射频消融术治疗室上性心动过速的疗效（附7例报告）

目的：观察射频消融术（ＲＦＣＡ）治疗上性心动过速（ＳＶＴ）效果。方法：采用ＲＦＣＡ对７例ＳＶＴ患者进行治疗。结果：７例ＳＶＴ患者均成功消融，其中５例为房室折返型心动过速（ＡＶＲＴ），２例为房室结折返型心动过速（ＡＶＮＲＴ）。结论：ＲＦＣＡ治疗ＳＶＴ安全有效，值得临床推广应用。     

202例快速心律失常射频消融的回顾分析

目的：总结经导管射频消融（ＲＦＣＡ）治疗２０２例快速心律失常的经验。　方法：对２０２ 例快速心律失常进行ＲＦＣＡ 治疗,其中房室旁路折返性心动过速（ＡＶＲＴ）１３６例,房室结折返性心动过速（ＡＶＮＲＴ）５６ 例,房性心动过速２ 例,心房扑动２ 例,心房纤颤１例,特发性室性心动过速５ 例。本文重点总结ＡＶＲＴ和ＡＶＮＲＴ 的ＲＦＣＡ 经验。　结果：２０２ 例中阵发性室上性心动过速１９２ 例（ＡＶＮＲＴ５６ 例,ＡＶＲＴ１３６ 例）,首次消融成功率９５．８％ （１８４／１９２ 例）,８例复发,其中６ 例经再次ＲＦＣＡ 治疗成功,最终治愈率为９４．８％ 。结论：ＲＦＣＡ治疗ＰＳＶＴ成功率高,严重并发症少,可作为这类快速心律失常治疗的首选方法。     

射频消融房室结慢径治疗室上性心动过速

２６例室上性心动过速（ＳＶＴ）采用导管射频消融（ＲＦＣＡ）房室结（ＡＶＮ）慢径治疗。２６例均为慢快型房室结折返性心动过速（ＡＶＮＲＴ），其中１例合并Ⅰ型心房扑动（ＡＦ），１例合并房室折返性心动过速（ＡＶＲＴ）。结果全部成功，无并发症出现，随访１～２０月无复发。结论：经导管ＲＦＣＡ房室结慢径是治疗ＡＶＮＲＴ首选的非药物根治方法，采用下位法定位简单、成功率高、复发率低。ＡＶＮＲＴ合并Ⅰ型ＡＦ者根治ＡＶＮＲＴ后ＡＦ同时也可能得到根治。     

射频导管消融治疗室上性心动过速

目的 探讨射射导管消融ＲＦＣＡ）治疗室上性心动过速（ＳＶＴ）的方法，方法 左侧旁道采用经股动脉逆行法在二尖环瓣环心室侧标侧和消融，左侧旁道在三尖瓣环心房侧标测和消融，用下位法消融慢径行房室结改良。结果 ６７例ＳＶＴ患者中房室折返性心运过速（ＡＶＲＴ）４２例，房室结折返性心动过速（ＡＶＮＲＴ）２５例，ＡＶＲＴ消融成功率９７．６％（左侧１００％，右侧８８．９％），ＡＶＮＲＴ消融成功率９６％，并发症为１     

射频消融治疗特发性室性心动过速的探讨(附17例临床分析)

总结射频消融（ＲＦＣＡ）治疗特发性室性心动过速（ＩＶＴ）１７例，根据ＩＶＴ发作时的体表心电图和心内标测的结果判定：ＩＶＴ的异位起搏点在左室间隔７例，右室１０例，其中在右室流出道９例，右室心尖部１例。成功靶点有效放电时间平均５．８秒，１例因手术时间较长血压下降而放弃ＲＦＣＡ，成功１６例中１周和１月内复发各１例，复发率１２．５％，均再次消融成功，余病人随访８～２４个月均无复发，以上结果表明ＲＦＣＡ是治疗ＩＶＴ安全有效的方法     

射频消隔房室旁路失败病例的原困分析

我院行射频消融（ＲＦＣＡ）治疗房室折返性心动过速（ＡＶＲＴ）６例，房室旁路（Ａｐ）共６９条，首次消融成功６５条，另４条旁路，再次消融全部获得成功。本文对４条旁路ＲＦＣＡ首次失败及再次成功的特点进行了初步分析，总结如下：１资料与方法６６例ＡＶＲＴ患者中...     

射频消融术治疗心动过速10例分析

目的：对１０例心动过速病人射频消融术（ＲＦＣＡ）进行分析。方法：全部病人行心内电生理检查,准确找到靶点后行ＲＦＣＡ。结果：诊断室速（ＶＴ）２例,房室结折返心动过速（ＡＶＮＲＴ）２例,右侧旁路（ＲＡＰ）１例,左侧旁路（ＬＡＰ）５例。７例消融成功无复发,１例ＬＡＰ术后３月复发,２例ＶＴ不成功,但长期随访比术前状况改善,随访７月所有病人均无并发症发生,效果良好,结论：准确靶点定位和导管操作技巧是ＲＦＣＡ     

持续性交界区反复性心动过速2例的电生理特征及射频消融

报告２例持续性交界区反复性心动过速（ＰＪＲＴ）患者的心腔内电生理检查及射频消融结果。２例均有反复发作的心动过速病史。服用多种抗心律失常药物无效。心动过速发作时的电图１例ＲＰ’＞Ｐ’Ｒ１例ＲＰ’＜Ｐ’Ｒ。心腔内电生理检查诊断为右后间隔旁道引起之房室折返性心动过速即ＰＪＲＴ。消融靶点ＣＳ＿（５６）（ＣＳ电极为６极）或ＣＳ＿（９、１０）（ＣＳ电极为１０极）处ＶＡ’不融合但最短且Ａ’最早，在此部位射频消融成功阻断旁道的逆传，术后随访３～４个月无阵发性室上性心动过速发作。     

室上性心动过速的临床电生理分析

本文对９７例室上性心动过速（ＳＶＴ）患者的食管心房调搏结果分析发现：国人房室旁道折返ＳＶＴ（ＡＶＲＴ）多于房室结折返性ＳＶＴ（ＡＶＮＲＴ）；约２／３旁道位于左游离壁（ＬＦＷ），１／３位于间隔及右游离壁；房室结可存在双径路（ＤＡＶＮＰ）或多条径路；ＡＶＲＴ的Ｐ′明显，Ｒ—Ｐ′≥７０ｍｓ，ＡＶＮＲＴ多无Ｐ′、Ｒ—Ｐ′＜７０ｍｓ；Ｐ′和Ｒ—Ｐ′对ＡＶＲＴ和ＡＶＮＲＴ手术前后符合率为１００％。提示：食管心房调搏检查可初步明确ＳＶＴ发生机制，对ＳＶＴ的诊断、治疗及预后估计具有重要价值。     

射频消融治疗阵发性室上性心动过速36例临床分析

自１９９７年７月～１９９９年２月,我们采用射频导管消融（ＲＦＣＡ）治疗阵发性室上性心动过速（ＰＳＶＴ）３６例,效果满意,报告如下。 １资料与方法 １．１病例选择：患者３６例,均为常规口服抗心律失常药物未能预防发作或不能坚持药物治疗者。男２０例,女１６例;年龄９～６１岁,平均４１．７±９．３岁;发病时间０．５～２５年。其中房室折返性心动过速（ＡＶＲＴ）２６例,房室结折返性心动过速（ＡＶＮＲＴ）１０例。合并先心病２例,高心病１例,冠心病１例。射频消融前均停用抗心律失常药物至少５个半衰期。 １．２心内电…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.