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1.
Hematopoietic bone marrow in the adult knee: spin-echo and opposed-phase gradient-echo MR imaging 总被引:1,自引:0,他引:1
Ph. Lang M.D. R. Fritz M.D. S. Majumdar Ph.D. M. Vahlensieck M.D. C. Peterfy M.D. Ph.D. Harry K. Genant M.D. 《Skeletal radiology》1993,22(2):95-103
Hematopoietic bone marrow in the distal femur of the adult may be mistaken for a pathologic marrow process in magnetic resonance imaging of the knee. We investigated the incidence of hematopoietic marrow in the distal femur in a series of 51 adult patients and compared spin-echo (TR/TE in ms: 500/35, 2000/80) and opposed-phase gradient-echo (0.35 T, TR/TE in ms: 1000/30, = 75°) magnetic resonance images. Zones with intermediate to low signal intensity on T1-weighted spinecho and opposed-phase gradient-echo sequences representing hematopoietic marrow within high signal intensity fatty marrow were observed in 18 of the 51 patients. Five patterns of marrow signal reduction were identified; type 0: uniform high signal, i.e., no signal change; type I, focal signal loss; type II, multifocal signal loss without confluence; type III, confluent signal loss; and type IV, complete homogeneous reduction in marrow signal. Opposed-phase gradient-echo sequences demonstrated markedly greater red-yellow marrow contrast than conventional spin-echo sequences. Follow-up studies in three patients using a gradient-echo sequence with TE varying from 10 to 21 ms at 1-ms increments showed a cyclic increase and decrease in red and yellow marrow signal intensity depending on the TE. The contribution of intravoxel chemical shift effects on red-yellow marrow contrast in opposed-phase gradient-echo images was verified by almost complete cancellation of the TE-dependent marrow signal oscillation with use of a chemically selective pulse presaturating the water protons.Hematopoietic marrow in the adult distal femur in the absence of hematologic abnormalities is found primarily in women of menstruating age. It may be residual and may represent a biologic variation in the normal adult pattern of red-yellow marrow distribution. Reconverted red marrow appears to be related to increased erythrocyte demand. Residual and reconverted red marrow should not be mistaken for bone marrow malignancy. Opposed-phase gradient-echo imaging is easily implemented and appears ideally suited to monitor the distribution of hematopoietic marrow as a function of age and erythrocyte demand in vivo. 相似文献
2.
Signal intensity for opposed-phase gradient-echo (GE) sequences of tissues composed of fat- and water-equivalent cells such
as red bone marrow is extremely sensitive to variation of the ratio of both cell populations (fat-to-water ratio QF/W). Because most bone marrow pathology results in variation of QF/W, GE sequences are characterized by high-contrast imaging of pathology. The aim of this study was to evaluate the influence
of TR, TE, FA, QF/W and histology on signal intensity. Signal intensity of opposed-phase GE sequences as a function of TR, TE, FA, and QF/W was measured for a fat-water phantom and cadaver specimens of normal bone marrow (red and yellow) and pathological bone marrow
(tumors). All specimens were correlated to histology. Opposed-phase GE imaging of red bone marrow pathology results in low-signal-intensity
imaging of intact red bone marrow and high-signal-intensity positive contrast imaging of pathology associated with a change
in QF/W. In first-order approximation the signal intensity of pathology is linearly correlated to the change in QF/W. Opposed-phase GE imaging is a sensitive imaging technique for red bone marrow pathology. Relative contrast of red bone marrow
pathology is similar to fat-suppressed imaging techniques. Acquisition time is identical to T1-weighted SE sequences.
Received: 23 May 1997; Revision received: 3 March 1998; Accepted: 31 July 1998 相似文献
3.
Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomas 总被引:3,自引:2,他引:1
Metz S Lohr S Settles M Beer A Woertler K Rummeny EJ Daldrup-Link HE 《European radiology》2006,16(3):598-607
To quantify permeability changes of the “blood–bone marrow barrier” (BMB) and to detect malignant bone marrow infiltrations
before and after conditioning therapy for subsequent leukapheresis using ferumoxtran-10-enhanced magnetic resonance (MR) imaging.
