重症急性胰腺炎的早期手术治疗体会(附12例报告)

重症急性胰腺炎(SAP)是病死率较高的疾病,其治疗上一直存在争议。我院1998年至2004年收治重症急性胰腺炎32例(按中华医学会胰腺外科组2000年关于SAP诊断标准),其中12例行早期手术治疗,均治愈出院,现就手术治疗体会总结如下。1临床资料1.1一般资料12例中,男9例,女3例;年龄最大68     

区域动脉灌注治疗重症急性胰腺炎

重症急性胰腺炎 (SAP)不易控制 ,病死率居高不下 ,是当前胰腺外科的难点之一 ,区域动脉灌注 (re-gional arterial infusion,RAI)是一种早期治疗重症急性胰腺炎的新方法。我院于 2 0 0 0～ 2 0 0 1年对 9例SAP患者采用 RAI治疗 ,现总结分析如下。1　临床资料1.1　一般资料 :男 6例 ,女 5例 ,年龄 34～ 78岁。均按中华医学会外科学会胰腺外科学组 2 0 0 1年提出的SAP临床诊断及分级标准分级 [1 ] (CT诊断 8例、B超诊断 1例 ) ,其中 级 2例 , a级 3例 , b级 2例 ,特重型 2例。血淀粉酶增高 7例 ,5 0 6～ 375 0 IU/ L。RAI治疗时间 ,…     

重症急性胰腺炎的综合治疗探讨

重症急性胰腺炎 (ScvcrcAcutcPancrcatitis,SAP)发病凶猛 ,病死率高。本文报告我们 1 995年1月 - 2 0 0 2年 8月收治的SAP患者 88例的治疗情况 ,以讨论SAP合理的治疗方案。1　资料与方法1 1临床资料本组 88例均符合SAP诊断标准[1 ] ,其中男性42例 ,女性 46例 ,年龄 2 1～ 69岁 ,平均 44 8岁。重症Ⅰ级 31例 ,重症Ⅱ级 5 7例。1 2　治疗方法本组 88例中非手术治疗 5 5例 (重症Ⅰ级 2 1例 ,重症Ⅱ级 34例 )。治疗方法包括 :①所有患者入院后均给持续胃肠减压 ,禁食水 ;根据患者的经济条例 ,2 5例患者选用西咪替丁注射液 0 6g静滴 ,…     

急性胰腺炎48例的诊断和治疗体会

我院自1995年3月至1998年12月共收急性胰腺炎(AP)48例,现将该组病例诊治体会总结如下。1　临床资料1.1　一般资料　本组48例中,男性19例,女性29例,男∶女为1∶1.53,年龄13～48岁(平均46岁),轻症急性胰腺炎(MAP)42例(87.5%),重症急性胰腺炎(SAP)6例(12.5%)。胆源性胰腺炎(GP)25例(52.1%),非胆源性胰腺炎(NGP)23例(47.9%)。1.2　诊断标准　根据中华医学会外科学会胰腺外科组1996年提出的AP临床诊断和分级标准第二次试行方案进行诊断[1]。1.3　治疗分组　1传统疗法:卧床休息,密切观察病情变化,禁食,胃肠减压,抗生素,抗胆碱药物,制酸剂,中…     

经腹腔镜引流治疗早期重症急性胰腺炎

2001年1月~2006年5月,我院对重症急性胰腺炎(SAP)9例实施了腹腔镜下引流术治疗,疗效满意,现报道如下。1临床资料9例中男5例,女4例,年龄26~63岁,平均44岁。诊断符合2000年中华医学会外科分会胰腺学组关于“SAP及相关器官功能衰竭的临床诊断与分级标准”[1]。属Ⅰ级6例,Ⅱ级3例。     

重症急性胰腺炎以营养支持为主的综合治疗体会

随着胰腺外科的发展 ,急性胰腺炎的认识和治疗观念有很大的改变。目前公认的对策是“原则上保守治疗 ,若病情恶变则手术”[1 ] 。营养支持在治疗过程中举足轻重 ,是保守治疗的主要措施 ,贯彻于治疗的始终。我院 1990～ 2 0 0 0年共收治重症急性胰腺炎 (SAP) 36例 ,分期进行营养支持。取得了较好的治疗效果 ,报告如下。1　临床资料　　本组 36例中 ,男 2 7例 ,女 9例。年龄 2 3～ 81岁 ,中位年龄 5 0 .6岁。非手术治疗 2 8例 ,手术治疗 8例。其中胰瘘 4例 ,残腔 2例 ,肠瘘 1例 ,胃瘘 1例。均符合重症急性胰腺炎的诊断标准 [2 ] ,入院 2 4h …     

