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1.
E. L. Lushnikova 《Bulletin of experimental biology and medicine》1995,120(1):737-740
It is shown that different regimens of general cooling and overheating of the organism produce different changes of the volume
and area of the major tissue components of the myocadium. The most pronounced alterations in the volume and area of the tissue
components are recorded after overheating. A marked decrease of the volume and area of the microcirculatory bed is a regular
feature of tissue reorganization in the myocardium under the influence of cooling and heating.
Translated fromByullenten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nulo 7, pp. 91–94, July, 1995
(Presented by V. V. Lyakhovich, Member of the Russian Academy of Medical Sciences) 相似文献
2.
G. I. Nepomnyashchikh S. V. Aidagulova L. M. Nepomnyashchikh 《Bulletin of experimental biology and medicine》1996,122(6):1239-1243
Ultrastructural analysis of epitheliocytes in the gastric mucosa of wild Muridae captured in three regions of the Altai with
various levels of ecological pollution reveals predominance of dystrophic and atrophic changes in the surface and glandular
epithelium. Stereological analysis demonstrates a universal character of structural response to a complex of anthropogenic
factors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 12, pp. 682–686, December, 1996 相似文献
3.
L. M. Nepomnyashchikh E. L. Lushnikova O. P. Molodykh 《Bulletin of experimental biology and medicine》1996,121(4):428-433
Ultrastructural stereological analysis revealed the fundamental reorganization of hepatocytes in Muridae from natural ecosystems
exposed to anthropogenic factors. An appreciable decrease of the volume density of mitochondria and granular endoplasmic reticulum
was associated with a many-fold increase of the volume density of glycogen. The detected hepatocyte glycogenosis was characterized
by a redistribution of organelles and the formation of large depots of glycogen with reduced electron density.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 470–476, April, 1996
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
4.
M. G. Klinnikova E. L. Lushnikova L. M. Nepomnyashchikh 《Bulletin of experimental biology and medicine》1995,120(5):1162-1166
It is shown that regenerative plastic insufficiency develops in cardiomyocytes of young and old rats after a one-time general
overheating. Atrophic and necrobiotic alterations of the cardiomyocytes together with a decrease of the heart weight are noted
as well. Intracellular alterations of cardiomyocytes of young and old rats are accompanied by a marked decrease of succinate
dehydrogenase activity under these conditions. There-after its activity rises appreciably in young animals during the course
of postheating restitution, while in old rats the activity of this enzyme remains low.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, № 11, pp. 540–544, November, 1995
Presented by V. V. Lyakhovich, Member of the Russian Academy of Medical Sciences 相似文献
5.
E. L. Lushnikova L. M. Nepomnyashchikh 《Bulletin of experimental biology and medicine》1994,117(5):545-547
Information analysis of the intracellular reorganization occurring in the cardiomyocytes of Wistar rats is performed after
total hypothermia and total hyperthermia. It is demonstrated that the structural and relative entropies decrease and the redundancy
coefficient increases after total hypothermia, indicating a reduction in the structural diversity of cardiac myocytes and
the formation of a new stable morphofunctional state of these cells. There are no significant changes in the information characteristics
of cardiomyocytes after a single total hyperthermia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 543–544, May, 1994
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences 相似文献
6.
E. L. Lushnikova L. M. Nepomnyashchikh O. A. Postnikova V. G. Tsimmerman 《Bulletin of experimental biology and medicine》1999,128(2):863-866
We studied ultrastructure of cardiomyocytes of W/SSM rats with inherited hypertrophic cardiomyopathy bred from Wistar rats
by hypersensitivity to cataractogenic action of high galactose doses. The observed dynamics of quantitative and qualitative
changes in the main sarcoplasmic organelles reflects general principles of spatial and temporal reorganization of cardiac
muscle cells induced by hypertrophy of different genesis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 233–237, August, 1999 相似文献
7.
E. L. Lushnikova L. M. Nepomnyashchikh B. I. Mazhbich 《Bulletin of experimental biology and medicine》1994,117(6):669-673
Disturbances of intracellular regeneration in cardiomyocytes (CMC) are demonstrated in rats kept for a prolonged period in
the mountains. These disturbances cause focal destruction and lysis of organelles. The spatial intracellular reorganization
of CMC under these conditions is characterized by an increased volume and surface density of myofibrils and decreased volume
density of mitochondria, agranular sarcoplasmic reticulum, and T-system.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 661–665, June, 1994
Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences 相似文献
8.
E. V. Koldysheva E. L. Lushnikova I. S. Proskuryakova 《Bulletin of experimental biology and medicine》1999,127(5):535-539
Single and repeated hypoxic exposures induced different ultrastructural changes of varying intensity in adrenocorticocytes
of rat adrenal zona fasciculata and zona reticularis. Destructive changes in cells were caused by the antianabolic effect
of hypoxia and inhibition of regeneration and plastic processes. Treatment with nandrolone (Nerobolil, Gedeon Richter) diminished
this effect and stimulated secretory activity of adrenocorticocytes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 588–592, May, 1999 相似文献
9.
10.
E. L. Lushnikova L. M. Nepomnyashchikh O. P. Molodykh M. G. Klinnikova 《Bulletin of experimental biology and medicine》1994,117(1):99-103
Hyperthermia results in the suppression of intracellular regeneration in cardiomyocytes, manifested as intensified lysis and
destruction of organelles, and leads to myocardial atrophy. Intracellular reorganization of cardiomyocytes is characterized
by increases in the volume and surface density of myofibrils, sarcoplasmic reticulum, and T system.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 96–100, January, 1994
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences 相似文献
11.
