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1.
Furuta K Kushiyama Y Kawashima K Shibagaki K Komazawa Y Fujishiro H Kitajima N Adachi K Kinoshita Y 《Journal of gastroenterology》2012,47(2):144-149
Background
The characteristics of symptoms reported by elderly patients with gastroesophageal reflux disease (GERD) have not been fully investigated. We performed this study to clarify these characteristics in elderly patients with GERD. 相似文献2.
Yoshiyuki Yamagishi Hajime Higuchi Motoko Izumiya Gen Sakai Hideko Iizuka Shoko Nakamura Masayuki Adachi Sigenari Hozawa Hiromasa Takaishi Toshifumi Hibi 《Journal of gastroenterology》2010,45(11):1146-1154
Background
Gemcitabine (GEM) is the key drug for the chemotherapy of unresectable pancreatic cancer. However, the efficacy and safety of GEM has not been established in elderly patients. We retrospectively examined the prognosis of elderly pancreatic cancer patients treated with GEM. 相似文献3.
Yasui T Takahata S Kono H Nagayoshi Y Mori Y Tsutsumi K Sadakari Y Ohtsuka T Nakamura M Tanaka M 《Journal of gastroenterology》2012,47(1):65-70
Background and aims
Although patients with cholecystocholedocholithiasis are generally referred to cholecystectomy after endoscopic sphincterotomy (ES) and common bile duct clearance, we often have a conflict whether cholecystectomy is necessary in very elderly patients with comorbid diseases. The aim of this study is to assess whether cholecystectomy in very elderly patients is justified after ES. 相似文献4.
Mark E. Benson Siobhan Byrne Donald J. Brust Bradley ManningIII Patrick R. Pfau Terrence J. Frick Mark Reichelderfer Deepak V. Gopal 《Digestive diseases and sciences》2010,55(11):3278-3283
Background
Further studies evaluating the safety of advanced endoscopic procedures in elderly patients are needed. 相似文献5.
Nobuo Omura Hideyuki Kashiwagi Fumiaki Yano Kazuto Tsuboi Katsuhiko Yanaga 《Esophagus》2010,7(1):31-35
Background
Assessment of the outcomes of laparoscopic fundoplication in elderly patients with gastroesophageal reflux disease (GERD) is insufficient. 相似文献6.
Massud Ali Greg Ward Doug Staley Donald R. Duerksen 《Digestive diseases and sciences》2011,56(2):586-590
Background
Pancreatobiliary disease is increased in elderly patients. Because of significant comorbidities, these patients may be at greater risk of developing complications related to endoscopic retrograde cholangiopantreatography (ERCP). 相似文献7.
Astrid Kerker Christian Hardt Hans-Eugen Schlief Franz Ludwig Dumoulin 《BMC gastroenterology》2010,10(1):11
Background
Although gastrointestinal endoscopy with sedation is increasingly performed in elderly patients, data on combined sedation with midazolam/propofol are very limited for this age group. 相似文献8.
Yakabe T Noshiro H Ikeda O Miyoshi A Kitajima Y Satoh S 《Journal of cancer research and clinical oncology》2011,137(10):1499-1504
Purpose
There is no standard second-line treatment for patients with unresectable advanced or recurrent gastric cancer (URGC) in the event that first-line treatment fails. Moreover, the benefits of second-line chemotherapy in elderly patients remain uncertain. The aim of this study was to identify the benefits of the second-line paclitaxel (PTX) plus doxifluridine (5′-DFUR) regimen for URGC in elderly patients in comparison to nonelderly patients. 相似文献9.
Charles J. Kahi Michelle van Ryn Beth Juliar Jennifer Schaffter Stuart Thomas F. Imperiale 《Journal of general internal medicine》2009,24(12):1263-1268
BACKGROUND
Decisions regarding colorectal cancer (CRC) screening in the elderly depend on providers’ assessment of likelihood of benefit partly based on patient comorbidity and past screening history. We aimed to describe providers’ experiences and practice patterns regarding screening for CRC in elderly patients in the VA system. 相似文献10.
