CT引导下经皮肺穿刺活检术并发症的影响因素分析

目的探讨CT定位下经皮肺穿刺活检术并发症发生的影响因素。方法 CT引导下应用意大利PRECISA 18 G切割针对110例患者行经皮肺穿刺活检术,将患者的年龄、性别、病灶大小、切割组织块的多少、穿刺胸膜次数、穿刺时间、病灶深度、病灶周围炎症、慢性肺部病变等相关因素分为不同等级资料,卡方分析不同等级资料之间并发症发生率有无差异性,Logistic回归分析并发症发生的独立危险因素。结果 110例患者术后出现出血28例(占25.5%),气胸27例(占24.5%),卡方分析显示术后出血在病灶大小、病灶深度、穿刺时间及病灶周围炎症之不同组别之间存在差异性(P<0.05);术后气胸在穿刺胸膜次数、穿刺时间、病灶深度、慢性肺部病变之不同组间之间差异有统计学意义(P<0.05)。多因素Logistic回归分析显示病灶大小、病灶深度、病灶周围炎症在出血并发症中具独立危险因素,穿刺时间、穿刺胸膜的次数、慢性肺部病变在气胸并发症中具独立危险因素。结论肺穿刺活检术并发症的发生与病灶大小、穿刺胸膜次数、穿刺时间、病灶深度、病灶周围炎症、慢性肺部病变等相关。     

关于CT引导下经肺活检出现气胸与肺内出血危险性的不同影响因素

就不同因素对CT引导下经肺活检出现气胸与肺内出血发生率的影响进行回顾性评价。133例病人接受了CT引导下肺内1个病灶的活检，2例病人活检2次。不同影响因素的分析包括病变大小、病变部位、穿刺针通过胸膜的次数、病变边缘、肺内活检径路长度与穿刺时间。活检针采用18G（gauge）切割针（Trucut，Somatex，Tehow，Germany）。135例活检中23例发生气胸（17％），其中3例需要胸部置管治疗（占全部病人的2％）。病变位于肺实质内时气胸的发生率明显高于病变位于胸膜或胸壁（P〈0．05），     

CT引导下肺实性结节切割活检术后出血与气胸的多因素分析

目的 探讨CT引导下经皮穿刺肺实性结节切割活检术后并发出血、气胸的危险因素.方法 回顾性分析肺实性结节(≤3 cm)320例经16 G半自动切割活检的临床及影像学资料,行单因素和多因素Logistic回归分析.结果 活检术后针道出血发生率33.1％,气胸发生率18.1％,良恶性诊断准确率约99.6％.针道长度是出血的独立危险因素,针道每增加3 cm,风险增加3.881倍,且风险也随穿刺时间(P=0.061)和穿胸膜次数(P=0.062)呈正相关.年龄、位置和针-胸膜夹角是气胸独立风险因素,年龄每增加10岁,风险增加2.102倍;上肺叶病灶显著低于下肺叶;针-胸膜夹角每增加20°,风险增加2.413倍,肺气肿以微弱差距(P=0.086)被排除方程之外.以出血、气胸概率值绘制ROC曲线,AUC值分别为0.753和0.725.结论 CT引导下肺实性结节切割活检术后出血、气胸的发生受多种因素影响,术前仔细评估,术中操作熟练度可以有效预判和降低出血、气胸的发生.     

经皮肺活检对肺部病变的临床诊断意义

目的 评价经皮肺活检术对原发性肺癌、肺转移性癌以及非恶性肺疾病的诊断价值.方法 回顾性总结近10年来436例经皮肺活检患者的临床资料,其中明确为原发性肺癌患者341例、肺转移性癌62例、非恶性肺疾病33例.统汁分析经皮肺活检术对上述疾病的诊断准确率及灵敏度.结'果原发性肺癌组经皮肺活检阳性321例,诊断准确率为94.7%、灵敏度94.1%;肺转移性癌组阳性32例,诊断准确率58.2%、灵敏度51.6%;非恶性肺疾病组阳性19例,诊断准确率以及灵敏度均为57.6%.436例患者中427例经皮肺活检获得足够病变组织标本,9例活检失败,活检成功率97.9%.全部患者共穿刺474例次,其中74例次出现并发症,发生率15.6%.主要并发症有气胸(63例次,13.3%)和肺内出血(56例次,11.8%).结论 临床上怀疑原发性肺癌的肺部病变,经皮肺活检术诊断准确率高,并发症少且轻微.对于考虑为肺转移性癌以及非恶性肺疾病,该技术尚有待进一步改进.     

