共查询到19条相似文献,搜索用时 78 毫秒
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新生儿窒息肾损害及肾功能监测 总被引:20,自引:0,他引:20
新生和窒息可引起多器官损害,其中肾损害发生率最高。肾损害在超微结构上表现为细胞骨架、细胞极性的改变,从而引起肾小管堵塞,肾损害与能量代谢障碍、Ca^2+与Ca^2+依赖性蛋白酶、一氧化氮、氧自由基、细胞间粘附分子有关,并可通过一些方法监测。 相似文献
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我们应用比色法对30例窒息足月儿和32例正常足月儿进行了所血一氧化氢(NO)水平的测定,旨在探讨其在新生儿窒息中的病理生理意义,为新生儿窒息的诊治和预后改并提供新的理论依据。对象及方法对象均为我院妇产科接生的足月新生儿。窒息组(1分钟APgar评分≤7分)30例,均为阴 相似文献
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胎儿窘迫孕妇血及脐血一氧化氮及其与新生儿窒息的相关研究 总被引:3,自引:1,他引:3
为了解胎儿窘迫时孕妇血及脐血中一氧化氮 (NO)水平的变化及其与胎儿窘迫及新生儿窒息的关系。对 42例胎儿窘迫孕妇 (胎儿窘迫组 )及 36例正常晚孕妇女 (对照组 )母血、脐血中 NO代谢产物亚硝酸 /硝酸基 (NO- 2 / NO- 3 )进行测定 ;以血气分析仪测定脐血 p H值。结果显示 胎儿窘迫组母血及脐血 NO水平均较对照组明显下降 (P均 <0 .0 1 ) ,胎儿窘迫组与对照组相比 :脐血 p H下降 (P<0 .0 1 ) ;新生儿Apgar评分下降 (P<0 .0 1 ) ;新生儿一分钟 Apgar评分≤ 7分的例数所占比例上升(P<0 .0 1 )。母血 NO≤ 2 .6 6 umol/ L,脐血 NO≤ 2 .0 3umol/ L时新生儿窒息率明显上升 (P<0 .0 1 ) ,与脐血 p H值 <7.2 0时相比 ,两者新生儿窒息率无显著差异 (P>0 .0 5 )。新生儿脐血 p H值与脐血 NO水平呈高度正相关 (r=0 .74,P<0 .0 1 )。结论 母血及脐血 NO下降与胎儿窘迫有一定关系 ;NO水平下降在预测新生儿窒息时与脐血 p H值有同等价值 ;监测母血及脐血 NO水平可作为诊断胎儿窘迫的指标之一。指导临床及时处理胎儿窘迫 ,为减少新生儿窒息的发生起很重要的作用。 相似文献
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复方丹参对窒息新生儿的心肌保护作用 总被引:3,自引:0,他引:3
复方丹参对窒息新生儿的心肌保护作用成都市第三人民医院儿科(610031)王晓蕾,何平,张黎蓉,代缨,余世禄,余涛成都市第三人民医院检验室郭平,杨均秀,黄杰成都市第三人民医院放免室李俊华,梁河涛,谢为,王立新,喻可为窒息新生儿除常发生缺氧缺血性脑病外,... 相似文献
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本文对20例新生儿窒息患儿分别采用镉还原层析一比色法及Percoll密度离心法进行血一氧化氮(NO)、循环内皮细胞(CEC)水平测定,并与30例健康新进行对照,发现新生儿窒息组织NO及CEC的均值显著高于对照组,并且有显著差异。由此可见新生儿窒息与NO、CEC有密切的关系,是判断表病情的辅助指标。 相似文献
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新生儿窒息后血一氧化氮水平的动态变化及其临床意义 总被引:10,自引:0,他引:10
目的了解窒息后新生儿血一氧化氮(NO)的动态变化。方法采用镉柱比色法,分别对40例窒息后新生儿及18例正常新生儿于生后1、3、7天测定血清NO水平。结果足月儿、早产儿轻度和重度窒息后7天内血清NO水平的动态变化差异均有非常显著意义(P<0.01),窒息后血清NO的水平第3天最高,至第7天几乎接近出生后第1天的水平,血清NO水平与窒息程度呈正相关。37例经颅脑B超证实伴缺氧缺血性脑病。结论血清NO水平与缺氧缺血性脑病密切相关 相似文献
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宫内窒息胎鼠肝组织一氧化氮及氧自由基作用的研究 总被引:1,自引:0,他引:1
研究表明肝脏缺血缺氧及再灌注(I/R) 损伤中一氧化氮(NO)和氧自由基有重要作 用。本文研究宫内窒息胎鼠在I/R过程中其 肝组织超氧化物歧化酶(SOD)、丙二醛 (MDA)、NO变化,以及肝脏病理变化。 材料和方法 一、动物模型制备 Wistar雌雄鼠以 4:1的比例合笼,自合 笼第二日起行阴道分泌物涂片,光学显微镜 下见精子满视野为妊娠第1日,提出单独饲 养。于妊娠第21日用2.5%戊巴比妥钠0.1~0.2ml/100g体重腹腔麻醉孕鼠,下腹正中 开腹,以无创动脉夹钳夹一侧血管,对侧未钳 相似文献
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本文对20例新生儿窒息患儿分别采用镉还原层析—比色法及Percoll密度离心法进行血一氧化氮(NO)、循环内皮细胞(CEC)水平测定,并与30例健康新生儿进行对照,发现新生儿窒息组的NO及CEC的均值显著高于对照组,并且有显著差异(P<0.05)。由此可见新生儿窒息与NO、CEC有密切的关系,是判断病情的辅助指标。 相似文献
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新生儿缺氧缺血性脑病(HIE)是因围产期宫内缺氧缺血及产后窒息影响新生儿脑细胞能量代谢,导致缺氧性脑病变,出生后出现的一系列脑部症状。其发病率高,重症患儿将会发生脑瘫等严重后遗症,给家庭和社会带来沉重负担。但是其发病机制到日前为止 相似文献
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围产期窒息母儿血浆催乳素水平变化研究 总被引:2,自引:0,他引:2
