共查询到19条相似文献,搜索用时 125 毫秒
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目的建立注射用奥美拉唑钠细菌内毒素检查方法。方法采用《中国药典》2010年版附录细菌内毒素检查法要求进行试验。结果注射用奥美拉唑钠稀释至0.5 mg·ml-1的浓度,用灵敏度为0.25 EU·ml-1的鲎试剂做干扰试验,无干扰影响。结论注射用奥美拉唑钠细菌内毒素限值确定为7.5 EU·mg-1,可应用鲎试剂进行细菌内毒素法检查。 相似文献
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奥硝唑氯化钠注射液的细菌内毒素检查 总被引:5,自引:0,他引:5
目的 考察奥硝唑氯化钠注射液的细菌内毒素检查法。方法 采用不同厂家、不同批号、不同灵敏度的鲎试剂对奥硝唑氯化钠注射液进行干扰试验。结果 奥硝唑氯化钠注射液经 7倍稀释后 ,用λ为 0 .2 5Eu·ml-1的鲎试剂 ,对细菌内毒素检查无干扰。结论 奥硝唑氯化钠注射液的热原检查可以被内毒素检查法取代。 相似文献
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中药巴戟天抗抑郁作用的大小鼠模型三级组合测试评价 总被引:11,自引:0,他引:11
目的系统评价中药巴戟天的抗抑郁作用.方法中药巴戟天依次用乙醇冷浸和水煎煮提取,得醇提物ME和水煎液;醇提物悬浮于水中依次用氯仿、乙酸乙酯、正丁醇萃取,分别得萃取物ME1(氯仿)、ME2(乙酸乙酯)、ME3(正丁醇)和ME4(水残留);水煎液经浓缩后用正丁醇萃取,得正丁醇萃取物MW1和水层残留物MW2.通过测试ME、ME1~ME4、MW1和MW2对小鼠自发活动的影响,检测药物的中枢兴奋作用;用小鼠悬尾和大、小鼠强迫游泳等抑郁模型评价药物的抗抑郁作用;利用5-HTP诱导小鼠甩头、APO诱导小鼠刻板、育亨宾致死小鼠等实验,初步解析药物作用的神经系统.结果巴戟天提取物在不影响小鼠自发活动的剂量下显著缩短了小鼠悬尾和大、小鼠强迫游泳等抑郁模型的不动时间,除ME4以外均显著增加了5-HTP诱导的小鼠甩头次数,ME1和ME2同时显著降低了APO诱导的小鼠刻板行为次数,但所有提取物对育亨宾对小鼠的致死作用没有显著影响.结论中药巴戟天主要通过作用于5-羟色胺神经系统来发挥其抗抑郁作用,部分提取物对多巴胺神经系统也有作用. 相似文献
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G.S. Metsios A.D. Flouris Y. Koutedakis Y. Theodorakis 《Journal of Science and Medicine in Sport》2006,9(3):263-266
We investigated the effects of performance feedback (PF) on predicting maximal oxygen uptake (VO2 max) using the 20 m Multistage Shuttle Run Test (MST) and 20 m Square Shuttle Test (SST). The agreement between these two field tests in relation to laboratory VO2 max was also examined. Forty healthy males (age: 21.5+/-2.3; BMI: 23.7+/-2.0) randomly performed four indirect VO2 max tests; that is the MST and SST, as well as a modified version of MST (MSTMD) and SST (SSTMD). During MST and SST subjects received PF with respect to both test stage and running pace. In contrast, MSTMD and SSTMD incorporated auditory feedback which solely emitted signals regulating the running pace. Participants also performed a laboratory VO2 max treadmill test (TT). ANOVA demonstrated significant mean predicted VO2 max decrements in both MSTMD (p<0.001) and SSTMD (p<0.05) compared to MST and SST, respectively. In predicting TTVO2 max, the '95% limits of agreement' analysis indicated errors equal to 3.6+/-9.6 and 1.4+/-10.3 ml kg-1 min-1 with coefficients of variation of +/-10.0% and +/-10.9%, for MST and MSTMD, respectively. The corresponding '95% limits of agreement' values for SST and SSTMD were 0.1+/-5.0 and -1.1+/-6.1 ml kg-1 min-1 with coefficients of variation of +/-5.4% and +/-6.7%, respectively. It is concluded that the application of PF leads to superior field testing performances. 相似文献
