单纯自体腓骨头移植治疗桡骨远端骨巨细胞瘤远期疗效

1998年3月-2009年3月,我院应用自体腓骨头移植治疗桡骨远端骨巨细胞瘤12例,未行血管吻合,临床效果满意,报道如下。1材料与方法1.1病例资料本组12例,男18例,女4例,年龄18-42岁。右侧7例,左侧5例。病理分级：1级8例,2级4例。破坏范围：φ3-5 cm,皮质骨菲薄或穿破。     

自体腓骨移植治疗桡骨远端骨巨细胞瘤

目的：探讨白体近端腓骨移植重建在桡骨远端骨巨细胞瘤临床治疗中的应用及效果。方法：对4例桡骨远端骨巨细胞瘤复发（Campanacci Ⅲ级）患者在行桡骨远端瘤段切除的同时,行自体近端腓骨移植重建手术。结果：所有患者随访27～50个月,疼痛症状消失,骨愈合时间5～9个月,平均愈合时间为6．5个月,无移植骨吸收和骨折,腕关节功能握持力为对侧手的55％（40～80％）,背伸活动度可达对侧50％（10～80％）,掌屈达40％（15～70％）,无神经血管损伤症状,恢复正常工作劳动。所有患者均未出现骨巨细胞瘤的复发及肺转移。结论：桡骨远端骨巨细胞瘤经广泛切除后,用自体近端腓骨移植进行保肢治疗,可较好地保留腕关节功能,是一种有效的治疗方法。     

自体腓骨移植治疗桡骨远端骨巨细胞瘤复发

目的探讨自体近端腓骨移植重建在桡骨远端骨巨细胞瘤临床治疗中的应用及效果。方法对4例桡骨远端骨巨细胞瘤复发患者在行桡骨远端瘤段切除的同时,行自体近端腓骨移植重建手术。结果患者随访27～50个月,疼痛症状消失,骨愈合时间5～9个月,平均6.5个月,无移植骨吸收和骨折,腕关节功能握持力为对侧手的55%(40%～80%),背伸活动度可达对侧50%(10%～80%),掌屈达40%(15%～70%),无神经血管损伤症状,恢复正常工作劳动。所有患者均未出现骨巨细胞瘤的复发及肺转移。结论桡骨远端骨巨细胞瘤经广泛切除后,用自体近端腓骨移植进行保肢治疗,可较好地保留腕关节功能,是一种有效的治疗方法。     

自体腓骨近端游离移植重建桡骨远端骨巨细胞瘤切除后骨缺损

桡骨远端骨巨细胞瘤约占全身骨巨细胞瘤10%,是骨巨细胞瘤的第三好发部位,随着肿瘤发展容易发生病理性骨折,由于缺乏骨质和临近桡腕关节,病灶刮除不是合适的处理方法,而且复发率高。作者自2004年1月至2009年1月     

游离自体腓骨移植并腕关节成形术治疗桡骨远端骨巨细胞瘤

[目的]回顾分析游离自体腓骨移植并腕关节成形术治疗桡骨远端骨巨细胞瘤的临床疗效。[方法]共纳入本院2008年8月～2016年12月收治的桡骨远端骨巨细胞瘤患者22例,采用自体腓骨移植修复肿瘤切除后骨缺损,随访记录复发、转移、骨愈合时间、关节脱位、患侧握力及腕关节功能等情况。[结果]本组病例术后平均随访(73.18±26.12)个月,1例局部复发,无远处转移病例;平均骨愈合时间(8.45±2.86)个月;3例出现下尺桡关节半脱位;术后握力平均恢复至健侧的72%。腕关节功能评价:背伸平均(44.77±9.22)°,掌屈(52.00±6.22)°,桡偏(16.50±3.28)°,尺偏(18.73±3.80)°。术后功能对比术前差异均有统计学意义(P<0.05)。[结论]游离自体腓骨移植并腕关节成形术是修复桡骨远端骨巨细胞瘤切除术后骨缺损的一种可靠选择。     

