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1.
Deborah W. Sevilla Erin M. Weeden Suzy Alexander Vundavalli V. Murty Bachir Alobeid Govind Bhagat 《Virchows Archiv : an international journal of pathology》2009,455(4):323-336
Different patterns of bone marrow (BM) infiltration by diffuse large B cell lymphomas (DLBCL) have been described. A pure
nodular pattern is uncommon, and the pathologic features, as well as the clinical correlates of DLBCL manifesting this pattern
in the BM have not been well characterized. We evaluated BM biopsies involved by large B cell lymphomas diagnosed at our institute
over an 11-year period to assess the morphology, phenotype, cytogenetic abnormalities, and clinical features of cases associated
with a nodular pattern. A distinct nodular pattern of BM involvement was noted in 14 out of 55 (25%) cases. Although both
EBV+ and EBV− DLBCL with this pattern were identified, a pure nodular pattern was significantly more common in EBV+ DLBCL
compared to EBV− DLBCL (8/9, 89% versus 6/46, 13%; P = 0.00002). The majority of EBV+ DLBCL associated with a nodular pattern had distinctive morphologic features (polymorphic
cellular infiltrate and pleomorphic cytology), and CD30 expression was more commonly observed in this group (P = 0.0163). All EBV+ DLBCL and two out of six (33%) EBV− DLBCL had nongerminal center phenotypes. No recurrent cytogenetic
abnormalities were detected in either group. Importantly, all EBV+ DLBCL occurred in individuals with immune dysfunction (organ
transplant recipients, HIV infection) or in those >50 years of age. Our study indicates a much higher predilection for EBV+
DLBCL to involve the marrow in a nodular pattern compared to EBV− cases and highlights similarities in the morphologic pattern
of BM involvement by previously recognized subsets of immunodeficiency-related EBV + lymphomas and the newer entity of “EBV+
DLBCL of the elderly.” 相似文献
2.
Rosario A. Caruso Patrizia Napoli Alberto Nania Antonino Parisi Francesco Fedele Valeria Zuccalà 《Virchows Archiv : an international journal of pathology》2010,456(5):499-505
Pathologic and prognostic data of nine patients with mitochondrion-rich carcinomas (MRC) were compared retrospectively to
data of 101 patients with conventional gastric adenocarcinomas. MRC was defined as a tumour composed predominantly, or entirely,
of columnar adenocarcinoma cells with eosinophilic cytoplasm and a strong supranuclear immunoreactivity for antimitocondrial
antibody. Electron microscopy confirmed supranuclear distribution of mitochondria in MRC while immunostaining pattern was
irregular or absent in the remaining 101 cases. MRC exhibited a tubulopapillary or cribriform growth pattern with focal infiltration
of neutrophils in the tumour stroma. Prominent necrosis was present including segmental and intraluminal “dirty necrosis”,
while mitotic and ki-67 proliferative rates were low. MRC showed immunohistochemical findings compatible with gastric differentiation
(CK7+/CK20−/CDX−).When MRC were compared with non-MRC carcinomas, tumour size (<4 cm vs >4 cm, P < 0.01), frequency of lymph node metastases (11% vs. 80%, P < 0.01), low stage (I, II) at diagnosis (100% vs. 56%, P < 0.01), Goseki’s group I (100% vs. 6%, P < 0.01), and better survival (0% vs. 70%, P < 0.01) differed significantly. Our results suggest that MRC of the stomach may be considered a low-grade malignancy with
an excellent prognosis. 相似文献
3.