Twenty-two patients with malignant non-Hodgkin lymphomas (NHL), including 9 patients (group A) before and 13 patients (group
B) after conditioning therapy, underwent MR of the spine before and after infusion of ferumoxtran-10 (0.045 mmol Fe/kg BW).
Pulse sequences comprised dynamic T1-GE and pre- and post-contrast T1-SE and STIR sequences. Dynamic ΔSI-data were correlated
with the quantity of mobilized CD34+ cells. In addition, the number of focal bone marrow lesions was compared before and after
ferumoxtran-10 administration. Dynamic ΔSI-data were higher in group B than in group A, indicating an increased BMB permeability
after conditioning therapy. However, ΔSI-data did not correlate with the quantity of mobilized CD34+ cells. Ferumoxtran-10-enhanced
STIR images demonstrated a significant signal decline of the normal, non-neoplastic bone marrow and a significantly increased
detection of focal neoplastic lesions compared to pre-contrast images (P<0.05). Ferumoxtran-10 depicted the bone marrow response to conditioning therapy by an increase in BMB-permeability, which,
however, did not correlate with the number of mobilized CD34+ cells. Ferumoxtran-10 improved the detection of focal bone marrow
lesions significantly (P<0.05). 相似文献
4.
Rumpel H Chan LL Chan LP Png MA Tan RK Lim WE 《Journal of magnetic resonance imaging : JMRI》2006,23(4):574-577
PURPOSE: To ascertain the suitability of vertebrae adjacent to spinal bone lesions as a signal intensity reference on MRI, and compare the MR spectroscopic appearance of vertebral body compression fractures due to malignant tumor infiltration, bone weakening (e.g., osteoporosis), and/or minor trauma. MATERIALS AND METHODS: Twenty-five patients with spinal compression fractures underwent routine spinal MRI with an additional 1H MRS study protocol to assess the percent fat fraction of the compressed vertebrae as well as the adjacent bony environment. Peak areas for water and total lipid were calculated from short-TE single-voxel 1H MR spectra using the LCModel analyzing tool. RESULTS: There were consistent water-only patterns in the fractured vertebra suggesting either near complete marrow replacement by malignant tissue or local edematous fluid/hemorrhage within the marrow spaces. However, the adjacent vertebrae showed a wide range of patterns from a dominant lipid signal to the inverse of a pronounced water level. These results far exceed the normal variation expected based on age and sex. CONCLUSION: The results suggest that the adjacent vertebrae may not be an accurate reference, especially in diffusion-weighted imaging (DWI), because of the large difference between the two compartments. Furthermore, in the case of gradient-echo measurements, the in-phase vs. opposed-phase effects are significant. 相似文献
5.
Plecha DM 《Seminars in musculoskeletal radiology》2000,4(3):321-327
Bone marrow imaging has been greatly advanced with magnetic resonance (MR) imaging. Bone marrow contains fat and nonfat cells, which makes imaging with MR imaging the modality of choice, particularly within the spine. Any alteration within the marrow makeup is usually well seen with different MR imaging sequences. Conventional spin-echo sequences are helpful because of their great signal-to-noise ratio, and anatomic detail. Other, newer sequences--such as short T1 inversion recovery (STIR), diffusion weighted, fat suppression techniques; as well as in- and opposed-phase images--may also help to increase detection of or characterize certain diseases of the bone marrow within the spine. This article deals with the different imaging sequences available to radiologists when imaging the spinal bone marrow. 相似文献
6.
Yoshimitsu K Irie H Tajima T Nishie A Asayama Y Hirakawa M Nakayama T Kakihara D Honda H 《Radiation Medicine》2004,22(6):371-376
Chemical shift gradient-echo MR imaging (CSI) can detect a small amount of fat as signal loss on opposed-phase images as compared with in-phase images. Cytoplasmic fat in clear cell renal cell carcinoma (RCC) or interstitial histiocytic fat in papillary cell RCC can be successfully demonstrated by this technique. T2*-weighted gradient-echo or echo-planar MR imaging can detect local susceptibility, for example, due to cytoplasmic or interstitial histiocytic hemosiderin deposition in papillary cell RCC. CSI can also show this focal susceptibility as excessive signal loss on in-phase images as compared with opposed-phase images. MR imaging can thus help predict the cell types (clear cell and papillary cell) of RCC. These findings may be important in the decision-making process in the management of patients with suspected RCC, particularly those who are not indicated for radical surgery. 相似文献
7.
