火针、温针及电针疗法治疗膝骨关节炎有效性的网状Meta分析

文题释义：网状Meta分析：基于间接比较或合并间接比较与直接比较而同时分析 2 个以上干预措施的Meta分析。包括如下2种情况：①间接比较Meta分析：当不存在直接比较情况下，基于共同对照对多个干预措施进行比较的Meta分析；②混合治疗效应Meta分析：当同时存在直接比较和间接比较的情况下，基于间接结果与直接结果的合并结果来同时分析多个干预措施的Meta分析。 温针灸：针刺与艾灸相结合的一种方法，又称针柄灸。即在留针过程中，将艾绒搓团捻裹于针柄上点燃，通过针体将热力传入穴位。 背景：针灸的方法主要包括温针灸、火针、电针，但这些疗法在治疗膝骨关节炎的有效性和安全性平衡仍不清楚。 目的：运用网状Meta分析，比较温针灸、火针、电针3种针灸疗法干预膝骨关节炎的有效性。 方法：检索Embase、Cochrane Library、PubMed及中国期刊全文数据库(CNKI)、万方数据库(Wangfang)、维普数据库(VIP)及中国生物医学文献数据库(CBMdisc)，检索时间为2019-09-20之前，搜集温针灸、火针、电针治疗膝骨关节炎的临床随机对照试验。采用 RevMan 5.3和Stata 14.0软件行数据分析。 结果与结论：最终纳入34个随机对照试验，共2 871例膝骨关节炎患者。网Meta分析结果示：①在临床总有效率方面，火针(OR=1.08，95%CI：1.00-1.17，P < 0.05)、温针(OR=1.08, 95%CI：1.02-1.14，P < 0.05)总有效率均优于电针，3种针灸疗法总有效率均优于西药，火针最佳；②在改善目测类比评分方面，火针(MD=-2.12，95%CI：-3.52至-0.71，P < 0.05)、温针灸(MD=-1.31，95%CI：-2.33至-0.29，P < 0.05)，电针(MD=-1.17，95%CI：-2.19至-0.16)，P < 0.05)的均优于西药，火针最佳；③在降低WOMAC总分方面，火针(MD=-15.38，95%CI：-27.88至-2.87，P < 0.05)、温针灸(MD=-11.48，95%CI：-16.45至-6.51)，P < 0.05)及电针(MD=-7.29，95%CI：-11.86至-2.72，P < 0.05)均优于西药，火针最佳；④结果证实，综合比较3种针灸疗法的相关结果排序后，在治疗膝骨关节炎中，优先推荐火针治疗。但仍需更多高质量随机对照研究来进一步证实。 ORCID: 0000-0002-8634-0633(张金焕) 中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程     

神经阻滞疗法在肱骨外上髁炎治疗中的应用

肱骨外上髁炎是门诊常见病，多发病。神经阻滞能阻断痛觉刺激传导的同时，又缓解了局部的肌紧张和痉挛，改善局部的血循环、供氧和组织代谢。神经阻滞疗法治疗肱骨外上髁炎，具有效果确切、疗程短、费用低，很适合疼痛门诊开展。我院疼痛门诊自2002年4月至2004年7月应用神经阻滞疗法治疗肱骨外上髁炎536例，取得了满意效果。现报道如下。     

臭氧治疗肱骨外上髁炎的临床疗效观察

<正>肱骨外上髁炎(网球肘),是肱骨外上髁部伸肌总腱起始处的慢性肌筋膜炎,是一种以肘部外侧疼痛为主的多发病,本病疼痛局限于前臂上端外侧,且主要在肱骨外上髁部位,在前臂提物及做旋转等动作时疼痛尤重,外上髁局部触压痛也较明显[1]。而早已有研究证明医用臭氧(medical ozone,O3)具有消炎、止痛和溶解髓核内的蛋白多糖等作用[2]。因此本研究试采用臭氧对肱骨外上髁炎患者进行探索治疗,观察医用臭氧治疗肱骨外上髁炎的临床疗效,并     

