Clinical comparative study with a large-area amorphous silicon flat-panel detector: image quality and visibility of anatomic structures on chest radiography.

OBJECTIVE: The objective of this study was to compare clinical chest radiographs of a large-area, flat-panel digital radiography system and a conventional film-screen radiography system. The comparison was based on an observer preference study of image quality and visibility of anatomic structures. MATERIALS AND METHODS: Routine follow-up chest radiographs were obtained from 100 consecutive oncology patients using a large-area, amorphous silicon flat-panel detector digital radiography system (dose equivalent to a 400-speed film system). Hard-copy images were compared with previous examinations of the same individuals taken on a conventional film-screen system (200-speed). Patients were excluded if changes in the chest anatomy were detected or if the time interval between the examinations exceeded 1 year. Observer preference was evaluated for the image quality and the visibility of 15 anatomic structures using a five-point scale. RESULTS: Dose measurements with a chest phantom showed a dose reduction of approximately 50% with the digital radiography system compared with the film-screen radiography system. The image quality and the visibility of all but one anatomic structure of the images obtained with the digital flat-panel detector system were rated significantly superior (p < or = 0.0003) to those obtained with the conventional film-screen radiography system. CONCLUSION: The image quality and visibility of anatomic structures on the images obtained by the flat-panel detector system were perceived as equal or superior to the images from conventional film-screen chest radiography. This was true even though the radiation dose was reduced approximately 50% with the digital flat-panel detector system.     

Low-dose digital computed radiography in pediatric chest imaging

A prototype digital computed radiographic imaging system that uses laser-stimulated luminescence was evaluated for its ability to achieve reproducible, high-detail, low-dose pediatric chest radiographs. Using this system, we performed a total of 401 examinations in infants and children, and achieved an 85% reduction in radiation dose, as compared with that delivered when film-screen techniques were used. We also achieved satisfactory image resolution, and the images obtained were of acceptable diagnostic quality. A direct comparison of analog and digital radiographs showed that comparable quality and clinical acceptability could be readily maintained between the two techniques. This study shows that high-quality images can be produced by this system at radiation doses reduced by 85% when compared with doses from standard radiographic techniques.     

Digital chest radiography with a large image intensifier. Evaluation of diagnostic performance and patient exposure

A digital system for chest radiography based on a large image intensifier was compared with a conventional film-screen system. The diagnostic performance was evaluated with special reference to the digital monitor images with a modified version of receiver operating characteristic (ROC) analysis--free response ROC (FROC) analysis--on a chest equivalent phantom. Measurements of spatial resolution and energy imparted were also performed. The detectability of low-contrast objects as well as spatial resolution was better for the full-size film-screen radiographs than for both the digital monitor images and the 100 mm photofluorograms. The image-intensifier system has a potential for considerable dose savings in relation to the conventional technique provided that fluoroscopy is excluded in the positioning of the patients.     

Traumatic injuries: imaging of peripheral musculoskeletal injuries

The current dominant role of conventional radiography must be reassessed at increasingly shorter intervals in view of the continuing emergence of new imaging modalities that are available to diagnose peripheral musculoskeletal injuries. In comparison with conventional radiography, digital radiographic techniques offer advantages for optimization of image quality and dose, such as a wider dynamic range and post-processing of images. Currently, digital luminescence radiography (storage phosphor radiography) is the most commonly used digital method for obtaining radiographs, using the established positioning projections and routines of the film-screen technique. A new process, radiography with flat-panel amorphous silicon detectors, is still under development. Computed tomography is a valuable tool for diagnosing injuries of the peripheral musculoskeletal system, especially when three-dimensional data sets are acquired; these allow reformating images in all planes desired (2D technique) or in a volumetric format (3D technique). Established indications for CT in the peripheral skeleton are hip fractures, wrist injuries and calcaneal fractures; however, CT may be used as a supplement to radiography in every region of the body. Sonography is beginning to play an increasingly important role in trauma. Muscle and tendon injuries are the most common indications, but worthwhile information can be gained of the shoulder, elbow, hip, and knee joints, supplementing conventional or digital radiography. Magnetic resonance imaging effectively visualizes traumatic changes of the skeleton and the peripheral soft tissues. It is the method of choice to detect occult fractures. It can be used to diagnose muscle and tendon injuries. Joint injuries, especially in the knee and the shoulder joint, are common indications for MRI in the posttraumatic setting.     

