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Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – Part 3: Mentha × piperita – Solanum dulcamara 下载免费PDF全文
Gioacchino Calapai Paola L. Minciullo Marco Miroddi Ioanna Chinou Sebastiano Gangemi Richard J. Schmidt 《Contact dermatitis》2016,74(3):131-144
This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph – now (since 2015)? called a European Union herbal monograph – has been produced. Part 3: Mentha × piperita L.–Solanum dulcamara L. 相似文献
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Allergic contact dermatitis caused by (meth)acrylates in nail cosmetic products in users and nail technicians – a 5‐year study 下载免费PDF全文
Inês Raposo Inês Lobo Cristina Amaro Maria de Lurdes Lobo Helena Melo Joana Parente Teresa Pereira Joana Rocha Ana P. Cunha Armando Baptista Pedro Serrano Teresa Correia Ana R. Travassos Margarida Dias Fátima Pereira Margarida Gonçalo 《Contact dermatitis》2017,77(6):356-359
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EunJin Bang Eun Kyeong Lee Sang‐Gyun Noh Hee Jin Jung Kyoung Mi Moon Mi Hwa Park Yeo Jin Park Min Kyung Hyun A Kyoung Lee Su Jeong Kim Jungho Yang Yujin Park Pusoon Chun Hyung Ryong Moon Hae Young Chung 《Experimental dermatology》2019,28(6):734-737
Tyrosinase is a key enzyme that catalyses the initial rate‐limiting steps of melanin synthesis. Due to its critical role in melanogenesis, various attempts were made to find potent tyrosinase inhibitors although many were not safe and effective in vivo. We evaluated tyrosinase inhibitory activity of six compounds. Among them, (Z)‐5‐(3‐hydroxy‐4‐methoxybenzylidene)‐2‐thioxothiazolidin‐4‐one (5‐HMT) had the greatest inhibitory effect and potency as the IC50 value of 5‐HMT was lower than that of kojic acid, widely‐known tyrosinase inhibitor. Based on in silico docking simulation, 5‐HMT had a greater binding affinity than kojic acid with a different binding conformation in the tyrosinase catalytic site. Furthermore, its skin depigmentation effect was confirmed in vivo as 5‐HMT topical treatment significantly reduced UVB‐induced melanogenesis in HRM2 hairless mice. In conclusion, our study demonstrated that 5‐HMT has a greater binding affinity and inhibitory effect on tyrosinase and may be a potential candidate for a therapeutic agent for preventing melanogenesis. 相似文献