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1.
Z Ogretmen A Akay C Bicakci HC Bicakci 《Journal of the European Academy of Dermatology and Venereology》2002,16(6):621-624
We report the case of a 49-year-old female who complained of hardening of the skin, with onset about 1.5 years before presentation. The laboratory data showed normal biochemistry profile. Routine haematochemical examinations showed slight anaemia, an increased erythrocyte sedimentation rate and negative rheumatological markers. Calcium excretion in a 24-h urine sample was normal, but the phosphate excretion was slightly low. The clinical diagnosis was verified by soft tissue ultrasound examination showing subcutaneous calcifications. X-ray examination of bones evidenced no abnormal calcification. Mammography revealed deep seated bilateral reticular calcifications, even in the axillary region. Histological examination showed calcinosis cutis. On these grounds, the diagnosis of idiopathic universal calcinosis cutis was made. The authors describe the clinical and histological picture and discuss the laboratory findings. 相似文献
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Satter EK Maari CH Morel KD Eichenfield LF Cunningham BB Friedlander SF Bergman JN 《The British journal of dermatology》2004,150(4):753-756
We present a unique case of an infant with acute monocytic leukaemia who presented at birth with multiple rubbery, erythematous to violaceous subcutaneous nodules secondary to leukaemia cutis. As these infiltrates regressed with chemotherapy, numerous white to yellow linear confluent papules appeared in a scratch-like pattern. These lesions were widely disseminated but were concentrated across her face, trunk and extremities with relative sparing of the napkin area and back. We propose that these lesions represent a form of dystrophic calcinosis cutis that occurred secondary to koebnerization in an infant with congenital leukaemia cutis. 相似文献
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Penny PL Lim Steven Kossard Karen Stapleton 《The Australasian journal of dermatology》2012,53(4):e66-e68
Calcinosis cutis is the deposition of insoluble calcium in the cutaneous tissue. Calcinosis cutis can be classified as metastatic, dystrophic, idiopathic or exogenous. We report a 48‐year‐old white man who was dismantling a portable ice skating rink when calcium chloride solution from the pipes spilt onto his clothing. Several days later, he started to develop mildly pruritic erythematous papules, some studded with white deposits and some with umbilication over the exposed areas corresponding to the spillage of the calcium chloride solution. Histological features revealed interstitial fibrohistiocytic reaction with calcium‐encrusted degenerated collagen bundles in the dermis which was further confirmed by von Kossa stain. He was commenced on topical corticosteroid cream twice daily and the lesions cleared completely between 6 to 10 weeks. 相似文献
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Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor
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Krishna Arudra Ravi Patel Michael T. Tetzlaff Sharon Hymes Vivek Subbiah Funda Meric‐Bernstam Carlos Torres‐Cabala Phyu P. Aung Priyadharsini Nagarajan Adi Diab Victor G. Prieto Kelly Nelson Jonathan L. Curry 《Journal of cutaneous pathology》2018,45(10):786-790
Small‐molecule inhibitors (nibs) have revolutionized cancer therapy with the emergence of clinically efficacious treatment for advanced‐stage malignancies. Fibroblast growth factor receptor (FGFR) inhibitors have shown therapeutic efficacy in malignancies with molecular‐genetic alterations in the FGFR/fibroblast growth factor pathway. In a phase 1 clinical trial, erdafitinib, a pan FGFR inhibitor, was well tolerated with a manageable toxicity profile. Hyperphosphatemia was a frequent adverse event in patients treated with erdafitinib; however, no serious complications were observed with this therapy. Here, we report the development of calcinosis cutis dermatologic toxicity in a patient with hyperphosphatemia while treated with a novel selective FGFR inhibitor, INCB 54828‐101. Awareness of this form of dermatologic toxicity from an FGFR inhibitor will be important for close monitoring of serum levels of phosphate, FGF23, vitamin D, and calcitriol, the management of adverse serum chemistry with chelators, and treatment decisions to either reduce dose or withhold FGFR inhibitor. 相似文献
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Calcinosis cutis is a common clinical feature of dermatomyositis and scleroderma but rarely reported in association with systemic lupus erythematosus (SLE). Calcinosis cutis in SLE occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. The pathophysiology remains unclear and no effective therapy is currently available. We report a 30-year-old woman with a 13-year history of SLE who developed multiple calcinosis cutis around both knees and we review the relevant published work. 相似文献
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Dong Won Lee Dou Hee Yoon Yeun Soo Lee Sang In Shim Baik Kee Cho 《The Journal of dermatology》1996,23(1):53-55
We report a unique case of solitary milialike idiopathic calcinosis cutis (MICC) in a healthy Korean woman, which is not associated with Down syndrome. This case of MICC would be a form of idiopathic calcinosis cutis, which can be solitary or multiple, sporadic or associated with Down syndrome. 相似文献
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Paolo Fiallo Enrico Nunzi 《Journal of the European Academy of Dermatology and Venereology》1995,5(3):285-288
We report the case of a 37-year-old woman who suffered for years of Raynaud's phenomenon associated with gangrene of digits. The patient displayed high levels of circulating antiphospholipid (aPL) antibodies, which on treatment with aspirin decreased significantly along with resolution of both Raynaud's phenomena and distal ischemic necrosis. To our knowledge this is the first report of an aPL syndrome featuring severe Raynaud's phenomenon as the only clinical sign. Possible pathogenetic correlations and the favourable therapeutic effect of aspirin are discussed. 相似文献
9.
