severe pain scores on the NPS. The mCOMPASS differentiated between subjects with and without SFN symptoms.
A significant correlation was obtained between the NPS and VAS, indicating good construct validity. Good reliability values
were obtained for all scales. The use of the NPS to evaluate SFN symptoms is suggested, as it shows differences between patients
with SFN symptoms with normal or reduced IENFD values. The mCOMPASS might be used to select patients for further testing. 相似文献
8.
Posterior fossa tumors in children: how long does it take to establish the diagnosis? 总被引:3,自引:0,他引:3
Lutz Dörner Michael J. Fritsch Andreas M. Stark Hubertus Maximilian Mehdorn 《Child's nervous system》2007,23(8):887-890
Objective The aim of this study is to evaluate, for our patient population, the time interval from the first chart-documented symptom
to the radiological diagnosis in children and infants with posterior fossa tumors.
Materials and methods We retrospectively analyzed 50 consecutive children (36 men, 14 women) with posterior fossa tumor treated at our department
between January 1999 and December 2003. The mean age at time of diagnosis was 98 months (6 months–16 years). The mean follow
up was 27 months (6–61 months). The diagnoses included astrocytoma (n = 17), medulloblastoma (n = 15), ependymoma (n = 6), and other tumors (n = 12).
Results The mean time interval between onset of symptoms and radiographic diagnosis was 142 days (5–535 days), the median was 59 days.
The mean time for Grade I and II tumors was 238 days (n = 19) and for tumors Grade III and IV 117 days (n = 31). The most common presenting symptoms were headache, nausea, vomiting, ataxia, and oculomotor deficits. Approximately
half of the patients were initially diagnosed and treated for other diseases (gastrointestinal infection, appendicitis, psychological
behavioral problems, cervical spine strains, different ophthalmologic entities). Specialists (ophthalmologists, orthopedics)
tended to diagnose and treat their specific diagnoses (e.g., strabism, torticollis). Parents play a significant role in the
process of establishing the correct diagnosis.
Conclusion We conclude that further information and education regarding symptomatology and diagnosis of posterior fossa tumors in children
is necessary. Communication has to be improved between parents and referring physicians of all specialties and neurosurgeons. 相似文献
9.
Christian Lampl Christine Schweiger Bernhard Haider Anita Lechner 《Journal of neurology》2010,257(8):1265-1273
This observational study examined the outcome of two different therapeutic strategies in the treatment of chronic neuropathic
pain by including pregabalin (PGB) as mono- or add-on therapy in one of two treatment options. Patients with a pain score
of ≥4, refractory to usual care for neuropathic pain for at least 6 months, were allocated consecutively to one of two treatment
strategies according to the decision of the physician: complete switch to a flexible-dosage, monotherapeutic or add-on therapy
with pregabalin (PGB group), or change established doses and combinations of pre-existing mono- or combination therapy without
pregabalin (non-PGB group). After 4 weeks (primary endpoint) a significant improvement in pain reduction was documented in
both intention-to treat (ITT) analysis (PGB group, n = 85: mean pain score reduction of 3.53, SD 2.03, p < 0.001; non-PGB group, n = 102; mean pain score reduction of 2.83, SD 2.23, p < 0.001) and per-protocol (PP) analysis (PGB group, n = 79: mean pain score reduction 3.53 vs. 2.83, p < 0.05; non-PGB group, n = 81; 3.5 vs. 2.9, p < 0.05) compared to baseline. Comparison of the results observed in the two groups shows that patients in the PGB group achieved
significantly greater pain reduction. These results demonstrate that PGB administered twice daily is superior to treatment
regimes without PGB in reducing pain and pain-related interference in quality of life. 相似文献
10.
Kerry S. Courneya PhD Donald C. McKenzie MD PhD Robert D. Reid PhD John R. Mackey MD Karen Gelmon MD Christine M. Friedenreich PhD Aliya B. Ladha MS Caroline Proulx MS Kirstin Lane PhD Jeffrey K. Vallance PhD Roanne J. Segal MD 《Annals of behavioral medicine》2008,35(1):116-122
Background
Exercise adherence is a challenge for breast cancer patients receiving chemotherapy but few studies have identified the key
barriers.