桡骨远端骨巨细胞瘤切除后三种重建方法的比较

[目的]探讨桡骨远端骨巨细胞瘤切除术后三种重建方法的临床效果。[方法]选取2000年10月~2013年12月间15例桡骨远端骨巨细胞进行瘤段切除,之后根据患者病情分别采取自体腓骨移植重建、同种异体骨移植、人工腕关节置换术三种重建方式,其中接受自体腓骨移植重建术5例,接受同种异体骨移植术6例,接受人工腕关节置换术4例,之后对三组患者进行为期5年的跟踪随访,比较三组患者腕部功能恢复情况,并统计不良症状发生的比例。[结果]MSTS保肢评分系统显示,接受自体腓骨移植重建术患者有4例优、1例良,明显优于接受同种异体骨移植术患者与人工腕关节置换术患者;在腕部功能方面,自体腓骨移植重建术患者腕关节屈伸功能分别为(51.32±9.31)°、(38.13±7.80)°,旋前、旋后功能平均为(71.32±5.63)°、(70.31±4.52)°,明显高于人工腕关节置换术患者、同种异体骨移植术患者(P<0.05);而在术后并发症方面,接受自体腓骨移植重建术患者较少。[结论]对于患有桡骨远端骨巨细胞瘤患者,自体腓骨移植重建,同种异体骨移植术,人工腕关节置换术三种重建方式均可以改善患者的病情,安全性较好,无明显不良并发症发生,自体腓骨移植重建术效果更优,可适当临床推广。     

腓骨近段移植重建桡腕关节治疗桡骨远端骨巨细胞瘤

腓骨近段移植重建桡腕关节治疗桡骨远端骨巨细胞瘤刘志成，李德甫，李天方桡骨远端骨巨细胞瘤治疗比较困难，刮除植骨复发率高，瘤段切除植骨及桡腕关节融合可引起腕关节的功能活动丧失。近２０年来，我们采用瘤段切除，以含腓骨头的胖骨重建桡腕关节，治疗１０例桡骨远端...     

自体髂骨移植重建桡骨远端关节面

桡骨远端严重粉碎性骨折常合并关节面及骨缺损，临床治疗效果不佳，晚期常留下腕部畸形，严重影响腕部、手部的功能。自2001年5月～2002年3月采取自体髂骨移植重建桡骨远端关节面治疗4例此类损伤，取得了一定疗效。现介绍如下。     

Giant cell tumor of the distal fibula: fifteen-year result after en bloc resection and fibula reconstruction

Introduction Giant cell tumor of the distal fibula is a very rare condition. The treatment of advanced tumors at this location can be challenging and has been described in the literature only in single cases.Materials and methods We report on a patient with a stage III giant cell tumor, according to the classification of Campanacci, of the distal fibula after en bloc resection and distal fibula reconstruction with a long bone graft from the iliac crest in a second procedure. The syndesmosis was reconstructed with a periosteal flap, the capsule and ligaments with local scar tissue.Results Fifteen years after the initial treatment the patient is free of local recurrence and demonstrates an excellent clinical outcome without any signs of instability, loss of function or osteoarthritis of the ankle joint.Conclusion We suggest the method to be worthwhile for treatment of this uncommon lesion in terms of recurrence and functional outcome.     

异体骨复合人工腕关节重建桡骨远端骨巨细胞瘤切除后骨缺损

目的:评价桡骨远端骨巨细胞瘤切除后异体骨复合人工腕关节修复重建方法及效果。方法:自2000年6月~2004年6月对8例桡骨远端骨巨细胞瘤患者行瘤段切除、异体骨复合人工腕关节修复重建术,其中男5例,女3例,年龄24~52岁,平均38岁,平均随访33.2个月;按改良Campanacci影像学分级系统对骨巨细胞瘤进行分级,其中Ⅱ级5例,Ⅲ级3例,病理骨折2例;采用肌肉骨骼肿瘤学会保肢评分标准评定术后功能。结果:随访期内所有患者未发现肿瘤局部复发和远处转移;术后无明显异体骨排异反应、感染、骨吸收和骨不连;异体骨与自体骨愈合时间平均5.6个月(4.3~8.2个月);近期人工关节假体无松动、断裂及脱位等并发症;腕关节平均活动度:掌屈38°,背伸45°,桡偏15°,尺偏20°,旋前40°,旋后65°;功能评价结果:优2例,良3例,可2例,差1例。结论:异体骨复合人工腕关节对桡骨远端肿瘤切除后骨缺损的重建是一良好的选择,远期效果尚待进一步观察。     

Unusual presentation in Haiti of a recurrent giant cell tumor of bone affecting the distal radius: A case report

