中年男性秃顶人群代谢综合征发生率与心血管病及糖尿病危险因素的相关性

目的：探讨中年男性秃顶人群中代谢综合征(metabolic syndrome，MS)的发生率以及与心血管病和糖尿病危险因素间的关系。方法：调查于2002—10／2004—09在江苏省东海县人民医院内分泌科完成。选择江苏省东海县内城镇企事业机关等单位体检人员中的35～59岁汉族符合Ebling秃顶分类Ⅱ级以上的头顶部脱发男性239例为秃顶组．以自愿参加研究的无秃顶男性体检人员236例为对照组。测定两组的腰臀围、体质量指数(body mass index，BMI)、血压、总胆固醇、三酰甘油、高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL-C)、血糖、胰岛素、胰岛素抵抗指数(homeostasis model assessment insulin resistance，HOMA-IR)、睾酮水平，通过比较两组上述指标的差异，分析男性秃顶人群MS、心血管病和糖尿病危险因素的发生率及聚集性；胰岛素抵抗与心血管病和糖尿病危险因素聚集性的关系；秃顶群体中的MS与心血管病和糖尿病危险因素的指标变化、聚集程度及其间的相关性。结果：两组被调查475例均进入结果分析。①秃顶组的BMI[(27．30&;#177;3．20)kg／m^2]、腰围[(93．10&;#177;5．90)cm]、臀围[(97．2&;#177;6．10)cm]、腰／臀比值(0．96&;#177;0．10)、收缩压[(139．30&;#177;11．00)mmHg，1mmHg=0．133kPa]、舒张压[(92．20&;#177;8．90)mmHg]、总胆固醇[(6．25&;#177;0．83)mmol／L]、三酰甘油[(4．32&;#177;0．67)mmol／L]、空腹血糖[(7．00&;#177;1．31)mmol／L]、2h血糖[(11．30&;#177;2．86)mmol／L]、胰岛素[(16．20&;#177;6．60)MIU／L]、HOMA-IR值(7．08&;#177;1．10)均高于对照组[上述指标分别为(23．90&;#177;2．80)kg／m^2，(77．20&;#177;6．10)cm，(90．10&;#177;5．60)cm，(0．84&;#177;0．13)，(120．60&;#177;10．50)mmHg，(80．80&;#177;9．10)mmHg，(4．01&;#177;0．50)mmol／L，(1．30&;#177;0．28)mmol／L，(4．80&;#177;0．83)mmol／L，(7．10&;#177;1．82)mmol／L，(7．20&;#177;4．50)MIU／L，(1．21&;#177;0．53)]，HDL-C[(1．09&;#177;0．36)mmol／L]、睾酮[(18．50&;#177;8．02)nmol／L]较对照组[分别为(1．57&;#177;0．35)mmol／L，(33．28&;#177;10．24)nmol／L]显著降低，差异均有显著性意义(u=13．80—64．23，P均&;lt;0．001)。②在超重、高血压、高血糖、血脂紊乱的危险因素中，秃顶组的总发生率为88．7％，高于对照组的49．0％。③秃顶组危险因素的数值随空腹血糖的增加而增加，空腹血糖与BMI、收缩压、舒张压、总胆固醇、三酰甘油、HDL-C、尿酸显著相关(r=0．096，0．103，0．091，0．142，0．139，0．149，0．09；P&;lt;0．05—0．001)。④秃顶组腰围与各项危险因素均呈剂量反应关系，随着腰围的增大危险因素的发生倍数显著上升(OR=1．29～19．52．P&;lt;0．05—0．001)，在腰围≥100cm层次的更为显著，≥2项危险因素聚集的OR值增高18．5倍。⑤秃顶组心血管病和糖尿病的危险因素在个体中呈聚集性，≥3项危险因素的HOMA-IR(7．22&;#177;1．66)与2项危险因素(4．60&;#177;0．92)、1项危险因素(1．70&;#177;0．61)、无危险因素(1．12&;#177;0．73)的相比，差异均有显著性意义(F=260．86，P&;lt;0．01)；聚集程度与胰岛素抵抗呈正相关(r=0．901，P&;lt;0．001)。结论：超重、高血压、高血糖、胰岛素抵抗、血脂异常等是男性秃顶MS、心血管病和糖尿病共同的危险因素，他们之间具有相随相伴及互相促进的协同作用及相关性。睾酮降低、胰岛素抵抗导致多种危险因素的形成及在个体中高度聚集并与秃顶密切共存。男性秃顶是MS和心血管病和糖尿病的危险因素。     

