粤东地区莱姆病血清流行病学调查

目的：检测健康人群血清莱姆病抗体水平。方法：间接免疫荧光抗体试验（ＩＦＡ）、酶联免疫吸附试验（ＥＬＩＳＡ）。结果：共检测２１８４人，阳性２２５人，感染率１０３０％。儿童（１３８５％）、学生（１１９３％）感染率最高，农民（１０５７％）次之，林业工人及管理人员（６４４％）相对较低；林区（１０３７％）与非林区（１０２７％）人群感染率差异无显著性（χ２＝０２１，Ｐ＞０７５）。１８０例莱姆病血清阳性者中，蜱叮咬率为４０％，未发现典型的慢性游走性红斑（ＥＣＭ）皮疹患者，红斑、风团、紫斑占３２７８％，肌痛占２３３３％，关节炎占４１１１％。结论：粤东地区人群莱姆病感染率较高     

江苏省2614名莱姆病高危人群血清检测结果分析

目的 检测健康人群血清莱姆病抗体水平。方法 采用间接免疫荧光试验（ＩＦＡ）法。结果 共检测２６１４人,阳性１９２人,感染率７．４９％。男性感染率７．２０％、女性感染率７．４９％,两者间差异无显著性差异。中年组２６￣３５岁（１０．４５％）、３６￣４５岁（１２．９４％）与５６岁以上（２．１８％）感染率差异有显著性意义。１５４例莱姆病血清阳性者中,蜱叮咬率为４３．５０％, 慢性游走性红斑（ＥＣＭ）皮疹患     

徐州市莱姆病血清流行病学调查

莱姆病是一种蜱传螺旋体疾病.为证实徐州市是否存在本病感染,作者于1999年9～12月对徐州市人群莱姆病感染情况进行了血清学调查.现将结果报告如下.     

江苏省莱姆病血清流行病学调查报告

1990年4～12月,我们在江苏省溧阳、宜兴两市的山区乡村进行了莱病姆血清流行病学调查。在316份血清标本中检出≥1:128的阳性标本13份,阳性率4.11%;另有29份可疑阳性(9.18%)。个案调查发现,13例阳性者中的12例有不同程度的莱姆病临床表现。本调查首次证实江苏省存在莱姆病感染者,并可能存在病人。     

吉林桦甸市人群莱姆病血清流行病学调查

吉林桦甸市人群莱姆病血清流行病学调查吉林省桦甸市卫生防疫站（邮编：１３２４００）全毓文，阎荣久，姬文贤红石林业局卫生防疫站石磊红石林业局职工医院白文福为了解我市林区莱姆病流行情况，笔者于１９９３年５月与有关单位协作，对红石林区进行了血清及临床流行病学...     

甘肃省天祝县莱姆病血清流行病学调查

甘肃省天祝县莱姆病血清流行病学调查白小嘉（解放军石家庄医学高等专科学校，石家庄，０５００８１）莱姆病是一种人畜共患蜱媒传播的自然疫源性疾病。为了解甘肃省天祝县炭山岭镇人群莱姆病感染情况，我们于１９９６年５月，随兰州军区军事医学研究所研究小组对该地区进...     

安徽省人群莱姆病血清流行病学调查

本文使用ＩＦＡ技术，对安徽省１０个县（市）１０７８份自然人群血清标本进行了抗莱姆病螺旋体抗体（ＩｇＧ）检测，结果阳性３６份，平均感染率力３．３４％。山区、淮北平原感染率分别为５．５６％和１．１２％，差异具有高度显著性（Ｐ＜０．０１）城镇低于农村，感染率分别为０．４５％和３．７６，差异有显著性意义（Ｐ＞０．０５）。调查表明，山区是我省莱姆病的主要疫区，人群对本病普遍易感，林业工人和生活在山区的农民为本病的高危人群。     

新安县莱姆病血清流行病学调查

我们于１９９１－１９９２年，采用免疫荧光技术检测了新安县２６６份血清中抗莱姆病螺旋体抗体，阳性３６例，人群感染率１３．５３％，不同年龄组差异明显；蜱中肠带菌检查阳性率２６．００％，初步认为长用血蜱和微小牛蜱为传播媒介；鼠血清中也检测出了莱姆病抗体。     

上海市莱姆病血清流行病学调查

上海市莱姆病血清流行病学调查李燕婷，曹永林，施锦明，路德祥，沈微娟，孙环珍，李秉权国内外关于莱姆病的研究进展很快，已证实世界五大洲２０多个国家有莱姆病流行。１９８７年我国张哲夫等［１］调查证实东北林区存在莱姆病，随后发现我国１９个省市，包括上海毗邻的...     

湖北省五峰县莱姆病流行病学调查

湖北省五峰县莱姆病流行病学调查湖北省宜昌市卫生防疫站潘会明，李万深，史良才，李枝金北京市流行病学研究所万康林湖北省五峰县卫生防疫站向选森，唐德华莱姆病自１９７７年被报告，１９８２年分离病原体以来，许多国家和地区已报告了本病。我国于１９８６～１９８７年...     

