基于CiteSpace的肿瘤干细胞研究态势的文献计量学分析

目的 通过对肿瘤干细胞(CSCs)研究文献进行计量学分析,探索CSCs领域的研究热点和研究趋势.方法 基于Web of Science核心数据库,通过CiteSpace对发表文章年度分布、作者、机构、国家、期刊、被引情况和关键词等进行分析,并对关键词的词频、中心性和聚类情况进行探讨.结果 (1)筛选后共纳入8131篇文...     

人工智能在癌症研究领域的文献可视化分析

目的 分析Web of Science核心合集数据库2010—2019年人工智能在癌症研究领域的文献,总结研究热点和发展趋势.方法 通过文献计量学方法 和CiteSpace信息可视化软件,对2010—2019年Web of Science核心合集数据库关于人工智能在癌症研究领域的相关文献进行可视化分析.结果 人工智能在...     

基于CiteSpace的中国肺癌筛查现状及趋势分析

目的:肺癌是影响人类生命健康的主要恶性肿瘤之一,其发病隐匿,临床就诊时常已进展至中晚期,预后较差,通过筛查实现肺癌早诊早治是当今肺癌防控工作的重要手段.方法:本文使用文献可视化分析软件CiteSpace对1989～2020年CSSCI、核心期刊、CSCD数据库中收录的肺癌筛查相关文献进行分析,梳理我国肺癌筛查研究领域的...     

基于CiteSpace的鼻咽癌研究文献计量学分析

目的 分析鼻咽癌领域的研究现状和发展趋势,以期对我国鼻咽癌研究提供借鉴。方法 检索Web of Science（WOS）核心数据库2009—2019年鼻咽癌相关研究性文章,通过CiteSpace和WOS数据库自带文献统计工具对发表文章篇数、研究机构、文献被引情况和关键词等进行分析,并对关键词的词频、中心性和聚类情况进行探讨。结果 筛选后共得到4 841篇文献,发表文章数量逐年上升。词频最高的10个关键词和中心性最高的10个关键词主要围绕鼻咽癌的治疗方式和致病机制展开。聚类结果集中在4个方面,分别是不良预后、晚期鼻咽癌、临床靶区描绘和异戊烯基异黄酮。结论 鼻咽癌研究热度与患者地理分布密切相关,当前研究热点为鼻咽癌的治疗和致病机制。     

基于Web of Science对再喂养综合征的文献计量学分析

目的 分析再喂养综合征领域的研究现状、热点及前沿。方法 以Web of Science核心合集数据库为数据来源,检索自建库以来至2021年12月31日再喂养综合征的相关文献,利用Citespace和VOSviewer进行分析,对相关研究的国家、期刊、作者及关键词等进行分析。结果 共纳入755篇相关文献,发文量总体上逐年增长,美国、英国、日本是该领域的重要国家。再喂养综合征高危因素的识别、临床表现、预防性管理和治疗是目前研究热点。研究对象主要是神经性厌食患者、危重症患者、住院患者及青少年。其中危重症患者的死亡率、危险因素及管理是研究前沿。结论 我国再喂养综合征领域研究仍有较大发展空间,未来应制订统一的筛查标准,开展循证探索及实践,为临床实践提供参考。     

坚持政府主导 推进中国癌症筛查发展

摘 要：癌症是导致我国居民早死的重要原因,对高危人群进行筛查已成为降低癌症负担的主要策略。我国癌症筛查项目在党的正确领导下取得了长足进展,项目逐步有规模、并有计划地向高发地区、农村和城市地区推进,为实现“健康中国”战略奠定重要基础。     

基于德尔菲法的中国癌症筛查体系初探研究

目的:基于德尔菲法进行中国癌症筛查体系初探研究。方法:于2019年12月至2020年4月邀请全国从事肿瘤防控、公共卫生监测相关领域的24位专家,采用德尔菲法进行两轮专家咨询,通过计算专家积极系数、专家权威系数和专家意见协调程度,了解专家意见,初步探究我国癌症筛查体系的建立。结果:两轮咨询的专家积极系数分别为100%和95.83%,专家权威系数分别为0.86和0.88。两轮咨询的专家意见协调系数分别为0.408(P<0.05)和0.419(P<0.05);专家认为我国目前开展癌症筛查有助于癌症的早诊早治,而目前实现癌症筛查的概率约为50%。如启动癌症筛查工作,应优先涵盖肺癌、上消化道癌、乳腺癌、肝癌、结直肠癌这五大癌种。筛查政策可以由国家或地方建立制度,并纳入医疗保险。结论:本研究基于德尔菲法探究我国癌症筛查体系的专家积极性高、权威程度和协调性好,科学性和可靠性较好,研究结果可为我国癌症筛查体系构建提供重要参考。     

