睡眠时间与空腹血糖受损关系

目的 探讨睡眠时间与空腹血糖受损（IFG）之间的关系,为完善糖尿病的一级预防提供参考依据。方法 于2008年6—12月采用多阶段分层整群随机抽样方法抽取江苏省徐州市18~75岁常住居民17 458人,分析空腹血糖与睡眠时间的关系。结果 徐州市居民IFG的患病率为4.2%,其中睡眠时间为<4、4~、6~及≥8 h/d居民IFG患病率分别为15.3%、6.6%、3.3%和6.2%,差异有统计学意义（χ²=115.89,P<0.05）;调整了年龄、性别、地区、职业、文化程度、婚姻状况、高血压、糖尿病家族史、吸烟、饮酒、睡眠质量、体力活动、紧张程度、BMI等因素后,多因素logistic回归分析结果显示,睡眠时间为<4及≥8 h/d患IFG的风险分别为6 h/d ~组居民的 2.756倍（OR=2.756,95%CI=1.710~4.443）和1.887倍（OR=1.887,95%CI=1.505~2.366）。结论 睡眠时间不足和睡眠时间过长均是IFG的危险因素。     

CYP1A1和CYP2E1基因多态性与燃煤型砷中毒发病风险关系

目的探讨CYP1A1基因和CYP2E1基因多态性与燃煤型砷中毒发病风险的关系。方法以130例燃煤型砷中毒患者为病例组, 以140名健康居民为对照组, 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法检测CYP1A1 Msp I、CYP2E1 Dra I和 CYP2E1 Pst I位点基因多态性, 并进行基因联合作用分析。结果CYP1A1基因 Msp I位点 m1/m1(纯合野生型) 基因型和m1/m2+m2/m2(杂合型+纯合突变型)基因型在病例组和对照组的分布频率分别为34.2%、65.8%和30.9%、69.1%; CYP2E1基因 Pst I位点 c1/c1(纯合野生型) 基因型和c1/c2+c2/c2(杂合型+纯合突变型)基因型在病例组和对照组的分布频率分别为62.6%、37.4%和57.4%、42.6%;CYP2E1基因 Dra I位点 DD(纯合野生型) 和DC+CC(杂合型+纯合突变型) 基因型在病例组和对照组的分布频率分别为58.7%、41.3%和61.4%、42.6%;上述3个多态位点各基因型在两组间的分布差异无统计学意义(P=0.341、0.574、0.972)。未发现CYP1A1 Msp I、CYP2E1 Pst I和 CYP2E1 Dra I多态位点与燃煤型砷中毒的发病风险存在统计学关联(P_校正= 0.433、0.219、0.832);上述多态位点各基因型之间未发现存在联合作用。结论CYP1A1和CYP2E1基因多态性与燃煤型砷中毒的发病风险无关。     

Relation of visfatin to cardiovascular risk factors and adipocytokines in patients with impaired fasting glucose

ObjectiveThe discovery of visfatin has great potential to significantly enhance our understanding of impaired fasting glucose and diabetes mellitus. The aim of the present study was to explore the relation of visfatin concentrations to cardiovascular risk factors and serum adipocytokine concentrations in patients with impaired fasting glucose.MethodsA sample of 55 patients with impaired fasting glucose was analyzed in a prospective way. All patients with a 2-wk weight-stabilization period before recruitment were enrolled. Weight, blood pressure, basal glucose, lipoprotein(a), C-reactive protein, insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols, blood, and adipocytokines (visfatin, leptin, adiponectin, resistin, tumor necrosis factor-α [TNF-α], and interleukin-6) levels were measured. Tetrapolar impedancometry, indirect calorimetry, and prospective serial assessment of nutritional intake with 3-d written food records were performed.ResultsFourteen men (25.5%) and 41 women (74.5%), with a mean age of 57.3 ± 11.7 y and mean body mass index of 35.8 ± 3.6 kg/m², were included. Patients were divided in two groups by median visfatin value (18.2 ng/mL): group I had low values and group II had high values. Patients in group I had greater weight, body mass index, fat mass, fat-free mass, and adiponectin than patients in group II. Patients in group II had higher total cholesterol, low-density lipoprotein cholesterol, resistin, and TNF-α levels than patients in group I. In the multivariate analysis with age- and sex-adjusted basal visfatin concentration as a dependent variable, only TNF-α remained an independent predictor in the model (F = 8.4, P < 0.05), with an inverse correlation. Visfatin concentration decreased 7.33 ng/mL (95% confidence interval 2.10–12.58) for each nanogram per milligram of TNF-α increase.ConclusionOnly TNF-α is related in an independent way to serum visfatin levels.     

