子痫前期患者胎儿脂质变化及与母体血脂关联性的研究

目的探讨正常妊娠和子痫前期患者胎儿脂质及血脂比值变化,并分析胎儿血脂与母体血脂的关联性及可能的机制。方法选择2015年6月至2017年10月四川省人民医院产科住院的子痫前期患者203例及正常妊娠孕妇210例,分别测定孕妇和胎儿血清各项脂质指标并计算血脂比值。结果子痫前期组胎儿脐血TC、TG、LDL-C、apo B100、AI和血脂比值TG/HDL-C、TC/HDL-C、LDL-C/HDL-C及log(TG/HDL-C)均显著性高于正常妊娠组。分析脐血和母体血脂谱的相关性,结果表明脐血TC与母体apo A1负相关,与母体log(TG/HDL-C)正相关;脐血apo A1与母体apo A1正相关,与母体apo B100、LDLC/HDL-C负相关;脐血apo B100与母体TC、apo A1、HDL-C负相关;脐血HDL-C与母体TG、TG/HDL-C和log(TG/HDL-C)正相关;脐血LDL-C与母体TG/HDL-C和log(TG/HDL-C)正相关,与母体apo A1和HDL-C负相关;脐血TG/HDL-C与母体log(TG/HDL-C)负相关;脐血log(TG/HDL-C)与母体TG、TG/HDL-C和log(TG/HDL-C)负相关。结论胎儿血脂与母体血脂存在弱相关,子痫前期组胎儿TG、TC水平显著高于正常妊娠组胎儿,可能是因为子痫前期组胎儿生长受限,对TG、TC利用减少,造成胎儿血液循环TG、TC堆积。     

非酒精性脂肪肝患者血清非高密度脂蛋白胆固醇水平检测分析

目的了解非酒精性脂肪肝患者血清非高密度脂蛋白胆固醇(non-HDL-C)代谢水平,评价其临床应用价值。方法通过对单位体检者的影像学检查及肝功能、血糖、血脂等血清生化指标检测,并对其中非酒精性脂肪肝与体检健康者(对照组)进行比较。结果脂肪肝总检出率为9.15%,男性检出率12.50%,显著高于女性的5.99%(P<0.05);男性患者丙氨酸转氨酶(ALT)、间接胆红素(IBil)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoA1)、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)等与对照组比较差异具有统计学意义(P<0.05或P<0.01),女性患者天冬氨酸转氨酶(AST)、总胆红素(TBil)、直接胆红素(DBil)I、Bil、葡萄糖(Glu)、TC、TG、LDL-C、apoA1、non-HDL-C、apoB100/apoA1、LDL-C/HDL-C、apoB100/HDL-C、TC/HDL-C与对照组比较差异具有统计学意义(P<0.05或P<0.01);non-HDL-C与TC、LDL-C、TG、HDL-C、apoA1、apoB100、apoB100/apoA1、TC/HDL均显著相关(r=0.411~0.989,P<0.01)。结论非酒精性脂肪肝普遍具有脂类代谢异常和肝脏受损特点,non-HDL-C的检测有助于全面了解非酒精性脂肪肝脂类代谢状况。     

银屑病患者血脂水平与血液粘度和微循环变化的研究

目的 探讨银屑病患者血脂水平与血液粘度和微循环变化的关系,以及在银屑病发病机制中的作用.方法 测定86例银屑病患者血清TC、TG、HDL-c、LDL-c、apoA I、apoB100和血液粘度等指标,观察甲襞微循环变化,并与正常人进行对比分析.结果 银屑病组与对照组比较:血清TC、TG、LDL-c及apoB100显著升高,apoA I、HDL-c下降(P均＜0.01)ηb、ηP、EAI、TK、ESR、血沉K值均明显升高(P均＜0.01).银屑病患者甲襞微循环明显异常,其形态、流态、袢周等指标积分值以及综合积分值与正常组比较有显著性差异(P均＜0.01).银屑病组η b与TC、LDL-c、TG、apoB100呈明显正相关;η P与TC、TG呈明显正相关,EAI、ESR与TC、TG呈明显正相关;TK与TC明显正相关(P均(0.01).结论 银屑病患者TC、TG、LDL-c及apoB100水平明显升高,造成红细胞膜成分改变,导致红细胞刚性增加、变形能力下降,引起血液粘度升高,造成微循环障碍.     