CT引导下经皮肺穿刺活检对不同大小肺结节的诊断效能及并发症相关因素分析

【摘要】目的：CT引导下经皮肺穿刺活检对不同大小肺结节的诊断效能,并分析并发症的相关影响因素。方法：回顾性分析2014年9月-2018年9月CT引导下经皮肺穿刺活检的202例患者的临床及穿刺数据资料。按结节大小分为直径（D）≤10mm组、10mm＜D≤20mm组、20mm＜D≤30mm组和D＞30mm组,分别统计各组穿刺活检诊断符合率。分别统计患者的年龄、性别、病灶大小、病灶密度、穿刺针穿越肺组织距离、取材组织数量等相关影响因素,采用χ2检验和Mann-Whitney U检验分析各因素组各并发症发生率的差异,Logistic回归分析并发症发生的危险因素。结果：所有病例均取材满意并进行组织病理学检查,各组诊断符合率分别为85.71%、84.13% 、83.64%和93.65%,差异无统计学意义;气胸的发生率为18.32%（37/202）,肺出血的发生率为19.80%（40/202）,咯血的发生率为0.99%（2/202）;影响气胸发生率的因素包括年龄（OR=1.037,95% CI：1.001～1.074,P=0.042）及穿刺针穿越肺组织距离（OR=1.030,95% CI：1.009～1.052,P=0.006）,且气胸发生率与两者均存在正相关;影响肺出血发生率的因素包括结节大小（OR=0.935,95% CI：0.895～0.977,P=0.003）及穿刺针穿越肺组织距离（OR=1.035,95% CI：1.013～1.058,P=0.002）,且肺出血发生率与结节大小呈负相关,与穿刺针穿越肺组织距离呈正相关。所有病例均未发生感染、针道种植转移及空气栓塞等严重并发症。结论：CT引导肺穿刺活检是安全、有效获得病理诊断的手段,适用于不同大小肺结节,具有可接受的较低的并发症发生率。     

CT导引下肺内病变穿刺活检影响气胸发生率因素分析

目的　探讨CT导引下肺内病变穿刺活检影响气胸发生率的因素。资料与方法　回顾复习肺内病变CT导引下穿刺活检 4 38例 ,观察因素包括患者相关因素 (性别、年龄 )、病灶相关因素 (病变的性质、病灶大小、位置、有无空腔 )、操作相关因素 (患者的体位、胸膜穿刺次数、活检所用时间、穿刺路径通过的肺组织有无肺气肿、穿刺路径经过通气肺组织的长度 )。对所有观察因素分别进行单因素和多元逐步Logistic回归分析观察其对气胸发生率的影响。结果　 (1) 4 38例中 5 9例 (13.5 % )发生气胸 ,其中 4例 (0 .9% )需胸部导管引流。单因素分析显示病灶大小(F =2 .0 88,P =0 .0 38)、胸膜穿刺次数 (χ2 =34.87,P <0 .0 0 1)、活检所用时间 (F =4 .2 0 9,P <0 .0 0 1)、穿刺路径通过的肺组织有无肺气肿 (χ2 =8.5 0 ,P =0 .0 0 4 )、穿刺路径经过通气肺组织的长度 (F =4 .84 2 ,P <0 .0 0 1)均是影响气胸发生率的相关因素 ;(2 )多元逐步Logistic回归分析显示胸膜穿刺次数 (waldχ2 =18.6 5 4 ,P =0 .0 0 0 1)、穿刺路径通过的肺组织有无肺气肿 (waldχ2 =10 .6 5 9,P =0 .0 0 1)和穿刺路径经过通气肺组织的长度 (waldχ2 =10 .16 9,P =0 .0 0 1)被列入回归方程。结论　胸膜穿刺次数、穿刺路径经过的肺组织有无肺气肿和     

CT-guided cutting needle lung biopsy using modified coaxial technique: factors effecting risk of complications

Purpose

We present our 7-year experience with coaxial computed tomography (CT)-guided cutting needle lung biopsy and evaluate the factors affecting risk of complications.