Cytologic features of pancreatic adenocarcinoma with “vacuolated cell pattern.” report of a case diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration
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Arbaz Samad M.D. Andrea B. Conway M.D. Rajeev Attam M.D. Jose Jessurun M.D. Stefan E. Pambuccian M.D. 《Diagnostic cytopathology》2014,42(4):302-307
The “vacuolated cell pattern” has only been recently described as a distinct morphologic variant of pancreatobiliary adenocarcinoma. Herein, we report the endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) cytologic features of a case of pancreatic adenocarcinoma with “vacuolated cell pattern” occurring in a 60‐year‐old man. The aspirate smears and cell block sections from the EUS‐FNA of a 23.5 mm hypoechoic pancreatic head mass were highly cellular, showing variably‐sized crowded three‐dimensional cell clusters, flat sheets, and numerous highly atypical single cells. The background was bloody and showed necrotic debris, but no discernible mucus. The most striking feature of the aspirate was the presence of numerous very large (20–50 µm) vacuoles, occupying the entire cytoplasm, pushing the nuclei to the side and indenting them, that imparted a cribriform appearance to the sheets of neoplastic cells. The non‐vacuolated neoplastic cells were large, had abundant dense (squamoid) cytoplasm, irregularly contoured hyperchromatic nuclei, and prominent macronucleoli. Histologic evaluation of the pancreatectomy specimen showed a “vacuolated cell pattern” adenocarcinoma composed of poorly formed glands, solid sheets, and infiltrating single cells with pleomorphic nuclei and large cytoplasmic vacuoles. To our knowledge, this is the first report describing the cytologic features of this rather uncommon morphologic variant of pancreatic adenocarcinoma. Recognition of this morphologic variant of pancreatic adenocarcinoma in ESU‐FNA samples allows its differentiation from primary and metastatic signet‐ring cell carcinomas. Diagn. Cytopathol. 2014;42:302–307. © 2014 Wiley Periodicals, Inc. 相似文献
4.
The objective of this paper is to examine the association between violence and postpartum depression (PPD). The data sources
of this study are: Web of Science, PubMed, Elsevier, Springer Link were examined from their start date through July1, 2011.
“Violence”, “domestic violence”, “physical violence”, “sexual violence”, “domestic violence”, “postpartum depression”, “postnatal
depression”, and “puerperal depression” were some of the terms included in the purview of MeSH terms. Relevant studies from
reference lists were also scanned. Studies examining the association between violence and postpartum depression have been
included. A total of 679 studies were included in this screening. Essential information of these included studies was independently
extracted by two raters. Newcastle–Ottawa scale was used to assess the clinical data of these research studies. Random-effects
model was chosen in this meta-analysis for maintaining significant heterogeneity. Publication bias was evaluated with the
help of a funnel plot. Six studies involving 3,950 participants were included in this clinical study. Violence was one of
the factors responsible for PPD [OR = 3.47; 95% confidence interval (CI; 2.13–5.64)]. Significant heterogenity was found in
this meta-analysis (P < 0.00001; I
2 = 79%)and publication bias was detected through a funnel plot. A sensitivity analysis of 3.00, 95%CI (2.44–3.68), p < 0.00001 indicated that our findings were robust and reliable. Our meta-analysis indicated a positive correlation between
violence and PPD. In women of reproductive age, PPD induced through violence can be prevented through early identification.
In addition, due to heterogeneity and wide CIs in this meta-analysis, further research is evidently required. 相似文献
5.
Fatih M. Awad-El-Kariem Heidi A. Robinson Franz Petry Vincent McDonald David Evans David Casemore 《Parasitology research》1998,84(4):297-301
Isolates of Cryptosporidium parvum obtained from infected humans, calves and lambs were typed using arbitrary primed polymerase chain reaction (AP-PCR) and
isoenzyme electrophoresis. All animal isolates tested (n = 17) showed similar profiles in AP-PCR and isoenzyme typing. In AP-PCR assays, 9 out of 15 human isolates showed a distinct
“human” profile while the remaining 6 isolates showed the “animal” profile. In isoenzyme typing, 5 human isolates which had
shown “human” profiles in AP-PCR demonstrated a unique isoenzyme banding pattern, while 2 isolates which had shown “animal”
profiles in AP-PCR gave the “animal” banding pattern. In a murine model of infection, all four animal isolates tested were
highly infective but only one of four human isolates identified as “human” type in the AP-PCR and isoenzyme typing systems
was infective. The good correlation between the data from the different typing systems supports the hypothesis that there
are genetically distinct human and animal populations of C. parvum.
