口腔扁平苔藓的临床治疗

口腔扁平苔藓(oral lichen planus，OLP)是发生于口腔黏膜的一种常见的慢性炎性免疫反应性疾病，其发病率为0．5％～2％，半数以上患有局部自发痛、粗糙不适等临床症状，极少数有癌变可能。1972年WHO将OLP定为癌前状态，因此，对OLP的治疗越来越备受关注。该病病因及发病机制至今尚不十分清楚，可能为多因素影响所致。目前，     

口腔扁平苔藓局部治疗进展

口腔扁平苔藓(OLP)是一种口腔黏膜慢性炎症性疾病,常表现为口腔黏膜对称性的白纹、丘疹、斑片或疱。因其病因复杂且尚不明确,故临床上仅以控制其病情、减少患者症状为主要目的,局部应用糖皮质激素仍是治疗OLP的主要方法。然而,为获得更理想、更安全的治疗效果,近些年一些新的、替代的局部治疗方法已被越来越广泛探索并应用。     

口腔扁平苔藓治疗近况

口腔扁平苔藓治疗近况李言君惠敏梅香（附属医院口腔内科，滨州市２５６６０３）口腔扁平苔藓（ｏｒａｌｌｉｃｈｅｎｐｌａｎｕｓ简称ＯＬＰ）是口腔粘膜慢性、表浅性、非感染性炎症损害，在口腔粘膜病中发病率较高，目前该病的病因还不十分清楚。它对粘膜的损害形态多种...     

中西药治疗口腔扁平苔藓的临床观察

目的观察中医辨证治疗和西药治疗口腔扁平苔藓(OLP)临床疗效.方法中医辨证分型以滋阴清热,理气活血祛瘀.西药用具有免疫抑制并具有抗组织胺,抑制血管渗透性亢进的磷酸氯喹治疗.结果中医辨证分型治疗口腔扁平苔癣,疗效确切.在中药对口腔扁平苔藓患者进行治疗中,疗效高于服用磷酸氯喹的对照组,两者之间的疗效有明显差异.结论中医辨证分型治疗OLP值得推广.     

75例口腔扁平苔藓临床治疗研究

目的对口腔扁平苔藓临床治疗进行研究。方法 2007年2月至2010年2月期间在我院共治疗75例OLP患者,治疗方案为初诊时先用曲安奈德,病情控制后,给予磷酸氯喹口服。结果 75例患者经第1个疗程治疗痊愈或显效65例,占88.67%,经第2个疗程治疗后痊愈或显效71例,占94.67%。结论磷酸氯喹可迅速有效地控制口腔扁平苔藓症状,改善病情,值得在临床合理应用。     

治疗口腔扁平苔藓的新方法

作者13年来治疗口腔扁平苔藓73例。用过多种方法,疗效不够理想,1990年后采用确炎舒松(Triamciolone Acetonide)粘膜下点注配合去霉综合疗法,特别是9例伴有粘膜糜烂的患者,7例治愈,2例好转,疗效满意。文中对过去疗法作了回顾,并对有关问题加以讨论。     

中西医结合治疗口腔扁平苔藓

将108例口腔扁平苔藓分3组治疗，并对其近，远期疗效进行分析。结果表明：单纯的西药和中药对口腔扁平苔藓均有效，但中西医结合治疗可产生协同作用，在短期内达到比单纯中药治疗明确优良的疗效，克服了单纯西药治疗停药后易复发的缺点。     

口腔扁平苔藓72例临床研究

采用复方苔藓片和昆明山海棠对72例口腔扁平苔藓（OLP）进行治疗，并用去除口腔局部刺激因素加以对照观察疗效。结果表明，复方苔藓片治疗OLP有效率为84．37％，而昆明山海棠的有效率为61．54％，两者有显著性差异（P＜0．05）。作者认为除药物治疗外，去除口腔局部刺激因素是治疗OLP重要的一环，它能使OLP得到客观积极的改善，从而缩短疗程。     

中医规范化治疗口腔扁平苔藓159例

目的观察中医规范化治疗口腔扁平苔藓（OLP）的临床疗效。方法将282例OLP患者中医辨证分为5型,随机分为治疗组与对照组,治疗组予中医辨证治疗及康复新液含漱,对照组予雷公藤多甙片口服及地塞米松局部涂擦,记录治疗前后的中医证候评分及局部体征、安全性指标各项数值,评价疗效。结果治疗组总有效率86.16%,高于对照组57.72%（P〈0.01）;对照组治疗后白细胞数降低、血尿素氮升高,与治疗前比较有统计学意义（P〈0.05）,与治疗组治疗后比较,有统计学意义（P〈0.01）;随访1年后,治疗组复发率7.55%,低于对照组60.16%（P〈0.01）。结论中医规范化治疗口腔扁平苔藓,能通过调节和控制OLP免疫反应达到治疗效果,且安全性高、复发率低。     