颈-股动脉脉搏波传导速度与空腹血糖受损的相关性研究

目的分析本地区成年人颈一股动脉脉搏波速度（cf-PWV）与空腹血糖受损（IFG）风险的相关性,探讨年龄、体重指数（BMI）、体脂率、颈围、腰围及血脂对空腹血糖受损风险相关因素的影响。方法对5099例本地区来自社区的健康体检人群测量cf-PWV、BMI、体脂率、颈围、腰围、血压、空腹血糖、空腹胰岛素及血脂水平。分析影响空腹血糖受损的相关因素。结果对年龄、性别、血脂、血压等多因素进行校正后,通过升高分组变量cf-PWV水平,计算cf-PWV各五分位组的空腹血糖受损（impairedfastingglucose,IFG）风险,IFG风险的比值比及95％的可信区间（ORs,95％CI）分别为1．00,1．07（0．83-1．39）,1．20（1．08-1．34）,1．13（1．04-1．23）,1．14（1．05-1．25）（P〈0．01）。cf-PWV与年龄、颈围交互作用对IFG风险产生影响（P〈0．01）。结论cf-PWV与IFG密切相关,并独立于其他代谢危险因素,cf-PWV与年龄、颈围交互作用影响IFG风险。     

Cardiac risk profile in diabetes mellitus and impaired fasting glucose

OBJECTIVE: Mortality of diabetic patients is higher than that of the population at large, and mainly results from cardiovascular diseases. The purpose of the present study was to identify the prevalence of cardiovascular risk factors in subjects with diabetes mellitus (DM) or abnormal fasting glucose (FG) in order to guide health actions. METHODS: A population-based cross-sectional study was carried out in a representative random cluster sampling of 1,066 adult urban population (> or =20 years) in the state of Rio Grande do Sul between 1999 and 2000. A structured questionnaire on coronary risk factors was applied and sociodemographic characteristics of all adults older than 20 years living in the same dwelling were collected. Subjects were clinically evaluated and blood samples were obtained for measuring total cholesterol and fasting glycemia. Statistical analysis was performed using Stata 7 and a 5% significance level was set. Categorical variables were compared by Pearson's chi-square and continuous variables were compared using Student's t-test or Anova and multivariate analysis, all controlled for the cluster effect. RESULTS: Of 992 subjects, 12.4% were diabetic and 7.4% had impaired fasting glucose. Among the risk factors evaluated, subjects who presented any kind of glucose homeostasis abnormality were at a higher prevalence of obesity (17.8, 29.2 and 35.3% in healthy subjects, impaired fasting glucose and DM respectively, p<0.001), hypertension (30.1, 56.3 and 50.5% in healthy subjects, impaired fasting glucose and DM, respectively, p<0.001), and hypercholesterolemia (23.2, 35.1 and 39.5 in healthy subjects, impaired fasting glucose and DM respectively, p=0.01). CONCLUSION: Subjects with any kind of glucose homeostasis abnormality represent a group, which preventive individual and population health policies should target since they have higher prevalence of coronary artery disease risk factors.     

负性生活事件与高血压和空腹血糖受损关系

目的了解负性生活事件与高血压和空腹血糖受损之间的关系。方法随机整群抽样选取安徽省六安市3个乡镇18个行政村40～70岁村民进行入户面询问卷调查, 邀请完成问卷调查的村民于次日清晨去村卫生室检测指端末梢血糖(空腹>8 h)并测量2次平均血压(静坐时间>30 min, 间隔时间≥15 min)。采用logistic回归分析高血压和空腹血糖受损与负性生活事件、年龄、性别、文化程度、吸烟指数、每日酒精摄入量和体质指数之间的关系。结果不同年龄、性别、吸烟指数、每日酒精摄入量、体质指数、负性生活事件指数的村民高血压患病率差异有统计学意义(P<0.05);不同年龄、性别、文化程度、体质指数、负性生活事件指数的村民空腹血糖受损率差异有统计学意义(P<0.05);logistic回归分析结果显示, 年龄(OR=0.35~0.66)、性别(OR=1.81)、文化程度(OR=1.21)和体质指数(OR=1.20) 是高血压患者患病的影响因素, 而负性生活事件对高血压的影响无统计学意义;文化程度(OR=0.77~0.72)、每日酒精摄入量(OR=1.64)、体质指数(OR=1.07)和负性生活事件(OR=1.32~1.80) 是空腹血糖受损的影响因素。结论负性生活事件与空腹血糖受损密切相关, 应注重构建生活事件干预理论, 以指导人们采取积极的态度应对负性生活事件。     