The aim of this study was to differentiate normal, hypercellular, and neoplastic bone marrow based on its MR enhancement after intravenous administration of superparamagnetic iron oxides in patients with cancer of the hematopoietic system. Eighteen patients with cancer of the hematopoietic system underwent MRI of the spine before and after infusion of ferumoxides ( n=9) and ferumoxtran ( n=9) using T1- and T2-weighted turbo spin-echo (TSE) and short tau inversion recovery sequences (STIR). In all patients diffuse or multifocal bone marrow infiltration was suspected, based on iliac crest biopsy and imaging such as conventional radiographs, MRI, and positron emission tomography. In addition, all patients had a therapy-induced normocellular ( n=7) or hypercellular ( n=11) reconversion of the normal non-neoplastic bone marrow. The MRI data were analyzed by measuring pre- and post-contrast signal intensities (SI) of hematopoietic and neoplastic marrow and by calculating the enhancement as deltaSI(%) data and the tumor-to-bone-marrow contrast as contrast-to-noise ratios (CNR). Changes in bone marrow signal intensity after iron oxide administration were more pronounced on STIR images as compared with T1- and T2-weighted TSE images. The STIR images showed a strong signal decline of normal and hypercellular marrow 45-60 min after iron oxide infusion, but no or only a minor signal decline of neoplastic bone marrow lesions; thus, deltaSI% data were significantly higher in normal and hypercellular reconverted marrow compared with neoplastic bone marrow lesions ( p<0.05). Additionally, the contrast between focal or multifocal neoplastic bone marrow infiltration and normal bone marrow, quantified by CNR data, increased significantly on post-contrast STIR images compared with precontrast images ( p<0.05). Superparamagnetic iron oxides are taken up by normal and hypercellular reconverted bone marrow, but not by neoplastic bone marrow lesions, thereby providing significantly different enhancement patterns on T2-weighted MR images; thus, superparamagnetic iron oxides are useful to differentiate normal and neoplastic bone marrow and to increase the bone marrow-to-tumor contrast. 相似文献
8.
Zampa V Carafoli D Grassi L Cosottini M Trippi D Ortori S Bagnolesi P 《La Radiologia medica》2000,99(1-2):31-35
PURPOSE: To investigate the usefulness of opposed-phase gradient-echo (GRE) technique in detecting occult posttraumatic bone injuries in the knee. Occult injuries account for pain and, if not properly treated, may progress to severe chondral and bone damage. An early diagnosis provided by MRI can help avoid interventional procedures. MATERIAL AND METHODS: We submitted to MRI of the knee 51 patients (32 men and 19 women) with negative plain radiographic findings and at least one traumatic bone injury at MRI. MR examinations were performed with a 0.5 T unit and included a conventional SE or GRE T1-weighted sequence and an opposed phase GRE sequence on the coronal or sagittal plane (2-3 minutes acquisition). To assess the lesion number and conspicuity, images were retrospectively reviewed by two readers. Injury conspicuity was graded as: 0 (poorly visible), 1 (visible), and 2 (well visible). Marrow-to-injury signal intensity ratio was calculated in 30 patients: a ROI was positioned in the site of highest signal intensity and adjacent bone marrow and the ratio analyzed with Student's "t"-test. RESULTS: In-phase and out-of-phase images showed 71 injuries in 51 patients. Conventional (in-phase) imaging missed 6/71 lesions. Injury conspicuity on out-of-phase images was of grade 2 in 58 cases (81.6%) and of grade 1 in 13 cases (18.3%), versus 23 (32.3%) and 42 (59.1%), respectively, on conventional images. Injury conspicuity was graded as 0 in 6 cases (8.4%) on conventional images. Quantitative analysis of marrow-to-injury signal intensity ratio showed higher values for out-of-phase GRE than conventional images. CONCLUSION: Opposed-phase GRE are quick sequences available on all MR systems which appear superior to conventional T1-weighted images in detecting occult injuries in the knee. Injuries are more conspicuous because their signal intensity is lower due to the simultaneous presence of fat and water protons, which is typical of bone trauma, GRE sequences make a useful and rapid complement to T1-/T2-weighted fat saturation acquisitions in the study of the post-traumatic knee. 相似文献
9.
