Kalk,Muzin, Myxödem,Sklerodermie, Calcinose

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超分子水杨酸联合粉刺挤压治疗寻常型痤疮疗效观察1姚露,彭红霞,周文瑞,勒尔布哈,赵皓森,张琴,唐秀兰,阿衣子扎

目的 观察30%超分子水杨酸(博乐达)联合粉刺挤压治疗寻常型痤疮疗效。方法 将我院(2019年7月～2019年12月)收治的寻常型痤疮患者80例作为观察对象。随机分成观察组40例(30%超分子水杨酸治疗+粉刺挤压),对照组40例(粉刺挤压),两周1次,连续4次。分别于治疗前、治疗两次后、治疗四次后、治疗完成后4周对其评分。记录治疗后的临床疗效、安全性和患者满意度。结果 两组患者在治疗前GAGS评分比较无显著性差异(P 0.05)。在治疗两次后、治疗四次后、治疗完成后4周,观察组患者GAGS评分明显低于对照组,差异具有统计学意义(P 0.001)。观察组患者治疗后临床总有效率为97.50%,明显高于对照组的82.50%,差异具有统计学意义(P 0.05)。观察组患者在治疗过程中总计发生7例并发症(17.50%),对照组患者在治疗过程中总计发生4例并发症(10.00%),两组间差异无统计学意义(P 0.05)。实验组患者对治疗的总满意率为100.00%,明显高于对照组总满意率90.00%,差异具有统计学意义(P 0.05)。结论 在寻常型痤疮患者的治疗中,采取30%超分子水杨酸联合粉刺挤压治疗,可明显降低患者的痤疮整体分级评分,获得较好的临床治疗效果,获得较高的患者总满意率,效果理想。     

Atrichia, ichthyosis, follicular hyperkeratosis, chronic candidiasis, keratitis, seizures, mental retardation and inguinal hernia: a severe manifestation of IFAP syndrome?

A boy with congenital atrichia, ichthyosis follicular, keratitis, cutaneous infections and a huge inguinal hernia, but without deafness is reported. We believe it represents a new case of a rare X-linked recessive syndrome known as ichthyosis follicularis, alopecia, photophobia syndrome (IFAP). The differential diagnosis from keratitis ichthyosis deafness is discussed. The cutaneous infections seen in our case suggest the possibility of considering a genetic link between these syndromes.     

Naming acquired melanocytic nevi. Common and dysplastic, normal and atypical, or Unna, Miescher, Spitz, and Clark?

Acquired melanocytic nevi are among the commonest neoplasms in man, yet classification of them has proven elusive and elucidation unsatisfactory. From "active junctional nevus" to "dysplastic nevus," the brains of clinicians and histopathologists have been boggled and the psyches and skin of patients have been served badly. This essay advocates eponymic designations for acquired melanocytic nevi, all of which are common, as the surest route to comprehensive classification of them.     

盐酸氨基酮戊酸光动力疗法联合CO2点阵激光治疗重度痤疮3例1宋杰,纳猛,钟庆坤,邵丹,李霞,张娴,蔡汶高,李金桑

目的 观察盐酸氨基酮戊酸光动力疗法结合CO2点阵激光对重度痤疮进行联合治疗的疗效。方法 对3例重度痤疮患者在进行点阵激光治疗后随即给予光动力治疗。结果 3例患者较单纯光动力治疗取得了较好的疗效。结论 通过治疗达到杀灭痤疮丙酸杆菌、控制和减轻皮脂腺分泌、重建皮脂腺及表皮结构的效果,降低复发,有效预防疤痕,对重度痤疮有显著疗效。     

Common Ground?: Tetracyclines,Matrix Metalloproteinases,Pustular Dermatoses,and Loxoscelism

The fear of spiders is ancient and common throughout much of the world. Skin ulceration and necrosis due to Loxosceles spider envenomation ("bites") is among the best known sequelae of a usually accidental encounter. Therapies for Loxosceles envenomations either are not well documented or have adverse side effects that limit their use by generalists. Based on in vitro and in vivo studies in rabbits injected with purified or recombinant sphingomyelinase D2, Paix?o-Cavalcante et al. (2007) propose in this issue that topical tetracyclines could become safe, efficacious therapy for cutaneous loxoscelism.     

银屑病皮损区IL—8,HLA—DR,PLA2,ANAE,EGFR mRNA,c—fos mRNA的 …

目的 探讨银屑病患者白介素８（ＩＬ－８）,人类白细胞抗原ＤＲ（ＨＬＡ－ＤＲ）,磷脂酶Ａ２（ＰＬＡ２）,酸性α－乙酸萘酯酶（ＡＮＡＥ）,表皮生长因子受体基因（ＥＧＦＲｍＲＮＡ）,ｃ－ｆｏｓ基因（ｃ－ｆｏｓｍＲＮＡ）在皮损的表达定位。方法 对２０例银屑病患者皮损和１０例正常人的皮肤标本进行了免疫组化,组化和原位要交技术检测,结果 ＩＬ－８免疫反应于主要定位于表皮的基层,棘细胞层和颗粒层,血管内皮细胞及     

