中晚期中央型肺癌介入治疗的临床研究

目的对比分析中晚期中央型肺癌支气管动脉介入治疗与全身静脉化疗的疗效。方法中央型中晚期肺癌85例,均经病理证实,分为支气管动脉介入治疗组与全身静脉化疗组。结果支气管动脉介入治疗组肺内原发病灶、远处转移灶、肺外淋巴结转移灶的有效率分别为59.52%、18.18%、55.56%;全身静脉化疗组分别为30.23%、53.85%、52.63%。肺内原发病灶、远处转移灶两组间有效率的差异有统计学意义(P<0.05)。结论支气管动脉介入治疗比全身静脉化疗能更有效地控制肺内原发病灶,但对远处转移灶治疗控制能力较低。     

Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals

BACKGROUND: Differences in levels of bioavailable iron (BAI) in coal may be responsible for the observed regional differences in the prevalence and severity of coal workers' pneumoconiosis (CWP). METHODS: Twenty-nine coal samples from three coal mine regions were tested in human lung epithelial Type II A549 cells. They were from Utah (UT), West Virginia (WV), and Pennsylvania (PA) with a prevalence of CWP of 4, 10, and 26%, respectively. RESULTS: Low molecular weight (LMW) chelators bound iron, a fraction of BAI in the cells released from coals, ferritin, and lipid peroxidation were significantly higher in cells treated with various coals than in control cells, with an increasing order of UT < WV < PA, in parallel to the prevalence of CWP in these coal mine regions. Deferoxamine (DFO), a specific iron chelator, was used to distinguish effects of BAI from those of other transition metals. Our results indicate that BAI in the coals of WV and UT is the main metal species in inducing ferritin and lipid peroxidation. In contrast, biological effects of PA coals are not only from BAI, but from other transition metals as well. CONCLUSIONS: Based on a large number of coal samples from various seams, the findings of this study provide further evidence that metals, particularly iron, play important roles in coal dust-induced cellular damage, ultimately leading to the development of CWP and contributing to the regional differences in the prevalence of the disease.     

支气管动脉灌注化疗中晚期肺癌的疗效分析

目的:分析支气管动脉灌注化疗中晚期肺癌的疗效和临床经验。方法:将60例中晚期肺癌,在500mA胃肠X线机监视下,采用Seldinger技术经股动脉穿刺插管,将导管选择性送入支气管动脉(靶血管)开口,经导管向靶血管内注入大剂量联合化疗药物,回顾性分析其治疗效果。结果:完全缓解7例(占11.7%),部分缓解46例(占76.7%),无变化7例(占11.7%),显效率88.3%。结论:应用该方法治疗中晚期支气管肺癌病人,可以缓解病情,提高生存率,可明显改善其生存质量和生存时间。     

Relationship between the body adiposity index and cardiometabolic risk factors in obese postmenopausal women

Objective

The purpose of the present secondary analysis study was to investigate the ability of the body adiposity index (BAI) to detect changes in % body fat levels before and after a weight loss intervention when compared to % body fat levels measured using dual-energy X-ray absorptiometry (DXA) and to examine the relationship between the BAI with cardiometabolic risk factors.

Methods

The study population for this secondary analysis included 132 non-diabetic obese sedentary postmenopausal women (age: 57.2 ± 4.7 years, BMI: 35.0 ± 3.7 kg/m²) participating in a weight loss intervention that consisted of a calorie-restricted diet with or without resistance training. We measured: (1) visceral fat using CT-scan, (2) body composition using DXA, (3) hip circumference and height from which the BAI was calculated, and (4) cardiometabolic risk factors such as insulin sensitivity (using the hyperinsulinemic-euglycemic clamp), blood pressure as well as fasting plasma lipids, hsC-reactive protein (CRP), leptin, and glucose.

Results

Percent body fat levels for both methods significantly decreased after the weight loss intervention. In addition, the percent change in % body fat levels after the weight loss intervention was significantly different between % body fat measured using the DXA and the BAI (?4.5 ± 6.6 vs. ?5.8 ± 5.9%; p = 0.03, respectively). However, we observed a good overall agreement between the two methods, as shown by the Bland–Altman analysis, for percent change in % body fat. Furthermore, similar correlations were observed between both measures of % body fat with cardiometabolic risk factors. However, results from the multiple linear regression analysis showed that % body fat using the BAI appeared to predict cardiometabolic risk factors differently than % body fat using the DXA in our cohort.