Computed radiography in musculoskeletal imaging

In conclusion, CR offers many advantages in comparison with conventional radiography. Musculoskeletal radiology particularly benefits from the wide dynamic range and image-processing capabilities of CR. Most studies have not shown a statistically significant difference in observer performance (diagnostic accuracy) of CR in comparison with conventional radiography in musculoskeletal applications. In addition, dose reduction in the range of 25% to 50% is possible with many musculoskeletal images. However, disadvantages are also apparent and include reduced spatial resolution, increased noise, and change in image size and format. Overall, the advantages of CR and digital technology outweigh its limitations and for these reasons continue to promote the conversion from conventional radiography.     

Detection of porcine bone lesions and fissures: comparing digital selenium, digital luminescence, and analog film-screen radiography.

OBJECTIVE: The purpose of our study was to compare the diagnostic performance of a digital selenium detector (Thoravision) with that of analog film-screen systems and digital luminescence radiography in skeletal radiography for the detection of fissures and lesions in porcine bones. MATERIALS AND METHODS: One hundred bones taken from domestic pigs (50 ribs and 50 femurs) were divided into two equal groups. Fissures and bone lesions were created in 50 bones and 50 served as controls. The bones were examined using film-screen systems, digital luminescence radiography, and digital selenium radiography at various doses. Digital selenium radiography exposure values were adapted to the image geometry differing from the reference methods with a detector focus distance of 2.15 m. Four radiologists independently evaluated image quality and detectability of fissures and lesions on a five-point scale of confidence. Statistical evaluation was based on receiver operating characteristic curve analysis. RESULTS: Fissures and bone lesions were detected most reliably using the mammography film-screen system, but the difference in the results of the analog and digital reference images did not achieve statistical significance. CONCLUSION: Compared with analog film-screen systems, the lower spatial resolution of the digital selenium and digital luminescence radiography systems does not affect detectability of fissures and bone lesions in porcine bone. Selenium is effective in skeletal radiography for detecting fissures and bone lesions. With digital selenium and digital luminescence radiography, the surface dose can be cut to half that required for 200-speed film-screen systems without losing any diagnostically relevant information.     

Efficacy of digital radiography for the detection of pneumothorax: comparison with conventional chest radiography.

As part of our continuing evaluation of the clinical applicability of digital radiography, we compared the abilities of radiologists to detect pneumothoraces on conventional chest radiographs with their performances when using three formats of digitally obtained images. Twenty-three frontal-view chest radiographs with pneumothoraces and 22 other chest radiographs, either normal or showing miscellaneous abnormalities, were interpreted by five experienced radiologists in each of four formats: conventional film-screen chest radiographs, small-format (17.8 x 21.6 cm) computed radiographs, large-format (35.6 x 43.1 cm) computed radiographs, and digital images viewed on an interactive electronic workstation. The receiver-operating-characteristic curve areas for each observer for the four types of images were compared by a z test on a critical ratio, and the mean sensitivity and specificity values were compared by the sign rank test. The mean areas under the receiver-operating-characteristic curves ranged from 0.869 for the digital workstation to 0.915 for film-screen images. The differences observed among formats were not statistically significant. Mean specificities also were not significantly different, ranging from 0.90 for large-format computed radiographs to 0.96 for the digital workstation. Mean sensitivity ranged from 0.65 for the digital workstation to 0.82 for film-screen images. Radiologists interpreting digital workstation images were significantly less sensitive in detecting pneumothoraces than with film-screen and small-format computed images (p = .06). In this study, radiologists detected pneumothoraces equally well on conventional film-screen radiographs and digital images printed on film; however, they detected pneumothoraces less well on electronic viewing consoles. This latter finding reflects an important practical difference in the working behavior of radiologists interacting with a digital workstation.     