揿针疗法在骨科常见慢性疼痛性疾病治疗中的应用

目的 观察揿针疗法在骨科常见慢性疼痛疾病中的临床疗效。方法 选取2018年2月~2019年1月在我院骨科慢性疼痛性疾病患者160例,行腧穴埋针法治疗,观察临床治疗总有效率及随访6个月复发率。结果 揿针疗法治疗骨科常见慢性疼痛性疾病总有效率为92.50%,其中治愈88例,好转60例,无效12例。随访6个月总复发率为4.38%,其中颈型颈椎病、肱骨内上髁炎未见复发病例,肱骨外上髁炎、桡骨茎突狭窄性腱鞘炎各复发1例,膝关节骨性关节炎内侧关节间隙疼痛复发5例。结论 揿针疗法治疗骨科常见慢性疼痛性疾病,操作简单、安全有效,不良反应少,复发率低,值得临床应用。     

肘关节镜三种远端前外侧入路对周围神经损伤风险比较

目的：比较肘关节镜3 种远端前外侧入路穿刺后对前臂外侧皮神经及桡神经（ 深支）的影响。 方法：选用 新鲜冰冻的成人肘关节标本,关节镜下对3 种入针点（ 肱骨外上髁远端3 cm,前方1 cm ;肱骨外上髁远端2 cm, 前方2 cm ;肱骨外上髁远端1 cm,前方1 cm）进行定位、穿刺克氏针,并在肘关节屈曲90°时,解剖、测量与 前臂外侧皮神经及桡神经（ 深支）的最短距离。结果：3 种入路距前臂外侧皮神经的最短距离分别为（18.51±2.07） mm、（19.14±1.53）mm、（21.95±1.83）mm,距桡神经（ 深支）的最短距离分别为（7.18±1.17）mm、（7.59±0.88） mm、（9.22±1.51）mm。后一入路点（ 肱骨外上髁远端1 cm,前方1 cm）距2 条神经的距离为最短,且与前2 者 的差异具有统计学意义。结论：肘关节镜前外侧入路（ 肱骨外上髁远端1 cm,前方1 cm）距前臂外侧皮神经及桡 神经（ 深支）的最短距离最远,建立远端前外侧入路时选此入路穿刺比较安全。     

合复位经皮克氏针内固定治疗儿童肱骨髁上骨折

目的：对闭合复位经皮克氏针内固定治疗儿童肱骨髁上骨折临床效果进行分析。方法资料随机选自我院2013年4月~2014年4月收治的儿童肱骨髁上骨折患儿60例,将其平均分为两组,研究组和对照组,给予对照组患儿闭合复位石膏外固定治疗,研究组采用闭合复位经皮克氏针内固定治疗,并对两组临床资料进行回顾性分析。结果治疗后,研究组治疗后总有效率96.67%,明显高于对照组治疗后总有效率80.00%;且研究组的愈合时间明显优于对照组,组间比较有差异具有统计学意义(<0.05)。结论给予肱骨髁上骨折闭合复位经皮克氏针内固定治疗的效果较为确切,能够有效的提高患儿的生活以及生存质量,值得在临床中推广和应用。     

痛息通配合针刀治疗肱骨外上髁炎30例临床疗效观察

目的 观察应用痛息通配合针刀治疗各种原因引起的肱骨外上髁的临床疗效.方法 痛息通配合针刀治疗.结果 总有效率100%.结论 综合治疗肱骨外上髁炎疗效满意,安全可靠.     