IntroductionGiant cell tumor of bone (GCTB) is a benign-aggressive tumor that has a high-rate of recurrence with curettage resection alone. Patients with GCTB in underserved regions of the world can have progression of the tumor with significant disability due to a lack of specialty care. We present a case of an en bloc resection of an aggressive, recurrent GCTB of the radius with excellent function and no evidence of tumor recurrence two years after surgery.Presentation of caseA 22-year-old right-hand dominant female in Haiti developed an aggressive recurrence of a giant cell tumor of bone (GCTB) of the distal radius. Treatment consisted of en bloc resection of the distal radius with the proximal row of the carpus and centralization of the ulna. At two-year follow-up, the patient maintained good functional capacity with no clinical or radiological evidence of recurrence.DiscussionGCTB can cause significant destruction of the bone and articular surface if not treated adequately. Treatment options should be considered carefully in underserved regions of the world based on the resources available. This case exemplifies that complex limb-salvage surgery is possible when coordination of care between international and local surgeons is provided with an emphasis on continuity of care post-operatively.ConclusionEn bloc resection with centralization of the ulna remains a viable technique to address aggressive GCTB of the distal radius and can be appropriate in resource-limited settings.     

病灶切刮骨水泥填充治疗肢体骨巨细胞瘤125例

目的 探讨病灶切刮骨水泥填充治疗肢体骨巨细胞瘤（ＧＣＴ）的临床应用价值,方法 对１９８０年３月～１９９７年１２月１２５例ＧＣＴ的治疗情况进行回顾分析。患者男６２例,女６３例,年龄１２－７１岁,平均年龄３１．５岁,其中原发ＧＣＴ１０１例,复发ＧＣＴ２４例。发病部位在膝关节周围者１００例（占８０％）。结果 １２５例患者均获随访,随访时间１３－１９４个月,平均９６个月。原发ＧＣＴＦ得,１３例复发,复发率     

地诺单抗联合手术治疗桡骨远端骨巨细胞瘤——外科降级及预后

目的 评估地诺单抗治疗桡骨远端骨巨细胞瘤（giant cell tumor of bone, GCT）的疗效和安全性,分析地诺单抗对手术方式及预后的影响。方法 回顾性分析2014年1月至2016年4月,在围手术期接受地诺单抗治疗的复杂桡骨远端GCT病人7例的临床资料。其中,男4例,女3例;年龄为23~33岁,平均28.43岁。所有病人均有明确GCT病理诊断,2例为手术后复发。病人术前接受120 mg 地诺单抗皮下注射3~4次,术后根据实际手术类型安排用药。比较病人应用地诺单抗前后手术方案的差异,监测用药过程中的不良反应;随访病人的肿瘤学预后及术后功能恢复。结果 病人均按计划用药,用药总次数为4~10次（平均7.71次）,用药期间无死亡病例,未见下颌骨坏死,实验室指标未见异常,RECIST评估结果显示：部分缓解5例、疾病稳定2例;6例病人（85.71%）实现外科手术降级（行囊内刮除术5例,瘤段广泛切除2例）,术后病理结果提示组织学巨细胞清除率为85.71%（6/7）;随访20~41个月,平均26.71个月,7例病人随访期内均未见肿瘤复发;病人术后的肌肉骨骼肿瘤学会（MSTS）93功能评分平均为27.86分（得分率为92.87%）,平均臂肩手功能障碍（DASH）评分为7.43分,平均疼痛视觉模拟量表（VAS）评分为1.00分。结论 地诺单抗是治疗桡骨远端GCT的有效手段,围手术期用药可降低手术难度,从而实现外科降级并降低复发风险。     

