窄谱中波紫外线治疗白癜风疗效观察

目的：观察窄谱中波紫外线(NB—UVB)N射治疗白癜风的疗效及其影响因素。方法：患者均用白癜酊或复方甘草酸钠霜剂，并内服药物，治疗组109例加用NB—UVB照射治疗，与对照组87例进行比较，根据皮损、照射时间来评价疗效。结果：治疗组有效率为83．49％，明显高于对照组的50．57％；皮损面积小则治疗效果优于面积大者．结论：窄谱NB—UVB照射治疗白癜风，安全有效，不良反心小。     

窄谱中波紫外线治疗白癜风34例疗效观察

目的探讨窄谱中波紫外线（NB-UVB）照射治疗白癜风患者的疗效及其影响因素。方法应用NB-UVB治疗白癜风34例，根据皮损、照射时间来评价疗效。结果痊愈12例，显效16例，好转6例，无效0例，有效率为82.35％，平均总剂量为24.5J／cm^2，达到显效时平均照射20.6次。结论NB-UVB照射治疗白癜风，疗效确切，且不良反应小。     

窄谱中波紫外线治疗白癜风102例疗效观察

目的:探讨窄谱中波紫外线照射治疗白癜风的临床疗效.方法:采用ss-03型紫外线光疗仪对102例白癜风患者进行局部照射治疗2-3个疗程,对白癜风部位的色素生长情况进行评价.结果:痊愈19例,显效64例,好转18例,无效1例,总有效率为81.38%.局限型、散发型、泛发型、肢端型的总有效率分别为96.43%、73.08%、0、55.56%.结论:窄谱中波紫外线照射治疗白癜风疗效确切,色素生长快,是临床上治疗白癜风的一种安全有效的方法.     

窄谱中波紫外线治疗白癜风的疗效观察

笔者采用窄谱中波紫外线(narrow band ultravioletB．NBUVB)照射治疗白癜风,取得较好疗效,现报告如下。     

窄谱中波紫外线联合薄芝糖肽治疗白癜风疗效观察

目的观察窄谱中波紫外线(NB-UVB)联合薄芝糖肽治疗白癜风的临床疗效及安全性。方法随机选取120例患者,治疗组60例采用NB-UVB照射治疗,初始剂量为0.4J/cm2,以后每次递增0.1J/cm2,最大剂量<3J/cm2,每周3次,同时肌肉注射薄芝糖肽2mL,隔日1次。3个月为1疗程,1疗程结束后判定疗效。对照组60例单独采用NB-UVB治疗,剂量、用法、疗程同治疗组。结果治疗组有效率为76.67%,对照组为48.33%,两组疗效差异有显著性(P<0.05),120例患者治疗期间均无严重的不良反应。结论NB-UVB联合薄芝糖肽治疗白癜风有效、安全性高。     

他卡西醇软膏联合窄谱中波紫外线治疗白癜风临床疗效观察

我们于2002年5月—2004年1月使用活性维生素D3他卡西醇软膏(商品名：萌尔夫，上海百润有限公司)外用，联合窄谱中波紫外线narrow-band ultraviolet B，NUVB)局部照射治疗白癜风，取得了较满意的疗效。现将临床观察结果及治疗体会报告如下。     

窄谱中波紫外线治疗白癜风研究进展

窄谱中波紫外线在白癜风的治疗中,取得了较为满意的效果.对其治理原理的研究也不断深入,现就近年来的研究进展作一综述.     

自体培养黑素细胞移植联合窄谱中波紫外线治疗白癜风疗效观察

目的评估自体纯培养黑素细胞移植联合窄谱中波紫外线(NB-UVB)治疗白癜风的临床疗效。方法应用自体纯培养黑素细胞移植治疗44例非节段型白癜风患者,其中23例患者在移植后2周进行NB-UVB治疗。结果共移植治疗了44例患者,其中联合NB-UVB组23例,两组中(联合NB-UVB组和单纯移植治疗组)获得较好复色效果(复色面积>50%)的患者分别为86.9%、76.2%,有统计学差异(P<0.05);两组的平均复色率分别为78.9%、70.0%。面颈部获得较好复色效果的患者分别为92.3%、90.9%,两组间对比无统计学差异;躯干部获得较好复色效果的患者分别为80.0%、60.0%,两组间对比有统计学差异(P<0.05)。结论自体纯培养黑素细胞联合NB-UVB是治疗白癜风的有效方法之一,且NB-UVB能够提高移植的疗效,尤其是对于局限于躯干的皮损。     