Modulatory effect of cattle on risk for lyme disease

To determine the effect of cattle on the risk for Lyme disease, we compared the prevalence of spirochete infection in questing vector ticks collected from a pasture with low-intensity cattle grazing with the prevalence in those collected from a site on which no cattle grazed. The presence of cattle limited the prevalence of Borrelia burgdorferi s.l., but not B. miyamotoi, in vector ticks. The reintroduction of traditional, nonintensive agriculture in central Europe may help reduce risk for Lyme disease.     

青岛市重要病媒生物调查及其控制对策

目的了解青岛市重要病媒生物的种群结构、地理分布和侵害情况。方法蚊类调查采用灯诱法、捞勺和水网法;蝇类调查采用笼诱法;鼠类调查采用夹夜法、盗饵法;蜚蠊调查采用粘捕法。结果青岛市主要病媒生物种类有鼠类2目3科5属6种,其中褐家鼠、小家鼠、黑线姬鼠等为主要鼠种;蚊类主要有淡色库蚊、三带喙库蚊、东乡伊蚊、白纹伊蚊、刺扰伊蚊、中华按蚊等;主要蝇种为大头金蝇、丝光绿蝇、巨尾阿丽蝇、厩腐蝇等;室内蜚蠊主要为德国小蠊和日本大蠊等。结论我们应该加强对病媒生物及其相关传染病的预防控制工作,为2008年青岛奥运会帆船比赛的成功举办保驾护航。     

承德地区莱姆病自然疫源性特征分析

目的了解承德地区莱姆病自然疫源地存在状况。方法于承德林区捕鼠、采蜱；巴伯-斯托纳-凯利培养基(BSK)分离蜱内病原体；PCR扩增蜱、鼠体内目的片段及序列测定；对林区居民及动物牛、羊进行血清抗体检测。结果全沟硬蜱为优势蜱种，从中PCR扩增出目的片段，基因序列同源性比较，提示此感染菌株与欧亚大陆常见的莱姆病螺旋体Borrelia afzelii种具有高度同源性。林区居民及动物牛、羊血清抗体检出阳性率较高，分别为13．3％，23．3％，30％。结论全沟硬蜱是承德地区的优势蜱种；并发现其感染有致病性莱姆病螺旋体Borrelia afzelii种。林区羊、牛为重要的贮存宿主。林区人群存在莱姆病螺旋体自然感染，可初步认定承德地区为莱姆病自然疫源地。     

浙江省首次在蜱中检测到莱姆病螺旋体DNA片段

目的：了解蜱、鼠中自然感染莱姆病螺旋体的状况。方法：用PCR法检测鼠类脾脏和蜱类中莱姆病DNA片段。结果：在浙江省金华市金东区及丽水市青田县捕到蜱215只。分别在微小牛蜱和长角血蜱中各检到阳性1份，阳性率为0．93％。结论：初步认为浙江省存在莱姆病病原，尚需进一步调查和病原分离加以证实。     

大兴安岭南段莱姆病的调查

1991年4～6月,我们在大兴安岭南段林区,对莱姆病进行了调查,应用间接免疫荧光抗体法检测496人居民血清,38人血清中抗莱姆病螺旋体IgG抗体效价≥1:128。根据临床表现和血清学调查,确诊莱姆病病例22例;从26只全沟硬蜱分离出4株莱姆病螺旋体。     

The rise and fall of the lyme disease vaccines: a cautionary tale for risk interventions in American medicine and public health

Context: Two vaccines to prevent Lyme disease (LD) were developed and tested in the 1990s. Despite evidence of their safety and efficacy in clinical trials and initial postmarketing surveillance, one vaccine was withdrawn before the regulatory review and the other after only three years on the market. An investigation of their history can illuminate (1) the challenges faced by many new risk‐reducing products and practices and (2) the important role played by their social and psychological, as distinct from their biomedical or scientific, efficacy in how they are used, and their ultimate market success or failure. Methods: This article reviewed medical and popular literature on LD vaccines, analyzed the regulatory hearings, and conducted interviews with key participants. Findings: Even if proved safe and effective, LD vaccines faced regulatory and market challenges because the disease was geographically limited, treatable, and preventable by other means. Pharmaceutical companies nevertheless hoped to appeal to consumers’ desire for protection and control and to their widespread fear of the disease. The LD advocacy community initially supported the vaccines but soon became critical opponents. The vaccines’ success was seen as threatening their central position that LD was chronic, protean, and difficult to treat. The activists’ opposition flipped the vaccines’ social and psychological efficacy. Instead of the vaccines restoring control and reducing fear, demand was undermined by beliefs that the vaccines caused an LD‐like syndrome. Conclusions: The social and psychological efficacy of many risk‐reducing practices and products, such as new “personalized vaccines,” is to provide insurance and reduce fear. Yet the actions of self‐interested actors can easily undermine this appeal. In addition to evaluating the scientific efficacy and safety of these practices and products, policymakers and others need to understand, anticipate, and perhaps shape the potential social and psychological work they might do.