双唑泰泡腾片治疗滴虫性阴道炎疗效观察

目的:探讨双唑泰泡腾片治疗滴虫性阴道炎的临床疗效.方法:选取2016年1月～2017年1月于我院妇科就诊的阴道炎患者120例,随机数字法将患者分为对照组和观察组各60例,对照组给予奥硝唑阴道栓治疗,观察组使用双唑泰泡腾片治疗.比较治疗后的有效率、症状消失时间和生活质量评分.结果:观察组治疗总有效率达到98.33％,显著高于对照组(P<0.05);观察组症状消失时间显著短于对照组(P<0.05),生活质量评价结果也显著高于对照组(P<0.05).结论:针对滴虫性阴道炎给予双唑泰泡腾片的疗效更加显著,具有积极的推广意义.     

双唑泰泡腾片治疗阴道炎220例疗效观察

目的：探讨双唑泰泡腾片治疗念珠菌、细菌性、滴虫性阴道炎的疗效。方法：220例阴道炎（滴虫性、细菌性、念珠菌阴道炎）患者，每晚清洁外阴后，阴道上双唑泰泡腾片1枚，治疗1疗程（7天）后复查。结果：双唑泰泡腾片对念珠菌阴道病的治愈率68．75％．有效90％。对细菌性阴道病和滴虫性阴道炎的治愈率分别为83.33％和84．21％。有效率达100％。结论：双唑泰泡腾片适于各种病型阴道炎（病）的治疗。     

双唑泰泡腾片配合可乐必妥治疗淋菌性和非淋菌性阴道炎

目的：淋菌性和非淋菌性阴道炎逐年增加,采用双唑泰泡腾片局部用药配合全身应用治疗。方法：观察资料１６８例随机分成两组,每组４８例,Ｉ组为口服可乐必妥加局部双唑泰加泡腾片,ＩＩ组为单纯口服可乐必妥。结果：治愈率比较和疗程比较,Ｉ组与Ⅱ组有显著差异（Ｐ〈０．０１）。结论：双唑泰泡腾片既保护单味药物的抑制细菌,霉菌,淋病双球菌,滴虫的生物活性,又 有治疗上的协同作用,是目前妇科常见性传播疾病的首选药。     

双唑泰泡腾片治疗细菌性阴道炎的疗效观察

目的　探讨双唑泰泡腾片及甲硝唑片对细菌性阴道炎的治疗效果。方法　经确诊后 ,92例细菌性阴道炎患者 ,年龄 1 9～ 42岁 ,随机分成两组 ,A组 5 0例用双唑泰泡腾片 ,每晚 1次 1片放置阴道 ,连续 7d为 1疗程。B组 42例用甲硝唑 1片 ,放药时间及方法同 A组。结果　A组总有效率 98% ,B组总有效率 88.1 9%。两组进行对比有显著性差异 (P <0 .0 5 )。结论　双唑泰泡腾片治疗细菌性阴道炎效果满意 ,使用方便     

双唑泰泡滕片治疗细菌性阴道炎的疗效观察

目的探讨双唑泰泡腾片及甲硝唑片对细菌性阴道炎的治疗效果.方法经确诊后,92 例细菌性阴道炎患者,年龄19～42 岁,随机分成两组,A组50 例用双唑泰泡腾片,每晚1 次1 片放置阴道,连续7 d为1 疗程.B组42 例用甲硝唑1 片,放药时间及方法同A组.结果 A组总有效率98%,B组总有效率88.19%.两组进行对比有显著性差异(P＜0.05).结论双唑泰泡腾片治疗细菌性阴道炎效果满意,使用方便.     

乳酸菌阴道胶囊联合双唑泰泡腾片治疗混合性阴道炎效果观察

目的：探讨乳酸菌阴道胶囊联合双唑泰泡腾片治疗混合性阴道炎疗效及对患者生活质量的影响。方法对160例符合入选标准的混合性阴道炎患者按治疗方案不同分为对照组和观察组各80例。对照组给予双唑泰泡腾片治疗,观察组联合应用乳酸菌阴道胶囊治疗。比较组间临床疗效、复发率、阴道pH值改变及生活质量改善情况。结果治疗后,与对照组相比,观察组治疗总有效率明显升高,复发率显著降低,阴道pH值显著降低。生活质量方面,观察组躯体角色、总体健康、活力、情绪角色及心理卫生等指标评分显著高于对照组,差异均有统计学意义。结论乳酸菌阴道胶囊联合双唑泰泡腾片在混合性阴道炎中应用效果良好,可减少复发,改善患者生活质量。     