The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine 总被引:4,自引:0,他引:4
BACKGROUND AND PURPOSE: Benign and malignant fractures of the spine may have similar signal intensity characteristics on conventional MR imaging sequences. This study assesses whether in-phase/opposed-phase imaging of the spine can differentiate these 2 entities. METHODS: Twenty-five consecutive patients who were evaluated for suspected malignancy (lymphoma [4 patients], breast cancer [3], multiple myeloma [2], melanoma [2], prostate [2], and renal cell carcinoma [1]) or for trauma to the thoracic or lumbar spine were entered into this study. An 18-month clinical follow-up was performed. Patients underwent standard MR imaging with an additional sagittal in-phase (repetition time [TR], 90-185; echo time [TE], 2.4 or 6.5; flip angle, 90 degrees ) and opposed-phase gradient recalled-echo sequence (TR, 90-185, TE, 4.6-4.7, flip angle, 90 degrees ). Areas that were of abnormal signal intensity on the T1 and T2 sequences were identified on the in-phase/opposed-phase sequences. An elliptical region of interest measurement of the signal intensity was made on the abnormal region on the in-phase as well as on the opposed-phase images. A computation of the signal intensity ratio (SIR) in the abnormal marrow on the opposed-phase to signal intensity measured on the in-phase images was made. RESULTS: Twenty-one patients had 49 vertebral lesions, consisting of 20 malignant and 29 benign fractures. There was a significant difference (P < .001, Student t test) in the mean SIR for the benign lesions (mean, 0.58; SD, 0.02) compared with the malignant lesions (mean, 0.98; SD, 0.095). If a SIR of 0.80 as a cutoff is chosen, with >0.8 defined as malignant and <0.8 defined as a benign result, in-phase/opposed-phase imaging correctly identified 19 of 20 malignant lesions and 26 of 29 benign lesions (sensitivity, 0.95; specificity, 0.89). CONCLUSION: There is significant difference in signal intensity between benign compression fractures and malignancy on in-phase/opposed-phase MR imaging. 相似文献
10.
Bruno C. Vande Berg Jacques Malghem Frederic E. Lecouvet Baudouin Maldague 《Skeletal radiology》1998,27(10):529-545
A logical approach to bone marrow alterations is proposed that takes into account the high sensitivity and specificity of
MR imaging for the detection of marrow fat. Marrow signal intensity on T1-weighted images is assumed to reflect the balance
between fat and nonfat marrow components. Elementary patterns of marrow change include marrow depletion, infiltration, replacement
and signal void. These patterns can be observed alone or in combination, and can be distributed in a focal or diffuse manner.
Marrow depletion pattern shows high signal intensity reflecting increase in fat content and is frequently irrelevant clinically.
Signal intensity is decreased in marrow infiltration, replacement and signal void patterns, which indicates partial or complete
disappearance of fat. Focal marrow infiltration is frequently reactive to an adjacent abnormality, whereas focal marrow replacement
more frequently indicates a more profound marrow alteration. The T1-weighted spin-echo sequence is satisfactory for lesion
detection by virtue of its relatively high sensitivity in the detection of alterated fat/nonfat marrow balance. T2-weighted
sequences with saturation of the signal of fat protons or out-of-phase gradient-echo sequences improve lesion conspicuity
in all situations in which the difference in fat/nonfat marrow balance between the abnormal area and the adjacent normal marrow
is reduced. 相似文献
11.