中国癌症筛查的发展、现状与挑战

癌症是我国的重大公共卫生问题,严重威胁我国居民健康。为减轻癌症造成的疾病负担,在党和政府的有力领导下,我国在癌症筛查和早诊早治方面取得了显著的成就。现今我国癌症筛查体系日趋成熟,常见高发癌种的筛查与早诊早治项目逐渐推广和普及。但我国癌症筛查工作仍存在诸多不足,政府仍需根据目前癌症筛查现状制定和推行相应政策,多措并举以提高我国癌症筛查效果。     

乌鲁木齐市社区居民癌症筛查依从性及影响因素分析

[目的]了解社区肿瘤高危人群参加筛查的依从性及影响因素,为提高癌症筛查效果提供依据.[方法]采用随机抽样的方法选取研究对象,并按照是否参加筛查分为筛查组(n=439)和非筛查组(n=529),采用问卷调查的方法对依从性影响因素进行分析.[结果]筛查人群总体依从性为30.04％(10297/34282).多因素Logistic回归分析显示受教育程度、肿瘤家族史、筛查部位疾病史、了解本次筛查目的和周围有认识人参加筛查是影响筛查依从性的主要因素.[结论]乌鲁木齐市社区患癌高危人群筛查依从性较低,应加强癌症筛查的健康宣教工作,尤其是受教育程度低、无肿瘤家族史和疾病史的人群,提高认知程度,进一步提高依从性.     

基于CNKI和Web of Science数据库2012—2021年中药治疗乳腺癌的文献计量学分析

目的 基于CNKI和Web of Science(WOS)数据库对2012—2021年中药治疗乳腺癌的文献进行计量学分析,分析中药治疗乳腺癌的研究现状及发展趋势。方法 检索CNKI和WOS数据库2012年1月1日至2021年12月31日已发表的中药治疗乳腺癌的相关文献,运用文献计量学及CiteSpace 5.8.R1软件对研究作者、研究机构及关键词进行可视化分析。结果 经筛选最终纳入960篇CNKI数据库文献、809篇WOS数据库文献。2012年以来,CNKI和WOS数据库中药治疗乳腺癌的发文数量总体呈上升趋势。CNKI和WOS数据库发文核心作者分别为32名和35名,占发文总人数的9.2%、9.7%。发文主要来源于中医药类院校及其附属医院,包括中国医科大学、北京中医药大学、上海中医药大学等。2012—2021年中药治疗乳腺癌的热点从早期的多药耐药、生存质量、互补治疗等临床相关研究,过渡至用药规律、网络药理学、数据挖掘、作用机制等多角度多方向。结论 中药治疗乳腺癌研究应结合现代科学技术对其进行信息化、数字化和知识化研究,有助于研究人员探索研究的新方向,并确定该领域潜在合作的新视角。     

基于CiteSpace的肺癌免疫治疗研究的可视化分析

Objective To understand the current status of research on lung cancer immunotherapy to provide a reference for further investigation and future topic selection in this field. Methods CiteSpace visualization analysis software was used to analyze 400 Chinese studies in CNKI and 5 001 English studies in the Web of Science database from 2005 to 2021, with “lung cancer” and “immunotherapy” as keywords. Keyword co-occurrence analysis was performed on 17 English studies of “Lung Cancer” “Immunotherapy” and “Single cell sequencing” in the Web of Science database. Results “Non-small cell lung cancer” “immunosuppressants” “PD-L1” “dendritic cells” and “cytokine-induced killer cells” are current research hotspots in lung cancer immunotherapy. Monoclonal antibody drugs including nivolumab, pembrolizumab, atezolizumab, and durvalumab are hotspot drugs. Immunotherapy combined with chemotherapy as well as PD-L1 expression have become the focus of continuous research. The majority of studies on lung cancer immunotherapy are conducted in the United States, followed by China. Conclusion Lung cancer immunotherapy has gradually become a research hot spot in China. In the future, in-depth research is needed to provide cutting-edge directions for lung cancer immunotherapy. © 2023, CHINA RESEARCH ON PREVENTION AND TREATMENT. All rights reserved.     