Purpose
In this paper, we report the barriers to supervised exercise in breast cancer patients participating in a randomized controlled
trial.
Methods
Breast cancer patients initiating adjuvant chemotherapy (N = 242) were randomly assigned to usual care (n = 82) or supervised resistance (n = 82) or aerobic (n = 78) exercise. Participants randomized to the two exercise groups (n = 160) were asked to provide a reason for each missed exercise session.
Results
The two exercise groups attended 70.2% (5,495/7,829) of their supervised exercise sessions and provided a reason for missing
89.5% (2,090/2,334) of their unattended sessions. The 2,090 reasons represented 36 different barriers. Feeling sick (12%),
fatigue (11%), loss of interest (9%), vacation (7%), and nausea/vomiting (5%) accounted for the most missed exercise sessions.
Disease/treatment-related barriers (19 of the 36 barriers) accounted for 53% (1,102/2,090) of all missed exercise sessions.
Demographic and medical variables did not predict the types of exercise barriers reported.
Conclusions
Barriers to supervised exercise in breast cancer patients receiving chemotherapy are varied but over half can be directly
attributed to the disease and its treatments. Behavioral support programs need to focus on strategies to maintain exercise
in the face of difficult treatment side effects.
Rapid Communication Accepted by Annals of Behavioral Medicine (October 8, 2007). 相似文献
11.
Cytochrome P450 1A1 (CYP1A1) is involved in the production of arachidonic acid-derived vasoactive substance. We hypothesized
that CYP1A1 polymorphism might be related to pathological conditions associated with cerebral infarction (CI). We investigated
the effect of genetic polymorphism in the 3′-flanking region (T6235C) of CYP1A1 gene in 353 patients with CI and 376 controls.
The distributions of T6235C CYP1A1 genotypes in patients with (TT: 36.0%; TC/CT: 64.0%; n = 353) and without CI (TT: 44.7%; TC/CT: 55.3%; n = 376) indicate that the C allele is associated with CI (P = 0.017, odds ratio (O.R.) = 1.44; 95% confidence interval (C. I.) = 1.07–1.94). Furthermore, we examined whether the glutathione
S-transferase (GST) gene, which is one of detoxification enzyme, influence the risk of CI. GST M1 null genotype increased
the relative risk for the CI in the subjects with the CYP1A1 C allele (P = 0.015, O.R. = 1.47; C. I. = 1.08–2.00). We conclude that T6235C CYP1A1 polymorphism is a risk factor for the development
of CI and suggest that GST polymorphism contribute to the odds of CI. 相似文献
12.
Simon Vermeire Kurt Audenaert André Dobbeleir Rudy De Meester Eva Vandermeulen Tim Waelbers Kathelijne Peremans 《Brain imaging and behavior》2009,3(4):342-349
Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been reported in humans with anxiety
disorders. This animal study reports the results of brain perfusion imaging with single photon emission computed tomography
(SPECT) in dogs with anxiety disorders. Based on the human literature, we hypothesized altered prefrontal and higher temporal
brain perfusion. SPECT acquisitions were performed using the 99mTc-labelled tracer ethyl cysteinate dimer (ECD). Eighteen dogs with pathological anxiety were compared with 18 normally behaving
reference dogs. We found, in the group of dogs with anxiety disorders, lower perfusion in the left frontal cortex (p = 0.003), in the subcortical region (p = 0.007) and increased perfusion in the right (p = 0.05) temporal cortex. Taken together, our rCBF findings are suggestive for a dysfunction of the prefrontal cortex and
the limbic system in canine anxiety disorders. 相似文献
13.
Objective This study aims to investigate whether intracranial arachnoid cysts (AC) compromise neurocognitive function and psychological
profiles in pediatric patients, depending on various clinical factors.