男性秃顶群体动脉粥样硬化及危险因素比较

【目的】比较男性秃顶群体与一般群体间动脉粥样硬化（As）及危险因素的变化。【方法】以湖南省郴州铁路地区男职工为样本总体，共普查符合条件的男性秃顶者348人，按年龄分层青年组132人，中老年组216人，并随机抽取相应年龄数量的非秃顶男士为对照组。【结果】青年秃顶群体和中老年秃顶群体与对照组间其心血管病危险因素和冠心病、动脉粥样硬化发生率均无显著差异（P〉0．05）。[结论]虽然血睾酮水平与男性秃顶有关，血睾酮水平影响血脂、血糖、心血管危险因素及As，但男性秃顶群体与对照组之间就整体而言其心血管危险因素及As发生率并无差异。     

成都市龙泉驿区自然人群代谢综合征患病率及危险因素调查

目的通过调查了解四川省成都市龙泉驿区代谢综合征(metabolic syndrome,MS)的患病率及危险因素。方法采用分层随机整群抽样的方法对龙泉驿区1个社区、2个村组20~75岁常住人口600名(男227名,女373名)进行现场问卷调查、体格检查及相关代谢指标的实验室检查,了解MS患病率及代谢异常症候群的分布特点。MS采用2004年中华医学会糖尿病学分会(CDS)的诊断标准。结果四川省成都市龙泉驿区20~74岁自然人群MS患病率为10.27%,男女患病率分别为14.03%和8.04%,男性患病率显著高于女性(P<0.05);城区农村患病率分别为7.76%和11.59%,农村高于城区,但差异无统计学意义(P>0.05);MS发病与年龄、体质指数显著相关。结论四川省成都市龙泉驿区成人自然人群MS患病率较高,男性患病高于女性,农村高于城区;肥胖、糖调节异常是MS的重要组分。应进行相关的健康教育及有效的干预措施控制患病率。     

糖尿病患者心血管病危险因素的研究进展

流行病学资料显示,我国目前糖尿病（diabetes mellitus,DM）患者人数已超过5 000万,而且正以每年10%的速度递增,预计2010年将猛增至8 000万至1亿.2型DM患者发生动脉粥样硬化（atherosclcrosis,AS）、冠状动脉疾病（coronary artery disease,CAD）的几率为非DM患者的2～4倍,此外DM患者发生心肌梗死时病死率亦较高.因此,DM作为一种代谢综合征和冠心病等危症已越来越受到基础、临床及预防医学等各门学科的高度重视.目前已知DM患者发生CAD的危险因素除非DM患者也会有的血脂异常、高血压、感染、氧化应激等外,血糖升高对多种细胞功能的不良影响,尤其是糖基化终末产物（advanced glycosylation end products,AGEs）的堆积更与DM患者多种慢性并发症有关.研究表明,遗传性与获得性因素相互联系、相互作用,共同促进了DM患者AS的发生与发展。     

非酒精性脂肪肝危险因素及与代谢综合征的相关性

代谢综合征（MS）是糖尿病、冠心病、脑卒中等疾病的主要危险因素，与脂肪肝的相关性也备受临床关注。本文通过158例非酒精性脂肪肝（NAFLD，以下简称脂肪肝）的回顾性分析，探讨其危险因素及与代谢综合征（MS）间的相关性。     

2型糖尿病非酒精性脂肪肝患者危险因素及与代谢综合征的相关性研究

目的研究2型糖尿病非酒精性脂肪肝的危险因素及其与代谢综合征的关系。方法选择2型糖尿病非酒精性脂肪肝患者358例,按有无脂肪肝分组进行临床分析。结果2型糖尿病脂肪肝组肥胖和高脂血症的发生率高于无脂肪肝组,且脂肪肝组代谢综合征的患病率明显升高。结论肥胖和脂代谢异常是2型糖尿病非酒精性脂肪肝患者的相关因素,且其发生率与代谢综合征相关。     

