皮肤Merkel细胞癌1例

患者女,63岁。发现右肘皮肤暗红色肿块3月。皮损组织病理示:肿块位于真皮呈巢状分布,肿瘤细胞大小形态较一致,胞质较少,略嗜碱性,胞核圆形,伴典型的细颗粒状(尘样)染色质及多个核仁,核分裂相及核碎片易见。免疫组化示:肿瘤细胞CK20,CHG,CD56,Syn均阳性,LCA阴性。诊断:右肘皮肤Merkel细胞癌。     

皮肤Merkel细胞癌一例

患者女,76岁,1年前无明显诱因,右眼外眦下方1 cm处长一绿豆大小的结节,呈淡红色,无任何自觉症状。近2月来明显增大,遂来我院门诊求治。体检:右眼外眦下方1 cm处有一直径约1．5 cm的突出半圆形结节,呈淡红色。结节表面光滑,质软,活动良好,无压     

Merkel细胞癌一例

Merkel细胞癌是一种罕见的皮肤恶性肿瘤 ,好发于暴露部位 ,有明显局部复发及早期转移倾向。我们见到一例 Merkel细胞癌 ,并出现眼睑、额部及胸部等多处转移 ,现报道如下。 患者男 ,66岁 ,2年前发现左前臂伸侧有一肿物 ,2.5 cm× 2.5 cm× 3 cm,质硬 ,活动 ,左上肢感觉运动正常 ,腋窝淋巴结不大。行手术切除 ,病理示表皮正常 ,真皮乳头层无浸润 ,真皮中下层广泛片状及条带状单一核细胞浸润 ,细胞核呈圆形、椭圆形 ,较一致 ,灰蓝染色 ,胞浆稀少 ,胞膜不明显 ,伴淋巴细胞浸润 ,可见分裂象（图 1,2）。免疫组化示突触素 (SY38)(＋ )(图 3)、嗜…     

Merkel细胞癌

患者男,75岁. 主诉:胸部新生物2年,迅速增大半年. 现病史:患者2年前无意间发现胸部一粟粒大暗红色丘疹,无瘙痒及疼痛,增长缓慢,未予诊治.半年前,皮损迅速增大,表面出现厚层痂壳,偶有轻度瘙痒,余无不适,为明确诊断及进一步治疗,于2018年4月15日来成都市第二人民医院皮肤科就诊. 既往史及家族史:患者既往有原发性高...     

皮肤Merkel细胞癌3例

目的：报告3例皮肤Merkel细胞癌，进一步了解该肿瘤的临床表现、组织病理学特点和电镜观察的特征。方法：采用光镜、免疫组化和电镜技术，对3例患者的皮损进行组织病理学观察及诊断。结果：光镜检查示肿瘤位于真皮内，呈团片状、巢状、岛状或散在分布，细胞大小较一致。免疫组化示NSE、CgA、Sy、EMA、α—ACT在肿瘤细胞呈阳性表达。电镜观察示肿瘤细胞胞质内可见神经分泌颗粒。结论：皮肤Merkel细胞诊断依赖病理学检查，早期诊断、早期治疗是提高生存率的关键。     

Merkel细胞癌1例

报道1例Merkel细胞癌，患者女，46岁，左臀部皮下肿块月余，直径2cm，质硬，边界较清，无压痛，表面皮色正常，免疫组化证实为Merkel细胞癌，手术后愈合良好。     

皮肤Merkel细胞癌临床与病理分析

@@@@目的：阐述皮肤Merkel细胞癌的临床、病理及免疫病理特点。方法：对1例面部Merkel细胞癌患者进行临床病理分析,同时进行免疫组化标记CK、CK20、CD56、Fli－1、LCA、CD99和HMB－45。结果：组织病理学示瘤细胞弥漫浸润生长,部分呈巢团状、梁索状分布;核圆形或类圆形,大小形态一致,核内染色质呈椒盐样细颗粒状,核仁较小,胞质少,核膜清晰,核分裂相及核碎片易见;免疫表型：肿瘤细胞CK－Pan、CK20强阳性,阳性表达在核周,呈特征性的逗点状或帽状分布,CD56和Fli－1均为胞质阳性,CD99、LCA和HMB－45阴性。结论：皮肤Merkel细胞癌是一种罕见的高度恶性神经内分泌癌,熟悉其临床病理特点对诊断和鉴别诊断有重要意义。     