痤疮与微生物相关性研究1房立亚1,洪文茜1,张家瑜2,周红英1,吴一菲3

痤疮是一种好发于青春期男女的毛囊皮脂腺慢性炎症性疾病。痤疮的发病因素较为复杂,且确切病因及发病机制尚不明确,但微生物是痤疮发病的重要因素。微生物种类繁多,其与痤疮的关系尚未完全阐明。为了深入了解痤疮发病与微生物的相关性,文章综合探讨微生物对痤疮的致病机制并进行综述。     

青霉素,氟哌酸,菌必治治疗淋病对比观察

青霉素、氟哌酸、菌必治治疗淋病对比观察陈运培（江苏省淮阴县皮防所，２２３３００）我所于１９８９年１月—１９９３年１２月底止，分别用青霉素、氟哌酸、菌必治治疗淋病１５６例，现将取得的疗效报告如下：一、临床资料：病例选择：严格选择无并发症的急性淋病１５６...     

What's eating you? Bees, part 1: characteristics, reactions, and management

Bee stings are common in the United States. We review the characteristics of bumblebees, honeybees, and Africanized honeybees; the types and pathophysiology of sting reactions; and the medical management and prevention of bee stings. In part 2 of this series, we will discuss the use of venom immunotherapy, the diagnosis of systemic mastocytosis that initially presents as anaphylaxis, and the efficacy of immunotherapy in patients with mastocytosis.     

过敏性皮肤病过敏原检测结果分析1吴智刚,李炜煊,李启欣,李小蓝

目的 分析过敏性皮肤病患者过敏原检测结果及其临床意义。方法 收集109例本院2018年7月～2019年6月收治的过敏性皮肤病患者为研究对象,采用酶联免疫吸附测定法检测吸入性、食入性过敏原。结果 109例皮肤受检者中,屋尘阳性率15.59%、户尘螨阳性率22.93%、霉菌组合阳性率19.26%、苋/藜/葎草/蒲公英阳性率13.76%、蒿/矮豚草阳性率8.25%、树类花粉阳性率6.42%、狗毛皮屑阳性率13.76%、猫毛皮屑阳性率11.01%;109例皮肤受检者中,牛肉/羊肉阳性率8.25%、贝/鱼阳性率2.75%、虾阳性率9.17%、芒果/桃/苹果/樱桃阳性率11.92%、腰果/花生/黄豆阳性率11.92%、蟹阳性率15.56%、鸡蛋白阳性率13.76%、牛奶阳性率25.68%、菠萝阳性率为1.83%。结论 过敏性皮肤病加重或诱发的潜在原因为接触吸入性过敏原,在防治过敏性皮肤病方面,检测过敏原具有重要意义,能够为临床预防、诊断、治疗过敏性皮肤病提供参考价值,值得全方位推广。     

Vitiligo pathogenesis: autoimmune disease,genetic defect,excessive reactive oxygen species,calcium imbalance,or what else?

Abstract: The pathobiology of vitiligo has been hotly disputed for as long as one remembers, and has been a magnet for endless speculation. Evidently, the different schools of thought – ranging, e.g. from the concept that vitiligo essentially is a free‐radical disorder to that of vitiligo being a primary autoimmune disease – imply very different consequences for the best therapeutic strategies that one should adopt. As a more effective therapy for this common, often disfiguring pigmentary disorder is direly needed, we must strive harder to settle the pathogenesis debate definitively – on the basis of sound experimental evidence, rather than by a war of dogmatic theories. Recognizing, however, that it is theories which tend to guide our experimental designs and choice of study parameters, the various pathogenesis theories on the market deserve to be critically, yet unemotionally re‐evaluated. This Controversies feature invites you to do so, and to ask yourself: Is there something important or worthwhile exploring in other pathogenesis scenarios than those already favoured by you that may help you improve your own study design, next time you have a fresh look at vitiligo? Vitiligo provides a superb model for the study of many fundamental problems in skin biology and pathology. Therefore, even if it later turns out that, as far as your own vitiligo pathogenesis concept is concerned, you have barked‐up the wrong tree most of the time, chances are that you shall anyway have generated priceless new insights into skin function along the way.     

推广性文明,普及性健康,加强性管理

性从来都与文化发展休戚相关。孟子的一句“食色性也”广为流传。彼时文化对性的解读相对开放；从宋代的程朱理学起，儒家搬出“男女授受不亲”的教条作为封建伦理道德规范，开始了长达一千多年的中国性压抑时代。直到五四新文化运动的出现，     

从虚,痰,瘀论治慢性皮肤病

本文从中医基础理论出发，结合笔者临床实践提出慢性皮肤病从虚、痰，瘀治疗可获得良效的观点，从虚，痰，瘀角度探讨了慢性皮肤病的治疗。     

继往开来,更上层楼

<正>梅花闹春意,爆竹迎新年。在壬辰龙年到来之际,《皮肤性病诊疗学杂志》全体工作人员谨向长期以来关心和支持本刊发展的领导、专家、作者、读者以及社会各界朋友致以最真心的感谢和最诚挚的祝福。