Ticlopidine hydrochloride is a platelet aggregation inhibitorthat is used for the prevention of vascular thrombosis. So far,only six cases of ticlopidine-induced lupus have been documentedin the literature [1–3]. We report here a first case ofticlopidine-induced lupus with renal involvement.   A  相似文献   

2.
  Patients with end-stage renal disease who require chronic dialysisare at high risk of developing malignancy. There are many reportedcases of the development of renal or urothelial cancer in suchpatients [1–8]. We report the first case, to our knowledge,of multifocal, invasive transitional cell carcinoma (TCC) andunilateral renal cell carcinoma (RCC) with acquired cystic disease,occurring simultaneously in a patient on haemodialysis treatedby complete urinary tract exenteration. Our patient was managedsuccessfully with an aggressive treatment.   A 69-year-old man was referred to our institution  相似文献   

3.
  Heavy chain deposition disease (HCDD) is a rare manifestationof plasma cell dyscrasia. Only 11 cases have been describedin the literature [1]. The clinical picture is variable, butin all patients renal biopsy showed a nodular sclerosing glomerulopathy[1–5]. We report a patient with rapidly progressive glomerulonephritisin whom the renal biopsy showed mainly intracapillary proliferativeglomerulonephritis due to HCDD.   The patient is a 55-year-old musician with an uneventful medicalhistory except ankylosing spondylitis diagnosed at the age of47. Six weeks before admission he noticed foamy urine, at 2weeks he developed generalized swelling, dyspnoea and a severeheadache. Upon admission  相似文献   

4.
  Primary renal glucosuria (OMIM 233100) is defined by an increasedurinary glucose excretion in a patient with a normal blood glucoseconcentration in whom all other filtered substrates are handledcompletely normally by the proximal tubules. Mild renal glucosuriais a relatively common condition that was first studied at thebeginning of the last century [1], but it was not until 1987that a study on a patient with virtual absence of renal tubularglucose reabsorption was published. This condition has beentermed type 0 renal glucosuria [2]. Here we report on the long-termhistory of this patient whose underlying genetic defect hasrecently been identified [3,4].   Patient P.M., a male of German descent, was born in  相似文献   

5.
  Early renal transplant dysfunction can be caused by acute rejection,acute tubular necrosis (ATN), infection, ciclosporin toxicity,bleeding, urethral obstruction, urinary leak, lymphocele andthrombosis [1]. Prompt treatment of early allograft dysfunctionis essential and therefore accurate diagnosis mandatory. Wedescribe a patient with an unusual cause of allograft dysfunction,which was resolved by a simple surgical intervention.   A 32-year-old man with congenital blindness, hypertension andend-stage renal disease underwent renal transplantation. Hehad been haemodialysis-dependant since the age of 24 years.Dialysis was performed through an  相似文献   

6.
  A wide spectrum of primary glomerular diseases may occur inpatients with type 1 diabetes mellitus (DM) due to autoimmunemechanisms [1,2]. We here report a patient with type 1 DM andHashimoto's thyroiditis who developed membranoproliferativeglomerulonephritis (MPGN).   A 35-year-old man with type 1 DM for 18 years and Hashimoto'sthyroiditis for 6 years was referred to  相似文献   

7.
  Jaccoud was a French clinician from the 19th century who reporteda peculiar joint deformity in patients with rheumatic fever[1]. He observed the development of an ulnar deviation thatwas reducible, which indicated that the joint spaces were notdestroyed. We have no evidence that Jaccoud was interested inthe kidney or that he ever saw a patient with nephritis. Perhapsthe patient reported here would have raised his interest inour specialty.   A 69-year-old woman was admitted because of generalized weaknessand decreasing renal function. Two months earlier, her  相似文献   

8.
  Acute renal failure due to phosphate nephropathy following bowelcleansing with an oral sodium phosphate solution is a rare,but well-known, complication [1]. Several authors have reporteddiffuse tubular injury and tubular deposition of calcium phosphatein biopsies taken from such patients [1–4]. In these patients,the term acute phosphate nephropathy more aptly describes thisentity than the previously used term acute nephrocalcinosis[1]. It has been a matter of debate whether these changes aredirectly induced by the phosphate load or whether they werebeing present before the procedure [3]. We, therefore, reporta patient with acute phosphate nephropathy who had kidney biopsiestaken before and after bowel cleansing with sodium phosphate.   In 2002, a 69-year-old woman was  相似文献   

9.
  Haemodialysis access graft is so important as to be called alifeline for the patient on maintenance haemodialysis. The vascularaccess problem is the leading cause of admission in patientswith end-stage renal disease. Many complications of the prostheticvascular access graft are reported, such as graft thrombosis,infection, aneurysm or pseudoaneurysm, and arterial steal syndrome[1]. We recently experienced two cases of graft thrombosis relatedto the iatrogenic fistula between haemodialysis access graftand autogenous vein at the needling site during haemodialysis.We report our cases with their clinical manifestation and thetreatment outcome and possible methods of prevention [2].   A 76-year-old female on long-term haemodialysis  相似文献   