空腹血糖受损预测模型与风险评分的建立

目的 构建北京市成年人10年内发生空腹血糖受损的预测模型,并建立风险评分可视化列线图。 方法 本研究利用2009—2018年北京市健康管理队列研究的数据。以2009—2013年第一次数据为基线数据,采用Cox比例风险回归来构建空腹血糖受损发生的预测模型,建立空腹血糖受损发生的可视化列线图,通过C指数来对列线图进行评估。 结果 共纳入18~89岁居民5 574例,其中训练集4 459例,平均随访(6.78±1.78)年,共有544例(12.20%)发生空腹血糖受损;验证集1 115例,平均随访(6.83±1.82)年,共128例(11.48%)发生空腹血糖受损。多因素Cox回归分析结果显示高龄、体质指数大、腰臀比大、高血压、甘油三酯异常、谷草转氨酶异常、有父母糖尿病史的人群更容易发生空腹血糖受损。验证结果:训练集C指数=0.74(95%CI:0.72~0.76),验证集C指数=0.73(95%CI:0.68~0.77)。 结论 本研究所构建的10年内成年人空腹血糖受损发生的列线图效能良好,对可能进展为空腹血糖受损的高风险人群有预测价值。     

Distribution of fasting plasma glucose and prevalence of impaired fasting glucose, impaired glucose tolerance and type 2 diabetes in the Mexican paediatric population

Published data on the distribution of fasting plasma glucose (FPG) in children are scarce. We therefore set out to examine the distribution of FPG and determine the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2-DM) in Mexican children aged 6–18 years in a community-based cross-sectional study. A total of 1534 apparently healthy children were randomly enrolled and underwent an oral glucose tolerance test. IFG was defined by an FPG value between ≥100 and <126 mg/dL, IGT by glucose concentration 2-h post-load between ≥140 and <200 mg/dL, and T2-DM by glucose concentration 2-h post-load ≥200 mg/dL.
The FPG level at the 75^th percentile of distribution was 98.0, 100.0 and 99.0 mg/dL for children aged 6–9, 10–14 and 15–18 years, respectively; the 95^th percentile of FPG was greater than 100 mg/dL for all the age strata. In the population overall, the prevalences of IFG, IGT, and T2-DM were 18.3%, 5.2% and 0.6%, respectively. Among obese children and adolescents, the prevalences of IFG, IGT, IFG + IGT and T2-DM were 19.1%, 5.7%, 2.5% and 1.3%. Our study shows a high prevalence of prediabetes and is the first that reports the distribution of FPG in Mexican children and adolescents.     

Weight gain and risk of impaired fasting glucose after smoking cessation

Background

Observation of early changes in fasting plasma glucose level induced by post-smoking cessation weight gain is useful in predicting the risks of diabetes mellitus (DM) and impaired fasting glucose (IFG). We investigated the effect of post-smoking cessation weight gain on early changes in the risk of a high fasting plasma glucose (IFG) level (≥100 mg/dL).

Methods

In 946 subjects who underwent repeated health examinations after smoking cessation, changes in body mass index (BMI) and the odds ratio (OR) for IFG risk (adjusted for sex, age, BMI, fasting plasma glucose at year 1, and alcohol consumption) were calculated every year for 3 years after smoking cessation.

Results

After smoking cessation, the rate of BMI increase significantly increased in quitters: 2.36% at year 2 (never smokers: 0.22%, current smokers: 0.39%) and 0.46% at year 3 (never smokers: 0.14%, current smokers: 0.32%). However, it decreased by 0.15% at year 4 (never smokers: 0.12%, current smokers: 0.26%). The ORs for quitters did not significantly increase at any time during the follow-up period. However, among quitters who had smoked at least 20 cigarettes per day, it was significantly higher (OR 1.51, 95% confidence interval 1.1–2.01 at year 1 and 1.71, 1.23–2.38 at year 2).