血清非高密度脂蛋白胆固醇水平对冠心病的临床诊断价值

目的：探讨血清非高密度脂蛋白胆固醇以及载脂蛋白B水平对冠心病的临床应用价值。方法检测118例冠心病（CHD）患者血清三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（apoAl）和载脂蛋白B（apoB）水平,并计算出非高密度脂蛋白胆固醇（non-HDL-C）及apoB/apoA1比值,分析各血脂指标与冠心病的关系。结果 CHD患者血清TG、non-HDL-C和apoB/apoA1比值均高于对照组（P〈0.01）,HDL-C和apo Al水平均低于对照组（P〈0.01）,差异有统计学意义。 HDL-C和apoA1的诊断灵敏度明显高于TC和LDL-C,而non-HDL-C、apoB以及apoB/apoA1的特异度均较高。结论血清non-HDL-C及apoB/apoA1比值的升高与心血管事件发生危险性明显正相关,其预警价值高于传统指标LDL-C和TC,与冠状动脉粥样硬化病变关系密切,尤其对于LDL-C和TC已经达标者控制其non-HDL-C和apoB水平在冠心病的防治中有重要意义。     

妊高症孕妇血脂和脂蛋白水平变化的观察

目的探讨妊高症孕妇、正常孕妇与正常妇女之间血脂和脂蛋白水平的变化及其相关性。方法按临床诊断分为三组,用杜邦AR型全自动生化分析仪及配套试剂分别检测TC、TG、HDL-C、LDL-C、apoA1、apoB,组间显著性用t检验。结果妊高症孕妇组TC、TG、LDL-C、apoB明显高于对照组,有极显著性差异(P﹤0.001);正常孕妇组的测定结果除apoB外均非常明显高于对照组(P﹤0.001);妊高症孕妇组除HDL-C、ApoA1外,其余4个项目均高于正常孕妇组。结论妊高症孕妇血脂及脂蛋白代谢的紊乱改变,提示其抗御动脉硬化的保护机能大为减弱。而正常孕妇虽然TC、TG、LDL-C及apoB等诱发动脉硬化的危险因素明显升高,但抗御动脉硬化作用的HDL-C及apoA1也升高明显,从而减少了动脉硬化的发生。因此,重视妊娠妇女血脂及脂蛋白的监测,早期预防、诊断和治疗妊高症是围产保健和优生优育十分重要的内容。     

妊高症孕妇血脂和脂蛋白水平变化的观察

目的探讨妊高症孕妇、正常孕妇与正常妇女之间血脂和脂蛋白水平的变化及其相关性.方法按临床诊断分为三组,用杜邦AR型全自动生化分析仪及配套试剂分别检测TC、TG、HDL-C、LDL-C、apoA1、apoB,组间显著性用t检验.结果妊高症孕妇组TC、TG、LDL-C、apoB明显高于对照组,有极显著性差异(P＜0.001);正常孕妇组的测定结果除apoB外均非常明显高于对照组(P＜0.001);妊高症孕妇组除HDL-C、ApoA1外,其余4个项目均高于正常孕妇组.结论妊高症孕妇血脂及脂蛋白代谢的紊乱改变,提示其抗御动脉硬化的保护机能大为减弱.而正常孕妇虽然TC、TG、LDL-C及apoB等诱发动脉硬化的危险因素明显升高,但抗御动脉硬化作用的HDL-C及apoA1也升高明显,从而减少了动脉硬化的发生.因此,重视妊娠妇女血脂及脂蛋白的监测,早期预防、诊断和治疗妊高症是围产保健和优生优育十分重要的内容.     

血清抵抗素、血脂水平与绝经后女性脑梗死的相关性研究

目的研究血清抵抗素、血脂水平与绝经后女性脑梗死的相关性。方法选取2015年4月至2016年4月该院收治的81例绝经后女性脑梗死患者视为观察组,另选取同期在本院进行健康体检的81例绝经女性视为对照组。比较两组研究对象的血清抵抗素、血脂水平,行logistic多元回归分析。结果观察组的抵抗素、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、载脂蛋白B(apoB)水平高于对照组,差异有统计学意义(P0.05);高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AⅠ(apoAⅠ)水平低于对照组,差异有统计学意义(P0.05)。行logistic多元回归分析,抵抗素、LDL-C、TG、TC、apoAⅠ、apoB是绝经后女性脑梗死的独立危险因素。观察组的LDL-C、HDL-C、TG、TC、apoAⅠ、apoB异常检出率高于对照组,差异有统计学意义(P0.05)。结论血清抵抗素、LDL-C、TG、TC、apoAⅠ、apoB和绝经后女性脑梗死存在相关性,是绝经后女性脑梗死疾病的独立危险因素。     