10.
  Renal transplant patients remain at risk of graft loss due toacute rejection, calcineurin inhibitor toxicity and chronicallograft nephropathy. Less frequent causes include opportunisticinfections related to immunosuppressive therapy. However, infectionsare a major clinical issue in the field of renal transplantation,impacting on graft and patient survival. Fungal infections accountfor about 5% of infections in renal transplant recipients [1].Candida species are the most common fungal pathogen, and themost common forms of infection are oral and esophageal candidiases,vascular access device-related and urinary tract infections[2]. The incidence of candidiasis of the renal allograft israre and not very well documented.   A 50-year-old white female with a prior medical history of hypertension,  相似文献   

11.
  Severe acute respiratory syndrome (SARS)-associated coronavirus(SARS-CoV) has been identified as the causal agent of SARS.Although not common, acute renal failure (ARF) in SARS patientsusually has a catastrophic outcome, with a mortality rate of77% [1]. The causes of ARF in association with SARS are unknown.An increase in creatine kinase (CK) may play a role [2]. Wepresent two patients who met the definition of probable SARS.   A 78-year-old man  相似文献   

12.
  Sezary syndrome is a cutaneous T-cell lymphoma (CTCL), characterizedby erythroderma and infiltration of the epidermis, the dermisand the bone marrow by monoclonal CD4+ T lymphocytes [1]. Renalcomplications of patients with CTCLs have rarely been reported[2–4]. In patients with other haematological malignancies,treated with interferon-   A 63-year old male, who had been diagnosed with Sezary syndrome  相似文献   

13.
  Common causes of gross haematuria include stones, neoplasms,tuberculosis, trauma and prostatitis. However, macroscopic haematuriacan occur in patients with IgA nephropathy. IgA nephropathyusually occurs in patients under 40 years of age, and loin painoften accompanies the haematuria [1]. Furthermore, macroscopichaematuria in IgA nephropathy often causes acute renal failurebecause of tubular obstruction by red blood cells [2–4].Obstruction or haematoma of the renal pelvis and lower urinarytract by gross haematuria in IgA nephropathy or any other diseasescausing haematuria has not been reported. Here, we report thecase of a patient with pelvic haematoma in IgA nephropathy,that was erroneously suspected for pelvic malignancy leadingto its radical resection.   A  相似文献   

14.
  Diffuse alveolar haemorrhage (DAH) often mimics, clinicallyand radiologically, severe pneumonia or ARDS [1]. The causesof DAH include a variety of non-infectious diseases, e.g. collagenvascular disease. In DAH associated with SLE, a regimen of corticosteroidscombined with cyclophosphamide and plasma exchange is generallyrecommended [2]. We describe here a ventilated SLE patient withDAH refractory to standard therapies. To our knowledge, thisrepresents the first successful application of rituximab inDAH.   A 29-year-old North African female presented to our institution  相似文献   

15.
  Pregnancy in women with end-stage renal disease (ESRD) undergoingdialysis treatment is uncommon but increasingly observed overthe last few years [1]. The outcome in pregnancies in dialysedwomen is greatly influenced by maternal risk factors. Duringgestation, various risks may appear including the mother's fluidoverload, hypertension, anaemia and an increased risk for fetaland perinatal complications such as neonatal mortality, prematurityand small-for-gestational-age [2,3]. Here, we report on a 40-year-oldfemale patient who developed ESRD due to an extended Stanford-B-aneurysmof the aorta 1 year prior to conception. Nonetheless, the childwas delivered successfully by caesarian section after 31 weeksof gestation.   A 39-year-old female was referred to our centre with a hypertensivecrisis, dizziness,  相似文献   

16.
Anaesthesia for lower limb revascularization     
Tovey  Gail; Thompson  Jonathan P 《CEACCP》2005,5(3):89-92
The first 150 words of the full text of this article appear below. Key points Surgery for lower limb revascularization is associatedwith a high risk of cardiac morbidity and mortality. Preoperativecardiac risk assessment is important and risk-reducing measuresshould be started appropriately. Perioperative ß-blockadedecreases perioperative cardiac complications in the highestrisk patients. The quality of anaesthetic practice rather thanspecific technique per se has the most important influence onpatient outcome. Acute limb ischaemia is an emergency thatprecludes prolonged preoperative cardiac evaluation.  
  Critical limb ischaemia (CLI) is defined as chronic ischaemicrest pain, ulcers or gangrene attributable to objectively provenarterial occlusive disease. Peripheral vascular disease (PVD)is a marker for severe multi-system atherosclerosis and patientswith critical limb ischaemia presenting for lower limb revascularizationpresent a significant challenge to the anaesthetist. They areusually elderly with a high prevalence of hypertension, diabetesmellitus, cerebrovascular and renal vascular disease, and smoking-relatedrespiratory disease. Only 8% of patients with PVD . . . [Full Text of this Article]Treatment strategies       MonitoringGeneral anaesthesiaRegional anaesthesia      相似文献   