为探讨窒息新生儿母、儿血浆催乳素( PRL)水平变化与相关性及其意义,采用放射免疫分析法对 25例围产期窒息儿及 20例正常对照组母血、脐血及新生儿血浆 PRL水平进行测定并进行动态观察.结果显示窒息组母血、脐血及新生儿血浆 PRL水平均显著高于正常对照组( P均 <0.01);重度窒息组母血、脐血及新生儿血浆 PRL水平均高于轻度窒息组,差异具有显著性( P<0.01, <0.001, <0.01),窒息儿母血、脐血及新生儿血浆 PRL水平具有显著的正相关关系( r=0.54,P<0.05).窒息新生儿复苏后血浆 PRL水平显著增高,生后第 2 d PRL水平逐渐下降,生后第 10 d血浆 PRL水平虽高于正常对照组,但差异无显著性( P>0.05).提示围产期窒息新生儿血浆、脐血、母血 PRL水平显著增高,其可能的机理是窒息时缺氧缺血导致脑组织释放兴奋性氨基酸增加,进而刺激垂体前叶释放 PRL,导致血浆及脐血 PRL水平增高.因此认为,血浆 PRL水平可作为判断新生儿窒息程度及由窒息缺氧所致新生儿脑损伤恢复状况的一项参考指标. 相似文献
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I Hamon H Gauthier‐Moulinier E Grelet‐Dessioux L Storme J Fresson JM Hascoet 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(10):1467-1473
Background: Inhaled nitric oxide (iNO), commonly used for hypoxic neonates, may react with haemoglobin to form methaemoglobin (MetHb). MetHb monitoring during iNO therapy has been questioned since low doses of iNO are used. Aim: To evaluate the incidence of and identify risk factors associated with elevated MetHb in neonates treated with iNO. Methods: Neonates who were treated with iNO and had at least one MetHb measurement were included. Demographic characteristics and methods of iNO administration (dosage, duration) at the time of each MetHb measurement were analysed. Results: Four hundred and fifty‐two MetHb measurements from 81 premature and 82 term and near‐term infants were analysed. MetHb was above 5% in one‐term infant, and between 2.5–5% in 16 infants. A higher maximum dose of iNO (22.7 vs 17.7 p.p.m.), but not gestational age, was a significant risk factor for elevated MetHb. Significantly higher oxygen levels (75.5% vs 51.7%) were associated with higher MetHb in term infants. Preterm infants had no risk for high MetHb when iNO was kept below 8 p.p.m. These data suggest the possibility of limiting blood withdrawal when low doses iNO are used. Conclusion: High MetHb is exceptional in neonates treated with low dose iNO. Associated risk factors are related to high iNO dose and the simultaneous use of high concentrations of oxygen. 相似文献
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新生儿缺氧缺血性脑病与NO、NOS、PRL水平的相关性研究 总被引:5,自引:0,他引:5
采用放免法和比色法测定68例新生儿缺氧缺血性脑病(HIE)及30例正常新生儿血浆一氧化氮(N0)、一氧化氮合酶(NOS)及血清催乳素(PRL)活性水平,以探讨NO、NOS及PRL在HIE中的发病机理、病情进展及预后中的作用。结果;HIE急性期NO、NOS、PRL水平较正常新生儿明显升高(P<0.05),中度和重度HIE的3项水平升高更显著(P均<0.01);HIE惊厥组急性期血清PRL水平显著高于非惊厥组(P<0.01),且与惊厥发作持续时间呈正相关(r=0.485,P<0.01)。提示:NO、NOS、PRL水平高低与HIE患儿脑损伤严重程度有关,可作为判断病情、预后及惊厥是否发作的指标。 相似文献
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目的探讨一氧化氮(NO)在合并脑室周围白质软化(PVL)的早产儿神经发育中的作用。方法采用随机、对照实验,对合并PVL的106例早产儿,在出生后24h内随机分成吸入NO组(第1天10×10-6,以后改为5×10-6继续用6d)和对照组(吸入氧气7d),在纠正胎龄18个月时采用贝利发育量表评估其神经发育。结果吸入NO组贝利评分明显高于对照组(P<0.05),贝利评分低于70分的发生率明显低于对照组(P<0.05)。结论合并脑室周围白质软化早产儿采用吸入NO治疗,有利于促进其神经发育。 相似文献