病灶内切除与整块切除治疗桡骨远端骨巨细胞瘤的Meta分析

目的 :用Meta分析的方法对国内外已发表较高质量的有关比较病灶内切除术和整块切除术对桡骨远端骨巨细胞瘤患者术后复发率、并发症发生率和功能康复结果的临床研究进行综合定量分析,为桡骨远端骨巨细胞瘤的外科治疗模式的选择提供参考依据。方法:计算机检索Cochrane图书馆(2014年8期)、Pub Med、Ovid、Elsevier、CNKI等数据库。检索从(1970-01-01/2013-01-01)年有关病灶内切除与整块切除治疗治疗桡骨远端骨巨细胞瘤的文献,筛选出符合纳入标准的文献,并对其进行严格的质量评价。利用Cochrane协作网提供的Rev Man 5.0软件对纳入研究结果进行Meta分析,并对数据进行异质性检验。计算病灶内切除术相对整块切除术其复发及并发症发生危险的优势比(OR),评价病灶内切除术与整块切除术对桡骨远端骨巨细胞瘤患者复发及并发症发生的影响。结果 :符合纳入标准的文献7篇,总样本量163例。其中病灶内切除术组92例(PMMA n=54,骨移植n=33,非PMMA或非骨移植n=5),整块切除术组71例。病灶内切除术组骨巨细胞瘤复发率比整块切除术组高[OR=3.87,95%CI(1.42,10.53)],而在Campanacci 3级GCTs中[OR=10.12,95%CI(1.57,65.27)],病灶内切除术组并发症发生率更少[OR=0.13,95%CI(0.04,0.40)],病灶内切除术组内用PMMA与骨移植物充填病灶的复发率没有明显差异[OR=0.96,95%CI(0.26,3.56)]。通过选择用MSTS系统评价、VAS系统评价和握力计系统评价时,病灶内切除术组在功能康复结果中优于整块切除组。结论:基于有限的资料,表明整块切除术更加适合治疗桡骨远端骨巨细胞瘤,而病灶内切除术在治疗桡骨远端骨巨细胞瘤的Campanacci 1、2级比3级更加适合,病灶内切除桡骨远端骨巨细胞瘤方面,PMMA并不优于骨移植物。病灶内切除桡骨远端骨巨细胞瘤在功能康复方面优于整块切除组。     

Reconstruction of the distal radius by fibula following excision of giant cell tumor

Thirty giant cell tumors of the distal radius were excised and reconstructed using a nonvascular fibular osteoarticular autograft. Four different surgical techniques for stabilization were used. There were ten recurrences, which could not be correlated with Campanacci's radiological or Jaffe's histological grading. Twenty cases without recurrence were followed up over 1.5-25.5 (average 8.5) years. Average time for incorporation of the graft was 5.2 months. The surgical technique using a radiofibular plate and K wire through the wrist had a low nonunion rate, no graft related complications, good range of movement, and good hand functions.     

骨盆骨巨细胞瘤临床治疗的系统文献综述

 目的 分析骨盆骨巨细胞瘤（giant cell tumor, GCT）的好发年龄、发病部位、不同治疗方式的复发率及并发症。方法 在医学常用外文数据库检索“giant cell tumor,pelvis”,在医学常用中文数据库检索“骨巨细胞瘤,骨盆”,时间选取1949至2012年,所有被检索的文献及参考文献均被用于分析,经文题、摘要、全文内容二次筛选,共筛选出38篇文献,将所涉及的骨盆GCT患者作为研究对象,删除重复报告的病例;收集每例入选患者的发病年龄、发病部位、手术方式、随访时间、并发症、复发率及死亡率等。采用系统分析的方法对数据进行分项研究。结果 筛选出的38篇文献中共165例骨盆GCT患者纳入研究进行系统分析,发病年龄14~73岁,平均33.2岁,高发年龄21~40岁;男、女比例为1∶1.7。发病部位：髂骨区（A区）48例,髋臼区（B区）60例,耻、坐骨区（C区）31例。随访时间1.5~35年,平均9.5年。27例（32.5%,27/83）患者出现治疗并发症,以病灶外整块切除方式进行治疗的患者（13/28）发生率最高;常见并发症为切口内感染、切口延迟愈合。9例（45.0%,9/20）接受单纯病灶放疗的患者术后复发,24例（33.3%,24/72）接受病灶内手术的患者术后复发,5例（35.7%,5/14）接受病灶内手术联合放疗或冷疗的患者术后复发,1例（2.0%,1/51）接受病灶外手术的患者术后复发,总复发率为24.6%（39/158）,死亡率为3.2%（5/158）。结论 骨盆GCT临床少见,常累及髋臼区（B区）,高发年龄为21~40岁,病灶外整块切除术后并发症最为常见,但术后复发率最低,骨盆GCT总体复发率较高,死亡率较低。     

Outcomes of short segment distal radius resections and wrist fusion with iliac crest bone grafting for giant cell tumor