连续性床边血液净化治疗高脂血症性急性重症胰腺炎疗效观察

正急性重症胰腺炎(severe acute pancreatitis,SAP)是消化科及外科临床上常见的一种高危急腹症,疾病进展快,病死率高~[1]。研究~[2-3]显示,高脂血症性急性重症胰腺炎占同期胰腺炎的32.7%。本研究对15例运用连续性床边血液净化(CRRT)技术治疗的高脂血症性SAP患者的临床资料进行回顾性分析,现总结如下。1临床资料1.1一般资料2014年1月—2016年3月我院收     

重症急性胰腺炎保守治疗的护理

重症急性胰腺炎(SAP)起病急骤,发展迅猛,病情凶险,并发症多,短时间内导致多系统、多脏器功能障碍,病死率高达20%～30%~[1].是目前外科急腹症中较棘手的疾病之一,从2002年10月～2007年10月,我科共收住38例重症胰腺炎病人,在进行综合治疗的同时给予高质量的护理,取得较好的效果,现结如下. 1 临床资料 1.1 本组病例38例,男28例,女10例,年龄23～68岁,平均45.8岁,本组病例均行腹部CT平扫+增强检查证实,其中急性出血性胰腺炎22例,急性出血坏死性胰腺炎16例.     

胰性脑病18例临床分析

资料与方法 2002年8月～2008年12月治疗重症胰腺炎（SAP）并发胰性脑病（PE）患者18例,男12例,女6例,年龄16—76岁,平均43．6岁。重症胰腺炎诊断标准：符合中华医学会胰腺外科制定的急性胰腺炎临床诊断与分级标准。其中经手术治疗的11例,未行手术的7例,胰性脑病症状出现时间距原发病时间3—20天。     

生长抑素治疗重症胰腺炎45例

重症急性胰腺炎 (SAP)是一种由多种因素诱发、多个脏器受累的疾病 ,病情凶险 ,发展迅速。由于缺乏有效的特异性治疗方法 ,SAP仍是高并发症和病死率的疾病。现将1995— 2 0 0 1年我院收治的 4 5例SAP生长抑素治疗结果回顾性分析 ,探讨生长抑素对SAP的多器官保护作用和临床疗效。1　临床资料1.1.　一般资料　 4 5例SAP患者中男 32例 ,女 13例。年龄2 3～ 87岁 ,平均 5 0岁。 10例并发高血压 ,4例并发糖尿病 ,SAP的诊断均符合 1998年第七届全国胰腺外科学术研讨会制定的急性重症胰腺炎诊疗规范[1] 。1.2. 　发病诱因　饮酒 15例 (33.3%…     

益智健脑颗粒联合针灸对阿尔茨海默病大鼠学习记忆的影响

目的观察益智健脑颗粒联合针灸对阿尔茨海默病（Alzheimers disease,AD）大鼠学习记忆的影响。方法将大鼠随机分为假手术组（A组）、模型组（B组）、针灸组（C组）、益智＋针灸组（D组）各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35（Aβ25-35）造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义（P〈0.05）;与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义（P〈0.05,P〈0.01）;与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义（P〈0.05）。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。     

表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌应用的瓶颈——获得性耐药

以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI）分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,     

Liuwei Dihuang,a traditional Chinese herbal formula,suppresses chronic inflammation and oxidative stress in obese rats

OBJECTIVE： To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang （LWDH）, a traditional Chinese herbal formula, in obese rats. METHODS： After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived （OP-CD） rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water （n=12 rats per group）. Twelve obese-resistant-CD （OR-CD） rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS： After 9 weeks of treatment, LWDH lowered serum C-reactive protein （CRP） and tumour necrosis factor-α （TNF-α） levels. Serum interleukin-6 （IL-6） levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase （SOD） activity was increased in response to all three doses of LWDH, while the levels of reduced （GSH） and oxidized glutathione （GSSG） and thiobarbituric acid reactive substances （TBARS） were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION： The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as     

程丑夫教授论治情志病验案举隅

程丑夫是国家级名老中医,湖南中医药大学第一附属医院主任医师、教授、博士生导师,享受政府特殊津贴专家,出身于中医世家,从医40余年,经验丰富,对于内科系统及疑难杂症的治疗颇有心得,笔者有幸跟师学习,聆听教诲,受益匪浅,现将程师论治情志病的经典验案略陈一二。1思虑伤脾案患者肖某,女,27岁。初诊：2014年5月20日。半年前因婚变后出现忧心忡忡,多思多虑,近1月来反复腹部胀满,刻诊：腹胀,食后为甚,呃逆,无反酸,通气后可减轻,无腹痛,不欲食,夜寐不安,二便调。舌红苔厚白腻,脉弦,BP：110／70mmHg。     