可吸收螺钉置入治疗小儿肱骨髁上骨折

背景：研究表明,可吸收螺钉置入内固定治疗儿童肱骨外髁骨折是较为理想的方法。 目的：综述可吸收螺钉置入治疗小儿肱骨髁上骨折的研究进展。 方法：应用计算机检索2000-01/2011-08万方数据库、维普数据库及PubMed数据库有关可吸收螺钉置入内固定治疗小儿肱骨髁上骨折的相关文章,检索词为“可吸收螺钉,内固定,儿童,肱骨髁上骨折,absorbable screw,fracture fixation,supracondylar fracture”。共检索到文献79篇,最终纳入符合标准的文献20篇。 结果与结论：目前临床上多倾向于手术开放复位植入物内固定治疗小儿肱骨髁上骨折,以克氏针交叉置入内固定应用最为广泛。随着置入内固定材料的发展,人们逐渐认识到可吸收螺钉置入内固定的优点。可吸收螺钉具有较好的韧性,固定加压效果确切。可以对断端施加压力,使骨折端端吻合紧密,置入后骨折块血供迅速恢复,能减少临床愈合时间。可吸收螺钉置入治疗儿童肱骨外髁骨折,方法简单,固定可靠。骨折断端紧密结合,临床愈合时间缩短,疗效确切,是一种较好的置入内固定治疗方法 关键词：可吸收螺钉;肱骨髁上骨折;儿童;内固定;材料;综述文献 doi:10.3969/j.issn.1673-8225.2012.13.035     

闭合复位经皮克氏针固定治疗小儿肱骨髁上骨折

目的探讨全麻下闭合复位经皮克氏针治疗小儿肱骨髁上骨折的方法及其效果。方法回顾性分析43例小儿闭合性完全移位的肱骨髁上骨折病例,在静脉全麻下,手法复位后经皮克氏针治疗,评价其临床疗效。结果经12~24个月随访,骨折全部愈合,未出现迟发性尺神经炎、骨化性肌炎、肘内翻畸形、肘关节僵硬等远期并发症,按Flynn评价,优38例,良3例,可2例。结论运用闭合复位经皮克氏针治疗小儿肱骨髁上骨折手术简单,并发症少,疗效较好。     

肱骨远端解剖参数相关性分析与假体个体化设计

目的:为肱骨远端假体个体化设计提供解剖参数。方法:对69块成人干燥肱骨标本,内上髁至外上髁最大宽度、内上髁至肱骨滑车内侧缘后点宽度、肱骨滑车小头总宽度、肱骨滑车宽度和肱骨滑车、小头有关径值及其前倾角等测量参数进行处理及相关与回归分析。结果:(1)内上髁至外上髁最大宽度和肱骨滑车最大矢径为(57.48±3.18)mm、(23.83±1.83)mm;肱骨滑车、小头的前倾角为(63.07°±3.97°)、(40.16°±2.23°)。(2)内上髁至肱骨滑车内侧缘后点的宽度、肱骨滑车小头及滑车的宽度均与内上髁至外上髁最大宽度呈正相关;肱骨滑车沟径、次径、小头滑车间沟径和小头径均与肱骨滑车最大矢径呈正相关;肱骨小头和滑车的前倾角无明显相关性。结论:由内上髁至外上髁最大宽度和肱骨滑车最大矢径的测量参数可推算出肱骨假体个体化设计所需的解剖参数。     

Acupuncture therapy for Alzheimer's disease: The effectiveness and potential mechanisms

Alzheimer's disease (AD) is a common neurodegenerative disease that accounts for approximately 70% of dementia. Following the global escalation of the aging process, the morbidity of AD is increasing rapidly. The current treatment for AD is mainly limited to medications, such as acetylcholinesterase inhibitors. However, the efficacy of acetylcholinesterase inhibitors in improving memory and cognitive functions is not satisfactory. It is a challenge to find an effective alternative therapy for ameliorating AD symptoms. As an important therapeutic technique in traditional Chinese medicine, acupuncture has been proved effective in treating many neurologic diseases including AD. The efficacy of acupuncture is also acknowledged by the National Institutes of Health of the United States. Here, we summarized the effectiveness of acupuncture for treating AD. Especially, the role of acupuncture at certain acupuncture points in modulating the brain function through meridians activity based on Chinese meridian theory is discussed. How acupuncture at a certain acupoint can improve AD symptoms is also described. Furthermore, the possible molecular mechanisms of acupuncture for AD are reviewed, and the role of acupuncture in modulating signaling molecules in neural protection and homeostasis is highlighted. This study may help to understand the theoretical basis and potential molecular mechanisms of acupuncture therapy for AD.     