Received: 27 May 1997 / Accepted: 15 September 1997 相似文献
6.
VS Shishkina SV Kashirina VN Sirotkin OP Il'inskaya EM Tararak 《Bulletin of experimental biology and medicine》2012,152(5):642-645
Morphometric analysis of 35 biopsy specimens from patients with stable (n = 10) and unstable (n = 25) atherosclerotic lesions was carried out. The structure of the plaques and their connective tissue caps was studied
by various methods of histological sections staining. A new morphometric approach to quantitative evaluation of atherosclerotic
lesions instability is suggested. It consists in calculation of the morphological “rigidity” coefficient, due to which the
plaque is characterized more accurately. The proportion of areas of the “rigid” (connective tissue and calcium salt deposition
areas) to “soft” (atheronecrotic nuclei, microvessels, clots and hemorrhages) structures of the plaque is evaluated. Plaque
instability (liability of a to rupture) is associated with changes in the extracellular matrix components in the cap: accumulation
of collagen and reduction of elastic fiber content reducing vessel elasticity and making its locally more rigid. 相似文献
7.
S. N. Langerhuus E. K. Tønnesen K. H. Jensen B. M. Damgaard P. M. H. Heegaard U. Halekoh C. Lauridsen 《European journal of clinical microbiology & infectious diseases》2010,29(11):1453-1456
Aortic vascular prosthetic graft infection (AVPGI) with Staphylococcus aureus is a feared post-operative complication. This study was conducted to evaluate the clinical signs and potential biomarkers
of infection in a porcine AVPGI model. The biomarkers evaluated were: C-reactive protein (CRP), fibrinogen, white blood cells
(WBC), major histocompatibility complex II (MHC II) density, lymphocyte CD4:CD8 ratio and tumour necrosis factor-alpha (TNF-α)
in vitro responsiveness. Sixteen pigs were included in the study, and randomly assigned into four groups (n = 4): “SHAM” pigs had their infra-renal aorta exposed by laparotomy; “CLEAN” pigs had an aortic graft inserted; “LOW” and
“HIGH” pigs had an aortic graft inserted and, subsequently, S. aureus were inoculated on the graft material (5 × 104 colony-forming units [CFU] and 1 × 106 CFU, respectively). Biomarkers were evaluated prior to surgery and on day 2, 5, 7, and 14 post-operatively in blood samples.
Of all biomarkers evaluated, CRP was superior for diagnosing S. aureus AVPGI in pigs, with a sensitivity of 0.86 and a specificity of 0.75. 相似文献
8.
Electromyogram changes during sustained contraction after resistance training in women in their 3rd and 8th decades 总被引:3,自引:1,他引:3
The present study aimed at investigating the neuromuscular adaptations to 6 weeks of resistance training in women in their
third (6 experimental, 8 controls) and eighth decades (8 experimental, 8 controls). The surface electromyogram (sEMG) was
measured from the biceps brachii muscle during constant-force isometric contractions lasting 12 s at 80% of maximal voluntary
contraction (MVC). All the signals were analysed adopting in the time domain the root mean square (RMS) as a measure of amplitude
and in the frequency domain the median frequency (MDF) of the power spectrum. Quantitative analysis was performed from the
3rd to the 6th second, to describe the early phase of the contraction (“Early”), starting from point at which 80% of the MVC
was reached, and from the 9th to the 12th second, to describe the last part of the constant-force sustained contraction (“Late”).
After training, the MVC increased by 22.4% in the young (P < 0.0001) and by 13.4% in the older (P < 0.05) women. The “Early” RMS increased by 60.4% with respect to the pre-training condition in the young (P < 0.01) but not in the older women. In contrast, the “Late” RMS increased by 46.7% in the older (P < 0.05) but not in the young women. The MDF remained unchanged in both groups. These results indicate that young and older
women showed different training-induced adaptation of the motor unit (MU) activation pattern, in order to keep a constant
level of force during a sustained isometric contraction at 80% of MVC.
