Chronic daily headaches in pediatric neurology practice

Using a comprehensive computerized database for a single general pediatric neurology ambulatory practice, the clinical profile, together with the precipitating features and outcomes, in a consecutive series of children with chronic daily headache was ascertained. Chronic daily headache was defined as persistent or daily headaches of at least 3 months' duration. Children with persistent headaches owing to a serious medical condition were specifically excluded from analysis. Of 1669 children (24% of total seen) referred over an 11-year inclusive interval for the evaluation of headaches, 50 (3%) merited a diagnosis of chronic daily headache. The overwhelming majority were female (45/50; 90%), with a mean age at diagnosis of 12.9 years (range 7-16 years). Transformed migraine was determined to be the etiology in the majority (35/50; 70%), with a minority attributable either to postconcussion syndrome (7/50; 14%) or new daily persistent headaches (6/50; 12%). Analgesic abuse was evident in a majority (26/50; 52%). Treatment consisted predominantly of migraine and analgesic education, with a majority of children (42/50; 84%) also receiving daily prophylaxis. Four fifths (41/50; 82%) returned for at least one follow-up. Of these, 56% (23/41) were improved, 32% (13/41) unchanged, and 12% (5/41) worse. Eventually, almost half (20/41) experienced complete resolution of their headache symptoms, with a mean time to resolution of 8 months (range 2-48 months). Children with chronic daily headache are thus a small subset of children with headache seen in general ambulatory practice. They tend to be females in the midteen years experiencing a transformed migraine complicated by analgesic abuse, suggesting potential preventability. Simple measures, which can include the use of prophylactic agents, can be expected to result in improvement and eventual resolution of headache symptoms.     

Reasons for switching between antipsychotics in daily clinical practice

BACKGROUND: Previous research that atypical antipsychotics were switched less often compared to typical antipsychotics, suggesting overall better treatment satisfaction. The objective of this study was to investigate the reasons for switching antipsychotics after initiating oral treatment with either typical or atypical antipsychotics in a clinical setting. PATIENTS AND METHODS: A total of 123 patients that switched antipsychotic therapy were recruited from 17 psychiatric hospitals, of which 46 % switched because of lack of effect and 45 % because of adverse effects. RESULTS: No significant differences were found between users of atypical versus typical antipsychotics in reasons for switching, both for overall adverse events, and lack of effect. In users of atypical antipsychotics extrapyramidal effects were reported less often as reason for switching (adjusted OR = 0.18 (95 % CI = (0.07 - 0.51)). Patients on atypical antipsychotics switched more often because of weight gain (adjusted OR = 12.8 (95 % CI = (1.50 - 109)). CONCLUSION: In conclusion, when switching occurred, no difference was found in the frequency of general tolerability or reported lack of effectiveness. However, the type of adverse event as a reason for switching differed between atypical and typical antipsychotics.     

Characterization of chronic daily headaches in children in a multidisciplinary headache center

BACKGROUND: Chronic daily headaches (CDH) occur in >4% of the adult population. The criteria for CDH, however, are controversial. In children, the characterization of frequent headaches and CDH is limited. METHODS: A Headache Center to characterize headaches in children (3 to 18 years old) was established. Over 34 months, 577 children have been evaluated. With use of a definition of > or =15 headaches per month, 200 (34.6%) children had CDH. RESULTS: The average age at the first headache in these children was 9.3 +/- 3.6 years, whereas the average age at presentation to the Headache Center was 12.5 +/- 3.1 years. Sixty-eight percent were girls, 88% were Caucasian, and 11% were African American. Ninety-two percent clinically had migraine headaches, whereas 60.5% met the International Headache Society migraine criteria. The pain was pulsatile in 79%, 63.5% had nausea with or without vomiting, and 59.5% had photophobia and phonophobia. Three subcategories emerged, with 37% having frequent headaches but not daily, 43.5% having episodic daily headaches, and 19.5% having a continuous headache. CONCLUSION: The features of CDH in children most closely match those of migraine. A clear division of these children using frequency identifies three groups: frequent headaches (15 to 29), daily intermittent, and daily continuous. The daily continuous group is the most unique; however, the nature of these headaches continues to remain migrainous.     

Rare primary headaches: clinical insights

Neurological Sciences - So-called “rare” headaches, whose prevalence rate is lower than 1% or is not known at all and have been reported in only a few dozen cases to date, constitute a...     

Usefulness of primitive reflexes in demented and non-demented cerebrovascular patients in daily clinical practice

The aim of this study was to investigate the usefulness of primitive reflexes (PRs) as additional alert signs in a routine clinical setting of cognitive decline in an elderly population of chronic ischemic cerebrovascular patients. We considered the occurrence of grasp, palmomental, glabellar and snout reflexes in 75 demented (VaD) and 75 non-demented (VaND) patients, and in 75 healthy elderly controls. We never elicited more than two PRs in controls. The occurrence of three or four PRs provided the strongest correlation with dementia (p < 0.0001), with 93% specificity irrespective of low sensitivity. In conclusion, the occurrence of more than two PRs might serve as an additional warning sign of possible mild cognitive impairment in chronic ischemic cerebrovascular patients.     