Kurt Ammer 《Skin research and technology》1996,2(4):182-185
Background/aims: The aim was to clarify whether cold fingers before a moderate cold stress test can predict a prolonged delay (more than 20 min) in rewarming, as diagnostic for Raynaud's phenomenon.
Methods: A retrospective study was conducted on 71 patients suspected of suffering from Raynaud's phenomenon. The thermal gradient from the metacarpophalangeal joints to the finger tips was calculated for each finger and cold fingers were defined by a temperature difference of more than −0.5°2C.
Results: Combining the frequencies of cold fingers with a diagnosis Raynaud's phenomenon resulted in a sensitivity of 78.4%, a specificity of 72.4% and diagnostic accuracy of 74.0%.
Conclusion: Based on a positive predictive value of 58.5%, it was concluded, that a prolonged delay of rewarming after a cold stress test cannot be predicted sufficiently by the presence of cold fingers alone, and that a cold stress test is necessary to confirm the diagnosis objectively. 相似文献
Methods: A retrospective study was conducted on 71 patients suspected of suffering from Raynaud's phenomenon. The thermal gradient from the metacarpophalangeal joints to the finger tips was calculated for each finger and cold fingers were defined by a temperature difference of more than −0.5°2C.
Results: Combining the frequencies of cold fingers with a diagnosis Raynaud's phenomenon resulted in a sensitivity of 78.4%, a specificity of 72.4% and diagnostic accuracy of 74.0%.
Conclusion: Based on a positive predictive value of 58.5%, it was concluded, that a prolonged delay of rewarming after a cold stress test cannot be predicted sufficiently by the presence of cold fingers alone, and that a cold stress test is necessary to confirm the diagnosis objectively. 相似文献
10.
Dystrophic calcinosis cutis is defined as the abnormal deposition of insoluble calcium salts in dead or degenerated cutaneous tissues in the absence of abnormal serum calcium or phosphate concentrations. Although dystrophic calcification can occur in various diseases, its occurrence on a burn scar has rarely been reported in the dermatologic literature. Herein we describe two patients who presented with a solitary non-healing ulcer in a postburn scar, with histopathologic evidence of calcium deposition in the dermis. 相似文献
11.
H. Baart de la Faille H. van Weelden J. D. Banga R. G. van Kesteren 《Archives of dermatological research》1986,279(1):3-7
Summary Fifteen patients suffering from Raynaud's phenomenon (RP) were exmined. They were placed in a climate, chamber (a small room in which the temperature and humidity could be varied). The temperature was gradually decreased, while the humidity was kept constant. After 60–90 min, distinct RP was induced and intravenous medication was administered. The whole trial was performed in a double-blind, crossover fashion. Every patient participated in two experiments performed 2 days apart. Either ketanserin or placebo was given during the first experiment. In the second experiment, the medication (or placebo) which had not been given was administered. The effects of ketanserin were highly significant: the bluish pallor changed into bright erythema and the skin temperature rose significantly. This was interpreted as a spasmolytic effect. Intravenously administered ketanserin has a place in the clinical treatment of acutely deteriorating RP of diverse etiologies. 相似文献
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A 65-year-old Japanese female developed a nodule on the distal interphalangealjoint of her right thumb. She also had multiple telangiectasias on her face, oral mucosa, tongue, nasal mucosa and upper extremities. A lip biopsy showed irregularly dilated capillaries and venules lined by flat endothelial cells. The nodule in the right thumb was resected. Histopathology revealed calcium deposits in the dermis. This case was diagnosed as dystrophic calcinosis cutis within hereditary hemorrhagic telangiectasia. Ophthalmologic examination showed bilateral retinal vascular lesions with dilated and tortuous retinal venules. 相似文献
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Study of a myo-inositol hexaphosphate-based cream to prevent dystrophic calcinosis cutis 总被引:1,自引:0,他引:1
Background Calcinosis cutis is a disorder caused by abnormal deposits of calcium phosphate in the skin and is observed in diverse disorders. Myo‐inositol hexaphosphate (InsP6) is a diet‐dependent molecule found in all mammalian fluids and tissues, which exhibits an extraordinary capacity as a crystallization inhibitor of calcium salts. Objectives To establish the effects of topically administered InsP6 cream on artificially provoked dystrophic calcifications in soft tissues. Methods Fourteen male Wistar rats were randomly assigned into two groups: control and treated groups. Rats were fed with an InsP6‐free or phytate diet. Plaque formation was induced by subcutaneous injection of 0·1% KMnO4 solution. From 4 days before plaque induction to the end of the experiment, control rats were treated topically with a standard cream, whereas treated rats were treated with the same cream with 2% InsP6 or phytate (as sodium salt). Calcification of plaques was allowed to proceed for 10 days. InsP6 in urine was determined. The plaques were excised and weighed. Results It was found that when InsP6 was administered topically through a moisturizing cream (2% InsP6‐rich), the plaque size and weight were notably and significantly reduced compared with the control group (1·6 ± 1·1 mg InsP6‐treated, 26·7 ± 3·0 mg control). The InsP6 urinary levels for animals treated with the InsP6‐enriched cream were considerably and significantly higher than those found in animals treated topically with the cream without InsP6 (16·96 ± 4·32 mg L?1 InsP6‐treated, 0·06 ± 0·03 mg L?1 control). Conclusions This demonstrates the important capacity of InsP6 as a crystallization inhibitor and also demonstrates that it is possible to propose topical use as a new InsP6 administration route. 相似文献
17.