窄谱中波紫外线在白癜风治疗中的应用

白癜风是皮肤科难治病之一，目前窄谱中波紫外线（NB—UVB）广泛应用于白癜风的治疗中，取得了不错的疗效。文中对近几年来文献中报道的单独应用NB—UVB、NB—UVB联合药物及其它治疗方法在白癜风治疗中的情况进行总结。     

复方白芷酊联合窄谱中波紫外线治疗白癜风临床疗效观察

目的 探讨复方白芷酊联合窄谱中波紫外线(NB-UVB)治疗白癜风临床疗效.方法 治疗组30例用复方白芷酊联合NB-UVB治疗.对照组30例单纯应用NB-UVB治疗.结果 7例患者因不良反应而终止.两组的有效率分别为68.00%、39.29%.结论 复方白芷酊联合NB-UVB治疗白癜风疗效明显高于单纯应用NB-UVB治疗.     

No additional effect of topical calcipotriol on narrow-band UVB phototherapy in patients with generalized vitiligo

BACKGROUND/PURPOSE: There is no definite cure for vitiligo; however, treatment responses with photobiological modalities are quite acceptable. Of all these, narrow-band UVB phototherapy was proposed rather recently. Calcipotriol has been shown to have stimulating activity on melanogenesis besides immunomodulatory and anti-inflammatory effects. This study was performed to determine whether adding topical calcipotriol to narrow-band UVB phototherapy enhances the efficacy of treatment. METHODS: In this prospective, single-blinded (investigator), right-left comparison clinical study, 20 patients with generalized vitiligo were enrolled. Symmetrical lesions with similar sizes, bilaterally distributed on arms, legs, hands, feet or trunk were selected as reference lesions. In addition to narrow-band UVB, totally 96 treatment sessions, received two or three times weekly, the patients were asked to apply 0.005% topical calcipotriol on the selected side of the reference lesions twice daily. Then, they were monitored at the end of every 24-session interval. RESULTS: Cosmetically acceptable repigmentation was observed in 55% (11/20) of the patients without taking calcipotriol into account. There was statistically significant better response on the side that calcipotriol was not applied at the 24th session (P < 0.05). No statistically significant difference was found between the calcipotriol-treated and non-treated sides at 48th, 72th, and 96th sessions (P > 0.05). CONCLUSION: Our data confirm that, narrow-band UVB phototherapy is effective by itself in vitiligo, and show that adding topical calcipotriol does not improve treatment outcome.     

Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study

BACKGROUND: The first choice treatment for vitiligo vulgaris is narrow-band UVB (NB-UVB), but no satisfactory treatment exists. OBJECTIVES: To investigate if Polypodium leucotomos, an antioxidative and immunomodulatory plant extract, improves NB-UVB-induced repigmentation. METHODS: Fifty patients with vitiligo vulgaris randomly received 250 mg oral P. leucotomos or placebo three times daily, combined with NB-UVB twice weekly for 25-26 weeks. RESULTS: Repigmentation was higher in the P. leucotomos group vs. placebo in the head and neck area (44% vs. 27%, P = 0.06). Small repigmentation increases (P = n.s.) were observed for the trunk (6% increased repigmentation), extremities (4%), and hands and feet (5%) in the P. leucotomos group vs. placebo. Patients attending more than 80% of required NB-UVB sessions showed increased repigmentation in the head and neck area in the P. leucotomos group vs. placebo (50% vs. 19%, P < 0.002); no significant differences were seen in the other body areas. Patients with skin types 2 and 3 showed more repigmentation in the head and neck area in the P. leucotomos group vs. placebo (47% vs. 21%, P = 0.01), and no significant differences were seen in the other body areas. No conclusions could be drawn on skin types 4 and 5 due to low patient numbers. CONCLUSION: There is a clear trend towards an increase in repigmentation of vitiligo vulgaris affecting the head and neck area when NB-UVB phototherapy is combined with oral P. leucotomos. This effect may be more pronounced in light skin types.     