Image-intensifier photofluorography and conventional chest radiography: comparison of diagnostic efficacy

Photofluorography with a large image intensifier, which provides an image field of 40 x 40 cm, reduces both the radiation dose and the imaging costs in chest radiography as compared with the film-screen technique. The two techniques were evaluated in a clinical study of 135 patients with suspected chest abnormalities. Photofluorographs and film-screen chest radiographs were interpreted independently by three radiologists. The diagnoses were confirmed by CT, follow-up radiographs, and clinical records. Among the 135 patients, 75 had primary lung cancer, 39 had pulmonary nodules, 52 had hilar or mediastinal abnormalities, 17 had pleural fluid, and 45 had pneumonic or atelectatic changes. Twenty-three normal subjects were included. Differences in diagnostic accuracy, measured by sensitivity and specificity, were not statistically significant. A larger number of true-positive cases (65%) with peripheral lung nodules were found by photofluorography than by film-screen radiography (54%) (p less than .05). The results suggest that the diagnostic accuracy of chest images made by photofluorography is sufficient to warrant using it instead of the film-screen technique in routine chest radiography, especially to detect lung tumors and metastases.     

Reducing the radiation dose during excretory urography: flat-panel silicon x-ray detector versus computed radiography

OBJECTIVE: The purpose of the study was to examine the possibilities for reducing radiation exposure in uroradiology using digital flat-panel silicon X-ray detector radiography. We compared the subjectively determined image quality of abdominal radiographs and urograms obtained on a digital flat-panel detector radiography system with those obtained on a computed radiography system. SUBJECTS AND METHODS. Fifty patients who had a clinical indication for urography underwent unenhanced abdominal imaging that was alternately performed using flat-panel silicon X-ray detector radiography or computed radiography. For patients who required a second radiograph with contrast medium, the examination modality was changed to avoid exposing the patients to excess radiation. The images obtained on flat-panel X-ray detector radiography were obtained at half the radiation dose of the images obtained on computed radiography (800 speed vs 400 speed). The resulting 50 pairs of images were interpreted by four independent observers who rated the detectability of structures of bone and the efferent urinary tract relevant to diagnosis and compared the image quality. RESULTS: At half the radiation dose, digital flat-panel X-ray detector radiography provided equivalent image quality of the liver and spleen, lumbar vertebrae 2 and 5, pelvis, and psoas margin on abdominal radiographs. The image quality obtained with digital flat-panel X-ray detector radiography of the kidneys, the hollow cavities of the upper efferent urinary tract, and the urinary bladder was judged to be statistically better than those obtained with computed radiography. CONCLUSION: With half the exposure dose of computed radiography, the flat-panel X-ray detector produced urograms with an image quality equivalent to or better than computed radiography.     

乳腺数字化X线射影术、计算机X线射影术和屏-胶片系统影像质量和放射剂量的比较

目的 比较增感屏-胶片乳腺X线摄影、数字乳腺摄影(DR)和计算机乳腺摄影(CR)3种系统的模体影像质量、辐射剂量和临床对疾病诊断的准确率.方法 选择3台临床使用中的屏-胶片、DR和CR乳腺摄影设备,进行性能测试,确保质量符合规定,具有可比性.以屏-胶片系统的辐射剂量为标准,使用DR和CR分别对Manuno-152模体和美国放射学院(ACR)模体摄影.再使用DR和CR的最优模式对模体摄影并记录辐射剂量.所获图像照片按模拟病变结构编号,由8名专业乳腺放射学医师在相同条件下分别进行ACR评分.3种方法的评分结果采用随机区组设计的方差分析进行统计学处理.连续收集一段时期内采用3种检查方法检查,并且有病理诊断结果的患者的影像资料,应用Kappa检验方法进行2种诊断结果一致性检验,并以病理结果为金标准,比较3种影像检查结果诊断的准确率.结果 对于Mammo-152模体,无论DR、CR的辐射剂量是否超过屏一胶片乳腺X线摄影的2.25 mGy乳腺平均剂量,屏-胶片摄影的空间分辨率都最高(7.0～8.0 Lp/mm),DR次之(4.7～5.2 Lp/mm),CR最差(2.5 Lp/mm).增加辐射剂量(27.0%～30.0%),DR的空间分辨率略有改善(上升11.0%),而CR几乎没有改变(上升1.5%).对ACR模体摄影时,DR的辐射剂量没有超过屏-胶片乳腺X线摄影的2.22 mGy乳腺平均剂量,且模拟结构显示度最好.屏-胶片乳腺x线摄影的团块显示优于CR,但CR的纤维和点阵显像优于屏-胶片乳腺X线摄影.CR检查时辐射剂量提高25.0%,纤维和点阵显像接近DR,团块显像接近屏-胶片乳腺x线摄影.3台设备的X线诊断和病理诊断结果的一致性极好(屏-胶片系统的一致率50/56,DR系统83/90,CR系统61/69,P值均<0.01且Kappa值均>0.75),在疾病诊断准确率上差异没有统计学意义[屏-胶片系统的准确率为89.3%(50/56),DR系统为92.2%(83/90),CR系统为88.4%(61/69),PearsonX2值为0.722,P=0.697].结论 屏-胶片乳腺X线摄影分辨率最高,DR的模拟病变显像最好且辐射剂量最低.当CR的辐射剂量与屏-胶片乳腺X线摄影相当时,两者对模拟病变的显像各有优劣;当增加CR的摄影剂量时,其模拟结构显像质量高于屏-胶片乳腺X线摄影,低于DR.在临床对疾病的诊断准确率方面,三者无明显差别.     