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Carmelo Gabriele Els C. van der Wiel Eveline M. Nieuwhof Henriette A. Moll Peter J. F. M. Merkus Johan C. de Jongste 《Pediatric allergy and immunology》2007,18(1):36-41
Guidelines for the measurement of fractional exhaled nitric oxide (FE(NO)) recommend refraining from lung function tests (LFT) and certain foods and beverages before performing FE(NO) measurements, as they may lead to transiently altered FE(NO) levels. Little is known of such factors in infants. The aim of the present study was to evaluate whether forced expiratory maneuvers, sedation, nasal contamination, and breastfeeding affect FE(NO) values in infants. FE(NO) was measured off-line during tidal breathing by means of a facemask covering nose and mouth. FE(NO) measurements were performed in 45 sedated infants (mean age 12.1 months) who underwent LFT because of airway diseases and in 83 unsedated healthy infants (mean age 4.3 months). In infants with airway diseases, no difference was found in FE(NO) values before and 5 min after LFT (n = 19 infants, p = 0.7) and FE(NO) values before sedation did not differ from FE(NO) values during sedation (n = 10 infants, p = 0.2).Oral FE(NO) values were significantly lower than mixed (nasal + oral) FE(NO) (n = 42 infants, p < 0.001). FE(NO) values before and 5 min after breastfeeding were not different (n = 11 healthy infants, p = 0.57). The short-term reproducibility in healthy infants (n = 54) was satisfactory (intraclass correlation coefficient = 0.94). We conclude that, in infants with airway diseases, LFT prior to FE(NO) measurement did not influence FE(NO) values and FE(NO) values did not change after sedation. Oral FE(NO) values were significantly lower than mixed (oral + nasal) FE(NO), and breastfeeding did not influence FE(NO). Short-term reproducibility in awake healthy infants was good. 相似文献
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MASAO TAKATA KATSUYUKI MIYASAKA HIROKAZU SAKAI HIROYUKI FUJIWARA YUSHI ITO TOSHIO KAWANO 《Pediatrics international》1995,37(2):171-173
Persistent pulmonary hypertension of the newborn (PPHN) may occasionally require an invasive treatment with extracorporeal membrane oxygenation (ECMO). Inhaled nitric oxide (NO) has recently been introduced as a selective pulmonary vasodilator for treatment of PPHN. We describe a case of PPHN in which neither inhaled NO nor ECMO was effective in reversing pulmonary hypertension. The clinical course of the patient suggested a potential role of NO inhalation in predicting the outcome of ECMO treatment for PPHN. 相似文献