Conclusions

The time course of the risk of IFG after smoking cessation was similar to that for the rate of BMI increase. In contrast to the findings of previous reports, the increase in IFG risk after smoking cessation was brief and disappeared in the absence of a significant increase in BMI.Key words: smoking cessation, fasting, glucose tolerance, weight gain     

睡眠与其他因素对空腹血糖受损的影响

目的探索睡眠时间及睡眠质量与常见危险因素对空腹血糖受损的交互作用。方法采用多阶段分层整群随机抽样,抽取徐州市18岁及以上常住居民17 458人,收集他们的一般状况、患病情况、家族史、生活行为方式及睡眠情况,并测量空腹血糖、血压、身高、体质量等指标;运用相加作用模型,评价睡眠与其他多种因素对空腹血糖受损的交互作用。结果调整了性别、吸烟、饮酒、体力活动等多因素后,腹型肥胖和睡眠质量及高龄和睡眠质量对空腹血糖受损的相对超危险度比(RERI)、归因比(AP)和交互作用指数(S)及其置信区间分别为1.915(0.100~3.729)、0.325(0.077~0.574)、1.645(1.025~2.642)和1.634(0.074~3.194)、0.358(0.067~0.650)、1.849(1.046~3.614)。结论腹型肥胖和高龄与睡眠质量对空腹血糖受损有相加交互作用。     

徐州市居民空腹血糖异常危险因素分析

目的 探讨徐州市人群空腹血糖异常(IFG)的危险因素.方法 采取多阶段分层整群抽样的方法进行调查,共调查≥15岁常住人口23 742人.调查内容涉及问卷调查、体格检查、空腹血糖(FBS)测量.采用单因素和多因素非条件Logistic回归分析方法进行资料处理.结果 共3 958例空腹血糖异常者入选,多因素Logistic回归分析显示,地区、年龄、文化程度、职业、婚姻状况、高血压病史、冠心病史、饮酒史、腌制食品摄入量、蔬菜摄入量、每天睡眠时间、睡眠质量、体质指数(BMI)、腹部肥胖(WC)、腰臀比(WHR)与空腹血糖异常有关.结论 年龄增大、文化程度低、经济收入高、有高血压病史、有冠心病史、饮酒、常吃腌制食品、体质指数(BMI)增大、腹部肥胖(WC)、腰臀比(WHR)大是空腹血糖异常的危险因素,常吃蔬菜、睡眠充足有利于减少空腹血糖异常的发生.     

Association of coffee consumption with gallbladder disease

Coffee consumption was recently shown to protect against symptomatic gallbladder disease in men. The authors examined the relation of ultrasound-documented gallbladder disease with coffee drinking in 13,938 adult participants in the Third National Health and Nutrition Examination Survey, 1988-1994. The prevalence of total gallbladder disease was unrelated to coffee consumption in either men or women. However, among women a decreased prevalence of previously diagnosed gallbladder disease was found with increasing coffee drinking (p = 0.027). These findings do not support a protective effect of coffee consumption on total gallbladder disease, although coffee may decrease the risk of symptomatic gallstones in women.     

Alcohol consumption and higher incidence of impaired fasting glucose or type 2 diabetes in obese Korean men

It is inconclusive whether moderate alcohol consumption reduces the diabetes risk. We observed the development of impaired fasting glucose or type 2 diabetes according to the amount of alcohol intake and body mass index. The annual health evaluation data of 2,500 male workers from 2002 to 2006 were reviewed retrospectively deleting personal identification code. The information contained sex, age, medical history, smoking status, alcohol consumption, participating regular exercise, anthropometric, and biochemistry measurement. Impaired fasting glucose or diabetes was determined when fasting plasma glucose was ≥100 mg/dL. Thousand seven hundred seven subjects were eligible after excluding medical history of diabetes or fasting glucose ≥100 mg/dL at baseline. The relative risks of its development in group of taking 1-14, 15-29, and ≥30.0 g ethanol were 0.842 (95% confidence interval [CI], 0.603-1.176), 1.068 (95% CI, 0.736-1.551), and 1.019 (95% CI, 0.662-1.568) within normal weight group, 1.164 (95% CI, 0.795-1.705), 1.421 (95% CI, 0.947-2.133), and 1.604 (95% CI, 1.031-2.495) within overweight group, and 1.498 (95% CI, 1.042-2.153), 1.634 (95% CI, 1.091-2.447), and 1.563 (95% CI, 1.019-2.396) within obese group each after adjusting age, family history of diabetes, smoking, exercise, serum fasting glucose, aspartate aminotransferase, and γ-glutamyltransferase with nondrinkers as a reference group. Not only high alcohol consumption but also moderate drinking was related with higher incidence of impaired fasting glucose or diabetes in obese Korean men.     