硝酸益康唑栓与双唑泰阴道膨胀栓治疗滴虫性阴道炎的临床疗效对比观察

目的探究硝酸益康唑栓与双唑泰阴道膨胀栓治疗滴虫性阴道炎的临床疗效.方法184例滴虫性阴道炎患者,根据随机数字抽取法分为对照组和治疗组,各92例.对照组患者给予硝酸益康唑栓进行治疗,治疗组患者给予双唑泰阴道膨胀栓进行治疗.比较两组患者临床疗效、不良反应发生情况、临床症状消失时间、治疗满意率.结果治疗组治疗总有效率94.57%显著高于对照组的79.35%,差异有统计学意义(P<0.05).治疗组患者腰腹疼痛、排尿疼痛、外阴瘙痒、白带异常消失时间分别为(3.41±0.63)、(2.19±0.41)、(2.43±0.34)、(1.52±0.22)d,均短于对照组的(5.72±0.78)、(4.25±0.52)、(4.56±0.37)、(2.63±0.45)d,差异有统计学意义(P<0.05).治疗组不良反应发生率3.26%明显低于对照组的15.22%,差异有统计学意义(P<0.05).治疗组治疗满意率97.83%明显高于对照组的81.52%,差异具有统计学意义(P<0.05).结论给予滴虫性阴道炎患者双唑泰阴道膨胀栓治疗,临床疗效显著,药物不良反应发生率低,毒副作用小,能够明显改善患者的生活质量,安全可靠,值得临床广泛推广.     

双唑泰阴道泡腾片微生物限度检查方法学验证

目的建立双唑泰阴道泡腾片微生物限度检查的验证方法。方法根据2005年版《中国药典（二部）》附录ⅪJ微生物限度检查法,对双唑泰阴道泡腾片的微生物限度检查进行方法学验证。结果平皿法可检查该制剂的霉菌、酵母菌数,薄膜过滤法可检查该制剂的细菌、控制菌数。结论薄膜过滤法能有效去除双唑泰阴道泡腾片中的杀菌成分,使污染的微生物得以生长,故能较好地对细菌和控制菌进行检测。     

双唑泰泡腾片治疗女性阴道炎59例疗效观察

阴道炎是妇科临床常见病,多发病.多由阴道毛滴虫、念珠菌、细菌等多种病原菌感染所致,目前临床上可供选择的药物甚多,疗效各家报道不一,了解双唑泰泡腾片治疗阴道炎的效果.我院妇科自2003年2-12月应用双唑泰泡腾片治疗女性阴道炎59例,临床效果满意,现总结如下.     

替勃龙片联合双唑泰泡腾片治疗老年性阴道炎疗效观察

目的探讨替勃龙片联合双唑泰泡腾片治疗老年性阴道炎的临床疗效。方法选取2016年1月—2016年7月在信阳市第四人民医院接受诊治的老年性阴道炎患者90例,所有患者根据用药方案的不同分为对照组和治疗组,每组各45例。对照组每晚清洁外阴后于阴道深处置入双唑泰泡腾片,1片/次,1次/d。治疗组在对照组基础上口服替勃龙片,1片/次,1次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的临床症状消失时间和生活质量。结果治疗后,对照组和治疗组的总有效率分别为77.78%、95.56%,两组比较差异有统计学意义(P0.05)。治疗后,治疗组外阴瘙痒、阴道黏膜充血和阴道分泌物消失时间明显短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组躯体功能、心理功能、社会功能和物质生活评分均明显升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的升高程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论替勃龙片联合双唑泰泡腾片治疗老年性阴道炎具有较好的临床疗效,可缩短临床症状消失时间,改善生活质量,具有一定的临床推广应用价值。     

双唑泰栓治疗滴虫性阴道炎的临床效果观察

目的 探究双唑泰栓治疗滴虫性阴道炎的临床效果.方法 100例滴虫性阴道炎患者,随机分为观察组与对照组,各50例.对照组给予奥硝唑治疗,观察组给予双唑泰栓治疗.比较两组患者临床症状改善情况、治疗效果.结果 观察组患者白带异常消失时间(4.47±1.22)d、外阴瘙痒消失时间(5.38±1.52)d、腰腹疼痛消失时间(10...     