Jang KA Lim YS Choi JH Sung KJ Moon KC Koh JK 《The British journal of dermatology》2000,143(3):641-644
Cutaneous necrotizing eosinophilic vasculitis is a recently identified type of vasculitis that is characterized by an eosinophil-predominant necrotizing vasculitis affecting small dermal vessels. Clinically, it presents with pruritic erythematous and purpuric papules and plaques, peripheral eosinophilia and a good response to systemic steroid therapy. This vasculitis can be idiopathic or associated with connective tissue diseases. Although the pathogenic roles of eosinophil-derived granule proteins and interleukins have been documented in diseases associated with eosinophilia, a role of CD40 (a glycoprotein of the tumour necrosis factor receptor superfamily) has rarely been described. We describe two patients with idiopathic hypereosinophilic syndrome (HES) presenting with multiple erythematous patches and plaques on the lower extremities and Raynaud's phenomenon. They satisfied the criteria for the diagnosis of HES by clinical and laboratory investigations. Histopathology of the cutaneous lesions revealed prominent eosinophilic infiltration with local fibrinoid change in vessel walls in the dermis and subcutis. Immunohistochemical detection of CD3, CD4, CD8 and CD40 was performed. Infiltrating eosinophils were strongly stained by anti-CD40 monoclonal antibody. One patient improved with prednisolone, pentoxifylline and nifedipine, without recurrence. The other patient initially improved with steroids, but after self-withdrawal of steroid developed digital ischaemia that evolved to severe necrosis and required amputation. Cutaneous necrotizing eosinophilic vasculitis, Raynaud's phenomenon and digital gangrene may develop as cutaneous manifestations of HES. CD40 may play a part in the pathogenesis of eosinophilic vasculitis in HES. 相似文献
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Ji Hyun LEE Hyun Jeong PARK Jun Young LEE Baik Kee CHO 《The Journal of dermatology》2008,35(10):675-677
Dystrophic calcinosis cutis is diagnosed when calcium is deposited into previously damaged tissue by connective tissue disease, panniculitis, pseudoxanthoma elasticum or trauma. We report a case of dystrophic calcinosis cutis arising from the lesion of an epidermal cyst on the verrucous epidermal nevus. A 20‐year‐old woman presented with a polypoid pinkish tumor on a brownish, verrucous plaque. Histopathological findings of the pinkish tumor showed calcium deposits as amorphous, basophilic material lining the true epidermis in the upper dermis, which were compatible with dystrophic calcinosis cutis and the plaque was diagnosed as a verrucous epidermal nevus. 相似文献
19.
Beau's lines are transverse depressions or ridgings of the nail surface that are the result of the temporary arrest of nail matrix formation. They are caused by systemic diseases, local trauma, drugs, and infection. Generally, Beau's lines after a fingertip injury occur on only the affected finger, not on the unilateral extremity. In this report, we present the case of a 36-year-old man who developed transverse ridgings in the nail plates of all five fingers of the affected extremity after a fingertip (thumb) crushing injury. During the follow up, the growth rate of affected fingernails was normal. The transverse ridgings advanced with the linear growth of the nails and eventually disappeared. To the best of our knowledge, no association between unilateral Beau's lines and fingertip injury has been reported in the English literature. 相似文献
20.
Norito Katoh Keiko Okabayashi Shunji Wakabayashi Saburo Kishimoto Hirokazu Yasuno 《The Journal of dermatology》1993,20(2):114-117
A 22-year-old man had had a dome-shaped tumor on his penis for one year. Neither his particular past history nor family history was available. The excised specimen contained numerous von Kossa-positive deposits. Four types of histologic pattern were identified: 1) a cystic structure filled with amorphous material lined by a few layers of epithelial cells, 2) a cyst containing calcified deposits in the keratinous material, 3) a large calcified nodule lined by attenuated epithelial cyst walls, 4) numerous calcium collections without an epithelial wall. The cystic structure showed the histologic features of syringoma or sweat duct milia. The luminal cells of the cyst showed positive immunoreactivity for both keratin and carcinoembryonic antigen. These findings suggested that the keratinous contents of syringoma had gradually calcified, the cyst wall had been attenuated, and, finally, numerous calcium collections without an epithelial wall were formed. Our case further supported the hypothesis that penile calcinosis as well as scrotal calcinosis might derive from syringoma. 相似文献