中波高能紫外线治疗儿童白癜风疗效评价

目的:评价中波高能紫外线治疗儿童白癜风的临床疗效及安全性。方法:采用美国Dua LightTM型高能紫外线治疗仪UV120-2型治疗40例儿童白癜风患者50处皮损,以l~2倍MED值作为治疗起始量,根据治疗后皮损的反应,每次照射剂量不变或增加15%,每周治疗1~2次,6个月后评价疗效。结果:皮损的总有效率为62%,痊愈率为26%。头面部、躯干部、四肢及肢端有效率分别为81.8%,83.3%,37.5%及0。无严重不良反应。结论:中波高能紫外线治疗儿童白癜风安全有效,病变部位与疗效相关。     

Narrow-band UVB treatment of vitiligo in Chinese

Narrow-band ultraviolet B (NBUVB) phototherapy has recently been reported to be an effective and safe treatment modality for vitiligo. In the present report, we evaluated the efficacy and safety of NBUVB therapy for vitiligo in Chinese patients. Seventy-two vitiligo patients treated from 2000 to 2003, were included retrospectively (male: female=33:39, mean age: 38.5). Among them, 61 were non-segmental type and 11 the segmental type. Treatments were given two to three times a week for a maximum period of one year with an initial dose of 0.2 J/cm2 and a 0-20% increment each session (mean accumulation dose: 155.3 J/cm2). Computer image analysis by Supervise classification was used to estimate the area of vitiligo involvement before and after treatment. An excellent response (75-100% area of repigmentation) was obtained in 9 patients (12.5%) and a good response (50-75%) in 24 (33.3%), a moderate response (25-50%) in 20 (27.8%), and a poor response (0-25%) in 19 (26.4%). In summary, 45.8% of our patients had more than 50% repigmentation. Burns were a side effect in 5 patients (7%) and transient erythema with itching or xerosis was noted in 5 patients (7%). These results indicate that NBUVB phototherapy is an effective and safe treatment choice for generalized vitiligo.     

窄谱中波紫外线治疗特应性皮炎疗效观察

目的：观察窄谱中波紫外线（NB—UVB）治疗特应性皮炎（AD）的疗效。方法：53例AD患者接受NB—UVB治疗仪照射治疗,每周治疗3次,连续治疗36次。采用欧洲AD评分标准（SCORAD）对AD的临床严重度进行评分,用视觉模拟尺度（VAS）评分法对瘙痒程度进行评分,同时记录SCORAD积分和VAS积分。疗程结束后评价疗效。结果：53例患者痊愈17例（32．08％）,显效28例（52．83％）,有效5例（9．43％）,有效率为84．91％,SCORAD积分和VAS积分较治疗前明显下降（P〈0．01）。结论：NB—UVB治疗AD安全性高,近期疗效好,操作简便,患者依从性好。     

Narrow-band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patients

BACKGROUND: Narrow-band ultraviolet B (NB-UVB) phototherapy and topical tacrolimus are included among the most innovative approaches to vitiligo. OBJECTIVE: To evaluate the efficacy and tolerability of combined treatment with NB-UVB and topical tacrolimus in vitiligo. METHODS: After informed consent, adult patients with chronic (> 1-year duration) stable vitiligo refractory to conventional treatments were enrolled in an open-labelled prospective study. Treatment regimen consists of once-daily application, in the evening, of tacrolimus 0.03% ointment to the lesions of the face, or tacrolimus 0.1% ointment to the vitiligous patches located on other areas. Concomitant NB-UVB phototherapy was performed twice weekly for 16 weeks. RESULTS: Study population included 110 patients (mean age, 42) with a total of 403 lesions. Within the treatment period, variable repigmentation was evident on more than 70% of lesions. Clinical response (repigmentation more than 50%) was observed in 42% of lesions. Response was strictly dependent on the site, being more frequent for face lesions (73%), followed by limbs (68%) and trunk (53.5%). The therapeutic effect on the extremities and genital areas was quite disappointing. Treatment was well tolerated. CONCLUSIONS: Our preliminary data suggest that the combination of topical tacrolimus with NB-UVB phototherapy can represent an alternative highly effective approach to refractory vitiligo located on the face, trunk and limbs. Long-term safety data and randomized controlled trials on a large number of patients are required.     