年龄与甘油三脂对中老年空腹血糖受损患者的交互作用

目的 研究年龄与甘油三脂的交互作用对中老年空腹血糖受损（impaired fasting glucose,IFG）发病的影响。方法 2012年7~11月在桂林医学院附属医院体检人群中抽取3 492名年龄≥ 45岁者进行研究,选择378例IFG患者作为病例组,选取性别、年龄与病例组相匹配的374例血糖正常的人群作为对照组,比较分析两组人群的代谢特征。应用Logistic回归模型研究危险因素的独立效应,应用相加模型、相乘模型对危险因素间的交互作用进行分析。结果 IFG组的收缩压、舒张压、身体质量指数、空腹血糖、尿酸、甘油三脂、血清总胆固醇、低密度脂蛋白水平高于对照组,而高密度脂蛋白水平低于对照组,差异均有统计学意义（均有P<0.05）。控制混杂因素后,多因素Logistic回归分析结果:年龄≥ 60岁及高甘油三酯的IFG患者的患病风险为年龄<60岁及甘油三酯正常者的3.513倍（OR=3.513,95%CI:2.360~5.230）。中老年IFG危险因素的交互作用分析显示,年龄≥ 60岁和高甘油三酯之间不存在相乘交互作用,但具有相加交互作用,相对超危险度比（the relative excess risk due to interaction,RERI）、归因比（the attributable proportion due to interaction,AP）、交互作用指数（the synergy index,S）分别为0.91、25.90%、1.57。结论 IFG患者同时存在多种代谢指标异常,高龄及甘油三酯的正交互作用为IFG患者的重要危险因素之一,两者共存可增加患病风险。     

空腹血糖受损的中老年人血糖变化及转归的影响因素分析

[目的] 了解空腹血糖受损（IFG）的中老年人空腹血糖变化及转归情况,并分析其影响因素。[方法] 采用多阶段随机抽样方法,在上海市闸北区随机抽取2个街道,再按随机抽样方法确定居委会和楼组。选择年龄 ≥ 40岁、空腹血糖（FPG）6.1~6.9 mmol/L的常住人口进入本次研究,共203人。对该部分人群于2011-2012年间2次清晨空腹采静脉血样,检测FPG、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL）等生化指标,测量身高、体重、腰围、臀围,并于2012年通过问卷调查了解其生活方式及对糖尿病的认知水平。[结果] 对IFG人群连续观测2年,FPG总体水平有所上升,差异有统计学意义。FPG₁、FPG₂分别有37.44%、30.05%的居民升高到7.0 mmol/L以上,同时有38.42%、33.50%的居民FPG下降到6.1 mmol/L以下。被确诊为糖尿病者占9.85%。多因素分析发现BMI为IFG人群FPG升高的危险因素。[结论] 40岁以上IFG人群FPG水平2年内随时间总体有所升高。BMI是IFG人群FPG水平的影响因素。     

65岁以上老年空腹血糖受损人群2年转归及影响因素分析

目的 探讨65岁以上空腹血糖受损人群2年后自然转归及影响因素。方法 对2019年武进区65岁以上老年人健康体检时发现的空腹血糖受损人群,2年后再次进行健康体检,健康体检内容包括问卷调查、体格检查和实验室检查。采用logistic回归来探讨相关影响因素分析。结果 共计14 790空腹血糖受损者完成2年后的体检,其中6 285(42.49%)人血糖转归正常,5 697(38.52%)人血糖仍为空腹血糖受损,2 808(18.99%)人发展为糖尿病患者。多因素逐步logistic回归结果显示,女性（OR=1.13,95%CI:1.02～1.24）、高血压（OR=1.36,95%CI:1.24～1.50）、FPG(OR=12.65,95%CI:10.63～15.05)、TG(OR=1.07,95%CI:1.04～1.11)和BMI(OR=1.05,95%CI:1.04～1.06)是空腹血糖受损人群进展为糖尿病的危险因素;饮酒（OR=0.82,95%CI:0.72～0.94）、体育锻炼（OR=0.80,95%CI:0.73～0.87）、HDL-C(OR=0.62,95%CI:0.58～0.67)...     