Methods We assessed neurocognitive functions and psychological tests in 35 AC patients and 35 healthy control subjects between October
2007 and April 2008. AC patients ranged in age from 3 to 15 (7.94 ± 3.12) years old and control patients from 5 to 13 (8.84 ± 2.17)
years old. The location of the AC were temporal (n = 22), frontal (n = 6), suprasellar (n = 4), and posterior fossa (n = 3). Patients underwent neurocognitive and psychological assessments before surgery. To investigate which AC impair neurocognitive
function and psychological profile, we assessed intelligence, memory, attention, executive function, behavioral problems,
emotional distress, and parenting stress.
Results AC caused some demonstrated impairment by both neurocognitive function and psychological assessments. Left hemisphere AC tended
to have more anxiety; mood changes can be detected depending on cyst grade. An incidental finding of AC after trauma is more
intelligent, well-reserved executive function. Frontal locations tended to cause more anxiety than temporal locations.
Conclusions Our results imply that intracranial AC impairs some neurocognitive and psychological functions. An incidental finding of AC
after trauma was a more intelligent, well-reserved executive function. AC in the left hemisphere, frontal location tended
to cause more anxiety. The AC itself did not cause differences in neurocognitive function from the control group. However,
parenting stress in the AC group was much higher than in the control group. 相似文献
14.
To understand how normal variations in white matter relate to cognition, magnetization transfer imaging ratios (MTR) of a
hypothesized neural network were associated with a test of visual selective attention (VST). Healthy adults (N = 16) without abnormal signal on brain scans viewed a version of DeSchepper and Treisman’s test of VST (1996) with two levels
of processing (novel shape matching with and without distractors, contingency feedback). A hypothesized neural network and
component regions was significantly associated with accuracy and response times when distractors were present, with betas
predicting 55% of variance in accuracy, and 59% of response times. MTR for anterior and posterior cingulate, prefrontal region,
and thalami comprised a model predicting 55% of accuracy when distractors were present, and the anterior cingulate accounted
for the majority of this effect. Prefrontal MTR predicted longer response times which was associated with increased accuracy.
Distal neural areas involved in complex, processing-driven tasks (error processing, response selection, and variable response
competition and processing load) may be dependent on white matter fibers to connect distal brain regions/nuclei of a macronetwork,
including prefrontal executive functions. 相似文献
15.
The aim is to investigate the effects of neuregulin-1β (NRG-1β) on expression of matrix metalloproteinase-9 (MMP-9) and neuron-specific
enolase (NSE) in brain tissue in rats following cerebral ischemia/reperfusion. One hundred and fifty adult healthy male Wistar
rats were used in the present study. Ten of them were randomized into a sham-operation group (n = 10) and the rest suffered surgery operation of middle cerebral artery occlusion/reperfusion with intraluminal monofilament
suture from the left external–internal carotid artery. As a result, 100 rats of successful models were randomly divided into
a control group (n = 50) and a treatment group (n = 50). Rats in the treatment group were injected 1.5% NRG-1β at a dosage of 0.3 μg/kg from the stump of the left external
carotid artery into the internal carotid artery. The expressions of MMP-9 and NSE proteins were determined by immunohistochemical,
immunofluorescent double labeling, and Western blot assay. Ischemia/reperfusion induced morphological changes of brain tissue,
including neurocyte shrinkage, chromatin condensation, nuclei fragment, and gliacyte and endothelial cell swelling. NRG-1β
obviously reduced and delayed the cerebral damage. With the duration of ischemia, the expression of MMP-9 gradually increased
in the control group. NRG-1β decreased the level of MMP-9 compared with that in the control group (P < 0.01). NSE immunoreaction transiently elevated at the early stage of cerebral ischemia insult, and then gradually decreased
in the control group. The administration of NRG-1β significantly increased the level of NSE, and thus delayed the time and
the degree of neuron damage. There were statistical differences in contrast to the control group (P < 0.01). There was no relationship between the expressions of the two proteins. MMP-9 might aim at various target cells at
different stages and contribute to the inflammatory reaction after cerebral ischemia–reperfusion insult. NRG-1β inhibits the
activation of MMP-9 and development of inflammation, enhances the activity of NSE, improves the microenvironment of neuron
survivals, and delays the phase of irreversible neuron necrosis. Therefore, NRG-1β may play a neuroprotective role in cerebral
ischemia/reperfusion.