Accepted: 11 March 2000 相似文献
9.
The kDNA minicircle size was analyzed in 15 species of choanomastigote-shaped trypanosomatids and four main groups of species
were identified: (1) “Crithidia”deanei, “C.”desouzai and “Herpetomonas”roitmani, which presented the largest molecules (≥ 3,800 bp), (2) “C.”oncopelti with minicircles of at least four different sizes within 1,300–2,650 bp, (3) C. fasciculata, C. guilhermei and C. luciliae, having at least two sizes of minicircle (2,650 bp and 3,000 bp) and (4) a heterogeneous group of species presenting minicircles
of a single size, including several Crithidia spp. (having 1,600 bp or 1,700 bp minicircles) and two Proteomonas spp. presenting the smallest minicircles (about 1,500 bp). These results were compared with other observations and discussed
from a taxonomic point of view.
Received: 7 January 2000 / Accepted: 1 March 2000 相似文献
10.
Infections with the human malaria parasite Plasmodium falciparum are characterized by cytoadherence of infected erythrocytes to the venular endothelium of several organs. Video microscopy
studies have shown that at the end of the asexual life of P. falciparum, the residual body containing haemozoin is released to the extracellular environment along with merozoites, leaving behind
an infected erythrocyte “ghost”. It is possible that these infected erythrocyte “ghosts” could remain sequestered within the
blood vessels of patients infected with P. falciparum even after merozoites have been released from infected erythrocytes. In this study an in vitro cytoadherence assay was developed
to show that infected erythrocyte “ghosts” can interact with C32 melanoma cells. Adherent infected erythrocyte “ghosts” contain
some of the subcellular compartments of the malaria-infected red blood cell such as the tubo-vesicular membrane network and
remnants of the parasitophorous vacuolar membrane, but lack haemozoin.
Received: 28 August 2000 / Accepted: 13 September 2000 相似文献
11.
Spermiogenesis and the ultrastructural characters of the spermatozoon of Echinobothrium euterpes are described by means of transmission electron microscopy, including cytochemical analysis for glycogen. Materials were
obtained from a common guitarfish Rhinobatos rhinobatos caught in the Gulf of Gabès (Tunisia). Spermiogenesis in E. euterpes is characterized by the orthogonal development of two unequal flagella followed by the flagellar rotation and the proximodistal
fusion of these flagella with the median cytoplasmic process. The most interesting pattern characterizing the diphyllidean
cestodes is the presence of a triangular body constituted by fines and dense granules without visible striation and assimilated
at the striated rootlets. This pattern, only related in the Diphyllidea cestodes may be a synapomorphy of this order. Spermiogenesis
is also characterized by the presence of a very short flagellum (around 1 μm long), observed in all the stages of spermiogenesis.
This type of flagellum has never been commented in the diphyllidean cestodes and should be considered as an evolved character
in this group. In the latest stage of spermiogenesis, this short axoneme probably degenerates. Thus, the mature spermatozoon
of E. euterpes possesses only one axoneme of 9 + “1” trepaxonematan pattern. It also exhibits a single helical electron-dense crested body,
a spiraled nucleus, few parallel cortical microtubules, and α-glycogen granules. Similitudes and differences between spermatozoa
of diphyllideans are discussed. 相似文献
12.
Cavaleiro FI Pina S Russell-Pinto F Rodrigues P Formigo NE Gibson DI Santos MJ 《Parasitology research》2012,110(1):81-93
13.
Steigert J Brenner T Grumann M Riegger L Lutz S Zengerle R Ducrée J 《Biomedical microdevices》2007,9(5):675-679
In this paper, we present a novel and fully integrated centrifugal microfluidic “lab-on-a-disk” for rapid colorimetric assays
in human whole blood. All essential steps comprising blood sampling, metering, plasma extraction and the final optical detection
are conducted within t = 150 s in passive, globally hydrophilized structures which obviate the need for intricate local hydrophobic surface patterning.
