Experience of ambulatory anesthesia in Charles Nicolle hospital

The authors report the experience of ambulatory surgery at Charles Nicoll's hospital on ophthalmology and ORL surgery in which 90% and 60% of acts can be realized on ambulatory. The organisation by means of structures and hospital workers makes an important gain. The anesthetic consultation, very important in this organisation, enable to avoid to rescue a patient at the last time.     

Cocaethylene-induced lethality in mice is potentiated by alcohol

Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg Ccaehylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v) alcohol. Results indicate that alcohol administration significantly potentiated cocaethylene-induced lethality. This observation suggests that alcohol is capable of enhancing the lethal effects of Ccaehylene. Results are discussed in terms of observations of sudden death in humans who abuse cocaine and alcohol.     

绵阳市保持无脊髓灰质炎强化免疫效果评价

为巩固我国无脊髓灰质炎(脊灰)证实成果,保持无脊髓灰质炎状态,进一步消除免疫空白人群,提高流动人口免疫接种率和免疫服务质量,减少易感人群,保护儿童健康,根据卫生部及四川省卫生厅要求,于2002-2005年先后开展了3次全市范围的口服脊灰疫苗(OPV)强化免疫活动,现将结果报告如下.……     

邻苯二甲醛和强化戊二醛杀灭细菌芽孢效果比较

目的比较邻苯二甲醛消毒剂与强化戊二醛消毒剂对枯草杆菌黑色变种芽孢的杀灭效果。方法采用载体定量杀菌试验对两者的杀灭效果和连续使用稳定性进行比较。结果0.53%邻苯二甲醛消毒液作用3 h对不锈钢片上枯草杆菌黑色变种芽孢的杀灭对数值为3.21,作用10 h杀灭对数值>6.10;而2.18%强化戊二醛消毒液作用3 h杀灭对数值>6.10;0.53%邻苯二甲醛消毒液连续使用7、14 d后,仍保持对芽孢有良好的杀灭能力。结论邻苯二甲醛消毒剂杀灭细菌芽孢的效果不如强化戊二醛,但可具备用于内镜高水平消毒效果和使用稳定性。     

2%强化戊二醛性能的实验室观察及研究

2 %强化戊二醛为戊二醛类复方消毒剂 ,其中加有强化剂、改良剂、增效剂。为了解其杀灭微生物与破坏HBsAg抗原性效果、对金属的腐蚀性、储存稳定性等性能 ,对含有 2 %戊二醛的强化戊二醛的杀灭微生物效果及金属腐蚀性、储存稳定性进行了试验观察。结果表明 ,含 0 5 %的戊二醛作用 5min ,对载体表面的金黄色葡萄球菌杀灭率达99 93 % ;作用 3min对大肠杆菌、白色念珠菌的杀灭率均达 99 91% ;含 1%的戊二醛作用 8h ,对载体表面的枯草杆菌黑色变种芽胞杀灭率达 99 91% ;当戊二醛含量为 2 %时 ,作用 10h可将不锈钢片表面HBsAg的抗原性完全破坏。小牛血清对其杀菌效果有一定影响 ;含 2 %戊二醛的强化戊二醛对四种金属片浸泡 72h ,依据腐蚀速率标准判断 ,对不锈钢片、铝片、铜片、碳钢片均属无腐蚀 ;该样品在 5 4℃、RH >75 %的条件下 ,放置 14d后 ,其有效成分下降率为 5 18%。     

Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats.

Lipid peroxidation may contribute to the nephrotoxicity of cephaloridine, a beta-lactam antibiotic. Copper and Se may protect against free radical damage, and dietary Se deficiency potentiates cephaloridine nephrotoxicity. The objectives of this study were to further investigate potentiation of cephaloridine toxicity by Se deficiency and to determine whether Cu deficiency increases cephaloridine-induced injury. Weanling male Sprague-Dawley rats were fed adequate, Cu-deficient, Se-deficient, and Se and Cu-deficient diets for 4 wk and subsequently injected i.p. with cephaloridine (1200 mg/kg body wt) or saline. Nephrotoxic response to cephaloridine occurred, with increased plasma urea, kidney weight, excretion of urinary enzymes, and kidney lesions. Cephaloridine also increased plasma sorbitol dehydrogenase activity. Selenium deficiency depressed kidney glutathione peroxidase activity (78%) and potentiated cephaloridine nephrotoxicity. Copper deficiency did not increase cephaloridine nephrotoxicity; the small depression (13%) in kidney Cu,Zn-superoxide dismutase activity may not have been sufficient to impair antioxidant status. However, the marked depression in kidney glutathione peroxidase activity during Se deficiency may have impaired antioxidant status and enhanced cephaloridine-induced injury. In contrast to results in the kidney, neither Se deficiency nor Cu deficiency potentiated cephaloridine hepatotoxicity, as assessed by plasma SDH activity.