Digital radiography of the spine, large bones and joints using stimulable phosphor. Early clinical experience

The value of digital radiography in musculoskeletal disorders was investigated by assessing its ability to depict anatomic structures and common radiologic features as compared with the conventional film-screen combination. The digital image that was frequency modified was superior to conventional films in delineating soft tissue structures and for areas with large attenuation differences. The conventional film-screen system was superior in depicting small anatomic structures and in identifying the zone close to prostheses. This was explained by the high spatial resolution of the conventional film system and the disturbing halo effect around the prosthesis seen with digital images. The halo effect is an overshoot caused by the unsharp masking operator, which was in this series not changed for individual examinations. The exposure (radiation dose) could be reduced to 50 per cent using the digital system, without any loss of information.     

Radiation dose reduction in chest radiography using a flat-panel amorphous silicon detector

AIM: The aim of this study was to evaluate the image quality and the potential for radiation dose reduction with a digital flat-panel amorphous silicon detector radiography system. MATERIAL AND METHODS: Using flat-panel technology, radiographs of an anthropomorphic thorax phantom were taken with a range of technical parameters (125kV, 200mA and 5, 4, 3.2, 2, 1, 0.5, and 0.25mAs) which were equivalent to a radiation dose of 332, 263, 209, 127, 58.7, 29, and 14 microGy, respectively. These images were compared to radiographs obtained by a conventional film-screen radiography system at 125kV, 200mA and 5mAs (equivalent to 252 microGy) which served as reference. Three observers evaluated independently the visibility of simulated rounded lesions and anatomical structures, comparing printed films from the flat-panel amorphous silicon detector and conventional x-ray system films. RESULTS: With flat-panel technology, the visibility of rounded lesions and normal anatomical structures at 5, 4, and 3.2mAs was superior compared to the conventional film-screen radiography system. (P< or =0.0001). At 2mAs, improvement was only marginal (P=0.19). At 1.0, 0.5 and 0.25mAs, the visibility of simulated rounded lesions was worse (P< or =0.004). Comparing fine lung parenchymal structures, the flat-panel amorphous silicon detector showed improvement for all exposure levels down to 2mAs and equality at 1mAs. CONCLUSION: Compared to a conventional x-ray film system, the flat-panel amorphous silicon detector demonstrated improved image quality and the possibility for a reduction of the radiation dose by 50% without loss in image quality.     