BackgroundDistal radius is third most common site for occurrence of Giant cell tumor (GCT) of bone. Most of Campanacci grade II & III cases require resection. Reconstructions of these defect are challenging. Though fibular arthroplasty provides mobility at wrist but is fraught with complications of donor site morbidity and instability with wrist pain. Wrist arthrodesis with ulna translocation provides stable reconstruction but is cosmetically less appealing. We present a series of 12 cases of GCT of distal radius treated with short segment (6 cm or less) resections and wrist fusion with iliac crest grafting. We evaluated donor site morbidity, functional and oncological outcomes.ObjectivesTo assess time to union, donor site morbidity, functional and oncological outcomes after wrist fusion with iliac crest bone grafting for distal radius resection (≤6 cm).MethodsRetrospective analysis was performed from a prospectively maintained database between January 2011 and December 2017, 12 patients (7 male and 5 female; 9 primary and 3 recurrent; all Campanacci grade III) were included. Mean age was 29 years (15–41 years) with mean resection length of 5.1 cm (4.5–6 cm). The dominant hand was involved in 6 patients. Time to union, donor site morbidity, functional and oncologiacal outcomes were evaluated. Functional outcomes were evaluated using Musculo-Skeletal Tumor Society (MSTS) score and Patient Rated Wrist Evaluation (PRWE) score. Grip strength and arc of forearm rotation were also evaluated.ResultsAll patients were available for analysis. No symptomatic donor site morbidity was observed. One patient had prominent implant following a fall and delayed union. Mean time to union for 22 osteotomy sites in rest of 11 patients (both proximal and distal) was 6 months (4–11 months). At median follow up of 45 months (18–78 months) 2 patients had soft tissue recurrence, 1 had a stable pulmonary metastasis. Local Recurrence rate was 17%. All patients returned to their pre surgery activity. Mean MSTS score was 25 (19–29) and PRWE score was 12 (6–28). Grip strength and Prono - supination measurements were available in 10 patients. Grip strength was 69% of non operated limb. Mean supination was 53° (0° to 80°) and mean protonation was 73° (40° to 80°). Mean arc of rotation was 126° (80° to 160°).ConclusionReconstruction of distal radius bone defects with Iliac crest bone grafting and wrist arthrodesis retains prono-supination while maintaining wrist girth (cosmesis). The oncologic and functional outcomes make it an acceptable modality in selected cases of distal radius tumours with short resection length (≤6 cm).     

Resection-reconstruction arthroplasty for giant cell tumor of distal radius

Background:

Giant cell tumor (GCT) of the distal radius poses problems for reconstruction after resection. Several reconstructive procedures like vascularized and non-vascularized fibular graft, osteo-articular allograft, ceramic prosthesis and megaprosthesis are in use for substitution of the defect in the distal radius following resection. Most authors advocate wrist arthrodesis following resection of distal radius and non vascularized fibular graft. Here we have analyzed the results of aggressive benign GCTs of the distal radius treated by resection and reconstruction arthroplasty using autogenous non-vascularized fibular graft.

Materials and Methods:

Twenty-four cases of giant cell tumor of the distal radius (mean age 32 years, mean follow-up 6.6 years) treated by en-bloc resection and reconstruction arthroplasty using autogenous non-vascularized ipsilateral fibular graft with a minimum followup of two years have been included in this retrospective study. Nineteen cases were of Campanacci grade III and five were of Grade II recurrence. The mean resected length of the radius was 9.5 (8-12) cm. Routine radiographs and clinical assessments regarding pain, instability, recurrence, hand grip strength and functional status were done at regular intervals and functional results were assessed using (musculoskeletal tumor society) MSTS-87 scoring.

Results:

Early radiological union at host-graft junction was achieved at mean 12.5 weeks, (range 12-14 weeks) and solid incorporation with callus formation was observed in mean 29 weeks (range 28-32 weeks) in all the cases. Satisfactory range of motion (mean 63%, range 52-78%) of the wrist was achieved in 18 cases. Grip strength compared to the contralateral hand was found to be 67% (range 58-74%). Functional results were excellent in six cases (25%), good in 14 cases (58.3%) and four (16.7%) cases had fair results. Soft tissue recurrence was seen in one patient. The most commonly encountered complication was fibulo-carpal subluxation (10 cases, 41.7%).

Conclusion:

Resection of the distal radius and reconstruction arthroplasty with non-vascularized proximal fibular graft is useful in preserving the functional movement and stability of the wrist as well as achieving satisfactory range of movement and grip strength.