催眠针法治疗心绞痛的疗效及血浆ET、NO改变的研究

冠心病是当代威胁人类生命的主要疾病之一 ,其病因学和发病学十分复杂。它的发生是多种致病因素通过多个环节综合作用的结果 ,其中社会心理因素如焦虑等 ,不仅是冠心病的病因及诱因 ,并且影响患者的生活质量 ,增加并发症和心源性猝死 ;治疗则需抗焦虑同治 ,才能取得较满意的效果[1] 。本研究运用自创的催眠针法治疗冠心病心绞痛 ,现将其疗效及其对患者生理、心理的影响报告如下。1　研究对象与方法1.1　研究对象病例来源于武警西藏总队医院及第四军医大学唐都医院 2 0 0 1.1～ 2 0 0 1.6住院病人及门诊病人。确诊为冠心病心绞痛、自愿接受催…     

中风偏瘫肩—手综合征甲襞微循环的变化及针刺对其的影响

为研究中风偏瘫肩—手综合征（ＳＨＳ）甲襞微循环的变化及针刺对其的影响，检查２６例ＳＨＳ患侧针刺前后及２０例对照组的甲襞微循环。结果表明，ＳＨＳ患侧甲襞微循环各类积分值均显著高于对照组（Ｐ＜０．００１）；且其总积分值和肩痛及手肿轻重程度有关。针刺后其流态、管周状态及总积分的积分值均显著下降（Ｐ＜０．０１０．００１）。结果提示，ＳＨＳ患侧甲襞微循环存在明显障碍且和临床表现轻重程度有关；针刺治疗能使其微循环障碍得到明显改善     

针灸联合多种方法治疗骨质疏松的网状Meta分析

文题释义： 网状 Meta 分析：是传统Meta分析的扩展,可以同时比较3个或者3个以上的干预措施的疗效。但是目前对网状Meta分析的定义相对混乱,按照“国际药物经济学和结果研究协会”的报告,网状Meta分析包括调整间接比较和混合治疗分析。混合治疗分析是在直接比较的基础上合并间接比较的证据,从而提高分析结果的精确性,但是这种方法主要是应用于干预措施可以形成具有闭合环路(loop)时。网状Meta分析的最大优势就是可以对治疗同类疾病的不同干预措施进行量化比较,并按照某一结果指标效果好坏进行排序,进而选择最优治疗方案。 针灸：是一门独具特色的传统医学学科。临床上,常将针灸作用于经络腧穴以防治疾病的方法和技术,称之为针灸疗法。针灸具有适应证广、疗效明显、应用方便、经济安全等优点。 背景：针灸及其联合其他疗法与标准西医疗法之间比较治疗骨质疏松有效性的研究结论存在争议,现有的原始研究和 Meta 分析多为单一针灸治疗、针灸联合西药治疗与标准西医疗法间的比较,缺乏针灸联合其他疗法之间的直接比较,使人们难以对针灸疗效有较清晰、全面的认识。 目的：采用网状Meta分析技术,比较针灸联合其他疗法治疗骨质疏松疗效的差异。 方法：在CNKI、维普、万方、SinoMed、PubMed、Cochrane Library数据库上进行检索,纳入不同针灸疗法对比治疗骨质疏松的临床随机对照试验(RCT)。根据相关纳入与排除标准对文献进行筛选后提取相关资料,并对纳入文献进行质量评价。运用Stata 14.0软件进行文献数据分析及作图。 结果与结论：最终纳入34篇随机对照试验,共涉及7种干预措施,包括：单一针灸治疗,单一西药治疗,单一中药治疗,针灸+西药联合治疗,针灸+中药联合治疗,中药+西药治疗,针灸+中药+西药联合治疗。①在治疗有效率上,针灸+中药的疗效最佳,且针灸+中药、针灸+西药以及针灸+中药+西药,均显著比中药+西药治疗的有效率高(P < 0.05);②在增加患者骨密度方面,针灸+中药、针灸+西药以及针灸+中药+西药,均优于单一中药或西药组(P < 0.05);③在缓解患者疼痛方面,与单一西药治疗相比,针灸+西药治疗能缓解患者的疼痛(P < 0.05),但其余治疗方式之间,并无明显的差异(P > 0.05)。在纳入的研究中,有极少数患者出现针刺后穴位瘀血现象,但均未出现晕针或未报道,也未发现其他毒副作用。提示：针灸联合其他疗法,可以提高有效率、增加骨密度、缓解患者疼痛。 ORCID: 0000-0001-7755-5563(岑卓灏) 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