Our technology features a plasma extraction structure (V = 500 nL, CV < 5%) where the purified plasma (c
RBC < 0.11%) is centrifugally separated, metered by an overflow and subsequently extracted by a siphon-based principle through
a hydrophilic extraction channel into the detection chamber. 相似文献
14.
Lassâd Neifar 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2008,53(3):258-262
Lamellodiscus crampus sp. nov. (Monogenea, Diplectanidae) is described from the gills of Dentex maroccanus (Valenciennes) collected from the Gulf of Gabès (Tunisia) in the oriental part of Mediterranean Sea. The new species belongs
to the “ignoratus” group (sensu Oliver 1987) characterized by a lamellodisc with complete lamellae and a “lyre” shaped male copulatory organ, and the “ignoratus”
sensu stricto subgroup, characterized by a haptor with simple lateral dorsal bars, as proposed by Amine and Euzet (2005). Lamellodiscus crampus can be easily distinguished from all the congeneric species of the subgroup “ignoratus” by the presence, in the “lyre” male
copulatory organ, of five spines in the distal portion on the axial side of the paired piece. 相似文献
15.
This study aimed to investigate whether endorsement of “difficulty coping” questions on two self-report measures would be
affected by whether or not women had to put their name on the questionnaires. In addition, a small survey of mental health
professionals was conducted to see what they thought the study would find. Women (n = 211) attending maternal and child health clinics completed two self-report measures of mood and experience of motherhood.
Women were either asked to write their name on the forms and were told that the project officer would check their forms once
completed (“named” condition) or asked not to put their name on the forms and that the forms would not be looked at (“anonymous”
condition). Perinatal mental health professionals (n = 44) completed an anonymous survey asking them what they considered the study would find. Most health professionals (77.3%)
expected that the anonymous condition would result in more “honest” responding by women—that is, there would be a higher rate
of women admitting to not coping in the anonymous condition. To the contrary, however, this was not found. There were no differences
between the rates of endorsement of “not currently coping” by women in the two conditions, a finding only expected by 13.6%
of the professionals. There was a small, but statistically significant, difference in women reporting whether they had a prior
history of difficulty coping, with more women in the named condition endorsing this. Rates of postnatal distress or depression,
based upon responses to self-report mood or similar questionnaires, are unlikely to be affected by whether participants are
required to put their name on the measures or not or whether they anticipate that their responses will be scrutinized. This
is an unexpected finding by a sample of mental health professionals interested in the perinatal mental health field, and thus,
the study has “new knowledge” significance. 相似文献
16.
Verwer PE Robinson JO Coombs GW Wijesuriya T Murray RJ Verbrugh HA Riley T Nouwen JL Christiansen KJ 《European journal of clinical microbiology & infectious diseases》2012,31(6):1067-1072
Due to a longstanding comprehensive “search and destroy policy”, methicillin-resistant Staphylococcus aureus (MRSA) is not endemic in Western Australian (WA) acute care hospitals. As the prevalence of MRSA in the community has increased,
healthcare workers (HCW) are at risk of importing MRSA into hospitals. We aimed to determine the prevalence of and risk factors
for nasal MRSA colonization in our HCW population. A period prevalence study was conducted at an 850-bed tertiary hospital.
Basic demographics and a nasal swab were obtained. A total of 1,542 HCWs employed in our centre were screened for MRSA, of
whom 3.4% (n = 52) were colonized. MRSA colonization was more common in patient care assistants (6.8%) and nurses (5.2%) than in allied
health professionals (1.7%) and doctors (0.7%) (p < 0.01). Working in “high-risk” wards that cared for MRSA colonized/infected patients was the strongest risk factor for HCW
MRSA colonization (p < 0.001). ST1-IV and ST78-IV (the most common community clones in the region) were the most frequently identified clones.