Supported by the Nature and Science Fund of Shandong Province (Y2004C04, Z2007D05). 相似文献
16.
J. van Os H. Verdoux S. Maurice-Tison B. Gay F. Liraud R. Salamon M. Bourgeois 《Social psychiatry and psychiatric epidemiology》1999,34(9):459-463
Background: It has been suggested that psychotic symptoms may be distributed along a continuum that extends from normality through depressive
states to schizophrenia with increasing level of severity. This study examined the hypothesis that the severity of positive
psychotic symptoms increases from normality, through depression/anxiety states to clinical psychosis. Methods: Consecutive general practice attenders completed a self-report questionnaire of 24 items of delusional ideation and hallucinatory
experiences and the GHQ-12. The following groups were compared: (1) subjects with a diagnosis of psychosis (n = 57), (2) GHQ cases (n = 245), and (3) GHQ non-cases (n = 378). Results: Quantitative differences were apparent in the great majority of items on delusional ideation and hallucinatory experiences,
in that normals scored lowest, psychosis patients scored highest and GHQ cases scored in between. This pattern of differences
was apparent for all dimensions of psychosis-like experiences, including the more “schizophrenic” ones, with the exception
of Grandiosity (GHQ cases similar to normals) and Paranormal Beliefs (no differences between the three groups). Conclusions: Similar to findings in aetiological research, phenotypic differences between normal controls, patients with anxiety/depression
and patients with psychosis appear quantitative rather than qualitative for core dimensions of psychosis.
Accepted: 15 June 1999 相似文献
17.
Ana Carolina R. Mathias Renata W. Vargens Felix H. Kessler Marcelo S. Cruz 《International journal of mental health and addiction》2009,7(1):239-249
There is a strong association between pathological gambling and substance abuse. The objective of this study is to identify
the differences between substance abusers with and without gambling problems. A cross sectional study was conducted interviewing
with Addition Severity Index (ASI) and South Oaks Gambling Screen (SOGS), alcohol and drug abusers (N = 147) who sought treatment in specialized treatment facilities. SOGS was used to access and classify individuals into two
groups: social gamblers (n = 96) and probable pathological gamblers (n = 32). Scores on ASI provided data about severity on seven areas. Several differences were found between the two groups.
Cocaine was the major reason for treatment among drug abusers with gambling problems. This group had more severity problems
in the areas of drug use, psychiatric, legal and family-social. Furthermore, they had more suicidal ideas, parents with gambling
problems and started to play earlier than the social gamblers group. These results indicate the need to improve the services
that provide treatment to alcohol and drug abusers, including routines for screening to early identification and professional
education on specific treatment to substance abusers with pathological gambling. 相似文献
18.
Background: This study examined rates of and risk factors associated with suicide attempts by psychiatric patients under active care.
It was especially focussed on the relative rates across three standard treatment settings: acute inpatient care, long-stay
inpatient care and community-based care. Methods: A total of 12,229 patients in 13,632 episodes of care were rated on the Health of the Nation Outcome Scales (HoNOS) Item
2. For the purposes of the current investigation, a score of 4 was deemed to indicate a suicide attempt. Results: Incidence densities per 1000 episode days were 5.4 (95% CI = 4.8–6.1) for patients under care in acute inpatient settings,
0.6 (95% CI = 0.5–0.8) for patients under care in long-stay inpatient settings, and 0.5 (95% CI = 0.5–0.6) for patients under
care in community-based arrangements. Predictors varied by treatment setting. Risk was elevated for personality disorders
across all settings: 22.7 attempts per 1000 episode days (95% CI = 17.2–30.0) in acute inpatient care; 2.1 (95% CI = 1.0–4.5)
in long-stay inpatient care; and 2.3 (95% CI = 1.7–3.0) in community-based care. This effect remained after adjustment for
demographics. Conclusion: Rates of suicide attempts among psychiatric patients are a major issue facing contemporary mental health care systems, and
risk factors vary across different treatment settings.
