复方樟柳碱治疗缺血性视神经病变的临床疗效与护理

目的探讨应用复方樟柳碱注射液在颞浅动脉区皮下注射治疗缺血性视神经病变的护理方法。方法 85例(128眼)缺血性视神经病变的病人,在病侧或双侧颞浅动脉区皮下注射复方樟柳碱注射液2ml,1次/d,14d为一个疗程。比较注射前、后视力情况。结果85例(128眼)缺血性视神经病变患者治疗显效率为82%,有效率为14%,无效率为4%,总有效率为96%。结论复方樟柳碱注射液在颞浅动脉区皮下注射配合适当的护理,治疗缺血性视神经病变可以提高患者的视力功能,是一种安全、简便、有效的治疗方法,且容易被患者接受。     

复方樟柳碱治疗眼部植物神经功能失调症的临床研究

目的:探讨复方樟柳碱治疗眼部植物神经动能失调症的临床应用。方法:患眼颞浅动脉旁皮下注射复方樟柳碱注射液2 ml,1次/d,15 d为1个疗程。结果:经复方樟柳碱双颞浅动脉旁注射3 d后,自觉症状即减轻,眼疲劳症状得观到明显改善,经过2个疗程的治疗,患者病情痊愈。结论:复方樟柳碱注射液颞浅动脉旁皮下注射能明显改善眼部植物神经功能紊乱症状。     

外伤性视神经病变应用复方樟柳碱的疗效观察与护理

目的 观察复方樟柳碱注射液在外伤性视神经病变中的治疗效果与护理.方法 应用复方樟柳碱注射液2 ml做颞浅动脉旁皮下注射1 次/d,14 d为一疗程,通过显效、有效、无效三个标准判断疗效.结果 治疗后63例(76眼)有效率为86.8%.结论 颞浅动脉旁皮下注射复方樟柳碱注射液是治疗外伤性视神经病变一种有效治疗方法.     

复方樟柳碱治疗缺血性视神经病变的疗效观察与护理

目的:探讨复方樟柳碱注射液治疗缺血性视神经病变的疗效。方法:32例缺血性视神经病变患者给与复方樟柳碱注射液2ml患眼颞浅动脉旁皮下注射,进行相应的护理。结果:显效为24例28只眼,有效为5例8只眼,无效为3例4只眼,有效率为90%。结论:颞浅动脉旁皮下注射复方樟柳碱注射液是治疗缺血性视神经病变的一种有效的治疗方法。     

复方樟柳碱在眼部植物神经功能失调症中的应用

目的 探讨复方樟柳碱在眼部植物神经功能失调症中的应用.方法 患眼颞浅动脉旁皮下注射复方樟柳碱注射液2ml,一日一次,15天为一疗程.结果 经复方樟柳碱双颞浅动脉旁注射3天后,自觉症状即减轻,眼疲劳症状得到明显改善,经过2个疗程的治疗,患者病情痊愈.结论 复方樟柳碱注射液颞浅动脉旁皮下注射能明显改善眼部植物神经功能紊乱症状.     

葛根素联合复方樟柳碱治疗缺血性视乳头病变

目的观察葛根素联合复方樟柳碱注射液颞浅动脉旁皮下注射对缺血性乳头病变的疗效。方法经诊断缺血性乳头变的23例患者26眼予葛根素静脉注射及复方樟柳碱颞浅动脉旁皮下注射治疗,疗程2个疗程。随访1年。结果治疗后良好57.69%,总有效率96.20%。结论葛根素联合复方樟柳碱治疗缺血性乳头病变,疗效确切、安全、并发症少,值得推广。     

复方樟柳碱注射液治疗后段缺血性视神经病变的疗效

目的：观察复方樟柳碱注射液治疗后段缺血性视神经病变的疗效。方法：采用复方樟柳碱注射液2 ml,患侧颞浅动脉旁皮下注射1次/d,每次2 ml（急重症者可加用球旁注射,1次/d）,14 d为1个疗程。以视力和视野改变为疗效指标。结果：经1～2个疗程治疗后,患者治愈率为34.9%,显效率为39.5%,有效率为12.8%。结论：复方樟柳碱注射液治疗后段缺血性视神经病变有良好的疗效。     

复方樟柳碱治疗缺血性视神经病变疗效观察

目的 观察复方樟柳碱治疗缺血性视神经病的效果.方法 用北京紫竹药业公司生产的复方樟柳碱注射液 2 ml 患侧颞浅动脉旁皮下注射或球后注射,1次/d,10 d为一个疗程.最少1个疗程,最多4个疗程,平均 1.8 个疗程,以治疗结束的结果统计疗效.结果 本组 45例,显效20例,有效7例,改善2例,无效1例,总有效率为95.56%.结论 复方樟柳碱是一种治疗缺血性视神经病安全、有效的药物.     

护理会诊在颞浅动脉旁皮下注射的应用

目的 探讨护理会诊在颞浅动脉旁皮下注射中的应用效果.方法 通过对我院其他科室2012年5月—2013年6月收治的合并眼部疾病的50例患者采取护理会诊的形式,使其得到颞浅动脉旁皮下注射复方樟柳碱治疗,总结护理会诊的成效.结果 通过护理会诊的实施,使需要应用复方樟柳碱颞浅动脉旁皮下注射的合并眼病的其他科室的患者在最佳时机得到救治,患者病情得到明显改善.结论 建立护理会诊制度,解决了需要颞浅动脉旁皮下注射复方樟柳碱的其他科室合并眼病患者的治疗问题,使眼病患者得到了同质护理和治疗,提高了护理质量,治疗效果也很明显,值得推广.     

金纳多联合复方樟柳碱颞浅动脉旁皮下注射治疗缺血性视神经病变

目的：探讨金纳多联合复方樟柳碱颞浅动脉旁皮下注射治疗缺血性视神经病变的疗效。方法：缺血性视神经病变临床上分为前部缺血性视神经病变（AION）与后部缺血性视神经病变（PION），对其静滴金纳多联合复方樟柳碱颞浅动脉旁皮下注射治疗，与常规口服复方丹参片、维生素等药物治疗缺血性视神经病变对比观察。结果：联合用药组有效率达93．27％。两组治愈率差异非常显著。结论：金纳多联合复方樟柳碱颞浅动脉旁皮下注射治疗缺血性视神经病变，提高了疗效，缩短了疗程，无不良反应，值得探讨。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.