基于CiteSpace肿瘤相关肌肉减少症研究的知识图谱分析

目的 了解、分析国内外肿瘤相关肌肉减少症患者的研究现状及热点。方法 检索中国知网、万方数据库、维普数据库和Web of Science（WOS）核心数据库1999-2018年收录的肿瘤相关肌肉减少症领域的相关文献,采用文献计量学方法,通过CiteSpace V软件对国家、机构、高被引文献及关键词进行可视化分析。结果 发文量整体呈上升趋势,亚洲国家发文量相对处于领先水平,但高被引文献主要集中于欧美地区;国内肿瘤相关肌肉减少症领域研究热点为胃肠道肿瘤手术患者肌肉减少症的相关影响因素及预后的调查性研究,WOS核心数据库在此领域的研究热点已延伸到对接受化疗及靶向药物治疗患者、泌尿系统肿瘤、胰腺癌、胆管癌等患者的预后影响研究,关注此领域发生机制及影响因素的深入研究,运动及营养的干预性研究等。结论 我国肿瘤相关肌肉减少症的研究尚处于初步阶段,临床一线工作人员应提高对患者的关注度,加强对肿瘤患者肌肉力量、机体功能及营养状况的评估和筛查。在借鉴国外研究方法的基础上,结合本国实际情况,拓宽研究范围,开展适宜研究。     

Awareness of General Public Towards Cancer Prostate and Screening Practice in Arabic Communities: a Comparative Multi-Center Study

The current study aimed at exploring the knowledge and beliefs of men aged forty years and over towardsprostate cancer screening and early detection in three Arab countries. The field work was conducted in threecountries; Saudi Arabia, Egypt and Jordan, during the period February through December 2011. Our targetpopulation were men aged 40 years and over. It was a population-based cross sectional study comprising 400subjects at each site. In addition to socio-demographic data, history of the present and past medical illness,practice history of prostatic cancer examination, family history of cancer prostate; participants were inquiredabout their knowledge and attitude towards prostate cancer and screening behavior using two different likertscales. The percentage of participants who practiced regular prostate check up ranged from 8-30%. They hadpoor knowledge and fair attitude towards prostate cancer screening behavior, where the mean total knowledgescore was 10.25±2.5, 10.76±3.39 and 11.24±3.39 whereas the mean total attitude score was 18.3±4.08, 20.68±6.4and 17.96±5.3 for Saudi Arabia, Egypt and Jordan respectively. The respondents identified the physicians as themain sources of this information (62.4%), though they were not the main motives for regular checkup. Knowledgewas the only significant predictor for participants’ attitude in the multiple regression models. Participants’attitudes depends mainly on level of knowledge and quantity of information provided to the patients and theirfamilies. Such attitudes should rely on a solid background of proper information and motivation from physiciansto enhance and empower behaviors towards prostate cancer screening practices.     

Review of the Cervical Cancer Burden and Population-Based Cervical Cancer Screening in China

Cervical cancer continues to be a serious public health problem in the developing world, including China. Because of its large population with geographical and socioeconomic inequities, China has a high burden of cervical cancer and important disparities among different regions. In this review, we first present an overview of the cervical cancer incidence and mortality over time, and focus on diversity and disparity in access to care for various subpopulations across geographical regions and socioeconomic strata in China. Then, we describe population-based cervical cancer screening in China, and in particular implementation of the National Cervical Cancer Screening Program in Rural Areas (NACCSPRA) and the challenges that this program faces. These include low screening coverage, shortage of qualified health care personnel and limited funds. To improve prevention of cervical cancer and obtain better cancer outcomes, the Chinese government needs to urgently consider the following key factors: reducing disparities in health care access, collecting accurate and broadly representative data in cancer registries, expanding target population size and increasing allocation of government funding for training of personnel, improving health education for women, enhancing quality control of screening services and improving a system to increase follow up for women with positive results.     