Conclusions

Estimating % body fat using the BAI seems to accurately trace variations of % body fat after weight loss. However, this index showed differences in predicting cardiometabolic risk factors when compared to % body fat measured using DXA.     

支气管动脉灌注长春瑞宾顺铂治疗非小细胞肺癌疗效分析

目的评价支气管动脉灌注(BAI)长春瑞宾(NVB)顺铂(DDP)治疗非小细胞肺癌(NSCLC)的近期疗效。方法对手术难度较大,难以手术切除或不愿意接受手术切除的非小细胞肺癌患者36例,用NVB+DDP行BAI共2次,每次间隔3w。结果经2次BAI后,其中CR4例,PR21例,有效率69.56%。结论支气管动脉灌注长春瑞宾顺铂治疗非小细胞肺癌具有较好的近期疗效。     

Visceral Adiposity in Relation to Body Adiposity and Nutritional Status in Elderly Patients with Stable Coronary Artery Disease

Introduction: The accumulation of visceral abdominal tissue (VAT) seems to be a hallmark feature of abdominal obesity and substantially contributes to metabolic abnormalities. There are numerous factors that make the body-mass index (BMI) a suboptimal measure of adiposity. The visceral adiposity index (VAI) may be considered a simple surrogate marker of visceral adipose tissue dysfunction. However, the evidence comparing general to visceral adiposity in CAD is scarce. Therefore, we have set out to investigate visceral adiposity in relation to general adiposity in patients with stable CAD. Material and methods: A total of 204 patients with stable CAD hospitalized in the Department of Medicine and the Department of Geriatrics entered the study. Based on the VAI-defined adipose tissue dysfunction (ATD) types, the study population (N = 204) was divided into four groups: (1) no ATD (N = 66), (2) mild ATD (N = 50), (3) moderate ATD (N = 48), and (4) severe ATD (N = 40). Nutritional status was assessed using the Controlling Nutritional Status (CONUT) score. Results: Patients with moderate and severe ATD were the youngest (median 67 years), yet their metabolic age was the oldest (median 80 and 84 years, respectively). CONUT scores were similar across all four study groups. The VAI had only a modest positive correlation with BMI (r = 0.59 p < 0.01) and body adiposity index (BAI) (r = 0.40 p < 0.01). There was no correlation between VAI and CONUT scores. There was high variability in the distribution of BMI-defined weight categories across all four types of ATD. A total of 75% of patients with normal nutritional status had some form of ATD, and one-third of patients with moderate or severe malnutrition did not have any ATD (p = 0.008). In contrast, 55–60% of patients with mild, moderate, or severe ATD had normal nutritional status (p = 0.008). ROC analysis demonstrated that BMI and BAI have poor predictive value in determining no ATD. Both BMI (AUC 0.78 p < 0.0001) and BAI (AUC 0.66 p = 0.003) had strong predictive value for determining severe ATD (the difference between AUC 0.12 being p = 0.0002). However, BMI predicted mild ATD and severe ATD better than BAI. Conclusions: ATD and malnutrition were common in patients with CAD. Notably, this study has shown a high rate of misclassification of visceral ATD via BMI and BAI. In addition, we demonstrated that the majority of patients with normal nutritional status had some form of ATD and as much as one-third of patients with moderate or severe malnutrition did not have any ATD. These findings have important clinical ramifications for everyday practice regarding the line between health and disease in the context of malnutrition in terms of body composition and visceral ATD, which are significant for developing an accurate definition of the standards for the intensity of clinical interventions.     

Brief alcohol intervention as pragmatic intervention: Who is voluntarily taking an offered intervention?