In conclusion, MRSA colonization of HCWs occurs primarily in HCWs caring for patients colonized or infected with MRSA. Surveillance
screening of HCWs should be regularly performed on wards with patients with high MRSA colonization prevalence to prevent further
spread in the hospital. 相似文献
17.
Effect of ageing on the ventilatory response and lactate kinetics during incremental exercise in man
Jacques Prioux Michèle Ramonatxo Maurice Hayot Patrick Mucci Christian Préfaut 《European journal of applied physiology》2000,81(1-2):100-107
We investigated the effects of age on breathing pattern, mouth occlusion pressure, the ratio of mouth occlusion pressure
to mean inspiratory flow, and venous blood lactate kinetics during incremental exercise. Mouth occlusion pressure was used
as an index of inspiratory neuromuscular activity, and its ratio to mean inspiratory flow was used as an index of the “effective
impedance” of the respiratory system. Nine elderly male subjects [mean (SD) age: 68.1 (4.8) years] and nine young male subjects
[mean (SD) age: 23.4 (1.3) years] performed an incremental exercise test on a bicycle ergometer. After a warm-up at 30 W,
the power was increased by 30 W every 1.5 min until exhaustion. Our results showed that at maximal exercise, power output,
breathing pattern, and respiratory exchange values, with the exception of tidal volume and the “effective impedance” of the
respiratory system, were significantly higher in the young subjects. The power output and oxygen consumption values at the
anaerobic threshold were also significantly higher in the young men. At the same power output, the elderly subjects showed
significantly higher values for minute ventilation, respiratory equivalents for oxygen uptake and carbon dioxide output (CO2), mean inspiratory flow, occlusion pressure and lactate concentration than the young subjects. At the same CO2 below the anaerobic threshold (0.5, 0.75, 1.00 and 1.25 l · min−1), minute ventilation and lactate concentration were also significantly higher in the elderly subjects. We observed a significantly
higher minute ventilation at CO2 values of 0.5, 0.75, 1.00 (P < 0.001) and 1.25 l · min−1 (P < 0.05) in the elderly men, and a significantly higher lactate concentration at CO2 values of 1.00 (P < 0.05) and 1.25 l · min−1 (P < 0.01). In conclusion, the ventilatory response in elderly subjects is elevated in comparison with that in young subjects,
both below and above the anaerobic threshold. This study demonstrates for the first time that this ventilatory increase, both
below and above the threshold, is partly due to an increased lactate concentration.
Received: 30 March 1999 / Accepted: 24 June 1999 相似文献
18.
Jutta Lindert Jaqueline Müller-Nordhorn Joaquim F. Soares 《Archives of women's mental health》2009,12(3):173-181
Little research has been carried out on prevalence rates of distress (e.g. depression, posttraumatic stress symptoms (PTSS),
hopelessness, and burnout) of women in different age groups. The aims of this study were to measure the prevalence rate of
depression, posttraumatic stress symptoms, hopelessness, and burnout among women and to clarify the associations between age
groups and distress. Cross sectional epidemiological study on women in Sweden (n = 6,000, aged 18–64 years, response rate 64.1%). Measures were questionnaires on socio-economic and work-related characteristics
and on depression, posttraumatic stress symptoms, hopelessness, and burnout. Depression was measured with the “General Health
Questionnaire” (GHQ), PTSS with the “Posttraumatic Symptom Scale”, hopelessness with the “Hopelessness Scale” and burnout
with the “Shiron-Melamed Burnout Questionnaire” (SMBQ). The prevalence rate of depression varied from 12.5% to 14.1%; of posttraumatic
stress symptoms from 23.5% to 33.3%; of hopelessness from 11.5% to 16%; and of burnout from 22.9% to 17.1%. Depression was
not associated with age group. Hopelessness was associated with age group in univariate analysis bur not in multivariate analysis
(OR = 0.7, 95% CI = 0.5–1.0). PTSS and burnout were associated with age group. Both symptoms were higher in the youngest age
group, compared to the eldest age group (posttraumatic stress symptoms: OR = 1.6, 95% CI = 1.2, 2.1; burnout: OR = 1.5, 95%
CI = 1.1–2.1). Younger women show higher prevalence rates of PTSS and burnout compared to elder women. The higher prevalence
rates of PTSS and burnout among younger women may be associated with job strain and/or with violent life events. 相似文献
19.
