Pyoderma gangrenosum treated with cyclosporin A

A 49-year-old woman with a 14-year history of pyoderma gangrenosum unresponsive to a variety of systemic and topical treatments was given oral cyclosporin A (CyA), a potent immunosuppressive agent widely used in organ transplantation for the prophylaxis of acute graft-versus-host disease. Improvement and subsequent healing of the lesions was evident within 3 weeks of starting treatment and has continued for the duration of treatment (12 months).     

Pyoderma gangrenosum treated with sulfasalazine and dapsone

A case of pyoderma gangrenosum treated initially with sulfasalazine and later with dapsone and being kept in remission with dapsone alone is being reported.     

坏疽性脓皮病

坏疽性脓皮病是一种慢性复发性溃疡性皮肤病。该文对坏疽性脓皮病的发病机制、临床表现及常见异型、合并症、诊断、鉴别诊断和治疗方法等作了较全面的复习。鉴于过去该病无诊断标准,其诊断一直沿用排除性诊断,故文中重点对该病的诊断进行阐述,并介绍最新的诊断标准。     

Pyoderma gangrenosum

Four patients aged 8, 35, 45 and 50 years (3 males and 1 female) were admitted to SCBMCH, Cuttack, skin and VD Department with multiple, painful, non healing phagadenic ulcers over body and not responding to the conventional therapeutic agents. The female patient was having severe seropositive rheumatoid arthritis. Pus culture was negative in all the cases. All the patients responded well to corticosteroid given systemically, but one male patient was having recurring episodes and ulcers healing hardly. He was given topical oxoferrin (TCDO) topically twice daily along with other supportive therapy. He responded well.