Accepted: 8 October 1999 相似文献
19.
Matthew J. McGirt Kaisorn L. Chaichana April Atiba Frank Attenello Graeme F. Woodworth George I. Jallo 《Child's nervous system》2008,24(1):93-97
Objective With modern surgical advances, radical resection of pediatric intramedullary spinal cord tumors (IMSCT) can be achieved with
preservation of long-term neurological function. Clinical and radiographic risk factors predictive of postoperative neurological
outcome may serve as a guide for surgical risk stratification.
Materials and methods We prospectively reviewed the outcomes of 16 consecutive cases of pediatric IMSCT resection at a single institution. Clinical,
radiographic, and operative variables were analyzed as predictors of postoperative neurological function defined by the modified
McCormick score (MMS).
Results Sixteen children 10 ± 5 years old presented with median (interquartile range) MMS score of 2 (1–2) with IMSCTs (eight cervical,
eight thoracic) involving 4 ± 2 levels. Pathology revealed astrocytoma in 12 cases (three pilocytic, four grade II, three
gradeIII, two GBM), gangliogliomas in two, ependymoma in one, and gliosis in one case. At median follow-up of 7 months, six
(38%) patients experienced improved neurological function, eight (50%) remained stable, one (6%) experienced a delayed decrease
in neurological function (GBM progression), and one (6%) died (GBM progression). Five (31%) patients developed persistent
dysesthetic symptoms. Four (80%) patients with cystic tumors experienced neurological improvement compared to only two (18%)
patients with noncystic tumors, p < 0.05. Preoperative steroid use (odds ratio, OR [95% confidence interval, CI] = 18.0 [1.24–260.1], p = 0.03) and cystic tumor (OR [95%CI] = 18.0 [1.24–260.1], p = 0.03) predicted neurological improvement after surgery.
Conclusion Radical resection of pediatric IMSCTs can be achieved with low incidence of neurological injury. Sensory syndromes frequently
occur after pediatric IMSCT resection and frequently affect patient’s quality of life. Tumors with compressive cysts may identify
patients more likely to experience improved neurological function after surgical resection. 相似文献
20.
Aline J. Pelle Ruud A. M. Erdman Ron T. van Domburg Marquita Spiering Marten Kazemier Susanne S. Pedersen 《Annals of behavioral medicine》2008,36(2):167-175
Background Type D personality is an emerging risk factor in coronary artery disease (CAD). Cardiac rehabilitation (CR) improves outcomes,
but little is known about the effects of CR on Type D patients.
Purpose We examined (1) variability in Type D caseness following CR, (2) Type D as a determinant of health status, and (3) the clinical
relevance of Type D as a determinant of health status compared to cardiac history.
Methods CAD patients (n = 368) participating in CR completed the Type D Scale, the Short-Form Health Survey 36 pre- and post-CR, and the Hospital
Anxiety and Depression Scale pre-CR, to assess health status and depressive and anxious symptomatology, respectively.
Results The prevalence of Type D decreased from 26.6% to 20.7% (p = 0.012) following CR, but Type D caseness remained stable in 81% of patients. Health status significantly improved following
CR [F(1,359) = 17.48, p < 0.001], adjusting for demographic and clinical factors and anxious and depressive symptoms. Type D patients reported poorer
health status [F(1,359) = 10.40, p = 0.001], with the effect of Type D being stable over time [F(1,359) = 0.49, p = 0.48]. Patients with a cardiac history benefited less from CR [F(1,359) = 5.76, p = 0.02]. The influence of Type D on health status was larger compared to that for cardiac history, as indicated by Cohen’s
effect size index.
Conclusions Type D patients reported poorer health status compared to non-Type D patients pre- and post-CR. In the majority of patients,
CR did not change Type D caseness, with Type D being associated with a stable and clinically relevant effect on outcome. These
high-risk patients should be identified in clinical practice and may require adjunctive interventions. 相似文献