Brief alcohol interventions (BAI) have shown the potential to decrease problematic alcohol use among adolescents and young adults. Most of the BAI studies have been efficacy trials designed to achieve high internal validity but have raised questions regarding the feasibility of large-scale implementation. Providing interventions for those voluntarily wanting them might offer an alternative, and studies using this design would be more similar to effectiveness studies. The present research compares randomly selected 20-year-old men who took part in a scientific trial (efficacy) with those who voluntarily sought an intervention (effectiveness). Sampling took place during army recruitment procedures that are mandatory for all males in Switzerland. At-risk drinking (20+ drinks per week, or more than one risky drinking occasion of 6+ drinks per month) was determined a posteriori; there was no screening. There were a higher percentage of at-risk drinkers in the volunteer arm at baseline, but at-risk drinkers did not differ from those in the trial arm on any of the assessed alcohol measures. This suggests that offering BAI on a large-scale, voluntary basis may reach at-risk drinkers as effectively as do more scientifically oriented trials, without needing to adhere to screening and stringent research procedures. Nevertheless, BAI was more effective for at-risk drinkers who were invited for trial participation versus those who volunteered. This could be due to behavior that is already consolidated and is difficult to change. Lacking further modifications, real-world implementations of BAI for young men may be less effective than randomized controlled trials designed to test the efficacy of BAI.     

支气管动脉灌注化疗联合全身化疗治疗中晚期肺癌的临床观察

目的 对比分析中晚期肺癌支气管动脉灌注化疗（BAI）与全身静脉化疗的疗效.方法 中晚期肺癌患者40例,均经病理证实,分为支气管动脉灌注化疗组（治疗组）与全身静脉化疗组（对照组）.结果 治疗组和对照组近期疗效有效率分别为75%和40%,半年、1年、2年生存率分别为95%、85%、45%和80%、45%、10%,组间差异有统计学意义（P〈0.05）,而且在毒副反应方面治疗组明显低于对照组.结论 支气管动脉灌注化疗是治疗中晚期肺癌的最有效方法之一,比全身静脉化疗能更有效地控制肺内原发病灶,延长患者的生存期,减轻患者的毒副反应.     

Endovascular stent-graft placement for vascular failure of the thoracic aorta

It still remains undetermined whether endovascular stent-graft placement (ESGP) is the optimal initial treatment for elective cases of thoracic aortic disease because of unknown long-term results. However, it is also recognized that ESGP contributes to better outcome as an initial treatment for aortic emergency, such as rupture, aortic injury, and complicated acute type B aortic dissection. Despite the fact that most patients are elderly, early mortality rates of ESGP are reportedly around 10% in cases of ruptured degenerative thoracic aortic aneurysm. Postoperative morbidity is also superior in ESGP compared with conventional open repair. Postoperative paraplegia has rarely occurred with ESGP. In cases of blunt aortic injury (BAI), other complications may also be present because of other serious injuries. ESGP has changed the surgical strategy for BAI and partially resolved some of the clinical dilemmas. Early mortality rate is almost zero when a stent graft can be placed before re-rupture. While BAI is a very good indication for ESGP, young patients need careful management and attention because of the unknown long-term outcome. In cases of complicated acute type B aortic dissection, the two main determinants of death, shock from rupture and visceral ischemia, could be managed by ESGP with or without conventional endovascular interventions. Recent reports disclosed less than 10% early mortality with ESGP for complicated acute aortic dissection. Even if the possibility of endotension remains, ESPG seems to be beneficial for these critical patients as the preferable initial treatment. The importance of close follow-up should be stressed to avoid some devastating late complications following ESGP.     

Potential Risk Factors Increasing the Severity of Sexual Dysfunction in Women with Fibromyalgia

The purpose of this study is to investigate the effect of clinical features including duration of FM and sexual partnership, and severity of pain, anxiety, and depression on the severity of sexual dysfunction in women with Fibromyalgia (FM). This cross-sectional study was conducted on 130 female patients with FM, who were admitted to Physical Therapy and Rehabilitation Polyclinic in August and September 2015, and 60 healthy controls. The data was collected with Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Women Sexual Function Index (FSFI), Fibromyalgia Impact Questionnaire (FIQ) and Visual Analogue Scale (VAS). Evaluating FM and control group according to the FSFI Score, it was found that 103 (84.4%) and 19 (15.6%) had sexual dysfunction, respectively. The median scores of FSFI scale and subscale, and VAS in the FM patients were significantly higher than those in the control group (p < 0.05). The mean scores of FIQ, BAI, and BDI in the FM patients were significantly higher than those in the control group (p < 0.05). The FSFI score was significantly predicted by FIQ, BAI, duration, and duration of partnership. FSFI score has a negative correlation with BAI score, disease duration and duration of partnership. This study supports that FM may affect all domains of sexual function. In our clinical settings, multiple regression analysis reveals that the duration and severity of FM and duration of sexual partnership, and severity of anxiety but not severity of pain and depression can increase the severity of sexual dysfunction. Knowledge about meaningful contributing factors of duration of FM and sexual partnership, and severity of FM and anxiety may be helpful for physicians for determining correct strategies for prevention and management of sexual dysfunction in FM.     