肺癌患者放疗过程中血脂的动态变化及意义

目的探讨肺癌放疗过程中血脂的动态变化及意义。方法测定65例肺癌及50例良性肿瘤患者放疗前、疗程中不同时段的甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、癌胚抗原(CEA)含量,并取32例健康体检者进行对照。结果与对照组比较,肺癌患者放疗前TC、HDL-C低下而TG、LDL-C、apOA、apoB及CEA均升高;与放疗前比较,第7d,TG、LDL-C、TC、HDL-C、CEA均下降;第14d-apoA、apoB开始下降(P<0.05);TC、HDL-C和TG、LDL-C、apoA、apoB分别在第21d、第28d降到最低;第28d,TC、HDL-C开始回升,CEA已极显著性下降(P<0.00l);第35d,TG、LDL-C开始升高;良性肿瘤患者中与放疗前比较疗程第7d～14d血脂参数均出现下降,但均无显著性差异(P>0.05);TC、HDL-C、TG、LDL-C与CEA均有良好相关性(r分别为-0.683、-0.502、0.539、0.346,P<0.0l)。结论肺癌患者有高血脂倾向而TC、HDL-C水乎低下;血脂参数与CEA的变化具有良好的相关性,可作为放疗过程中监测病情、观察疗效的辅助指标。     

肺癌患者放疗过程中血脂的动态变化及意义

目的探讨肺癌放疗过程中血脂的动态变化及意义.方法测定65例肺癌及50例良性肿瘤患者放疗前、疗程中不同时段的甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、癌胚抗原(CEA)含量,并取32例健康体检者进行对照.结果与对照组比较,肺癌患者放疗前TC、HDL-C低下而TG、LDL-C、apOA、apoB及CEA均升高;与放疗前比较,第7d,TG、LDL-C、TC、HDL-C、CEA均下降;第14d-apoA、apoB开始下降(P＜0.05);TC、HDL-C和TG、LDL-C、apoA、apoB分别在第21d、第28d降到最低;第28d,TC、HDL-C开始回升,CEA已极显著性下降(P＜0.001);第35d,TG、LDL-C开始升高;良性肿瘤患者中与放疗前比较疗程第7d～14d血脂参数均出现下降,但均无显著性差异(P＞0.05);TC、HDL-C、TG、LDL-C与CEA均有良好相关性(r分别为-0.683、-0.502、0.539、0.346,P＜0.01).结论肺癌患者有高血脂倾向而TC、HDL-C水乎低下;血脂参数与CEA的变化具有良好的相关性,可作为放疗过程中监测病情、观察疗效的辅助指标.     

血清脂蛋白相关磷脂酶A2在子痫前期的应用价值研究

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)在子痫前期中的应用价值。方法选择2014年1月至2016年1月在该院行剖宫产术终止妊娠的孕妇63例,其中正常妊娠组31例,子痫前期组32例,轻度子痫前期组15例,重度子痫前期组17例,收集患者的一般资料和血清指标,非条件Logistic逐步回归分析子痫前期的独立危险因素。结果子痫前期组总胆固醇(TC)、三酰甘油(TG)、极低密度脂蛋白胆固醇(VLDLC)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)和动脉硬化指数(AI)显著高于正常妊娠组,高密度脂蛋白胆固醇(HDL-C)显著低于正常妊娠组(P0.05);子痫前期组Lp-PLA2显著高于正常妊娠组(P0.05);Lp-PLA2和TC、TG、LDL-C呈正相关,和HDL-C呈负相关(P0.05);Lp-PLA2、TG和LDL-C是子痫前期的独立危险因素(P0.01),HDL-C是子痫前期的保护因素(P0.01)。结论子痫前期中存在脂质代谢紊乱,高Lp-PLA2水平可作为子痫前期预测的重要指标。     

Fliformine effects on blood lipid spectrum and lipid peroxidation in obese patients

Blood lipid spectrum and lipid peroxidation are compared in patients with different obesity types. Diet treatment is compared to biguanides derivatives (gliformine) in patients with body obesity combined with dislipidemia. Gliformine proved more effective in correction of changed lipid spectrum of atherogenic origin, improves lipid peroxidation. Biguanides seem perspective in management of lipid disbolism in patients with body obesity.     