Yu. I. Borodin V. G. Selyatitskaya L. A. Obukhova N. A. Pal'chikova S. V. Odintsov T. A. Kukushkina 《Bulletin of experimental biology and medicine》1999,127(6):637-639
In control rats and animals receiving polyphenol compounds extracted fromAlchemilla vulgaris, intense cooling stimulated synthesis of thyroid hormones and promoted their peripheral deiodination. In control rats, the
period of recovery after cooling (readaptation period) was characterized by a compensatory reduction in thyroid function.
In rats receiving test preparation, this period was characterized by significant activation of thyroid hormone synthesis and
by further growth of reserve follicles that appeared during the cooling.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsyni, Vol. 127, No. 6, pp 697–699, June, 1999 相似文献
12.
L. M. Nepomnyashchikh E. L. Lushnikova G. I. Nepomnyashchikh 《Bulletin of experimental biology and medicine》1994,117(5):539-544
It is shown that as soon as the 1st day after transfer to high latitudes, the regenerative processes are suppressed in some
cardiomyocytes, this manifesting itself in lytic changes of the sarcoplasm and organelles in the perinuclear zone. After flight
in the middle latitudes morphological signs of disturbances in the processes of intracellular regeneration are observed only
toward the end of the experiment. Intracellular spatial reorganization of cardiomyocytes for transfer to high latitudes and
for flight in the middle latitudes has a stereotypic pattern and primarily manifests itself in an increase of the volume density
of myofibrils and a decrease of this parameter for mitochondria.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 538–542, May, 1994
Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences 相似文献
13.
Ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium 总被引:1,自引:0,他引:1
L. M. Nepomnyashchikh E. L. Lushnikova D. E. Semenov 《Bulletin of experimental biology and medicine》2000,130(6):1196-1201
We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium
induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under
these conditions is almost complete disappearance of the heterochromatin lumps. The earliest changes in nucleoli under conditions
of disturbed DNA-dependent RNA synthesis are segregation of the granular and fibrillar nucleolonema components. Deep alterations
in the nucleoli manifested by fragmentation and annulation correlate with pronounced changes in cardiomyocytes ultrastructure,
intensive lysis of the myofilaments, reduction of the organelles, and enhanced autophagocytosis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 12, pp. 681–687, December, 2000 相似文献
14.
15.
The principal forms of acute cardiomyocyte damage of metabolic and ischemic genesis are accompanied by changes in the contractile
apparatus, which is reflected in double refraction of myofibrils. Thus, polarization microscopy is the most sensitive method
allowing one to detect the early stages of cardiomyocyte damage. Individual types of cardiomyocyte lesions are identified
on the basis of parallel histological studies and polarization and electron microscopy of prenecrotic alterations and myocardial
infarction using experimental and autopsy material. They are: I, II, and III degree myofibrillar contracture, intracellular
myocytolysis, primary lumpy degradation of myofibrils, and cytolysis. These types of damage form the morphological basis of
acute myocardial pathology with a possible outcome of coagulative or colliquative necrosis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp. 4–13, January, 1996 相似文献
16.
Inhibition of contractile activity of cultured rat cardiomyocytes in response to reduced oxygenation
M. I. Leikina E. V. Stel'mashuk V. B. Koshelev 《Bulletin of experimental biology and medicine》1995,119(2):209-211
Hypoxia completely abolishes the spontaneous contractile activity of cardiomyocytes. Once the original oxygenation is restored,
the cells regain their functional activity, which exceeds the control level (particularly after a 2-h hypoxia). It can be
assumed that the rapid restoration of cardiomyocyte functional activity is due to the preservation of a sufficiently high
oxygen content and to the compensatory activation of glycolysis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
2, p. 215–217, February, 1995
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
17.
I. A. Polyakova M. V. Shornikova I. V. Samorukova Yu. S. Chentsov 《Bulletin of experimental biology and medicine》1999,127(1):86-90
Twelve-minute blockade of blood circulation caused different changes in cardiomyocyte organelles, particularly in the mitochondria.
The initial cardiomyocyte structure was restored within 3.5 h of the postresuscitation period. Ultrastructural changes in
cardiomyocytes were observed again 1 month after resuscitation. They disappeared after 5 months.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 95–100, January 1999 相似文献
18.
L. M. Nepomnyashchikh D. E. Semenov V. G. Tsimmerman 《Bulletin of experimental biology and medicine》1994,117(6):665-668
Sixty-four male Wistar rats were subjected to repeated complete starvation with free access to water. Each starvation period
lasted 6 days and was followed by a 7-day recovery period. The concentration of cardiomyocytes (CMC) and their total number
in the left ventricle (LV) were measured after alkaline dissociation of the myocardium. The volume density of muscle fibers
and their absolute total mass in the LV were determined by stereological analysis. It is shown that after 6 successive starvation
periods the proliferative potential of the CMC population is reduced.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 658–660, June, 1994
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
19.
20.
M. M. Kalashnikova 《Bulletin of experimental biology and medicine》1996,121(6):543-548
A detailed ultrastructural analysis of liver cells in a comparative morphological series of animals from various classes has
provided insight into how liver structure was perfected in the course of evolution. Specific features of the adaptive responses
acquired by hepatocytes in different animal classes for maximizing their many functions in the framework of the existing organ
structure are identified. It is shown that the adaptations found in lower animals also normally occur in more highly organized
animals, and that the same adaptations developed by hepatocytes during phylogeny are used in responding to various influences
exerted upon the organism.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 604–609, June, 1996 相似文献