Material and method

Between June 2000 and March 2007, we performed 225 CT-guided coaxial lung biopsies in 213 consecutive patients (161 men, 52 women). Lesion size, lesion depth, lesion location, needle-pleural angle, presence of pleural effusion, patient's position, and complications secondary to biopsy procedure (pneumothorax and bleeding) were noted. Pneumothorax was graded as mild, moderate, and severe. Bleeding complications were graded as mild, moderate, and severe.

Results

Two hundred twenty-five biopsy procedures were performed in 213 patients. The mean diameter of the lung lesion was 41.3 ± 20.1 mm. The mean distance from the peripheral margin of the lesion to the pleura was 17.3 ± 19.2 mm. After 225 procedures, there were 42 mild (18.6%), 13 moderate (5.7%), and 4 severe (1.7%) pneumothoraxes. Small hemoptysis occurred in 27 patients (12%), and mild parenchymal hemorrhage occurred in 2 patients (0.8%). The overall complication rate was 39.1%. Although, a statistically significant correlation was found between female sex, presence of emphysema, lesion depth, and pneumothorax, none of these factors had a predictive value for pneumothorax. Although, statistically significant correlations were found between female sex, lesion size, and bleeding, only lesion size had a predictive value for bleeding.

Conclusion

The most frequent and important complications of this procedure are pneumothorax and bleeding. But any factor is the predictor of pneumothorax and lesion depth is a poor predictor of bleeding complication.     

CT-guided lung biopsy: factors influencing diagnostic yield and complication rate

AIM: To determine factors influencing diagnostic yield in computed tomography (CT)-guided biopsy of lung lesions. MATERIALS AND METHODS: One hundred and ninety-five consecutive CT-guided lung biopsies were performed in 182 patients between August 1995 and September 2000 and either fine-needle aspirate samples for cytology or core biopsy samples for histology were collected. Procedures were divided into a diagnostic group (true-positive and true-negative results) and a non-diagnostic group (false-positive and false-negative results) and the factors affecting diagnostic accuracy assessed. RESULTS: One hundred and fifty-six lesions (86%) were malignant, and 26 (14%) were benign. More than one biopsy was performed for 12 lesions. One hundred and thirty-two biopsies were true-positive, 27 true-negative and 36 false-negative. No false-positive results occurred in the study. Overall diagnostic accuracy was 81.5%. Significantly more core biopsies than fine-needle aspirates were diagnostic: 93 versus 78% (p<0.005). No difference was found in frequency of pneumothorax between these two groups. There was a difference in the average depth from the pleural surface of lesions in the diagnostic and non-diagnostic groups, but this did not attain statistical significance: 9.8 versus 17.2 mm (p=0.054). CONCLUSION: In this study CT-guided lung biopsy core biopsy was a more accurate method of tissue sampling than fine-needle aspiration, and was not associated with an excess of complications.     

CT引导下经皮肺穿刺活检对肺部病变的诊断价值

目的 探讨CT引导下经皮肺穿刺活检的效果及临床价值.方法 回顾性分析60例行CT引导下经皮肺穿刺活检术患者的临床与影像资料.结果 60例患者中,57例经病理明确诊断,其中原发性肺癌47例(腺癌21例,鳞癌18例,小细胞癌3例,肺泡癌5例),转移性肺癌7例,结核3例.3例病理报告为慢性炎症,未做出明确诊断, 术后病理证实干酪性肺炎2例,真菌感染1例.60例患者穿刺成功率100.0%,诊断准确率95.0%,并发症发生率21.7%(气胸7例,占11.7%,出血5例,占8.3%,针道出血1例,占1.7%).结论 CT引导下经皮肺穿刺活检术是一种安全、准确、有较高临床应用价值的诊断和鉴别肺内病变的方法.     

超声引导经皮肺穿刺活检在肺外周型病变诊断中的价值

目的探讨超声引导下经皮肺穿刺活检对肺外周型病变定性诊断的应用价值。方法在超声引导下对80例胸部影像学检查显示的肺周边型肿块需明确诊断者行超声引导下经皮肺穿刺活检术。结果 80例病人均穿刺成功,成功率100%。病理诊断结果:恶性肿瘤64例,其中鳞癌38例,腺癌20例,大细胞癌2例,小细胞癌2例,恶性淋巴瘤1例,恶性间皮瘤1例;良性病变16例,其中良性错构瘤1例,结核8例,炎症7例。并发气胸、咯血各1例,并发症发生率为3%。结论超声引导下经皮肺穿刺活检术具有定位准确、操作简便、安全性好、并发症少及重复性强等优点,可作为肺外周型病变定性诊断的首选诊断方法。     

CT引导下肺活检和并发症的预防

CT引导肺活检作为一种安全有效的活检技术已广泛应用于临床,在肺部疾病的诊断和治疗中的地位日益突出.本文对该技术的适应证、禁忌证、术前准备、介入技术和常见的并发症及其预防进行总结,供大家参考和借鉴.     