Effect of taurine administration on serum lipid and biliary lipid composition in man

The effect of oral administration of taurine (3.2 g/day, 2 weeks) on the metabolism of lipids and bile acids was studied with healthy humans. Four male subjects were fed taurine. Another five male subjects were administered 1 g of cholesterol daily for two weeks and, at intervals of two weeks, cholesterol and taurine simultaneously. Serum lipoprotein and duodenal bile were analyzed. Oral administration of taurine resulted in the increase of taurine-conjugated bile acids. However, neither serum lipid nor biliary lipid composition was altered. Addition of taurine with cholesterol administration showed elevation of both the serum low density lipoprotein cholesterol level and the lithogenic index in bile. The ratio of glycine-to taurine-conjugated bile acids was changed from 4.1 to 0.63. The ratio of cholic acid/chenodeoxycholic acid was augmented from 0.57 to 0.81. The percentage of taurocholic acid, taurochenodexycholic acid and taurodeoxycholic acid were increased about 4-fold, 2.5-fold and 3-fold, respectively. Our results suggested that taurine administration alone did not influence the serum lipid level although taurine-conjugated bile acids were increased. The taurine intake would increase serum low density lipoprotein cholesterol and biliary cholesterol levels when excessive cholesterol is administered simultaneously.     

Relationship of vascular reactivity to blood lipid spectrum and lipid peroxidation in unstable angina

AIM: To examine the relationship between the vascular response of the microcirculatory bed to vasoactive agents and lipid peroxidation (LPO) and antioxidative defense in patients with unstable angina pectoris. MATERIALS AND METHODS: Thirty male patients (mean age 58.0 +/- 2.4 years) were examined. The patients were divided into 2 groups: 1) those with high alpha-cholesterolemia alone and 2) those with high alpha-cholesterolemia concurrent with hyperglyceridemia and elevated total cholesterol levels. Photoplethysmographic determination was used to evaluate vascular responses to norepinephrine (vasopressor function) and histamine (vasodilating function), the blood levels of cortisol, LPO products, antioxidative protection components, histamine, and serotonin. RESULTS: Vascular dilating function was found to be most pronounced in Group 1. Moreover, Group 1 patients had a significant depression of the antioxidative defense system and the highest blood levels of cortisol, and serotonin. The levels of LPO products did not differ significantly in both groups though they were significantly higher than those in healthy individuals. CONCLUSION: Impairment in the antioxidant system and in coordination of vasodilating function to histamine stimulation are typical of patients with unstable angina.     

脂肪抽吸术与脂类代谢

目的：通过综述国内外脂肪抽吸术对人体脂类代谢影响的研究与应用,探讨脂肪抽吸术的安全性和有效性.资料来源：应用计算机检索Medline 1995-01/2004-12相关脂肪抽吸术和脂类代谢的文献,检索词“lipectomy,lipids”,并限定文献语种为English.同时计算机检索万方数据库2000-01/2004-12相关脂肪抽吸术和脂类代谢的文献,检索词“脂肪切除术”,并限定文献语种为中文.资料选择：对资料的摘要进行阅读初审,开始查找全文.纳入标准：[1]临床研究性文章.[2]基础研究文章.排除标准：重复研究、综述、Meta分析类文献.资料提炼：共收集到28篇研究脂肪抽吸术对脂类代谢影响的文献,26篇符合纳入标准.排除的2篇文献为综述.纳入的试验包括281例患者（或实验动物）,分别对脂肪抽吸术后脂类代谢的变化情况进行评价.资料综合：吸脂术可能会改变受术者的血脂水平,从而影响其心血管疾病的发病率.吸脂术可能有助于提高受术者体内胰岛素的敏感性,降低其胰岛素抵抗状况.脂肪组织能够调节性激素和糖皮质激素的代谢,性激素也反馈调节体内的脂类代谢.瘦素通过与中枢神经系统的瘦素受体直接结合来调节体内的能量平衡、脂肪贮存及某些内分泌功能,某些研究认为吸脂术后受术者体内瘦素水平发生一定变化.脂肪细胞能够合成分泌肿瘤坏死因子α,肿瘤坏死因子α能调节食欲、产热和脂质代谢等,从而限制体质量的增加,有研究认为吸脂术不会影响肿瘤坏死因子α的合成与分泌.吸脂术直接引起手术区脂肪含量减少,受术者体质量降低,同时体脂的分布比例发生变化.结论：脂肪抽吸术后脂类代谢在一定时期内有一定的变化,但是脂类代谢变化所维持的时间和对人体健康的影响尚不肯定.     

Sirtuin 1 in lipid metabolism and obesity

Abstract

Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved NAD⁺-dependent protein deacetylase that has emerged as a key metabolic sensor that directly links environmental nutrient signals to animal metabolic homeostasis. SIRT1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and insulin secretion in the pancreas. Recent studies have shown SIRT1 to regulate fatty acid oxidation in the liver, sense nutrient availability in the hypothalamus, influence obesity-induced inflammation in macrophages, and modulate the activity of the circadian clock in metabolic tissues. The activity of SIRT1 also appears to be under the control of AMPK and adiponectin. This review focuses on the involvement of SIRT1 in regulating metabolic diseases associated with obesity. It includes brief overviews of sirtuin signaling, with emphasis on SIRT1's role in the liver, macrophage, brain, and adipose tissue as it relates to obesity.     