肺癌选择性支气管动脉灌注化疗的临床分析

目的：探讨选择性支气管动脉灌注化疗（ＢＡＩ）对中晚期肺癌的疗效及影响因素。方法：对６９例中晚期肺癌进行ＢＡＩ治疗,根据不同病期、组织类型、病变部位、肿瘤血管构型、血供类型及操作技术进行分析。结果：（１）中央型,小细胞未分化癌及鳞癌、多血管构型、少血供者与周围型、腺癌、少血管构型、多血供患者之间疗效差异有显著性,前者优于后者（Ｐ＜０．０５）。（２）６９例中ＢＡＩ后肺内局部病变完全缓解（ＣＲ）１５例（２１７％）,部分缓解（ＰＲ）３２例（４６４％）,缓解（ＣＲ＋ＰＲ）４７例,缓解率６８１％。其中小细胞未分化癌、鳞癌、腺癌的缓解率分别为９３２％、７９４％、５１５％。结论：（１）Ⅳ期病人不适合ＢＡＩ治疗。（２）鳞癌首选ＢＡＩ治疗,小细胞未分化癌以全身化疗为基础,辅助应用ＢＡＩ治疗,腺癌可先行ＢＡＩ治疗,几次ＢＡＩ治疗中间或之后,配合全身化疗或放疗,治疗或消灭远处转移。     

Brief alcohol interventions: do counsellors' and patients' communication characteristics predict change?

AIMS: To identify communication characteristics of patients and counsellors during brief alcohol intervention (BAI) which predict changes in alcohol consumption 12 months later. METHODS: Tape-recordings of 97 BAI sessions with hazardous drinkers were analysed using the Motivational Interviewing Skill Code (MISC). Outcome measures were (i) baseline to a 12-month difference in the weekly drinking quantity, and (ii) baseline to a 12-month difference in heavy drinking episodes per month. Bivariate analyses were conducted for all MISC measures, and significant variables were included in multiple linear regression models. RESULTS: Patient communication characteristics (ability to change) during BAI significantly predicted the weekly drinking quantity in the multiple linear regression model. There were significant differences for some of the counsellor skills in bivariate analyses but not in the multiple regression model adjusting for patients' talk characteristics. Changes in heavy drinking showed no significant association with patient or counsellor skills in the multiple linear regression model. CONCLUSION: Findings indicate that the more the patient expresses ability to change during the intervention, the more weekly alcohol use decreases. The role of the counsellor during the interaction, and influence on the outcomes was not clearly established. Implications for BAI and related research are discussed.     

Mapping and prediction of coal workers' pneumoconiosis with bioavailable iron content in the bituminous coals

Based on the first National Study of Coal Workers' Pneumoconiosis (CWP) and the U.S. Geological Survey database of coal quality, we show that the prevalence of CWP in seven coal mine regions correlates with levels of bioavailable iron (BAI) in the coals from that particular region (correlation coefficient r = 0.94, p < 0.0015). CWP prevalence is also correlated with contents of pyritic sulfur (r = 0.91, p < 0.0048) or total iron (r = 0.85, p < 0.016) but not with coal rank (r = 0.59, p < 0.16) or silica (r = 0.28, p < 0.54). BAI was calculated using our model, taking into account chemical interactions of pyrite, sulfuric acid, calcite, and total iron. That is, iron present in coals can become bioavailable by pyrite oxidation, which produces ferrous sulfate and sulfuric acid. Calcite is the major component in coals that neutralizes the available acid and inhibits iron's bioavailability. Therefore, levels of BAI in the coals are determined by the available amounts of acid after neutralization of calcite and the amount of total iron in the coals. Using the linear fit of CWP prevalence and the calculated BAI in the seven coal mine regions, we have derived and mapped the pneumoconiotic potencies of 7,000 coal samples. Our studies indicate that levels of BAI in the coals may be used to predict coal's toxicity, even before large-scale mining.     