Detection of pulmonary edema in pigs: storage phosphor versus amorphous selenium-based flat-panel-detector radiography

PURPOSE: To compare diagnostic accuracy of soft-copy selenium-based digital radiographic images and soft-copy computed radiographic images obtained for detection of pulmonary edema in pigs. MATERIALS AND METHODS: Oleic acid was injected intraatrially into three pigs (weight, 20-25 kg) at doses of 0.04, 0.05, and 0.06 mL/kg to induce pulmonary edema. Thirty-seven sets of computed radiographic, digital radiographic, and thin-section computed tomographic (CT) scans were obtained every 20-30 minutes in three pigs over 4-6 hours. Images were masked for identity, randomly sorted, and displayed on a monitor. Four radiologists rated each image for presence of parenchymal opacities by using a dichotomous scoring system in two sessions. Presence of pulmonary edema was determined with thin-section CT and a severity scale. Intra- and interobserver variations were determined with the kappa statistic and the Z test and with the Cochran Q test and the McNemar test, respectively. True-positive, true-negative, false-positive, and false-negative rates were determined. McNemar test was used to determine statistical significance of differences in detection between computed and digital radiographic images. RESULTS: There was no significant intra- or interobserver variation, except for one pair of observers during the first interpretative session with computed radiographic images (P =.016, McNemar test). Overall sensitivity (92.1%) and diagnostic accuracy (90.2%) of digital radiography were significantly higher than those of computed radiography (79.6% and 83.4%, respectively) (P <.001 for sensitivity, P =.01 for diagnostic accuracy, McNemar test). In detection of minimal and mild pulmonary edema, sensitivity of digital radiography (84%) was significantly higher than that of computed radiography (58%) (P <.001). CONCLUSION: Soft-copy digital radiographic images are superior to soft-copy computed radiographic images obtained for detection of mild pulmonary edema in pigs.     

Simulated bone erosions in a hand phantom: detection with conventional screen-film technology versus cesium iodide-amorphous silicon flat-panel detector

PURPOSE: To assess the diagnostic performance of an active-matrix flat-panel x-ray detector for reduced-dose imaging of simulated arthritic lesions. MATERIALS AND METHODS: A digital x-ray detector based on cesium iodide and amorphous silicon technology with a panel size of 43 x 43 cm, matrix of 3,000 x 3,000 pixels, pixel size of 143 micrometer, and digital output of 14 bits was used. State-of-the-art screen-film radiographs were compared with digital images obtained at doses equivalent to those obtained with system speeds of 400, 560, and 800. The phantom was composed of a human hand skeleton on an acrylic plate with drilled holes simulating bone erosions of different diameters and depths. Results of four independent observers were evaluated with receiver operating characteristic curve analysis. RESULTS: The cesium iodide and amorphous silicon detector resulted in better diagnostic performance than did the screen-film combination, with the dose being the same for both modalities (P <.05). For digital images obtained at reduced doses, no significant differences were found. CONCLUSION: The improved diagnostic performance with digital radiographs obtained with the cesium iodide and amorphous silicon detector suggests that this detector technology holds promise in terms of dose reduction for specific diagnostic tasks, without loss of diagnostic accuracy.     

Direct radiographic magnification with computed radiography

Computed radiography was combined with a 0.1-mm microfocus radiographic tube to obtain radiographic magnification of a x3 to x5. Gray-scale image processing compensated for the loss of radiographic contrast associated with the high-kilovoltage, short-exposure technique. The high-pass spatial frequency filtering capability of the computed radiography resulted in enhanced edges and increased displayed latitude. The improved image quality obtained by magnification computed radiography allowed delineation of subtle abnormalities and small anatomic structures not apparent on conventional screen-film contact or magnification radiographs.     

Single-exposure conventional and computed radiography image acquisition

A technique for simultaneously acquiring a conventional film-screen radiographic image and a digital computed radiography (CR) image with a single x-ray exposure is described. Measurements of image contrast, spatial resolution, and signal-to-noise ratios demonstrate that a modified film cassette in which the first intensifier screen has been replaced with a CR imaging plate permits dual-image, single-exposure imaging with only nominal degradation in film and CR image quality relative to the two standard image counterparts. This technique may be used to acquire matched image pairs for research or as a way to provide full-size conventional film images in the clinical environment, while retaining the advantages offered by computed radiography systems.     

Image enhancement using computed radiography

Computed radiography (CR) is emerging as a digital imaging modality for use in conventional radiography. An advantage of CR over film-screen systems is the separation of image acquisition, processing and display. Selection of many different image display characteristics are possible. The system is also able to alter or enhance image details after the radiographic examination has been completed.     