Sirtuin 1 in lipid metabolism and obesity

Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor that directly links environmental nutrient signals to animal metabolic homeostasis. SIRT1 is known to be involved in gluconeogenesis in the liver, fat mobilization in white adipose tissue, and insulin secretion in the pancreas. Recent studies have shown SIRT1 to regulate fatty acid oxidation in the liver, sense nutrient availability in the hypothalamus, influence obesity-induced inflammation in macrophages, and modulate the activity of the circadian clock in metabolic tissues. The activity of SIRT1 also appears to be under the control of AMPK and adiponectin. This review focuses on the involvement of SIRT1 in regulating metabolic diseases associated with obesity. It includes brief overviews of sirtuin signaling, with emphasis on SIRT1's role in the liver, macrophage, brain, and adipose tissue as it relates to obesity.     

脂肪抽吸术与脂类代谢

目的:通过综述国内外脂肪抽吸术对人体脂类代谢影响的研究与应用,探讨脂肪抽吸术的安全性和有效性。资料来源:应用计算机检索Medline1995-01/2004-12相关脂肪抽吸术和脂类代谢的文献,检索词“lipectomy,lipids”,并限定文献语种为English。同时计算机检索万方数据库2000-01/2004-12相关脂肪抽吸术和脂类代谢的文献,检索词″脂肪切除术″,并限定文献语种为中文。资料选择:对资料的摘要进行阅读初审,开始查找全文。纳入标准:①临床研究性文章。②基础研究文章。排除标准:重复研究、综述、Meta分析类文献。资料提炼:共收集到28篇研究脂肪抽吸术对脂类代谢影响的文献,26篇符合纳入标准。排除的2篇文献为综述。纳入的试验包括281例患者(或实验动物),分别对脂肪抽吸术后脂类代谢的变化情况进行评价。资料综合:吸脂术可能会改变受术者的血脂水平,从而影响其心血管疾病的发病率。吸脂术可能有助于提高受术者体内胰岛素的敏感性,降低其胰岛素抵抗状况。脂肪组织能够调节性激素和糖皮质激素的代谢,性激素也反馈调节体内的脂类代谢。瘦素通过与中枢神经系统的瘦素受体直接结合来调节体内的能量平衡、脂肪贮存及某些内分泌功能,某些研究认为吸脂术后受术者体内瘦素水平发生一定变化。脂肪细胞能够合成分泌肿瘤坏死因子α,肿瘤坏死因子α能调节食欲、产热和脂质代谢等,从而限制体质量的增加,有研究认为吸脂术不会影响肿瘤坏死因子α的合成与分泌。吸脂术直接引起手术区脂肪含量减少,受术者体质量降低,同时体脂的分布比例发生变化。结论:脂肪抽吸术后脂类代谢在一定时期内有一定的变化,但是脂类代谢变化所维持的时间和对人体健康的影响尚不肯定。     

Association of thyroid stimulating hormone and coronary lipid risk factors with lipid peroxidation in hypothyroidism

Abstract Background: Hypothyroidism is the second most prevalent disorder in India and most cases require lifelong treatment. Disordered myocardial function is one of the complications of overt hypothyroidism. Dyslipidemia and lipid peroxidation are two biochemical derangements of hypothyroidism and both have been found to be associated. Still uncertainty remains regarding the origin of lipid peroxidation in this clinical condition. Besides, thyroid stimulating hormone or thyrotropin at a higher concentration can induce secretion of inflammatory cytokines and decrease the antioxidant status. Methods: Hence, we analyzed the association of lipid risk factors and thyrotropin in hypothyroidism with the extent of lipid peroxidation. A total of 42 primary hypothyroid patients volunteered to give fasting blood samples prior to therapy for the analysis of oxidative stress, thyroid and lipid profiles. Results: Oxidative stress was confirmed by the increased levels of malondialdehyde and protein carbonylation and decreased levels of reduced glutathione. Simple correlation analyses revealed the association of lipid peroxidation with both thyrotropin and lipid risk factors. Partial correlation analyses showed that thyrotropin and lipid risk factors mutually influence their association with the higher malondialdehyde levels in these patients. Conclusions: Hyperthyrotropinemia may be considered not only as an index of the severity of hypothyroidism but also of the extent of the associated lipid peroxidation. Clin Chem Lab Med 2008;46:674-9.