Neural mechanism underlying acupuncture analgesia

Acupuncture has been accepted to effectively treat chronic pain by inserting needles into the specific "acupuncture points" (acupoints) on the patient's body. During the last decades, our understanding of how the brain processes acupuncture analgesia has undergone considerable development. Acupuncture analgesia is manifested only when the intricate feeling (soreness, numbness, heaviness and distension) of acupuncture in patients occurs following acupuncture manipulation. Manual acupuncture (MA) is the insertion of an acupuncture needle into acupoint followed by the twisting of the needle up and down by hand. In MA, all types of afferent fibers (Abeta, Adelta and C) are activated. In electrical acupuncture (EA), a stimulating current via the inserted needle is delivered to acupoints. Electrical current intense enough to excite Abeta- and part of Adelta-fibers can induce an analgesic effect. Acupuncture signals ascend mainly through the spinal ventrolateral funiculus to the brain. Many brain nuclei composing a complicated network are involved in processing acupuncture analgesia, including the nucleus raphe magnus (NRM), periaqueductal grey (PAG), locus coeruleus, arcuate nucleus (Arc), preoptic area, nucleus submedius, habenular nucleus, accumbens nucleus, caudate nucleus, septal area, amygdale, etc. Acupuncture analgesia is essentially a manifestation of integrative processes at different levels in the CNS between afferent impulses from pain regions and impulses from acupoints. In the last decade, profound studies on neural mechanisms underlying acupuncture analgesia predominately focus on cellular and molecular substrate and functional brain imaging and have developed rapidly. Diverse signal molecules contribute to mediating acupuncture analgesia, such as opioid peptides (mu-, delta- and kappa-receptors), glutamate (NMDA and AMPA/KA receptors), 5-hydroxytryptamine, and cholecystokinin octapeptide. Among these, the opioid peptides and their receptors in Arc-PAG-NRM-spinal dorsal horn pathway play a pivotal role in mediating acupuncture analgesia. The release of opioid peptides evoked by electroacupuncture is frequency-dependent. EA at 2 and 100Hz produces release of enkephalin and dynorphin in the spinal cord, respectively. CCK-8 antagonizes acupuncture analgesia. The individual differences of acupuncture analgesia are associated with inherited genetic factors and the density of CCK receptors. The brain regions associated with acupuncture analgesia identified in animal experiments were confirmed and further explored in the human brain by means of functional imaging. EA analgesia is likely associated with its counter-regulation to spinal glial activation. PTX-sesntive Gi/o protein- and MAP kinase-mediated signal pathways as well as the downstream events NF-kappaB, c-fos and c-jun play important roles in EA analgesia.     

针刺辅以静电治疗失眠的临床观察

目的:利用传统针刺与静电疗法的结合,治疗失眠临床疗效显著。方法:利用传统针刺同时辅以静电疗法这种理疗仪器,临床治疗112例失眠患者。结果:发现该组合疗法比单纯用针刺治疗,疗效迅速,效果稳定、持久。结论:通过对其机理的深入阐述,认为在针刺取得效果的同时,静电疗法所独具的静电感应及极化作用,不仅加强了针刺局部的治疗效果,对神经系统乃至人体整体也起到了调整作用,其中西医结合的特色,于临床确有一定的应用价值。     

A controlled trial of real and simulated acupuncture in the management of chronic asthma