皮肤Merkel细胞癌伴前列腺癌1例

患者男,78岁,右侧跟腱结节2个月。手术切除皮损组织病理示：真皮深部见嗜碱性细胞团块,胞浆呈颗粒状,部分细胞核大深染、有异型性。免疫组织化学结果示：CK(2+)、CK19(+)、CK20(点状+)、CD56(+)、CgA(+)、Syn(+)、vimentim(+)、Ki-67(50%+)。诊断考虑Merkel细胞癌。全身PET-CT检查发现前列腺肿瘤,前列腺组织病理回报腺泡腺癌。诊断：皮肤Merkel细胞癌合并前列腺癌。     

皮肤Merkel细胞癌伴鳞状细胞癌一例

患者男,76岁,因左耳前肿物2个月,破溃1个月就诊.2个月前左耳前面颊部无明显诱因出现一约黄豆大小的丘疹,迅速长大,1个月前表面出现破溃,无自觉症状.2周前左耳后出现一蚕豆大小肿大的淋巴结,有触痛,抗炎治疗后缩小.     

Merkel细胞癌合并原位鳞状细胞癌一例并文献复习

Merkel细胞癌是一种罕见的、具有高度侵袭性的皮肤神经内分泌癌,好发于老年人的日光暴露部位,尤其是头颈部(41%～50%),其次是四肢(32%～38%)。Merkel细胞癌可与鳞状细胞癌、鲍温病、基底细胞癌等皮肤肿瘤合并发生。我们报道一例发生在非光暴露部位的Merkel细胞癌合并原位鳞状细胞癌,并对相关文献进行复习。     

Granular cell basal cell carcinoma: A case report

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields, with a Ki‐67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl‐2.     

Merkel cell carcinoma: case report

Merkel cell carcinoma (MCC), also termed cutaneous small cell carcinoma or trabecular carcinoma, is a rare tumor that most often presents as a solitary nodule on the head, neck, or extremities of older adults. It is an aggressive tumor that usually is fatal due to rapid metastasis. Involvement of lymph nodes at presentation can be used to predict survival. Because MCC is sensitive to radiation, it can be used as an adjunct to surgery. We report a case of MCC to alert clinicians of this potentially fatal tumor because early diagnosis and proper treatment may improve patient survival rates.     

Merkel细胞癌多瘤病毒阳性的皮肤原发性Merkel细胞癌二例

【摘要】 目的 报道Merkel细胞癌多瘤病毒阳性的Merkel细胞癌2例。 方法 对诊治的2例Merkel细胞癌进行光镜观察及免疫组化标记,聚合酶链反应（PCR）检测Merkel细胞癌多瘤病毒并测序。 结果 2例均为男性,例1右下肢胫前肿物1年余,皮肤科检查见右胫前密集粉红色结节,融合成10 cm × 8 cm肿块,质硬,部分表面糜烂伴渗出及结痂,肿块周围亦可见多个大小不一的红色结节,活动性差。例2左膝肿物6月余,皮肤科检查见左膝内侧5 cm × 4 cm紫蓝色结节型肿物,质硬,边界不清,活动性差。2例患者皮损组织病理表现相似,肿瘤细胞大小一致,细胞核大、深染,染色质细腻,核分裂象易见;胞质少,红染。免疫组化：广谱细胞角蛋白（pan-CK）、细胞角蛋白20（CK20）、突触素（Syn）、嗜铬素（CgA）和神经元特异性烯醇化酶（NSE）均阳性,Ki-67（≥60%）阳性;细胞角蛋白7（CK7）、S100蛋白、HMB45、CD34、甲状腺转录因子1（TTF-1）和白细胞共同抗原（LCA）表达均阴性。2例Merkel细胞癌均经PCR检测到Merkel细胞癌多瘤病毒,而5例皮肤T细胞淋巴瘤、2例正常人皮肤和2例T细胞淋巴瘤细胞系MAC1和MAC2A均未检测到Merkel细胞癌多瘤病毒。 结论 Merkel细胞癌具有特征性的临床和组织病理表现,免疫组化标记、PCR检测Merkel细胞癌多瘤病毒对明确诊断具有重要作用。 【关键词】 癌,Merkel细胞; 多瘤病毒属     