Cyberchondria in First Year Medical Students of Yogyakarta

Abstract

Cyberchondria is a relatively new term addressing health anxiety associated with online information. Research data is scarce, as most instruments measuring anxiety do not consider online behavior an important factor. Medical students are arguably assumed to have frequent health anxieties, i.e. “medical student syndrome.” Moreover, they are exposed to large amounts of information. We aimed to measure the level of cyberchondria severity of first-year medical students. First-year medical students of the regular program at Universitas Gadjah Mada completed self-reported instruments (the Cyberchondria Severity Scale (CSS) and the Beck Anxiety Inventory (BAI)). Cut off was determined using ROC analysis to find the best score that corresponded to BAI cut off of 16. Data were analyzed using chi square and t-tests to analyze any differences between gender. Respondents were 162 students, 54 males and 108 females, with mean age 18.18-year-old ± 0.696. Based on ROC analysis, cut off of 75.5 corresponded with BAI score of 16. Mean CSS score was 70.73 ± 16.292. There was no significant difference of CSS scores between genders. Based on the analysis of individual items, compared to male students, female students more frequently searched for physical symptoms on the Internet, and afterwards, consulted the results with a General Practitioner (GP), discussed with a GP, or went to other specialists; and thus, more frequently required reassurance after online search. In contrast, male students more frequently had difficulty relaxing after searching online for physical symptoms. We concluded that there was no difference of overall cyberchondria severity score, but there were slight but significant differences of online behavior between genders.     

特发中枢性性早熟女童血清神经激肽B和神经肽吻素表达与骨龄指数的相关性研究

目的 研究特发中枢性性早熟(ICPP)女童血清神经激肽B(NKB)、神经肽吻素(kisspeptin)水平变化及其与骨龄指数(BAI)的相关性,以期寻找评估此类儿童发育情况及治疗效果的标志物。方法 选择2017年6月-2019年5月在洛阳市妇幼保健院治疗的ICPP女童89例,另选取同期健康体检女童90例作为对照组,检测血清NKB、Kisspeptin、激素水平及骨龄、骨龄指数(BAI)等,比较治疗前、治疗后患者各指标变化,采用Pearson分析ICPP女童治疗前血清NKB、Kisspeptin水平与BAI相关性,Logistic回归分析影响骨龄指数(骨发育)的因素。结果 与对照组比较,ICPP组女童骨龄、BAI、子宫体积、血清雌激素、黄体生成素、卵泡刺激素、催乳素及NKB、Kisspeptin水平均显著升高,差异均有统计学意义(t=14.245、22.089、8.321、18.619、27.727、14.241、28.152,17.655,9.668,P<0.05);相关性分析显示,治疗前ICPP女童血清NKB、Kisspeptin水平与BAI呈正相关(r=0.591、0.634...     

Factors influencing health-related quality of life of Asians with anxiety disorders in Singapore

As little is known about health-related quality of life (HRQoL) in Asians with anxiety disorders, we assessed HRQoL in Singaporeans with anxiety disorders and identified factors influencing their HRQoL. Outpatients with anxiety disorders (n = 119) attending a hospital psychiatric clinic completed the Short Form 36 Health Survey (SF-36), Beck Anxiety Inventory (BAI) and General Health Questionnaire (GHQ-12). SF-36 score reduction from population norms (quantified as the number of standard deviations below the mean) in these subjects was compared with existing data on Singaporeans with various medical conditions and Americans with panic disorder (PD). Factors influencing HRQoL were examined using stepwise multiple linear regression models. SF-36 score reduction in these subjects (0.3-1.4 SD) was greater than that in Singaporeans with systemic lupus erythematosus or thyroid cancer survivors for seven scales but similar to that in Americans with PD (0.5-1.7 SD). BAI and GHQ-12 scores, presence of PD/generalized anxiety disorder, presence of chronic medical conditions, being married or increasing age accounted for 19-61% of the variance in six selected SF-36 scales. In conclusion, it can be said that Singaporeans with anxiety disorders experience clinically important reductions in HRQoL; both clinical and socio-demographic factors influence HRQoL in such subjects.     

