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Effectiveness,safety and feasibility of extended‐release naltrexone for opioid dependence: a 9‐month follow‐up to a 3‐month randomized trial 下载免费PDF全文
Kristin Klemmetsby Solli Zill‐e‐Huma Latif Arild Opheim Peter Krajci Kamni Sharma‐Haase Jūratė Šaltytė Benth Nikolaj Kunoe 《Addiction (Abingdon, England)》2018,113(10):1840-1849
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Brantley P. Jarvis August F. Holtyn Shrinidhi Subramaniam D. Andrew Tompkins Emmanuel A. Oga George E. Bigelow Kenneth Silverman 《Addiction (Abingdon, England)》2018,113(7):1188-1209
Aims
To review systematically the published literature on extended‐release naltrexone (XR‐NTX, Vivitrol®), marketed as a once‐per‐month injection product to treat opioid use disorder. We addressed the following questions: (1) how successful is induction on XR‐NTX; (2) what are adherence rates to XR‐NTX; and (3) does XR‐NTX decrease opioid use? Factors associated with these outcomes as well as overdose rates were examined.Methods
We searched PubMed and used Google Scholar for forward citation searches of peer‐reviewed papers from January 2006 to June 2017. Studies that included individuals seeking treatment for opioid use disorder who were offered XR‐NTX were included.Results
We identified and included 34 studies. Pooled estimates showed that XR‐NTX induction success was lower in studies that included individuals that required opioid detoxification [62.6%, 95% confidence interval (CI) = 54.5–70.0%] compared with studies that included individuals already detoxified from opioids (85.0%, 95% CI = 78.0–90.1%); 44.2% (95% CI = 33.1–55.9%) of individuals took all scheduled injections of XR‐NTX, which were usually six or fewer. Adherence was higher in prospective investigational studies (i.e. studies conducted in a research context according to a study protocol) compared to retrospective studies of medical records taken from routine care (6‐month rates: 46.7%, 95% CI = 34.5–59.2% versus 10.5%, 95% CI = 4.6–22.4%, respectively). Compared with referral to treatment, XR‐NTX reduced opioid use in adults under criminal justice supervision and when administered to inmates before release. XR‐NTX reduced opioid use compared with placebo in Russian adults, but this effect was confounded by differential retention between study groups. XR‐NTX showed similar efficacy to buprenorphine when randomization occurred after detoxification, but was inferior to buprenorphine when randomization occurred prior to detoxification.Conclusions
Many individuals intending to start extended‐release naltrexone (XR‐NTX) do not and most who do start XR‐NTX discontinue treatment prematurely, two factors that limit its clinical utility significantly. XR‐NTX appears to decrease opioid use but there are few experimental demonstrations of this effect. 相似文献5.
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Feasibility and safety of extended‐release naltrexone treatment of opioid and alcohol use disorder in HIV clinics: a pilot/feasibility randomized trial 下载免费PDF全文
Philip T. Korthuis Paula J. Lum Pamela Vergara‐Rodriguez Keith Ahamad Evan Wood Lynn E. Kunkel Neal L. Oden Robert Lindblad James L. Sorensen Virgilio Arenas Doan Ha Raul N. Mandler Dennis McCarty for the CTN‐ CHOICES Investigators 《Addiction (Abingdon, England)》2017,112(6):1036-1044
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Effects of injectable extended‐release naltrexone (XR‐NTX) for opioid dependence on residential rehabilitation outcomes and early follow‐up 下载免费PDF全文
Douglas L. Leslie PhD William Milchak LCSW Philip L. Herschman PhD Edward O. Bixler PhD Diana L. Velott MPA MS Roger E. Meyer MD 《The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions》2015,24(3):265-270
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Cost‐effectiveness of extended release naltrexone to prevent relapse among criminal justice‐involved individuals with a history of opioid use disorder 下载免费PDF全文
Sean M. Murphy Daniel Polsky Joshua D. Lee Peter D. Friedmann Timothy W. Kinlock Edward V. Nunes Richard J. Bonnie Michael Gordon Donna T. Chen Tamara Y. Boney Charles P. O'Brien 《Addiction (Abingdon, England)》2017,112(8):1440-1450
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Cost‐effectiveness of hydromorphone for severe opioid use disorder: findings from the SALOME randomized clinical trial 下载免费PDF全文
Nick Bansback Daphne Guh Eugenia Oviedo‐Joekes Suzanne Brissette Scott Harrison Amin Janmohamed Michael Krausz Scott MacDonald David C. Marsh Martin T. Schechter Aslam H. Anis 《Addiction (Abingdon, England)》2018,113(7):1264-1273
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Effects of incentives for naltrexone adherence on opiate abstinence in heroin‐dependent adults 下载免费PDF全文
Brantley P. Jarvis August F. Holtyn Anthony DeFulio Kelly E. Dunn Jeffrey J. Everly Jeannie‐Marie S. Leoutsakos Annie Umbricht Michael Fingerhood George E. Bigelow Kenneth Silverman 《Addiction (Abingdon, England)》2017,112(5):830-837
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Kaitlin Rainwater‐Lovett Kevin Chun Justin Lessler 《Influenza and other respiratory viruses》2014,8(1):74-82