Chronic daily headache in pediatric practice

Improving the quality of life of the patient presenting with chronic daily headache proves to be challenging both diagnostically and with regard to their short- and long-term management. Continued progress has been made in the classification of chronic daily headache. The extent to which an initial evaluation should be conducted to obtain a diagnosis is a paramount consideration for both the patient and the family. The introduction of disability tools targeted for this population, both in use and under evaluation, will assist in both the initial assessment and in guiding management. The chronic daily headache patient in most cases requires both a non-pharmacological and a pharmacological approach with clearly defined short- and long-term goals. The management of the expectations of both the patient and family are the key to a good outcome.     

Drug-drug interactions as a determinant of elevated lithium serum levels in daily clinical practice

OBJECTIVE: Lithium is a drug with a narrow therapeutic window. Concomitantly used medication is a potentially influencing factor of lithium serum concentrations. We conducted a multicentre retrospective case-control study with the aim of investigating lithium-related drug interactions as determinants of elevated lithium serum levels in daily clinical practice. METHODS: Cases were patients with an increase of at least 50% in lithium serum concentrations resulting in an elevated lithium serum level of at least 1.3 mmol/L, and who were not suspected of a suicide attempt. Controls were patients who showed stable lithium serum levels within the therapeutic range. Use and start of non-steroidal anti-inflammatory drugs, diuretics, renin-angiotensin inhibitors, theophyllin and antibiotics were investigated as potential determinants of the elevated lithium serum levels. Irregularity in lithium dispensing pattern, change in lithium dosing regimen, age, gender, prescribing physician and laboratory parameters were investigated as potential confounders. RESULTS: We included 51 cases and 51 controls in our study. Five (9.8%) controls and 15 (29.4%) cases used potentially interacting co-medication [OR of 3.83 (95%CI 1.28-11.48)]. Start of potentially interacting co-medication was observed in eight (15.7%) cases and in zero (0%) controls resulting in an OR of 20.13 (95% CI 1.13-359). After adjustment for co-medication, irregularity in lithium dispensing pattern, change in lithium dosing regimen, and age, the statistically significant association was lost. We report an OR of 2.70 (95% CI 0.78-9.31) for use of concomitant medication, with a large contribution of antibiotic agents, and an OR of 3.14 (95% CI 1.15-8.61) for irregularity in lithium dispensing pattern. CONCLUSION: Use of co-medication, especially antibiotics, tends to be associated with elevated lithium serum levels.     

Clinical subtypes of delirium and their relevance for daily clinical practice: a systematic review

BACKGROUND: Delirium is a disorder that besides four essential features consists of different combinations of symptoms. We reviewed the clinical classification of clusters of symptoms in two or three delirium subtypes. The possible implications of this subtype classification may be several. The investigation and exploration of clinical subtypes of delirium may provide information concerning the etiology, the pathogenesis, and the prognosis of delirium, but also may have therapeutic consequences. METHODS: We searched several database for English-language articles. Selected articles were cross-checked for other relevant publications. DATA SYNTHESIS AND CONCLUSION: We conducted a systematic review and retrieved ten clinical studies. The studies described in this review show different results, partly due to methodological problems and possibly by lack of a standard classification for delirium subtypes. According to the present literature a useful and reproducible method to classify (patterns of) symptoms in delirium subtypes seems to be the general rating of and division in to psychomotor subtypes. The Memorial Delirium Assessment Scale (MDAS) and the Dublin Delirium Assessment Scale (DAS) appear to be reliable methods, together with the new version of the Delirium Rating Scale (DRS-R-98).     

Hypocretins and primary headaches: neurobiology and clinical implications

Hypocretins (or orexins) are two neuropeptides synthesized by neurons located exclusively in the hypothalamus. Hypocretin-containing neurons have widespread projections throughout the CNS; with particularly dense excitatory projections to monoaminergic and serotonergic brainstem centers. The hypocretin system influences a wide range of physiological processes in mammals, such as feeding, arousal, rewards and drug addiction. Recently, a number of studies in experimental animals showed that hypocretins are involved in pain modulation within the CNS, and suggested the presence of a link between these peptides and nociceptive phenomena observed in primary headaches. The aim of this review is to describe and discuss recent studies in humans suggesting a role for the hypocretin neuronal system in cluster headache and chronic migraine.     

Treatment of cervical dystonia with abo- and onabotulinumtoxinA: long-term safety and efficacy in daily clinical practice

Journal of Neurology - Treatment with botulinum toxin A is the evidence-based first-line therapy of cervical dystonia. The aim of this study was to analyze long-term data of the most commonly used...     

Electroconvulsive therapy in forensic psychiatry--ethical problems in daily practice

There is a widespread similarity between diagnoses in general psychiatry compared with those found in forensic psychiatry. Consequently, forensic psychiatrists face serious cases that need to undergo treatment by electroconvulsive therapy (ECT). Although it is a well known and valid treatment, ECT is rarely applied to forensic-psychiatric patients or prisoners as well. This might be due to the general assumption that detained individuals, either in forensic psychiatry or in prisons, will not be chosen for a therapy, which is merely looked on as an emergency treatment. Besides, informed consent might be estimated not valid in such persons. However, the use of ECT in forensic psychiatry or prisons cannot be denied anymore because diagnoses and indications for ECT parallel the situation in general psychiatry. With the numbers of schizophrenic and depressive patients considerably increasing in the past years in our forensic unit, we estimate the indication for ECT in forensic psychiatry of approximately 3% and 12.5%, respectively.