Monochromatic excimer light 308 nm in the treatment of vitiligo: a pilot study

OBJECTIVE: To study the efficacy and safety of monochromatic excimer light (MEL) on 37 vitiligo patients referred to our clinic. METHODS: In a pilot study, 37 patients (17 males, 20 females) with acrofacial (n=21), focal (n=11), segmental (n=1), and generalized (n=4) vitiligo were treated twice weekly with MEL for a maximum period of 6 months. RESULTS: Thirty-five patients (95%) showed signs of repigmentation within the first eight treatments. The treatment resulted in good repigmentation in 16 patients, and excellent repigmentation in 18 patients. Adverse events were limited to transient erythema. In addition, some patients (n=3) not responding to prior narrow-band UVB (NB UVB) phototherapy showed good results with MEL in our series. CONCLUSIONS: Treatment with 308 nm MEL for vitiligo may be more effective in obtaining rapid repigmentation than phototherapy with NB UVB. The results in this study are similar to those recently reported with a 308 nm excimer laser, but 308 MEL could present some advantages: the possibility of treating larger areas compared to the 308 nm excimer laser, with shorter treatment times and better patient compliance. The overall good results and the early appearance of repigmentation contribute to reducing the cumulative exposure to UV radiation.     

窄谱中波紫外线治疗白癜风临床研究

目的:评估窄谱中波紫外线(NB-UVB)治疗白癜风的临床疗效及安全性;探讨NB-UVB对稳定期白癜风患者治疗前、后免疫功能的影响.方法:对138例不同临床类型稳定期白癜风患者的652片皮损予NB-UVB照射治疗,在治疗前、后采用散射比浊速率法及流式细胞仪检测其中42例患者外周血IgA、IgM、IgC.C3、C4及T细胞亚群水平.结果:经NB-UVB照射治疗,138例患者有效率为64.72%.平均照射10.12次时皮损处出现色素沉着斑点,面颈部及躯干部疗效显著,局限型及泛发型白癜风患者疗效尤佳.主要不良反应为瘙痒与干燥.42例白癜风患者外周血IgA、IgM、IgG、C3、C4及T淋巴细胞亚群水平在治疗前、后差异无统计学意义.结论:NB-UVB治疗白癜风疗效显著、见效快、不良反应少.NB-UVB对稳定期白癜风患者治疗前、后免疫功能无影响.     

Quantitative assessment of narrow-band UVB induced tanning during phototherapy in Korea

BACKGROUND/PURPOSE: Narrow-band (TL-01) UVB lamps are being increasingly used for phototherapy of psoriasis and other dermatoses, for their excellent effect compared with broad-band UVB sources. Many patients receiving phototherapy have complained about the tanning effect of ultraviolet radiation especially in dark-skinned ones. So we wished to know the degree of pigmentation induced by phototherapy during narrow-band UVB treatment. METHODS: A total of 20 psoriasis patients receiving narrow-band UVB phototherapy were included in this study. A Minolta spectrophotometer CM-2002 was used to measure pigmentation. All patients were evaluated for skin color every seventh day for 7 weeks. The L* value (luminance) gives information about the relative lightness ranging from total black to pure white. The a* value represents the balance between red and green, and the b* value between yellow and blue. RESULTS: The L* values which indicate luminance decreased continuously until the 5th week, when maximum tanning was obtained. Afterwards minimal change was observed until the 7th week. The change of a* and b* values also showed the pattern that was compatible with the above results. The mean individual typology angle of our subjects was 41.9 degrees, which indicated they fell into "light" group of constitutional skin color category. CONCLUSION: From this study, we found that pigmentation induced by narrow-band UVB phototherapy increased continuously until the 5th week and then did not progress. Our results provide standard data of skin pigmentation during narrow-band UVB phototherapy in Korean brown skin.