Natália António Carolina Lourenço Rogério Teixeira Fátima Saraiva Lourenço Coelho Miguel Ventura João Cristóvão Luís Elvas Lino Gonçalves Luís A. Providência 《Journal of interventional cardiac electrophysiology》2010,27(1):61-68
Purpose
The purpose of this study was to compare the effects of cardiac resynchronization therapy (CRT) in elderly patients (≥65 years) with younger patients and to assess the impact of comorbidities in CRT remodeling response. 相似文献11.
Sandra Eloranta Elsa Brånvall Fredrik Celsing Karin Papworth Maria Ljungqvist Gunilla Enblad Karin Ekström‐Smedby 《European journal of haematology》2018,100(1):61-68
Objectives
This study aims to characterize the epidemiology of immunocompetent Primary central nervous system lymphoma (PCNSL) diagnosed 2000‐2013 in Sweden.Methods
Cases were identified in the population‐based Swedish Lymphoma Register. Incidence per 100 000 person‐years and 95% confidence intervals (CI) were calculated, and PCNSL‐specific survival was estimated using relative survival. Tests for temporal trends were performed using Poisson regression. Population incidence of all brain tumors was retrieved for comparison.Results
With 359 identified PCNSL cases (median age 66 years), overall incidence was 0.26 (95% CI: 0.24‐0.29) and the average annual increase 4% (P = .002). The increasing trend was primarily observed among elderly individuals (70+ years). Similarly, an increase in incidence of all brain tumors was noted only among the elderly. There was no significant improvement in relative survival across the study period although, among fit patients (with Eastern Cooperative Oncology Group, EGOC 0), survival plateaued 6 years after diagnosis.Conclusion
The increasing PCNSL incidence in the elderly was consistent with an increasing incidence of brain tumors of any type and may in part be attributable to improved diagnostics and reporting in this group. New treatment options have not yet translated into general survival improvements in a population‐based setting, although the presence of long‐term survivors among fit patients is encouraging. 相似文献12.
M. A. Maselli P. Trisolini I. Demma F. Pezzolla F. De Ponti 《Digestive diseases and sciences》2011,56(2):352-358
Background
Gender- and age-related differences in muscular and nerve-mediated responses in human colon are poorly characterized. We studied carbachol-induced motor responses and electrically evoked contractions in sigmoid circular muscle from adult and elderly patients of different gender. 相似文献13.
Wu L Li X Su J He Q Zhang X Chang C Pu Q 《Journal of cancer research and clinical oncology》2011,137(10):1563-1569
Background
To evaluate the efficacy and toxicity of CHG regimen (low-dose cytarabine, homoharringtonine with G-CSF priming) as an induction chemotherapy for elderly patients with high-risk MDS or acute myeloid leukemia transformed from MDS (MDS–AML). 相似文献14.
Ryo Takagawa Chikara Kunisaki Hirochika Makino Takashi Oshima Yasuhiko Nagano Syoichi Fujii Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Hiroshi Shimada 《Esophagus》2008,5(3):133-139
Background
In an aging population, it is important to evaluate the therapeutic management of diseases. Esophagectomy is a reliable treatment for esophageal cancer, but it remains controversial for elderly patients as it could carry additional postoperative risks. 相似文献15.
Isidoro Di Carlo Adriana Toro Elia Pulvirenti Monica Zisa Antonio Galia 《BMC gastroenterology》2010,10(1):41
Background
Gallbladder adenomyomatosis is an epithelial proliferation and hypertrophy of the muscularis mucosae of the gallbladder. Rokitansky-Aschoff sinuses are a characteristic of this condition. The segmental adenomyomatosis has a higher risk of developing into gallbladder carcinoma, especially in the fundal region of elderly patients. 相似文献16.