Digital radiography: fundamentals and future potentials

Digital radiography consists of four major steps which include X-ray detection, digitization, image processing and display. Important parameters in digitization process is the pixel size and the number of grey levels which affect the quality of digitized images. A number of digital radiographic systems have been or are being developed which include the point-beam, line-beam, slot-beam and multiple slit-beam systems as well as conventional wide-beam systems such as image intensifier-TV system, storage phosphor system and film-based system. Important physical properties of digital radiographic systems are the sensitivity, resolution, noise, system response, scatter rejection, contrast sensitivity and image acquisition time. The resolution property is affected by the pixel size, sampling distance, display pixel size, image processing, detector response and X-ray beam characteristics. From ROC studies on chest images, the pixel size of approximately 0.2 mm and the corresponding image matrix of about 2,000 x 2,000 is considered optimal choice of these parameters. Future potentials of digital radiography are likely to be in the areas of computer-aided diagnosis (CAD) and PACS. Preliminary results obtained from recent studies on quantitative analysis of digital radiographic images are promising. The rms variation and the first moment of the texture of abnormal lungs with various interstitial diseases were clearly different from those of normal lungs. Automated detection scheme of nodules in chest images indicated approximately 70% true positive rates and a few false positives in each lung.(ABSTRACT TRUNCATED AT 250 WORDS)     

Digital radiography of the skeleton using a large-area detector based on amorphous silicon technology: image quality and potential for dose reduction in comparison with screen-film radiography

AIM: The purpose of this study was to evaluate a large-area, flat-panel X-ray detector (FD), based on caesium-iodide (CsI) and amorphous silicon (a-Si) with respect to skeletal radiography. Conventional images were compared with digital radiographs using identical and reduced radiation doses.MATERIALS AND METHODS: Thirty consecutive patients were studied prospectively using conventional screen-film radiography (SFR; detector dose 2.5 microGy). Digital images were taken from the same patients with detector doses of 2.5, 1.25 and 0.625 microGy, respectively. The active-matrix detector had a panel size of 43 x 43 cm, a matrix of 3 x 3K, and a pixel size of 143 microm. All hard copies were presented in a random order to eight independent observers, who rated image quality according to subjective quality criteria. Results were assessed for significance using the Student's t -test (confidence level 95%).RESULTS: A statistically significant preference for digital over conventional images was revealed for all quality criteria, except for over-exposure (detector dose 2.5 microGy). Digital images with a 50% dose showed a small, statistically not significant, inferiority compared with SFR. The FD-technique was significantly inferior to SFR at 75% dose reduction regarding bone cortex and trabecula, contrast and overall impression. No statistically significant differences were found with regard to over- and under-exposure and soft tissue presentation.CONCLUSION: Amorphous silicon-based digital radiography yields good image quality. The potential for dose reduction depends on the clinical query.     

Effects of optimization and image processing in digital chest radiography: an ROC study with an anthropomorphic phantom.

A digital system for chest radiography based on a large image intensifier was compared to a conventional film-screen system. The digital system was optimized with regard to spatial and contrast resolution and dose. The images were digitally processed for contrast and edge enhancement. A simulated pneumothorax and two simulated nodules were positioned over the lungs and the mediastinum of an anthropomorphic phantom. Observer performance was evaluated with ROC analysis. Five observers assessed the processed digital images and the conventional full-size radiographs. The time spent viewing the full-size radiographs and the digital images was recorded. For the simulated pneumothorax, the results showed perfect performance for the full-size radiographs and detectability was high also for the processed digital images. No significant difference in the detectability of the simulated nodules was seen between the two imaging systems. The results for the digital images showed a significantly improved detectability for the nodules in the mediastinum as compared to a previous ROC study where no optimization and image processing was available. No significant difference in detectability was seen between the former and the present ROC study for small nodules in the lung. No difference was seen in the time spent assessing the conventional full-size radiographs and the digital images. The study indicates that processed digital images produced by a large image intensifier are equal in image quality to conventional full-size radiographs for low-contrast objects such as nodules.