面部鳞癌伴巨大皮角一例

患者，女，85岁。左侧面部角状褐色肿物2年余。组织病理示：基底部分区域细胞增生明显活跃。免疫组化示P63（+）、Ki-67（局灶指数30%）。临床症状结合病理及免疫组化结果，诊断为面部鳞癌伴巨大皮角。全麻手术下行皮肤恶性肿物切除术，随访3个月，未复发。     

Recurrent Merkel cell carcinoma of the gluteal region: A case report

Merkel cell carcinoma (MCC) is a rare malignant tumor of the skin. The development of MCC on non‐sun‐exposed skin is extremely rare, with few cases reported in the literature. The present authors aimed to highlight the characteristic features and treatment options of this tumor. The present authors present a 50‐year‐old man who developed MCC on the left gluteal region (non‐sun‐exposed skin). After surgery with clear margins, adjuvant radiotherapy was given. Three months after radiotherapy, lymphatic recurrence was observed and he was treated with chemotherapy. On follow‐up, systemic metastases were found and palliative treatment was planned.     

Molecular pathogenesis of Merkel cell carcinoma

Abstract:  Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer. Although MCC, which primarily affects elderly and immune suppressed individuals, is very rare to date, its incidence is rapidly increasing. In contrast to the immense progress that has been made in the elucidation of the molecular pathogenesis of other cancer entities, until recently there were no clear-cut indications which events drive the carcinogenesis of MCC. Important findings published last year have changed this radically. Hypermethylation of the p14^ARF promoter and a striking correlation between expression of p63 and the clinical course of MCC have been reported. Most important, however, is the discovery that MCC development in the majority of cases is preceded by the integration of genomic sequences of the hitherto unknown Merkel cell polyomavirus (MCPyV). Now a fundamental improvement in the understanding of MCC pathogenesis as well as the development of new therapeutic approaches based on this knowledge appear to be possible within the near future.     

Merkel cell carcinoma arising within a poroma: report of two cases

Merkel cell carcinoma (MCC) has been reported in association with other types of cutaneous neoplasms within the same lesion, including squamous cell carcinoma, Bowen's disease, actinic keratosis, follicular cysts, trichoblastoma and lentigo maligna, among others. However, the association of MCC and sweat gland tumors has never been described in the literature. We report two unique cases of MCC that developed within cutaneous poromas. A 56‐year‐old male (Patient 1) and an 81‐year‐old female (Patient 2) presented with nodules on the upper arm and lower back, respectively. Histopathologic study of both cases revealed a tumor in the dermis composed of poroid and cuticular cells intermingled with a proliferation of small round cells that showed characteristic histopathological and immunohistochemical features of MCC. In both cases, the two neoplasms were tightly admixed and distinct, suggesting that the MCC could have developed within a previously existing poroma. No morphological features of transition between the two tumors were seen. Neoplastic cells of MCC expressed immunoreactivity for chromogranin, synaptophysin, neuron‐specific enolase, CAM 5.2 and cytokeratin 20, the last two markers showing the characteristic paranuclear dot‐like pattern. In contrast, the poroma cells only expressed cytokeratin MNF116. Metastatic deposits were not identified in the regional lymph nodes or distantly.