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眩光试验及其在航空医学中的应用 总被引:1,自引:0,他引:1
曾宪英 《中华航空航天医学杂志》1994,(3)
介绍了眩光研究的意义、眩光现象的产生、不适眩光、失能眩光、眩光失能值的表达、眩光试验等概念。对眩光试验在某些眼科疾病诊断中的意义和实用价值以及其在航空医学中的应用前景作了探讨,提出眩光试验作为机功能的一种检查方法,其重要临床意义不可忽视。 相似文献
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概述舱外航天服热真空试验技术,介绍国内外舱外航天服试验设备,分析中美舱外航天服热真空试验技术差异,结合中国未来载人航天发展特点探讨中国舱外航天服热真空试验技术发展方向。 相似文献
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目的评价吡哌酸骨架散皮肤局部用药的安全性。方法将0.1 g吡哌酸骨架散均匀撒布于豚鼠背部皮肤,3次致敏接触,隔14 d后,再涂药激发接触,观察过敏反应;吡哌酸骨架散多次重复撒布在豚鼠完整及破损皮肤,采用同体左右侧自身对比,用药期间每日观察局部皮肤红斑及水肿情况;将高、低剂量的吡哌酸骨架散用于豚鼠背部完整或破损受试皮肤,观察其产生的急性毒性情况。结果吡哌酸骨架散未见皮肤与全身过敏反应;一次或多次给药对豚鼠完整皮肤及破损皮肤均无刺激性;大剂量也未见急性毒性反应。结论本品用于豚鼠皮肤安全性较好。 相似文献
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Claes Lagerstedt Carl-Gustav Olsson Birger Fagher Björn Öqvist 《European journal of nuclear medicine and molecular imaging》1989,15(12):771-775
Three hundred and ninety four consecutive outpatients with suspected deep venous thrombosis (DVT) were investigated with the 99mTc-plasmin test and physical examination and 307 of them with phlebography. Fresh thrombi were present in 124 patients and the plasmin test was pathological in 118 of these (sensitivity 95%). The thrombi that were missed were all located below the knee and measured less than 10 cm on the phlebographic films. The predictive values of negative and positive tests were 91% and 49%, respectively. The predictive value of a positive test was higher with an increasing number of measuring points with a pathological uptake. To get the final result, a single series of measurements 5 min after injection was sufficient. If clinical signs of inflammation were present, the plasmin test was usually pathological. Median time for the plasmin test to become normal during anticoagulant therapy was 14 days for calf DVT and 6 months for proximal DVT. The plasmin test was found to be useful as a screening test in patients without extensive signs of inflammation in the legs. It has a high sensitivity even in patients with long-standing symptoms. 相似文献
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过程分析考察不同厂家盐酸二甲双胍片的溶出度 总被引:1,自引:0,他引:1
目的利用光纤溶出度过程分析方法,监测盐酸二甲双胍片的溶出度,通过实时在线监测药片溶出情况反映不同厂家生产的药片质量的差异。方法采用《中国药典》中规定的检测盐酸二甲双胍片溶出度的条件,利用光纤传感溶出度实时过程分析方法对6个不同厂家的盐酸二甲双胍片进行了实时监测。结果6个厂家的溶出曲线明显不同,可真实地反映每粒药片的溶出过程。结论光纤溶出度过程分析,真实地反映了不同厂家药片的溶出行为,对评价药品内在品质提供了有效方法。 相似文献