In 25 patients with moderate to severe asthma, we compared the therapeutic effectiveness of classic Chinese acupuncture with that of "placebo" acupuncture administered in a randomly ordered, subject- and evaluator-blind, crossover fashion twice weekly for 4 weeks. Real and placebo acupuncture periods were each preceded and followed by 3- to 4-week periods during which no acupuncture was administered. Outcome variables consisted of the following: daily symptoms and medication use self-scored on patient diaries, spirometry and whole body plethysmography performed once weekly during the entire course of the study and repeated serially during 3 hours after real and placebo acupuncture treatment, patients' self-assessment of acute efficacy of acupuncture therapy, and physician's physical findings before and after acupuncture treatment. Two-way analysis of variance failed to reveal a significant effect of either form of acupuncture on symptoms, medication use, or lung function measurements. Similarly, no significant acute effect of acupuncture on lung function, self-ratings of efficacy, or physician's physical findings was found by covariance analysis or the Wilcoxon signed-rank test. When data during the entire course of the study were examined on an individual basis by analysis of variance with repeated measures, only two subjects demonstrated significantly favorable responses to real versus placebo acupuncture, but one subject demonstrated the reverse, suggesting that these responses were not specifically related to acupuncture therapy. Thus, our findings failed to demonstrate any short- or long-term benefit of acupuncture therapy in the management of moderate to severe asthma.     

Efficacy and safety of acupuncture in the treatment of depression: A systematic review of clinical research

As a common mental disorder, depression is one of the leading causes of disability around the world. Clinical studies have shown that acupuncture is an effective therapy without obvious side effects compared to limited efficacy and adverse reactions of drug therapy, cognitive behavioral therapy, and neuromodulation technology in treating depression. The objective of this review is to systematically evaluate whether acupuncture therapies for depression are safe and effective in order to provide a high-quality reference for clinical trials of acupuncture. A systematic search of the literature was carried out through bibliographic search engine PubMed. Subsequently, the study design, intervention methods, control group, results, and safety of acupuncture were analyzed. The results showed that acupuncture as an adjunct to antidepressants or as a single treatment can exert a positive impact on patients' depressive symptoms. Compared with antidepressants, acupuncture has the advantages of fast onset and long-term efficacy in the treatment of depression, and can enhance the efficacy of antidepressants. Moreover, the efficacy and safety of acupuncture in the treatment of depression maybe related to the qualification of the acupuncturist, the selection of acupoints, and intervention measures.     

Integrative traditional Korean medicine management,including acupuncture and Chuna-manual therapy,for stroke-related central facial palsy: A study of three case reports

Central facial palsy, which is a sequela of stroke, is associated with decreased quality of life and psychosocial function. Integrative Korean medicine management, including acupuncture and Chuna-manual therapy, has been used to treat neurological diseases, including facial palsy. We report three cases of central facial palsy patients who had these symptoms over three months after a stroke. They had received rehabilitation treatment for the paralyzed upper and lower extremities. However, as their central facial palsy symptom did not improve, Chuna-manual therapy (SJS nonresistance technique) for facial palsy was started along with acupuncture.Oral region movement improved after four weeks of integrative acupuncture and Chuna-manual therapy. After ten to sixteen weeks of treatment, the facial nerve grading system 2.0 grades improved by one in two cases. In one case, although there was no significant change in the grade, she was satisfied with the results after adding Chuna-manual therapy to acupuncture. There were no adverse events. Integrative management, including acupuncture and Chuna-manual therapy, might be an effective treatment strategy for central facial palsy. Further prospective, controlled studies are warranted.     

Acupuncture for allergic disease therapy – the current state of evidence

This review summarizes current evidence for acupuncture treatment of allergies. Several randomized controlled trials have demonstrated a specific effect of acupuncture for allergic rhinitis; while a few studies have shown positive effects for atopic dermatitis, asthma and itch. Specifically for allergic rhinitis and asthma, acupuncture may be cost-effective in terms of money spent per quality-of-life gained. Acupuncture plays an increasingly important role as an evidence-based therapy for allergy relief and can be recommended as adjunct therapy for allergic rhinitis. Future randomized controlled trials need to further explore acupuncture efficacy for the treatment of itch, atopic dermatitis and asthma. More experimental research is also needed to investigate mechanisms of action underlying acupuncture for allergy relief.