糖皮质激素治疗口腔黏膜扁平苔藓40例临床体会

目的:探讨糖皮质激素治疗口腔黏膜扁平苔藓的临床效果。方法:选取收治的80例口腔黏膜扁平苔藓患者的临床资料,患者分为对照组(n=40)和观察组(n=40),1个疗程结束后,比较两组患者的疗效差异。结果:观察组患者,经糖皮质激素地塞米松磷酸钠注射液治疗,总有效率为92.5%,对照组总有效率为65.0%,两组比较,差异具有统计学意义(P<0.05)。两组患者治疗后的TNF-ɑ、IL-6、IL-8水平,与治疗前比较,明显降低,差异具有统计学意义(P<0.05)。观察组治疗后的TNF-ɑ、IL-6、IL-8水平,与对照组治疗后比较,明显降低,差异具有统计学意义(P<0.05)。结论:糖皮质激素地塞米松磷酸钠注射液治疗口腔黏膜扁平苔藓的临床效果确切,值得推广应用。     

扁平苔藓药物治疗进展

扁平苔藓(lichen planus,LP)是慢性或亚急性炎症性疾病,病因未明,治疗较困难。现在有多种药物用于治疗LP,除类固醇激素、维甲酸类、免疫抑制剂等常用药物外,还有柳氮磺吡啶、左旋咪唑、生物制剂等药物。文中就近年来治疗LP的药物研究进展做一综述,为正确治疗LP提供药物信息和指导。     

他克莫司与曲安奈德治疗口腔扁平苔癣的临床研究

目的 探讨局部外用他克莫司膏与曲安奈德对口腔扁平苔藓(OLP)的临床疗效。方法 选取2019年6月至2019年12月于安徽医科大学第一附属医院口腔科就诊的60例OLP患者作为研究对象,按随机数字表法分为他克莫司组、曲安奈德组与对照组,每组20例。他克莫司组、曲安奈德组在接受规范治疗基础上分别局部外用0.1%他克莫司及0.1%曲安奈德软膏治疗6周,观察疗效及不良反应,停药4周后观察复发率。结果 他克莫司组患者总有效率为90.00%,曲安奈德组患者有效率为55.00%,对照组患者有效率为10.00%,3组患者疗效比较,差异具有统计学意义(P<0.001)。他克莫司组、曲安奈德组患者的无效率均低于对照组,且他克莫司组的无效率低于曲安奈德组,差异有统计学意义(P''< 0.0167)。治疗期间,他克莫司组1例患者,曲安奈德组2例患者出现不良反应,停药4周后,他克莫司组1例复发,曲安奈德组2例复发,两组不良反应发生率和复发率差异无统计学意义(P>0.05)。结论 他克莫司较曲安奈德对OLP患者口腔黏膜有更好的治疗效果。     

Oral lichen planus. Clinical aspects and management in fifty-two Brazilian patients

This study aimed to characterize the clinical profile of patients with oral lichen planus (OLP) and to evaluate the efficacy of topical, systemic and/or intralesional corticosteroids in the management of symptomatic cases. Fifty-two patients with OLP, 33 females and 19 males, aged from 17 to 75 years (mean 49.7 years) were studied. Information regarding the clinical forms, sites of involvement, patients' medical history and habits were recorded. Diagnosis of OLP was made using clinical criteria alone in 32 cases, while biopsy examination was required in the remaining 20. Symptomatic lesions were seen in 29 patients, who were treated with corticosteroid. Asymptomatic cases (23) were only clinically monitored. The forms of OLP found in this study were reticular (47%), atrophic (24%), erosive (21%) and plaque-like (8%). The buccal mucosa was the site predominantly affected. Systemic diseases were found in 17 patients (seven diabetic and ten with hypertension) but these data lacked statistical significance (p > 0.05) when compared with a control group of age and gender matched patients without any type of mucocutaneous disease. A habit of tobacco and/or alcohol use was reported by 11.5% of the patients, most of them with the reticular form of the disease. Topical corticosteroid therapy alone was effective in producing relief of symptoms in 18 of the 29 patients, although some relapses occurred after discontinuation. For lesions non-responsive to topical treatment, intralesional injection and/or short-term use of systemic corticosteroids were used.     

Oral lichen planus. Clinical aspects and management in fifty-two Brazilian patients

This study aimed to characterize the clinical profile of patients with oral lichen planus (OLP) and to evaluate the efficacy of topical, systemic and/or intralesional corticosteroids in the management of symptomatic cases. Fifty-two patients with OLP, 33 females and 19 males, aged from 17 to 75 years (mean 49.7 years) were studied. Information regarding the clinical forms, sites of involvement, patients' medical history and habits were recorded. Diagnosis of OLP was made using clinical criteria alone in 32 cases, while biopsy examination was required in the remaining 20. Symptomatic lesions were seen in 29 patients, who were treated with corticosteroid. Asymptomatic cases (23) were only clinically monitored. The forms of OLP found in this study were reticular (47%), atrophic (24%), erosive (21%) and plaque-like (8%). The buccal mucosa was the site predominantly affected. Systemic diseases were found in 17 patients (seven diabetic and ten with hypertension) but these data lacked statistical significance (p > 0.05) when compared with a control group of age and gender matched patients without any type of mucocutaneous disease. A habit of tobacco and/or alcohol use was reported by 11.5% of the patients, most of them with the reticular form of the disease. Topical corticosteroid therapy alone was effective in producing relief of symptoms in 18 of the 29 patients, although some relapses occurred after discontinuation. For lesions non-responsive to topical treatment, intralesional injection and/or short-term use of systemic corticosteroids were used.