结合雌激素联合甲硝唑阴道给药治疗老年性阴道炎的Meta-分析

目的 系统评价结合雌激素联合甲硝唑阴道给药治疗老年性阴道炎的疗效和安全性。方法 检索PubMed、Medline、中国知网（CNKI）、万方数据库、维普全文数据库（VIP）中结合雌激素软膏（乳膏）联用甲硝唑栓（复方甲硝唑栓）与甲硝唑栓（复方甲硝唑栓）单用对照治疗老年性阴道炎临床随机对照研究,时间为2000年1月—2017年8月,采用RevMan 5.2软件进行Meta-分析。结果 纳入13篇文献（1 269例患者）。Meta-分析显示：与甲硝唑栓（复方甲硝唑栓）单用组相比,结合雌激素软膏（乳膏）联用甲硝唑栓（复方甲硝唑栓）组治愈率高[RR=1.55,95% CI（1.39～1.72）,P<0.001]、复发率低[RR=0.35,95% CI（0.24～0.49）,P<0.001],同时血清雌二醇（E₂）低[MD=-12.94,95% CI（-14.45～-11.42）,P<0.001]和血清促卵泡（FSH）水平高[MD=44.56,95% CI（41.25～47.87）,P<0.001],不良反应发生率高[RR=2.66,95% CI（1.37～5.15）,P=0.004],但是不良反应以乳房胀痛、轻度恶心等为主,停药后明显好转。结论 结合雌激素联合甲硝唑局部阴道给药治疗老年性阴道炎治愈率高,复发率低,不良反应轻,患者依从性好。     

Formation, properties and antimicrobial activities of cotton xanthate-Cu(II)-homosulfamine complex

To develop a cotton derivatives with prolonged antimicrobial activities, homosulfamine (Hs) was coupled to cotton xanthate (CX) via chelate bond in the presence of Cu(II) ion by one-and two-bath processes. In one-bath process, CX was treated with Cu(II)-Hs solution. In two-bath process, CX was treated with Cu(II) ion solution to produce CX-Cu(II) complex, which was isolated and treated in turn with Hs solution. Effects of concentration, Cu(II)/Hs ratio, and pH on the binding of Hs were investigated at 10°C. In one-bath process, binding of Hs took place readily with optimum pH around 5∼6. The amount of binding increased to give a maximum within 5 min and decreased slowly to establish an equilibrium within an hour. In two-bath process, binding of Hs was much lower than that of one-bath process. Release of Hs from CX-Cu(II)-Hs was investigated by batch and flow method. Antimicrobial activities of CX-Cu(II)-Hs were tested againstStaphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa andEscherichia coli and it showed prolonged activity compared to that of free Hs.     

保妇康栓联合欧维婷软膏治疗对老年性阴道炎的疗效

目的探讨保妇康栓联合欧维婷软膏对老年性阴道炎的治疗作用,并观察治疗对患者生活质量的作用。方法收集老年性阴道炎患者280例,分为两组,观察组共140例,应用保妇康栓联合欧维婷治疗,对照组共140例,应用甲硝唑进行治疗。结果观察组治疗的总有效率明显高于对照组,治疗后观察组患者的生活质量明显高于对照组。结论保妇康栓联合欧维婷对老年性阴道炎的效果明显,并能改善患者的生活质量,临床中可以应用。     

Clarithromycin的体内抗菌作用研究

新的１４元大环内酯ｃｌａｒｉｔｈｒｏｍｙｃｉｎ（ＣＲＭ）与红霉素（ＥＭ）对金葡球菌、化脓链球菌、肺炎链球菌、嗜血流感杆菌感染小鼠体内保护作用结果显示：口服ＣＲＭ对金葡球菌、化脓链球菌及肺炎链球菌的体内抗菌作用优于ＥＭ６．３～８．６倍。尤其对金葡球菌耐药菌及嗜血流感杆菌感染小鼠的半数保护剂量作用有效于ＥＭ的保护作用１７及１８倍，ＣＲＭ在体内具有良好的抗菌作用。     

Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents

Tamarix gallica is a halophytic species having hepatotonic and stimulant properties, as it was traditionally used in the treatment of various liver disorders. Leaf and flower infusion have anti-inflammatory and anti-diarrheic proprieties. In this work, we have investigated antioxidant and antimicrobial activities of leaf and flower extracts and their phenolic composition. Results showed that flowers exhibit a higher antioxidant activity as compared to the leaves, IC₅₀ values of the flower extracts are being 1.3 (β-carotene bleaching) to 19 times (lipid peroxidation inhibition) lower than those for leaves. Accordingly, flower extracts exhibited the highest total phenolic content (135.35 mg GAE/g DW) and RP-HPLC analysis showed that syringic acid, isoquercitin as well as catechin were the major phenolics. Furthermore, Tamarix extracts showed appreciable antibacterial properties against human pathogen strains. The mean inhibition zone was from 0 to 6.5 mm when the concentration increased from 2 to 100 mg/l. The strongest activity was recorded against Micrococcus luteus and the lowest activity was observed against Escherichia coli. Moreover, organ extracts show a weakly to moderate activity against the tested Candida. These findings suggest that Tamarix may be considered as an interesting source of antioxidants for therapeutic or nutraceutical industries and for food manufactures.     