Nondysplastic nodules that are hyperintense on T1-weighted gradient-echo MR imaging: frequency in cirrhotic patients undergoing transplantation 总被引:2,自引:0,他引:2
OBJECTIVE: Our objective was to determine the frequency and MR imaging findings of nondysplastic nodules that are hyperintense on T1-weighted gradient-echo imaging in patients with cirrhosis who undergo liver transplantation. MATERIALS AND METHODS: Two observers retrospectively evaluated in-phase (4-5 msec), opposed-phase gradient-echo (2.0-2.4 msec), and turbo short tau inversion recovery (STIR) MR images in 68 patients with cirrhosis--but without dysplastic nodules or hepatocellular carcinoma--who underwent MR imaging at 1.5 T within 150 days before liver transplantation. The size, number, signal characteristics, and arterial enhancement pattern of nodules that appear hyperintense on T1-weighted gradient-echo images were evaluated as well as the presence or absence of signal loss on opposed-phase imaging. These imaging findings were correlated with pathologic findings of whole explanted livers. RESULTS: Eleven (16%) of 68 patients had at least one nondysplastic nodule that was hyperintense on T1-weighted MR imaging. Three patients had diffuse nondysplastic hyperintense nodules (>10 nodules) measuring less than 0.5 cm, and the remaining eight patients had 22 nondysplastic hyperintense nodules ranging in size from 0.5 to 2.5 cm (mean, 1.2 cm), of which 13 were isointense and nine were hypointense on turbo STIR images. No lesion lost signal on opposed-phase imaging or enhanced during the hepatic arterial phase. CONCLUSION: In cirrhotic patients undergoing liver transplantation, nondysplastic nodules that are hyperintense are common findings on T1-weighted gradient-echo MR imaging and do not lose signal intensity on opposed-phase imaging or enhance during the hepatic arterial phase. These nodules may be indistinguishable from dysplastic nodules. 相似文献
12.
Diagnosis of marrow disorders of the foot and ankle is among the more challenging aspects of MR interpretation. Evaluation of normal and abnormal bone marrow with regard to pattern, distribution, and signal characteristics on different sequences often allows a specific diagnosis. This pictorial review illustrates MR imaging findings of normal variants of bone marrow of the foot and ankle, and the varied responses of bone marrow to trauma, stress, or disease. 相似文献
13.
Sugihara E Murakami T Kim T Hori M Takamura M Kawata S Okada A Khankan AA Tomoda K Nakamura H 《Journal of computer assisted tomography》2003,27(2):110-116
PURPOSE: The technique of double-phase echo chemical shift gradient-echo magnetic resonance (MR) imaging with the fast low-angle shot sequence (double-echo FLASH) provides in-phase and opposed-phase (double-phase) images simultaneously. The purpose of this study was to assess whether the dynamic study with a combination of in-phase and opposed-phase (double-phase) echo images improves the detectability of hypervascular hepatocellular carcinoma (HCC) compared with that with either in-phase or opposed-phase images alone. METHOD: Thirty-seven patients with 107 hypervascular HCCs who underwent the whole-liver double-phase echo dynamic MR imaging were enrolled in the study. Three radiologists blindly read in-phase images alone, opposed-phase images alone, and then double-phase images together. Sensitivity and positive predictive values as well as the areas below the alternative-free response receiver operating characteristic curve (Az values) for each imaging technique were calculated and compared statistically. RESULTS: The mean sensitivity, positive predictive values, and Az values for hypervascular HCCs were 51%, 77%, and 0.52 for in-phase imaging; 55%, 86%, and 0.58 for opposed-phase imaging; and 57%, 84%, and 0.63 for double-phase imaging, respectively. The mean sensitivity for opposed-phase imaging was significantly higher than that for in-phase imaging (P < 0.05), and the mean sensitivity for double-phase imaging was higher than that for in-phase imaging (P < 0.01). The mean Az value for the double-phase imaging was significantly higher than that for in-phase imaging (P < 0.01). CONCLUSION: Dynamic MR imaging with double-phase images was recommended for the detection of hypervascular HCC. 相似文献
14.