多重PCR检测铜绿假单胞菌耐药基因

目的了解铜绿假单胞菌耐药现状。方法采用多重PCR方法检测铜绿假单胞菌中的常见耐药基因。结果 39株铜绿假单胞菌耐药基因TEM、AmpC、VIM阳性率分别为84.6%、76.9%、17.9%,OXA基因扩增阴性。铜绿假单胞菌对替卡西林、妥布霉素、环丙沙星、头孢他啶耐药率均大于28.2%（11/39）,耐药率最高为庆大霉素59.0%,对多粘菌素E最敏感92.3%,本组菌株中有25.6%（10/39）表现为多重耐药。结论研究表明,携带TEM、AmpC、VIM是导致本组铜绿假单胞菌耐药的重要机制,β-内酰胺类抗生素耐药性及多重耐药性均较严重。     

Assessment of Factors Related to Diminished Appetite in Hemodialysis Patients with a New Adapted and Validated Questionnaire

Appetite loss is a common phenomenon in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD). We aimed to (i) adapt and validate a Spanish language version of the Council on Nutrition Appetite Questionnaire (CNAQ) and (ii) to identify psychological and biological factors associated with diminished appetite. We recruited 242 patients undergoing HD from four hemodialysis centers to validate the Spanish-translated version of the CNAQ. In another set of 182 patients from three HD centers, the Appetite and Diet Assessment Tool (ADAT) was used as the gold standard to identify a cut-off value for diminished appetite in our adapted questionnaire. The Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Distorted Thoughts Scale (DTS), Dialysis Malnutrition Score (DMS), anthropometric, values and laboratory values were also measured. Seven items were preserved in the adapted appetite questionnaire, with two factors associated with flavor and gastric fullness (Cronbach’s alpha = 0.758). Diminished appetite was identified with a cut-off value ≤25 points (sensitivity 73%, specificity 77%). Patients with diminished appetite had a higher proportion of females and DMS punctuation, lower plasmatic level of creatinine, blood urea nitrogen, and phosphorus. Appetite score correlated with BDI score, BAI score and DTS. Conclusions: This simple but robust appetite score adequately discriminates against patients with diminished appetite. Screening and treatment of psychological conditions may be useful to increase appetite and the nutritional status of these patients.     

食品中单增李斯特菌的脉冲场凝胶电泳分型

目的分析吉林省食品中分离的单核细胞增生李斯特菌(Listeria monocytogenes,LM)的脉冲场凝胶电泳(PFGE)型别,探讨吉林省食品中单核细胞增生李斯特菌污染的同源性。方法将市售熟制米面制品、熟肉制品、中式凉拌菜和即食非发酵豆制品中分离出的39株单核细胞增生李斯特菌进行PFGE分子分型,BioNumerics version软件分析比较同源性。结果 39株单核细胞增生李斯特菌的PFGE结果主要分为6大群,其中1群包括6株,相似度为86.0%以上;2群包括16株,分为2个亚群,2A亚群包括7株,相似度为94.1%以上,2B亚群9株,相似度为74.8%;3群包括3株,相似度为80.0%以上;4群包括14株,亦分为4个亚群;5群包括3株,相似度为85.7%以上;6群包括1株,相似度为63.3%以上。结论吉林省食品中的LM来源于不同的克隆株,但部分LM有不同程度的相关性;PFGE是分析LM同源性的有效方法,对LM的流行趋势、分布特点和分子流行病学研究具有重要意义。     

2006-2010年高密市小肠结肠炎耶尔森菌调查

目的了解高密市食品中小肠结肠炎耶尔森菌及动物带菌情况。方法 2006-2010年采集家畜家禽粪便、冷冻食品共2 097份,4℃冷增菌后用选择性培养基进行病原菌分离培养并作生化鉴定,将可疑菌株做进一步的血清学鉴定和生物分型及毒力检测。结果 2 097份标本中分离出131株小肠结肠炎耶尔森菌,总的检出率为6.25%,其中O∶3(携带毒力基因ail+、ystA+、rbfc+)和O∶9血清型的检出率分别为0.76%和1.52%。108株仅携带ystB基因(82.44%);26株不携带任何基因(19.85%)。131株小肠结肠炎耶尔森菌分布在3个生物型,其中生物1A型占74.80%;生物3型占1.52%;生物4型占0.76%。结论本地区存在致病性小肠结肠炎耶尔森菌,有感染人和动物及引起食源性型疾病的可能,因此必须加大该菌的监测力度,以预防小肠结肠炎耶尔森菌病的感染流行。