Measurement and evaluation of the effects of pH gradients on the antimicrobial and antivirulence activities of chitosan nanoparticles in Pseudomonas aeruginosa

Objective

The purpose of this study was to study the antimicrobial activity of chitosan nanoparticles (CSNPs) on Pseudomonas aeruginosa with special emphasis on their sensitivity to pH and the effect of pH on their activity.

胆宁片对实验性急慢性肝损伤的保护作用

目的：研究胆宁片对实验性小鼠急性肝损伤预防作用，及对大鼠慢性肝损伤的预防和治疗作用。方法：分别用D-氨基半乳糖和四氯化碳复制小鼠急性肝损伤和大鼠慢性肝损伤模型，检测小鼠和大鼠血清谷草转氨酶（AST）和谷丙转氨酶（ALT）的改变，观察胆宁片对大鼠血清总蛋白、白蛋白、A／G的影响、同时观察肝脏病理学改变。结果：胆宁片可明显抑制D-氨基半乳糖和四氯化碳引起的ALT、AST升高（P〈0．05或P〈0．01）；可显著升高四氯化碳引起的血清总蛋白和白蛋白含量降低（P〈0．05或P〈0．01）；肝脏病理组织学检查显示胆宁片可减轻肝细胞脂肪变性程度和纤维化程度。结论：胆宁片对小鼠D-氨基半乳糖急性肝损伤有较好的保护作用，对四氯化碳所致大鼠慢性肝损伤有一定的预防及治疗作用。     

Cytotoxic and antimicrobial activities of Cu(II), Co(II), Pt(II) and Zn(II) Complexes with N,O-chelating heterocyclic carboxylates

A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid. The complexes were characterized by IR, UV-VIS, elemental analysis, and some by (1) H-NMR, X-ray crystallography, HPLC and LC/MS spectroscopy. All complexes consist of a 2:1 ratio of ligand to metal ion. IR and X-ray crystallography show that coordination is through the nitrogen and carboxylate oxygen donor atoms of the ligand to form chelating rings. DFT calculations predict that the trans-coordinated isomers are thermodynamically more stable than their cis-forms. Only one of five complexes studied by X-ray crystallography, Cu(II) complex of 1-methylimidazole-2-carboxylic acid showed a cis-configured metal ion center. HPLC analysis indicated that Pt(II) complex of 1-methylimidazole-2-carboxylic acid is dominated (>90%) by the trans-configured complex. All other complexes showed one isomer, presumably the trans-form. The cytotoxic activity was investigated in human cancer cell lines in vitro; only the Pt(II) complexes were active. The antimicrobial activity against four bacterial strains and one fungi was estimated by the MIC method and best results were found amongst the Co(II) complexes. These results indicate that trans-coordinated bischelating N,O-heterocyclic carboxylates of Pt(II) are an interesting new class of potential antitumor agents.     

Beneficial effect of a novel non-steroidal anti-inflammatory agent with basic character and antioxidant properties on experimental colitis in rats

Ulcerative colitis is a chronic disorder of unknown etiology. Conservative treatment remains empirical, even today. The aim of this study was to test the efficacy of a novel non-steroidal anti-inflammatory agent [5-(2-hydroxy-ethylamino)-1-cyclohexyl-2-pentanone] (compound A), with basic character and antioxidant properties on an experimental model of ulcerative colitis in rats. The effect of this compound was compared with that of methylprednisolone on the histological abnormalities and serum levels of tumor necrosis factor-alpha (TNF-alpha) in experimental colitis produced by 2,4,6-trinitrobenzenesulfonic acid (TNB). A total number of 24 rats were randomly assigned to one of four groups of six rats each. Group 1: colitis without treatment (disease control), group 2: normal animals (control), group 3: induction of experimental colitis treated with methylprednisolone (5.3 x 10(-3) mmol/kg i.v. every day for 7 days) and group 4: induction of experimental colitis plus administration of compound A (0.6 mmol/kg i.v. every day for 7 days). The administration of compound A resulted in a statistically significant reduction of the extent of tissue damage and of certain histological features (edema, inflammatory infiltration) (P<0.05). Compound A also resulted in a statistically significant reduction of the levels of serum TNF-alpha, compared to those of controls (P<0.005). The beneficial effect of this compound was probably due to the combination, on a single molecule, of anti-inflammatory and antioxidant properties as well as to its basic character. The reduction of the serum TNF-alpha levels could be one of the possible mechanism(s) of action of the compound. Further studies are necessary to establish the direct mechanism of action(s) of the drug and to evaluate its long-term efficacy and safety.