斑点追踪技术评价空腹血糖受损对高血压患者左室扭转与解旋运动的影响

目的探讨空腹血糖受损（IFG）对高血压患者左室扭转与解旋运动的影响,为防治高血压提供依据。方法入选140例高血压患者及37例正常对照组,高血压患者分为非空腹血糖受损组（非IFG组）66例、空腹血糖受损组（IFG组）74例。应用二维斑点追踪技术（STI）测量并计算左室短轴心尖部旋转角度峰值（PAR）及达峰时间（PART）、基底部旋转角度峰值（PBR）及达峰时间（PBRT）、左室整体扭转角度峰值（Ptw）及达峰时间（PtwT）、平均扭转速度（PtwM）、平均解旋速度（UntwM）、解旋率（UntwR）。结果 IFG组、非IFG组PBR（分别为-8.49°±3.06°、-8.36°±3.07°）、UntwR[分别为（40.86±14.92）、（44.46±16.56）%/ms]均小于对照组[（分别为-6.31°±2.08°、（51.62±17.23）%/ms],差异均有统计学意义（P〈0.01）;IFG组PAR（11.55°±4.63°）、Ptw（19.18°±5.18°）、PtwM[（56.37±15.19）°/s]、UntwM[（41.95±13.32）°/s]大于对照组[分别为8.20°±3.27°、13.82°±3.41°、（40.61±9.76）°/s和（27.68±8.80）°/s]、非IFG组[分别为10.03°±3.95°、17.49°±4.58°、（50.71±13.14）°/s和（35.69±11.87）°/s],差异均有统计学意义（P〈0.01）。高血压患者Ptw与空腹血糖水平呈正相关（r=0.184,P〈0.05）。结论 IFG可作为评价左室构型正常的高血压患者左室功能改变的预测因素。     

Effects of pre-germinated brown rice on blood glucose and lipid levels in free-living patients with impaired fasting glucose or type 2 diabetes

White rice (WR) is made by polishing brown rice (BR) and has lost various nutrients; however, most people prefer it to BR, maybe because of the hardness of BR. Pre-germinated brown rice (PGBR) improves the problem of BR. It is made by soaking BR kernels in water to germinate and becomes softer than BR. In this study we compared the effects of WR and PGBR on blood glucose and lipid concentrations in the impaired fasting glucose (IFG) or type 2 diabetes patients. Six men and 5 women with impaired fasting glucose (IFG) or type 2 diabetes were randomly allocated to 6 wk on WR or PGBR diet separated by a 2 wk washout interval in a crossover design. Each subject was instructed to consume 3 packs of cooked WR or PGBR (180 g/pack) daily in each intervention phase. Blood samples were collected 4 times (in study weeks 0, 6, 8 and 14) for biochemical examination. Blood concentrations of fasting blood glucose, fructosamine, serum total cholesterol and triacylglycerol levels were favorably improved on the PGBR diet (p<0.01), but not on the WR diet. The present results suggest that diets including PGBR may be useful to control blood glucose level.     

糖调节受损患者空腹胰岛素与亚临床大血管病变相关性分析

目的 了解糖调节受损(IGR)患者的空腹胰岛素(FINS)水平与发生亚临床大血管病变之间的相关性,为研究IGR患者发生亚临床大血管病变的危险因素提供依据.方法 将115例IGR患者根据颈动脉彩超结果,分为亚临床大血管病变组(n=57)和无病变组(n=58),进行既往史、个人史调查,测量体重、身高、臀围和腰围,测定空腹及餐后2h血糖、空腹胰岛素(FINS)、血脂、丙氨酸转氨酶(ALT)和肾功能,并计算稳态模型胰岛素抵抗指数(HOMA-IR).结果 亚临床大血管病变组年龄[(64.8±7.8)岁]高于无血管病变组[(55.0±8.6)岁],差异有统计学意义(P＜0.01).与无血管病变组比较,亚临床大血管病变组高血压检出率(70.2％)明显升高,高血压病程[(5.64±7.08)年]明显延长,SBP[(141.88±16.96) mm Hg]、UA[(368.00±74.20) μmol/L]明显升高,FINS[(6.43±3.51) mIU/L]、HOMA-IR(1.76±1.07)明显降低,差异均有统计学意义(P＜0.01,P＜0.05).两组体质指数(BMI)、腰臀比(WHR)、舒张压(DBP)、血脂、尿素氮(BUN)、血肌酐(Cr)差异均无统计学意义(P＞0.05).多因素非条件logistic回归分析显示,FINS(OR=0.10,95％CI:0.01～0.91,P=0.040)和年龄(OR=1.21,95％CI:1.08～1.36,P=0.001)是IGR患者亚临床大血管病变的影响因素.结论 低水平的FINS可能是IGR患者发生亚临床大血管病变的危险因素.