Altehoefer C Bertz H Ghanem NA Langer M 《Journal of magnetic resonance imaging : JMRI》2001,14(2):141-146
The aim of this study was to assess the time course and extent of signal alterations of red bone marrow after short-term stimulation by recombinant human granulocyte-colony stimulating factor (rHuG-CSF) in healthy peripheral blood stem cell donors using magnetic resonance imaging (MRI) at low-field strength. Twelve healthy blood stem cell donors without evidence of bone marrow disorders were prospectively investigated and underwent four MRI studies of their lumbar spine. Sagittal T1- and T2-weighted spin-echo sequences and a gradient-echo (GE) sequence with an echo time for out-of-phase imaging were performed prior to rHuG-CSF application (baseline MRI), on the day of first stem cell harvest (after 70 microg/kg body weight rHuG-CSF, second MRI) followed by two studies 9-18 days (median 14.5 days, third MRI) and 26-48 days (median 39.5 days, fourth MRI) after discontinuation of rHuG-CSF application. Baseline MRI showed normal marrow signal in all patients. The second MRI revealed a decrease of quantified bone marrow signal relative to nucleus pulposus in T1- and T2-weighted images and an increase of relative signal in out-of-phase GE sequences. The greatest changes of relative marrow signal were observed at the third MRI. Compared to baseline MRI, relative marrow signal was diminished by 12% in T1-weighted images and increased by 59% in GE sequences, consistent with a rise in marrow cellularity simulating diffuse marrow disease. At the fourth MRI quantified relative marrow signal returned to baseline levels in all sequences. In healthy individuals rHuG-CSF application leads to significant signal changes of bone marrow in lumbar vertebra that are maximal about 2 weeks after discontinuation of rHuG-CSF application. In patients with underlying marrow disorders who receive hematopoietic growth factors during treatment, these changes should not be confused with disease progression. 相似文献
15.
P. Soyer Y. Rondeau A.-C. Dufresne L. Spelle E. Somveille A. Scherrer R. Rymer 《European radiology》1997,7(7):1048-1053
The goal of our prospective study was to compare quantitatively and qualitatively in-phase and opposed-phase T1-weighted
breath-hold spoiled gradient-recalled-echo (GRE) MR imaging technique for imaging focal hepatic lesion. Thirty-eight patients
with 53 focal hepatic lesions had in-phase (TR = 12.3 ms, TE = 4.2 ms) and opposed-phase (TR = 10.1 ms, TE = 1.9 ms) GRE (flip
angle = 30°, bandwidth ± 32 kHz, matrix size 256 × 128, one signal average) MR imaging at 1.5 T. Images were analyzed quantitatively
by measuring the lesion-to-liver contrast and for lesion detection. In addition, images were reviewed qualitatively for lesion
conspicuity. Quantitatively, lesion-to-liver contrast obtained with in-phase (3.22 ± 1.86) and opposed-phase pulse sequence
(3.72 ± 2.32) were not statistically different (Student's t-test). No difference in sensitivity was found between in-phase and opposed-phase pulse sequence (31 of 53, sensitivity 58
% vs 30 of 53, sensitivity 57 %, respectively). Two lesions not seen with opposed-phase imaging were detected with in-phase
imaging. Conversely, one lesion not seen on in-phase imaging was detected on opposed-phase imaging so that the combination
of in-phase and opposed-phase imaging yielded detection of 32 of 53 lesions (sensitivity 60 %). Qualitatively, lesion conspicuity
was similar with both techniques. However, in-phase images showed better lesion conspicuity than opposed-phase images in 9
cases, and opposed-phase images showed better lesion conspicuity than in-phase images in 7 cases. No definite advantage (at
a significant level) emerged between in-phase and opposed-phase spoiled GRE imaging. Because differences in lesion conspicuity
and lesion detection may be observed with the two techniques in individual cases, MR evaluation of patients with focal hepatic
lesion should include both in-phase and opposed-phase spoiled GRE imaging.
Received 30 October 1996; Revision received 6 January 1997; Accepted 8 January 1997 相似文献
16.