Mills SE 《Endocrine pathology》1996,7(4):329-343
Virtually every variant of neuroendocrine neoplasia can occur, at least rarely, in the head and neck region. This review focuses
on the terminology surrounding neuroendocrine carcinomas of the larynx and their distinction from morphologically similar
but biologically distinctive neoplasmas. It is suggested that rare typical laryngeal carcinoids be labeled as such. There
is little evidence that these lesions are part of a morphologic continuum. In contrast, more common “carcinoid-like” carcinomas,
previously referred to as “atypical carcinoids” are more appropriately labeled as “moderately differentiated neuroendocrine
carcinomas”. These neoplasms should, in turn, be distinguished from “small cell neuroendocrine carcinomas,” although these
latter two neoplasms do represent a morphologic and behavioral spectrum. Light microscopic and immunohistochemical features
distinguishing neuroendocrine carcinomas of the larynx from paraganglioma, metastatic medullary carcinoma, malignant melanoma,
and basaloid squamous cell carcinoma are presented. The second portion of this review outlines the clinicopathologic features
of two head and neck neoplasms exhibiting varying degrees of neuroendocrine differentiation. Olfactory neuroblastomas have
well-developed neuroendocrine differentiation, almost invariably arise from the olfactory mucosa, typically exhibit low-grade
cytologic features, and may have protracted clinical course with an approximately 50% overall 5-yr survival. In contrast,
sinonasal undifferentiated carcinoma is a microscopically high-grade neoplasm with minimal, abortive neuroendocrine features,
a highly aggressive clinical course, and virtually 100% mortality. They can arise throughout the sinonasal region.
Presented at the Endocrine Pathology Society—USCAP Meeting, Washington, DC, March 23, 1996. 相似文献
20.
Yuan-Zhi Shao Li-Zhi Liu Meng-Jie Bie Chan-chan Li Yao-pan Wu Xiao-ming Xie Li Li 《Journal of digital imaging》2011,24(5):764-771
In this study, we explore a mathematical model to characterize the clustered microcalcifications on mammograms for predicting
the pathological classification and grading. Our database consists of both retrospective cases (78 cases) and prospective
cases (31 cases) with pathologically diagnosed clusters of microcalcifications on mammograms. The microcalcifications were
divided into four grades: grade 0, benign breast disease including mastopathies (n = 12) and fibroadenomas (n = 20); grade 1, well-differentiated infiltrating ductal carcinoma (n = 12); grade 2, moderately differentiated infiltrating ductal carcinoma (n = 38); grade 3, poorly differentiated infiltrating ductal carcinoma (n = 27). A feature parameter, defined as the pattern form factor of microcalcification cluster θ by us, combines five computer-extracted image parameters of microcalcification clusters of those mammograms. In every case,
only one imaging was selected for modeling analysis. A total of 109 imagings were adopted in current study. We find the existence
of a positive relationship between the feature parameter θ and pathological grading G of microcalcifications in retrospective cases, which was expressed as G =
6.438 + 1.186 ×
Ln <θ>. The model above has been verified further by the prospective study with a comparative evaluation accuracy of approximately
77.42%. The binary predication simply for both benignancy and malignancy was also included using same but reshuffled data,
and the receiver operating characteristic (ROC) analysis was performed with ROC value 0.74351∼0.79891. As one candidate for
feature parameter in computer-aided diagnosis, the pattern form factor θ of clustered microcalcifications may be useful to predict the pathological grading and classification of microcalcification
clusters on mammography in breast cancer. 相似文献