中国癌症早诊早治的实践与思考

文章概述癌症早诊早治示范基地及中央转移支付项目的进展,并以检出率、早诊率及治疗率作为近期评价工作的指标。5年工作经验表明,试点示范工作在癌症早诊早治的推广中具有重要意义,而政府重视及基层队伍的技术培训在其中起着关键作用。中国癌症早诊早治工作的目标是,使癌症早诊早治逐步成为经常性公共卫生服务的一部分。为此应积极准备条件：加强健康促进,使更多筛查对象积极主动地参与;加强基层能力建设,造就合格的基层技术队伍;合理的制度安排,使符合成本—效益原则的筛查方案与医疗保障制度相结合。     

Knowledge,Attitudes, and Behaviour Regarding Breast Cancer Screening among Women from Different Socio-economic Regions in Southwest China: A Cross-sectional Study

Background: In most developed countries, breast cancer screening (BCS) is a well-established practice whichis widely accepted by women. In contrast, national BCS projects in China were only launched in the last twoyears, so little is known about their public response. Methods: We surveyed 1,162 Chinese women from differentsocio-economic regions in Sichuan Province to assess participants’ knowledge, attitudes, and behaviour regardingBCS. ANOVA/t-test, Chi-square test, SNK test, and covariance analyses were used to compare subgroupsand a multinomial logistic regression model was adopted to examine factors associated with BCS attendance.Results: Statistically significant differences in scores of BCS knowledge were seen across regions. Most womenfrom all four regions were interested in knowing the risk factors for (1,053, 90.6%) and means of prevention(912, 78.5%) of breast cancer. Eight hundred thirty-seven (72.0%) women expressed willingness to pay extrainsurance fees when young in exchange for reimbursement for cancer screening when they reached the age atwhich screening is recommended. Approval of primary medical institutions was generally low. Regional socioeconomiclevel, work status, and education were strong predictors of BCS attendance. Conclusion: To eliminategeographic disparities and raise the participation rate of BCS, future health education should be adjusted to localconditions and strengthened for women in under-developed regions. Incorporating BCS into a regular programof community-based prevention of chronic non-communicable diseases, and increasing medical insurance fundsto cover BCS, especially in rural areas, may be effective means to increase BCS attendance.     

Estimating the Costs of Esophageal Cancer Screening,Early Diagnosis and Treatment in Three High Risk Areas in China

Background: The incidence and mortality of esophageal cancer (EC) in some rural areas with poor healthresources in China are the highest around the world. In these areas, screening programs for EC are conducted forprevention and control. However, costs associated with esophageal cancer screening have not been characterized indetail. This study is aimed to estimate the screening, early diagnosis and treatment costs of EC using micro-costingmethods, which could provide basic cost inputs for further systematic health economic evaluation. Materialsand Methods: Micro-costing methods were adopted to collect data on quantity and unit cost of used resources.Data was obtained from face-to-face interview with medical staff, local hospitals’ database, and experts’ input.We used 80% capacity utilization and 3% discount rate to annualize capital investments, and all costs wereadjusted to year 2008 using the gross domestic production deflator, and then converted from Chinese currencyunit to international dollars (I$) using purchasing power parity. Results: Screening costs per case were aroundI$60. For severe dysplasia, carcinoma in situ and intramucosal carcinoma, the costs per capita of endoscopicmucosal resection were I$1292~I$1620, and around I$450 for argon plasma coagulation. For submucosalcarcinoma (T1N0M0), and invasive carcinoma treated by esophagectomy, the treatment costs ranged from I$1485to I$2171. The costs of treatment of invasive carcinoma were: I$497~I$685.2 for radiotherapy; I$4652~I$7966.15for chemotherapy; I$1928~I$2805 for combination of esophagectomy and radiotherapy; I$6632~I$8082 foresophagectomy, radiotherapy and chemotherapy in combination. Conclusion: The cost analysis found screening,early diagnosis and treatment for EC could provide great cost savings. The results provide important informationfor further health economic evaluation, and to help the local policy makers on updating such screening programin high risk areas in China.