G. Tisserand H. Gil N. Méaux-Ruault N. Magy-Bertrand 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2014
Purpose
To date only a few studies regarding pulmonary embolism (PE) in elderly have been published. The aim of this study was to determine the clinical features of PE in elderly patients (≥ 75 years).Methods
All patients hospitalized for PE in our internal medicine department from January 2005 to December 2010 were included in the study. The aim was to compare the features of PE in elderly patients (≥ 75 years) to those of patients younger than 75 years. The following data were recorded: past medical history, risk factors for venous thrombo-embolism (VTE), clinical features, and PE etiologies.Results
The population was composed of 64 patients (women 56%) with a median age of 82 years (IQR: 13.5). There was no statistical difference for risk factors of VTE. Syncope was more frequent in elderly patients (33% versus 7%, P = 0.04) whereas thoracic pain predominated in younger patients (36,5% versus 7%, P = 0.005). Chronic obstructive pulmonary disease was more frequent in the past medical history of elderly patients. The diagnostic of PE was less suspected in elderly patients (47% versus 72%, P = 0.035). The etiologies were similar between the two groups.Conclusion
Our study highlights the frequency of syncope as the presenting feature of PE in elderly, whereas thoracic pain is uncommon. We confirmed the difficulty to diagnose PE in elderly population. 相似文献17.
Nils Winkelmann Iver Petersen Michael Kiehntopf Hans Joerg Fricke Andreas Hochhaus Ulrich Wedding 《Journal of cancer research and clinical oncology》2011,137(4):733-738
Purpose
The prevalence of elderly and comorbid patients (pts) with malignant lymphoma (ML) will steadily increase in future. Elderly patients comprise a heterogeneous population. Comprehensive geriatric assessment (CGA) is an established diagnostic tool in geriatric medicine. However, the prognostic value in patients with ML is unclear. We sought to establish a relationship between results of CGA and survival time in patients with ML. 相似文献18.
Predicting the ability of elderly diabetes patients to acquire the insulin self‐injection technique based on the number of animal names recalled
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Taichi Minami Masayo Yamada Ryutaro Furuta Kentaro Kamata Sho Katsuragawa Sakiko Terui Tomoaki Akiyama Taishi Yoshii Tetsuji Tsunoda Yasuo Terauchi 《Journal of diabetes investigation.》2018,9(3):623-628
Aims/Introduction
To our knowledge, no studies have reported that cognitive tests can be used to evaluate whether or not patients can acquire the insulin self‐injection technique. We investigated whether or not the number of animal names recalled in 1 min by elderly diabetes patients could be used as a predictor of the patients’ ability to acquire the insulin self‐injection technique within 1 week.Materials and Methods
We enrolled 57 inpatients with type 2 diabetes aged >60 years who were starting insulin therapy. We carried out the Mini‐Mental State Examination and verbal fluency tests, which included recalling animal names and common nouns starting with the letters ‘a,’ ‘ka’ and ‘shi’ (Japanese letters). We used 12 checkpoints for insulin self‐injection to judge the patients’ levels of acquisition of the technique. The most predictive cognitive test was determined by multivariate logistic regression analysis.Results
In the present study, multivariate logistic analysis showed that the number of animal names recalled was the most reliable predictor of the ability to acquire the insulin self‐injection technique within 1 week. A figure of 11 animal names predicted a successful acquisition, with a sensitivity of 73% and a specificity of 91% being observed (area under the curve 0.87, 95% confidence interval 0.76–0.97, P < 0.01).Conclusions
The number of animal names recalled in 1 min was the most useful indicator of the ability of elderly diabetes patients to learn to manage insulin self‐injection therapy within 1 week. The cut‐off value was 11 animal names. 相似文献19.
Duane T. Smoot Jason Collins Sharif Dunlap Amira Ali-Ibrahim Mehdi Nouraie Edward L. Lee Hassan Ashktorab 《Digestive diseases and sciences》2009,54(11):2484-2487
Background
Average-risk individuals should be offered a screening colonoscopy beginning at 50 years of age. However, there is no clear consensus on an age at which patients should no longer be offered a screening colonoscopy. The purpose of this study was to analyze the outcome of colonoscopy in elderly individuals based on the preprocedure indication. 相似文献20.