补肾活血方对PCOS大鼠模型卵巢中PAI-1mRNA表达的影响

目的探讨补肾活血方对大鼠PCOS模型卵巢局部纤溶酶原激活物抑制因子-1（PAI—1mRNA）表达的影响。方法选用未成年24d龄SD雌性大鼠60只,随机分为模型组、克罗米酚组、补肾活血方高剂量组、补肾活血方低剂量组、正常对照组5组。用Bogovich法建立大鼠多囊卵巢病理模型。以克罗米酚为对照。用原位杂交法观察补肾活血方对多囊卵巢大鼠局部PAI—1mRNA的影响。结果模型组卵巢局部PAI—1mRNA存在卵泡膜间质细胞显著增高,用补肾活血方高、低剂量与克罗米酚药后,卵巢局部PAI-1mRNA的表达明显降低．差异具有统计学意义（P〈0．05、P〈0．01）。补肾活血方高剂量组与克罗米酚组比较,差异具有显著统计学意义（P〈0．01）;低荆量组与克罗米酚组比较差异无统计学意义（P〉0．05）,补肾活血方高、低剂量组比较,低剂量组卵泡膜间质细胞上PAI-1的基因表达增高更明显,但二者差异无统计学意义（P〉0．05）。结论PAI-1mRNA可能与多囊卵巢综合征的发病机制有关。以补肾活血立法的补肾活血方能降低多囊卵巢大鼠局部PAI—1mRNA的显著增高表达．降低PAI—1mRNA卵巢局部的作用。提示补肾活血方可能通过PAI—1mRNA途径促进卵巢排卵的机制。     

UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model （Papio Anubis）

Objective To determine the safety and efficacy of UniPron as a reversible contraceptive.
Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages.
Results All the five females （100%） that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%, UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal.
Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model （Papio anubis）.     

New Mechanism of Herb-herb Interaction between Ginseng and Trogopterus Based on CYPs in Rat Livers

The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus （Trg） based on Cytochrome P450 isozymes （CYPs） in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.     

中医疗法治疗运动性疲劳的研究进展

随着竞技体育的发展，运动员经常承受着大负荷、超强度的体力训练，因此极易产生运动性疲劳。疲劳的出现使肌内压增高，局部缺血，造成氧化代谢、H^＋排出率与pH值降低，血乳酸增高，从而影响肌纤维神经传导速度和肌内收缩力量，减弱了肌肉保护能力。致使较多的冲击力传到骨骼上，故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩，对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。     

Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis

Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome （MetS） and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio （RR）：1.06,95％ confidence interval （C/）：0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia （RR：0.50,95％ CI：0.39-0.64,P ＜0.01）.Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension （RR：0.91,95％ CI：0.83-1.00,P=0.06） after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation （RR：1.79,95％ CI：0.98-3.27,P=0.06） compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.     

Mechanical tests on the reconstructed anterior cruciate ligament fixed with allogenetic cortical bone cross-pin on the femoral side

Background Anterior cruciate ligament reconstruction （ACLR） has developed dramatically in the last century.Now,ACLR has become a reliable and productive procedure.Patients feel satisfied in 〉90% cases.The aim of this study was to evaluate the feasibility of allogenetic cortical bone cross-pin （ACBCP） used as a clinical fixation method in anterior cruciate ligament reconstruction on the femoral side based on biomechanical tests in vitro.Methods The specimens were provided by the bone banks of the First Affiliated Hospital of People＇s Liberation Army of General Hospital from September 2011 to June 2012.Fresh deep frozen human allogenetic cortical bone was machined into cross-pins which is 4.0 mm in diameter and 75.0 mm in length.Biomechanical parameters compared with Rigidfix were collected while cross-pins were tested in double-shear test.The load-to-failure test and cycling test were carried out in a goat model to reconstruct anterior cruciate ligament with Achilles tendon autograft on the femoral side fixed by human 4.0 mm ACBCP and 3.3 mm Rigidfix served as control.Maximum failure load,yield load,and stiffness of fixation in single load-to-failure test were compared between the two groups.Cycle-specific stiffness and displacement at cycles 1,30,200,400,and 1 000 were also compared in between.Results In double-shear test both maximum failed load and yield load of 4.0 mm humanACBCP were （1 236.998±201.940） N.Maximum failed load and yield load of Rigidfix were （807.929±110.511） N and （592.483±58.821） N.The differences of maximum failed load and yield load were significant between ACBCP and Rigidfix,P 〈0.05.The shear strength of ACBCP and Rigidfix were （49.243±8.039） MPa and （34.637±3.439） MPa,respectively,P 〈0.05.In the load-to-failure test ex vivo,yield load and maximum failed load of ACBCP fixation complexity （（867.104±132.856）N,（1 032.243±196.281） N） were higher than those of Rigidfix （（640.935±42.836） N,（800.568±64.890） N,P 〈0.05）.However,s