Fritz Schick Hermann Einsele Renate Kost Stephan Duda Wulf-Ingo Jung Otto Lutz Claus D. Claussen 《Journal of magnetic resonance imaging : JMRI》1994,4(1):71-78
Magnetic resonance (MR) studies were performed in 14 patients as early as possible (21–110 days) after bone marrow transplantation (BMT). MR characteristics of lumbar vertebral bone marrow were studied with T1-weighted spin-echo imaging, water- and fatselective imaging with a frequency-selective excitation technique, and point-resolved spatially localized proton spectroscopy. Signals from water and fat protons and their T1 and T2 values were analyzed. Water proton signal intensity correlated well with cellularity within bone marrow, as determined with parallel iliac crest biopsies. The fraction of signal from water in red bone marrow of patients with allogeneic transplants from siblings (four cases) was significantly higher than in four patients with autologous transplants. The latter showed very low cellularity in the period of about 4 weeks after BMT because of the cytotoxic pretreatment of the bone marrow. The MR results in six patients with allogeneic transplants from unrelated donors ranged widely, depending on the complications after BMT. Analysis of data obtained with the different techniques showed that water- and fat-selective MR imaging and spectroscopic methods are useful for noninvasive monitoring of hematopoietic reconstitution after BMT. 相似文献
17.
Herman M. Kroon M.D. Johan L. Bloem M.D. Herma C. Holscher M.D. Henk-Jan van der Woude M.D. Monique Reijnierse M.D. Anthoni H. M. Taminiau M.D. 《Skeletal radiology》1994,23(4):261-269
To evaluate the incidence, quantity, and presentation of intra- and extraosseous edema accompanying benign and malignant primary
bone lesions, the magnetic resonance (MR) studies of 63 consecutive patients with histologically proven primary bone tumors
were reviewed. MR scans were assessed for the presence and quantity of marrow and soft tissue edema and correlated with peroperative
findings, resected specimens and follow-up data. The signal intensity and enhancement of tumor and edema prior to and after
intravenous administration (if any) of gadolinium-labled diethylene triamine pentaacetate (Gd-DTPA) was analyzed. Marrow edema
was encountered adjacent to 8 of 39 malignant tumors and 14 of 24 benign lesions. Soft tissue edema was found accompanying
28 of 39 malignancies and 10 of 24 benign disorders. On unenhanced T1-weighted MR images tumor and edema were difficult to
differentiate. Tumor inhomogeneity made this differentiation easier on T2-weighted sequences. In 36 patients the contrast
medium Gd-DTPA was used. Edema was present in 27 of these patients and the respective enhancement of tumor and edema could
be compared. Edema always enhanced homogeneously, and in most cases it enhanced to a similar degree as or more than tumor.
Marrow and, more specifically, soft tissue edema is a frequent finding adjacent to primary bone tumors. The mere presence
and quantity of marrow and soft tissue edema are unreliable indicators of the biologic potential of a lesion. Unenhanced MR
scans cannot always differentiate between tumor and edema, but the administration of Gd-DTPA is of assistance in differentiating
tumor from edema. Awareness of marrow and/or soft tissue edema adjacent to bone lesions is of importance because edema can
be a pitfall in the diagnostic work-up and staging prior to biopsy or surgery. 相似文献
18.
PURPOSE: To retrospectively determine the relative accuracy of liver fat quantification with out-of-phase gradient-echo magnetic resonance (MR) imaging and fat-saturated fast spin-echo MR imaging in patients with and without cirrhosis, with histologic analysis as the reference standard. MATERIALS AND METHODS: Committee on Human Research approval was obtained. Patient consent was not required. Data collection ended before HIPAA regulations were implemented, but patient anonymity was maintained. Twenty-seven patients, 16 with cirrhosis, were retrospectively identified who underwent MR imaging before histopathologic evaluation of liver fat at biopsy or surgery. The patient population consisted of 15 male and 12 female patients (mean age, 55 years; range, 16-75 years). One radiologist blinded to the histopathologic results recorded mean signal intensity derived from three regions of interest placed in the right and left lobes of the liver on three sections and signal intensity of the spleen from one region of interest within the same section. Liver fat was quantified with the relative loss of signal intensity on out-of-phase images compared with that on in-phase T1-weighted gradient-echo images and with relative loss of signal intensity on T2-weighted fast spin-echo MR images obtained with fat saturation compared with those obtained without fat saturation. Hotelling t test was used to compare correlation coefficients between relative signal intensity differences and histopathologically determined percentage of fat. RESULTS: In patients without cirrhosis, liver fat quantification with fat-saturated fast spin-echo MR imaging was significantly better than it was with out-of-phase gradient-echo MR imaging (r = 0.92 vs 0.69, P < .01). In patients with cirrhosis, liver fat quantification was correlated only with fat-saturated fast spin-echo MR imaging (r = 0.76, P < .01); the relative signal intensity loss on out-of-phase gradient-echo MR images was not correlated with histopathologically determined percentage of fat (r = 0.25, P = .36). CONCLUSION: Preliminary results suggest liver fat may be more accurately quantified with fat-saturated fast spin-echo MR imaging than with out-of-phase gradient-echo MR imaging, especially in patients with cirrhosis. 相似文献
19.