17.
Atrial fibrillation     
Bajpai  Abhay; Rowland  Edward 《CEACCP》2006,6(6):219-224
The first 150 words of the full text of this article appear below. Key points
  • Atrial fibrillation (AF) is the commonest cardiacarrhythmia; its incidence increases with age.
  • Diabetes mellitus,hypertension and ventricular hypertrophy are commonly associatedwith non-valvular atrial fibrillation.
  • Primary aims of managementof AF are conversion to sinus rhythm, maintenance of sinus rhythmand prevention of thromboembolic complications.
  • In elderlypatients who are asymptomatic, adequate rate control of AF appearsto offer the same benefits as rhythm control.
  • Chronic AF carriesa high risk of ischaemic stroke from thromboembolism; all patientsat risk must receive adequate anticoagulation.
  • Anticoagulationshould be continued in patients with risk factors despite successfulconversion to sinus rhythm.
  Atrial fibrillation (AF) is the commonest cardiac arrhythmia.The incidence increases with age and affects 5% of UK populationabove the age of 65 yr and 10% above 75 yr.1 2 In the UnitedStates, AF accounts for more than 35% of all admissions forcardiac arrhythmias.3 Men are . . . [Full Text of this Article]
            Direct current cardioversionPharmacological restoration of sinus rhythm       Non-pharmacological management   Cardiac surgeryAcute myocardial infarctionPregnancyVentricular pre-excitationHyperthyroidismPulmonary disease  相似文献   

18.
  The intravenous rapid ACTH (250 mcg) stimulation test [shortsynacten® test (SST)] is the investigation of choice insuspected hypoadrenalism. We describe a patient with nephroticsyndrome in whom the initial SST was abnormal due to low cortisolbinding globulin (CBG). Repeat testing, after the patient haddeveloped end-stage renal failure, revealed a normal response.   A 53-year-old woman presented with peripheral oedema. Nephroticsyndrome was diagnosed on the basis of hypoalbuminaemia, proteinuriaand dyslipidaemia. She had  相似文献   

19.
Complications of blood transfusion     
Maxwell  Melanie J; Wilson  Matthew J A 《CEACCP》2006,6(6):225-229
The first 150 words of the full text of this article appear below. Key points
  • Complications of blood transfusion are rare but canbe life-threatening.
  • Since 2005, it has been a legal requirementthat all serious adverse reactions attributable to the safetyor quality of blood are reported.
  • Most reported complicationsare because of transfusion of mismatched blood products andare avoidable through clinical vigilance.
  • Massive blood transfusionsresult in abnormalities of coagulation status, serum biochemistry,acid–base balance and temperature homeostasis.
  • Transfusion-relatedacute lung injury is the most common cause of major morbidityand death after transfusion.
  The serious hazards of transfusion (SHOT) scheme has collecteddata on significant adverse events resulting from transfusionof blood components from volunteer organizations since 1996.However, after the implementation of the European Union Directiveon Blood Safety and Quality in 2005, it is now a requirementthat all ‘Blood Establishments and Hospital Blood Banksreport to the Secretary of State for Health all serious adversereactions . . . [Full Text of this Article]
  CoagulationBiochemistryHypocalcaemiaHyperkalaemiaAcid–base abnormalitiesHypothermia   Clinical features       Immediate reactionsDelayed reactions       BacterialViralPrion      相似文献   

20.
  Tenofovir is an antiviral nucleotide with activity against humanimmunodeficiency virus type I (HIV-1). Tenofovir is extensivelyand rapidly excreted in the urine by the kidneys [1]. Thereare no available data on tenofovir pharmacokinetics in patientswith renal failure. We report here on the clinical effects andthe pharmacokinetics of tenofovir in one patient with end-stagerenal disease (ESRD) undergoing haemodialysis.   The patient was a 46-year-old Caucasian man co-infected withHIV-1 and hepatitis B virus (HBV) who was undergoing haemodialysistwice a week for end-stage renal failure (ESRD) secondary toautosomal polycystic kidney disease. At the time of the study,his creatinine clearance was 10 ml/min with a urinary outputof  相似文献   

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   Introduction    Case    Introduction    Case    Introduction    Case    Introduction    Case    Introduction    Case report    Introduction    Case    Introduction    Case    Introduction    Case report    Introduction    Case 1    Introduction    Case report    Introduction    Case 1    Introduction    Case    Introduction    Case    Introduction    Case report    Introduction    Case    Critical limb ischaemia    Preoperative assessment    Preoperative management    Perioperative management    Postoperative management    Acute limb ischaemia    Definition and electrocardiographic patterns    Classification    Pathophysiology and mechanisms    Causes and risk factors    Principles of management    Restoration of sinus rhythm    Maintenance of sinus rhythm    Rate control of atrial fibrillation    Prevention of thromboembolism    Management in special situations    Introduction    Case    Massive transfusion    Transfusion-related acute lung injury    Pathogenesis    Incidence    Haemolytic transfusion reactions    Non-haemolytic febrile reactions    Allergic reactions    Transfusion-related infections    Transfusion-associated graft-vs-host disease    Immunomodulation    Introduction    Case
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