脂联素与代谢综合征危险因素相关性的临床研究

近年来研究发现,脂肪组织不再仅仅是储存、提供能量的器官,还具有内分泌功能;其分泌的以血清瘦素、抵抗素和脂联素为代表的脂肪因子在代谢综合征发病中的作用已受到广泛关注.脂联素与肥胖、2型糖尿病、胰岛素抵抗及动脉硬化等均有一定的相关性,在代谢综合征发病过程中可能起着重要的作用.本研究选择代谢综合征患者为研究对象,探讨脂联素与体质量指数(BMI)、血压、血脂、血糖、空腹胰岛素(FINS)及胰岛素抵抗的相关性,以明确脂联素在代谢综合征中的作用,旨在为早期发现、诊断、药物干预代谢综合征探索一种新方法提供临床资料.     

江苏省金坛市职业人群代谢综合征危险因素分析

代谢综合征(MS)是以肥胖、糖尿病或糖调节受损、高甘油三酯(TG)血症和低高密度脂蛋白(HDL)血症为特点的血脂紊乱以及高血压(BP)等为临床表现的一组综合征.近年来随着我国社会经济的发展和生活方式的改变,MS的患病率正逐年上升.作者对江苏省金坛市职业人群代谢综合征危险因素进行了调查分析,现将报告如下.     

体检人群代谢综合征患病情况及危险因素调查与分析

目的调查体检人群代谢综合征的发生率,并分析其危险因素,为早期干预提供参考。方法对深圳市8 884名体检者的体重指数、血压、空腹血糖及血脂的指标进行调查分析。结果代谢综合征的患病率为15.89%,其中男性和中年组患病率较高(P<0.01);空腹血糖、甘油三酯、性别、收缩压、舒张压和体重指数、高密度脂蛋白是代谢综合征相关因素。结论深圳市体检人群代谢综合征总患病率处于较高水平,医务人员应及早对该人群进行干预,以预防和减少心脑血管疾病的发生,提高生活质量。     

代谢综合征特征指标与老年人2型糖尿病的相关性

背景：代谢综合征指标即血压升高、腹部肥胖、三酰甘油水平升高，高密度脂蛋白胆固醇水平降低，在个体中聚集存在，是糖尿病的预测因子。但类似老年人的资料相对较少。目的：分析代谢综合征各特征指标与老年人2型糖尿病危险性的相关性，为糖尿病的一级预防提供依据。设计：横断面调查。单位：卫生部北京老年医学研究所。对象：调查于2001—02／11完成，选择北京市西城、海淀、石景山科研单位年龄60岁以上老年人共4499名作为调查对象，均自愿参加调查。排除调查资料不全者。方法：对调查人群进行观察性分析，用调查问卷收集相关信息。糖尿病的诊断标准为空腹血糖≥7．0mmol／L或有糖尿病现患史。计数资料用，检验进行分析，计量资料均数的比较用调整年龄、性别的协方差分析。应用非条件多因素Logistic逐步回归法分析与糖尿病独立相关的指标。分析代谢紊乱的聚集与糖尿病的关系时，以无任何因素聚集为对照，按1，2，3，4个聚集数设亚变量，用Logistic回归模型分析各种聚集数目时糖尿病的危险程度，并调整年龄、糖尿病家族史、受教育水平的影响。主要观察指标：调查对象的血糖、腹围、体质量指数、血压、血清三酰甘油、高密度脂蛋白胆固醇、糖尿病现患史及家族史。结果：有4444名老年人进入结果分析。①调查共检出556名糖尿病患者。②统计结果显示年龄、糖尿病家族史、血压、腹围和血清三酰甘油与糖尿病独立相关[OR（95％CI）=1.02（1.00-1.04），3．48（2．76—4．39），1．02（1．01—1．02），1．03（1．00-1．03），1．13（1．05～1．21）]。③当血清三酰甘油不在模型中，高密度脂蛋白胆固醇与糖尿病成显著负相关，OR（95％CI）=0．67（0．49-0．91）。④随腹部肥胖、血压升高、三酰甘油水平升高、高密度脂蛋白胆固醇水平降低这4个变量在个体内聚集数目的增加，糖尿病的危险性亦逐渐增大。结论：除遗传和年龄因素外，代谢综合征指标尤其是指标的聚集与糖尿病密切相关，是提示糖尿病危险性的重要指征。     