Reichenbach JR Hopfe J Rauscher A Wurdinger S Kaiser WA 《Journal of magnetic resonance imaging : JMRI》2005,21(5):565-575
PURPOSE: To develop and to evaluate an advanced image acquisition and analysis method for collecting T(1)-weighted dynamic 3D MR mammography data sets by using a combined in-phase (IP) and opposed-phase (OP) imaging procedure. MATERIALS AND METHODS: 3D MR mammography data sets were acquired by applying an interleaved gradient-echo OP and IP imaging sequence during administration of contrast agent. A phantom data set, two volunteer breast data sets, and six patient breast data sets were recorded. Subtraction of dynamic in-phase magnitude images was performed for clinical assessment. In addition, the magnitude subtraction (SIPOP) as well as the complex subtraction (cSIPOP) of the IP and OP magnitude and phase images were considered. RESULTS: The detection of small lesions, lesion boundaries, and tumor offshoots in fatty tissue was improved by the subtraction of IP and OP images without the risk of signal cancellation due to partial volume effects. CONCLUSION: Dynamic MR mammography acquisition of IP and OP images in combination with appropriate data processing yields important supplementary information that can support routinely applied diagnostics of breast lesions that are fully embedded in fatty tissue by only marginally increasing acquisition time. 相似文献
20.
Ultrasmall superparamagnetic iron-oxide-enhanced MR imaging of normal bone marrow in rodents: original research original research 总被引:1,自引:0,他引:1
Simon GH Raatschen HJ Wendland MF von Vopelius-Feldt J Fu Y Chen MH Daldrup-Link HE 《Academic radiology》2005,12(9):1190-1197
RATIONALE AND OBJECTIVES: The objective is to compare three different ultrasmall superparamagnetic iron oxides (USPIOs) for magnetic resonance (MR) imaging of normal bone marrow in rodents. MATERIALS AND METHODS: Femoral bone marrow in 18 Sprague-Dawley rats was examined by using MR imaging before and up to 2 and 24 hours postinjection (PI) of 200 mumol of Fe/kg of SHU555C (n = 6), ferumoxtran-10 (n = 6), or ferumoxytol (n = 6), using T1-weighted (50 ms/1.7 ms/60 degrees = repetition time [TR]/echo time [TE]/flip angle) and T2*-weighted (100 ms/15 ms/38 degrees = TR/TE/flip angle) three-dimensional spoiled gradient recalled echo sequences. USPIO-induced bone marrow was evaluated qualitatively and quantified as signal-to-noise ratio (SNR) and change in signal intensity (DeltaSI) values. A mixed-effect model was fitted to the SNR and DeltaSI values, and differences among USPIOs were tested for significance by using F tests. RESULTS: At 2 hours PI, all three USPIOs showed marked positive signal enhancement on T1-weighted images and a corresponding marked signal loss on T2*-weighted images. At 24 hours PI, the T1 effect of all three USPIOs disappeared, whereas T2*-weighted images showed persistent signal loss on SHU555C and ferumoxytol-enhanced MR images, but not ferumoxtran-10-enhanced MR images. Corresponding SNR and DeltaSI values on T2*-weighted MR images at 24 hours PI were significantly different from baseline for SHU555C and ferumoxytol, but not ferumoxtran-10. CONCLUSION: All three USPIO contrast agents, ferumoxtran-10, ferumoxytol, and SHU555C, can be applied for MR imaging of bone marrow. Ferumoxtran-10 apparently reveals a different kinetic behavior in bone marrow than ferumoxytol and SHU555C. 相似文献