改良的CT引导下同轴法经皮肺穿刺活检术应用

目的：探讨CT引导下同轴法经皮肺穿刺活检术的临床应用价值。方法：选择因肺内病变需活检的116例患者,所有患者均采用CT引导下自动活检枪同轴法经皮肺穿刺活检术。结果：116例患者均成功获取病理标本,穿刺成功率100％,病变阳性率94．8％,并发症6例（5．2％）,经对症处理后2～7天后患者身体逐渐恢复。结论：改良CT引导下经皮肺穿刺活检术器材简单易得,费用低廉操作简便,穿刺成功率高、并发症发生率低。     

CT fluoroscopy-guided vs. multislice CT biopsy mode-guided lung biopsies: accuracy, complications and radiation dose

Background

The aim of this retrospective study was to compare the diagnostic accuracy, the frequency of complications, the duration of the interventions and the radiation doses of CT fluoroscopy (CTF) guided biopsies of lung lesions with those of multislice CT (MS-CT) biopsy mode-guided biopsies.

Methods

Data and images from 124 consecutive patients undergoing CTF-guided lung biopsy (group A) and 132 MS-CT-biopsy mode-guided lung biopsy (group B) were reviewed. CTF-guided biopsies were performed on a Siemens Emotion 6 CT scanner with intermittent or continuous CT-fluoroscopy, MS-CT biopsy mode-guided biopsies were performed on a Siemens Emotion 16 CT scanner. All biopsies were performed with a coaxial needle technique.

Results

The two groups (A vs. B) did not differ significantly regarding sensitivity (95.5% vs. 95.9%), specificity (96.7% vs. 95.5%), negative predictive value (87.9% vs. 84%) or positive predictive value (98.8% vs. 98.9%). Pneumothorax was observed in 30.0% and 32.5% of the patients, respectively. Chest tube placement was necessary in 4% (group A) and 13% (group B) of the patients. The duration of the intervention was significantly longer in group A (median 37 min vs. 32 min, p = 0.04). The mean CT dose index (CTDI) was 422 in group A and 36.3 in group B (p < 0.001).

Conclusion

Compared to CTF-guided biopsies, chest biopsies using the MS-CT biopsy mode show dramatically lower CTDI levels. Although the diagnostic yield of the procedures do not differ significantly, biopsies using the MS-CT-biopsy mode have a three-fold higher rate of chest tube placement.     

Systemic arterial air embolism and tension pneumothorax: two complications of transthoracic percutaneous thin-needle biopsy in the same patient

Systemic arterial air embolism and tension pneumothorax are two rare and severe complications of transthoracic fine-needle biopsy. We report on a patient who developed both complications during the same procedure and recovered successfully after resuscitation and hyperbaric oxygen therapy. Favourable outcome of systemic air arterial embolism has been reported infrequently in the literature. In our case tension pneumothorax may have influenced favourably the course of the illness due to collapse of distal airways and the reduction of the venous return to the heart from the affected side. Received: 25 October 1995; Revision received 29 March 1996; Accepted: 9 April 1996     

CT引导下经皮肺穿刺活检对周围型肺部病变的诊断价值

目的探讨CT引导下经皮肺穿刺活检对周围型肺部病变的诊断价值及其安全性。方法对58例周围型肺部病变的患者,在CT引导下行经皮肺穿刺活检。结果 58例患者中穿刺标本经组织病理学检查确诊病例48例,确诊率为82.8%,其中恶性肿瘤32例,良性病变16例。术后出现有症状并发症7例,其中咯血2例,气胸4例,高热伴脓胸1例,总发生率为12.1%。结论 CT引导下经皮肺穿刺活检定位准确,成功率高,安全可靠,在周围型肺部病变诊断中具有较高的应用价值。