Self-rated health and risk factors for metabolic syndrome among middle-aged men

OBJECTIVES: To examine lifestyle and clinical risk factors for metabolic syndrome (MBO) and compare their significance between levels of self-rated health among middle-aged men. DESIGN: A cross-sectional baseline study. SAMPLE: 273 men, aged 40, living in Helsinki, Finland. METHODS: Postal questionnaires and health examinations by public health nurses were used in data collection. Statistical differences between groups of self-rated health and risk factors were analyzed by chi-square tests. RESULTS: Of all the respondents, 55% rated their health as good and 45% as average. Two thirds were overweight or obese, and 35% had waist-hip ratio more than 100 cm. Approximately 43% had diastolic blood pressure greater than 90 mmHg. Over half of the men smoked daily, and 28% used alcohol excessively. CONCLUSIONS: The men in this sample were found to be at high risk of developing MBO. The results underscore the importance of understanding the contradiction that exists between subjective and objective health ratings. Public health nurses are in a key position to educate men on how to use simple measurements to objectively assess their risk factors and, thus, potentially reduce their risk of developing diabetes, heart attack, or stroke.     

Association of conventional risk factors for cardiovascular disease with IMT in middle-aged and elderly Chinese

To study the association between known risk factors for cardiovascular disease and intima-media thickness (IMT) in the carotid and popliteal arteries in middle-aged and elderly Chinese adults. 686 middle aged and elderly Chinese adults from the China Da Qing Diabetes Prevention Study who had full clinical, laboratory, ultrasound examination results were enrolled in the study. Common carotid artery (CCA) and popliteal artery (PA) IMT were obtained using high resolution ultrasound machine. Pearson’s or Spearman’s correlation analysis and logistic regression analysis were used to determine association between risk factors [age, gender, tobacco smoking, body mass index (BMI), diabetes mellitus (DM), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol, total triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, glycosylated hemoglobin (HbA_1c)] and CCA- or PA–IMT. The age range of the study population was 45–87 years, 384 of them (56 %) were women. The prevalence of high blood pressure and DM was 60.6 and 68.8 %, respectively. Participants in DM group tended to be older, had greater value for SBP, HbA_1c and PA–IMT, but smaller value for DBP than those in control group. Smoke status, BMI, blood lipids and CCA–IMT were not statistically different between groups. Pearson’s or Spearman’s rank correlation analysis showed that CCA–IMT had a positive correlation with age, gender, DM, SBP, BMI and HbA_1c, negative correlation with HDL-C. PA–IMT showed a positive correlation with age, gender and SBP. Univariate logistic regression analysis showed that elevation of age, SBP, BMI, HbA_1c and having DM were significant predictors of CCA–IMT thickening, so was reduction of HDL-C. Risk factors that predicted significant thickening of PA–IMT were age, gender, tobacco smoking. After adjusted for age and gender, except HDL-C, the other four risk factors (SBP, BMI, HbA_1c and having DM) that predicted CCA-IMT thickening remained significant; however none of the risk factors predicted PA–IMT thickening after adjusted for age and gender. The current results provide evidence that CCA–IMT is a superior marker for atherosclerosis compared with PA–IMT. Aggressive control of SBP, HbA_1c and proper control of weight may postpone thickening of CCA–IMT.     

Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men

OBJECTIVES: Interleukin-6 (IL-6) has been implicated in the development of cardiovascular disease. We have examined the relationship between plasma IL-6 and insulin resistance, and metabolic, inflammatory and hemostatic markers. METHODS: We examined 3490 men aged 60-79 years who were drawn from general practices in 24 British towns. The men were not diabetic and were not taking warfarin. RESULTS: IL-6 was significantly associated with age, body mass index (BMI), waist circumference (WC), cigarette smoking, low physical activity, social class and alcohol intake (U-shaped). IL-6 showed no association with insulin resistance or its other components (blood glucose, triglycerides, blood pressure) except high-density lipoprotein-cholesterol (inversely), and no association with hematocrit, factor (F) VII or adiponectin after adjustment for age and WC. IL-6 was strongly associated with markers of inflammation (C-reactive protein, fibrinogen, white cell count); plasma viscosity; elevated markers of coagulation (fibrin D-dimer, FVIII, FIX); markers of endothelial dysfunction (von Willebrand factor, tissue plasminogen activator); and to a smaller extent with platelet count, APC ratio and gamma glutamyltransferase. Risk of the metabolic syndrome increased significantly with increasing IL-6 but was attenuated after adjustment for BMI. CONCLUSION: IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease.     

Butyrylcholinesterase activity, cardiovascular risk factors, and mortality in middle-aged and elderly men and women in Jerusalem

BACKGROUND: The association of butyrylcholinesterase (BuChE) with Alzheimer disease and the association of this disease with cardiovascular risk factors raise interest in the association of BuChE activity with cardiovascular risk factors and mortality. METHODS: A baseline cross-sectional study was conducted between 1985 and 1987, encompassing residents > or =50 years of age living in a Jewish neighborhood in western Jerusalem. Interviews were followed by examinations and nonfasting blood sampling (available for 1807 participants). Follow-up data to April 1996 on mortality and causes of death were obtained through record linkage with the Israeli Population Registry. RESULTS: BuChE activity was inversely related to age and was positively associated with serum concentrations of albumin (r = 0.35; P <0.001), cholesterol (r = 0.31; P <0.001), and triglycerides (r = 0.30; P <0.001). Enzyme activity was associated with measures of overweight, obesity, and body fat distribution (e.g., body mass index, r = 0.20; P <0.001). In multivariate analysis, the associations of enzyme activity with serum cholesterol, triglycerides, and albumin persisted strongly. After adjustment by Cox proportional hazards regression for other predictors of mortality in this population, individuals in the lowest quintile of BuChE activity had significantly higher mortality than those in the highest quintile [hazard ratios (95% confidence intervals): all-cause mortality, 1.62 (1.15-2.30); cardiovascular deaths, 1.79 (1.05-3.05)]. The association was attenuated by introduction of serum albumin into the models. CONCLUSIONS: This is the first study to report on the association between BuChE and mortality. The relatively strong association of BuChE with serum lipid and albumin concentrations requires elucidation. Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in the elderly.     

Metformin-pioglitazone and metformin-rosiglitazone effects on non-conventional cardiovascular risk factors plasma level in type 2 diabetic patients with metabolic syndrome

BACKGROUND AND OBJECTIVE: Metformin is considered the gold standard for type 2 diabetes treatment as monotherapy and in combination with sulphonylureas and insulin. The combination of metformin with thiazolidinediones is less well studied. The aim of the present study was to assess the differential effect, and tolerability, of metformin combined with pioglitazone or rosiglitazone on glucose, coagulation and fibrinolysis parameters in patients with type 2 diabetes mellitus and metabolic syndrome. METHODS: This 12-month, multicentre, double-blind, randomized, controlled, parallel-group trial was conducted at three study sites in Italy. We assessed patients with type 2 diabetes mellitus (duration >or=6 months) and with metabolic syndrome. All patients were required to have poor glycaemic control with diet, or experienced adverse effects with diet and metformin, administered up to the maximum tolerated dose. Patients were randomized to receive either pioglitazone or rosiglitazone self-administered for 12 months. We assessed body mass index (BMI), glycaemic control [glycosylated haemoglobin (HbA(1c)), fasting and postprandial plasma glucose and insulin levels (FPG, PPG, FPI, and PPI respectively), homeostasis model assessment (HOMA) index], lipid profile [total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) and triglycerides (TG)], lipoprotein (a) [Lp(a)] and homocysteine (HCT) at baseline and at 3, 6, 9 and 12 months of treatment. RESULTS AND DISCUSSION: No BMI change was observed at 3, 6, 9 and 12 months in either group. Significant HbA(1c) decreases were observed at 9 and 12 months in both groups. After 9 and 12 months, mean FPG and PPG levels decreased in both groups. Decreases in FPI and PPI were observed at 9 and 12 months compared with the baseline in both groups. Furthermore, in both groups, the HOMA index improved but only at 12 months. Significant TC, LDL-C, HDL-C, TG improvement was present in the pioglitazone group at 12 months compared with the baseline values, and these variations were significantly different between groups. No TC, LDL-C, TG improvement was present in the rosiglitazone group after 12 months. Significant Lp(a) and HCT improvement was present in the pioglitazone group at 12 months compared with the baseline values, and Lp(a) change was significant compared with the rosiglitazone group. Significant HCT decrease was observed in the rosiglitazone group at the end of the study. In our type 2 diabetic patients, both drugs were safe and effective for glycaemic control and improving HCT plasma levels. However, long-term treatment with metformin plus pioglitazone significantly reduced Lp(a) plasma levels, whereas metformin + rosiglitazone did not. CONCLUSION: For patients with type 2 diabetes mellitus and metabolic syndrome, combined treatment with metformin and rosiglitazone or pioglitazone is safe and effective, However, the pioglitazone combination also reduced the plasma Lp(a) levels whereas the rosiglitazone combination did not.     

Treatment of hypertension and other cardiovascular risk factors in patients with metabolic syndrome

Metabolic syndrome (MetS), a concurrence of hypertension, abdominal obesity, impaired fasting glucose, and dyslipidemia, has been shown to be a risk factor for cardiovascular disease. Insulin resistance has been thought to be one of the pathophysiologies of the syndrome. Reduction of the underlying causes of MetS, such as obesity, physical inactivity, and atherogenic diet, is first-line therapy. Treatment of hypertension and other cardiometabolic risk factors of MetS is also required. This article reviews the treatment of the metabolic syndrome with a focus on the importance of lifestyle changes and treatment of hypertension.     

青岛港人群高尿酸血症患病率与心血管病危险因素的关系

目的：调查青岛港人群中血尿酸分布特点，分析其与心血管病危险因素的关联。方法：调查于2000—04／12完成。选择18-54岁青岛港职工11926名，从中整群抽样8640名进行了尿酸测定，均自愿参加调查。调查内容包括问卷、体格检查、实验室检查和特殊检查。通过问卷收集一般资料、个人疾病史、饮食和生活习惯和家族史等。测量职工的血压、身高及体质量。抽取空腹12h以上的静脉血，测定生化指标，血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、尿酸均用酶法测定，肌酐用苦味酸法测定。尿酸与心血管病的传统危险因素为血压、超重和肥胖、血糖、血脂。高尿酸血症为男性尿酸≥416μmol／L，女性尿酸≥357μmol／L。 结果：纳入青岛港职工8640名，全部进入结果分析，无脱落；①青岛港职工尿酸水平及高尿酸血症分布：男性尿酸水平明显高于女性[（320．0&;#177;66．1），（250．6&;#177;56．3）μmol／L]。男性总高尿酸血症患病率明显高于女性[7．3％，3．3％（χ^2=46．2，P〈0．01）]。②血浆尿酸与传统心血管病危险因素的相关性：除了男性年龄、血糖水平与尿酸水平无显著相关外，其他各因素均与尿酸有显著相关性（r=-0．128-0．286，P〈0．01）。③不同尿酸水平职工的心血管病危险因素水平比较：根据高尿酸血症评估标准，将全部职工按性别分别分为正常尿酸组和高尿酸血症组。除男性年龄、女性高密度脂蛋白胆固醇和心率外，两组间其他各危险因素水平比较．差异均有显著性意义（P〈0．05—0．01）。④不同尿酸水平职工的高血压、糖尿病、血脂异常等患病率比较：无论男女，高尿酸血症组的高血糖（空腹血糖受损＋糖尿病）、高血压、血脂异常和超重（包括肥胖）患病率均显著高于正常尿酸组（在20．33—249．30，P〈0．01）。（5）不同尿酸水平职工危险因素的个体聚集情况：无论男女2个及2个以上的危险因素的聚集比率在高尿酸血症组显著高于正常尿酸组[男：62．0％，29．2％；女：44．9％，13．2％（χ^27．75-164．20，P〈0．05-0．01）]。 结论：青岛港职工中高尿酸血症患病率较高，血尿酸水平与传统心血管病危险因素紧密相关，提示尿酸可以作为中国人心血管病危险因素的标志物。