胸腺肽治疗骨结核T淋巴细胞亚群变化的临床研究

目的 :观察胸腺肽在骨结核治疗过程中T淋巴细胞亚群的变化 ,以期了解胸腺肽对于结核患者免疫功能的影响。方法 :将 74例骨结核患者在正规抗结核治疗的基础上随机分为治疗组 (加用胸腺肽组 )、对照组 ,同时进行两组患者的T淋巴细胞亚群的动态检测。将所得数据进行统计分析 ,采用SPSS11 5统计软件进行数据处理。结果 :经 3个月的治疗后 ,对照组T淋巴细胞亚群的改变与治疗前差异无显著性。而治疗组CD3 及CD4 升高、CD8 降低、CD4 /CD8 比值增高 ,均具有统计学意义(P <0 0 1)。结论 :胸腺肽对于骨结核患者免疫功能有一定的调节功能。     

骨胶原肽对老年骨质疏松症患者骨密度和骨代谢指标的影响

目的观察骨胶原肽对老年骨质疏松症患者的骨密度和血清骨代谢指标水平的影响。方法 138例老年骨质疏松症患者纳入本研究,将其随机分为治疗组和对照组,每组各69例。对照组患者应用阿仑膦酸钠治疗,治疗组患者给予骨胶原肽联合阿仑膦酸钠治疗,治疗为期12个月。检测治疗前和治疗12个月后两组患者腰椎正位(L1-L4)、左股骨颈的骨密度、血清血钙、血磷、骨碱性磷酸酶(bone alkaline phosphatase,BALP)和抗酒石酸酸性磷酸酶-5b(tartrate-resistant acid phosphatase-5b,TRAP-5b)水平变化情况以及治疗有效率和不良反应。结果治疗12个月后,治疗组腰椎正位、左股骨颈的骨密度患者均明显高于对照组,差异均有统计学意义(P0.05);治疗12个月后,两组患者血清BALP及血磷水平较治疗前明显降低,血清TRAP-5b及血钙水平均较治疗前明显升高,和治疗前比较差异均有统计意义(P0.05);而治疗组较对照组改善更为明显(P0.05)。治疗组的患者治疗有效率优于对照组(P0.05),而不良反应无明显差异(P0.05)。结论骨胶原肽联合阿仑膦酸钠能安全有效提高老年骨质疏松症患者的骨密度,改善骨代谢。     

合并不同疾病的男性骨量异常患者骨代谢、骨密度及骨折情况研究

目的了解合并不同疾病的男性骨量异常患者骨代谢指标、骨密度(bone mineral density,BMD)及骨折的情况。方法对2006年1月至2017年12月在上海市第一人民医院内分泌科骨质疏松亚专科就诊的928例男性骨量异常患者进行回顾性研究。根据研究目的不同,将患者分为有或无糖尿病组、有或无慢性肝病组、有或无慢性肾病组、有或无慢性胃病组、有或无心血管疾病组及骨量减低组和骨质疏松组。分别观察各组各项指标的差异。结果单因素回归分析提示受试者年龄、体重、L1~4BMD、股骨颈BMD、全髋BMD、β-CTX、慢性胃病、骨质疏松症是骨折史的影响因素,差异具有统计学意义(P<0.05);骨折史与受试者年龄、β-CTX、慢性胃病、骨质疏松症因素成正相关,与体重、L1~4BMD、股骨颈BMD、全髋BMD成负相关;多因素回归分析提示年龄、BALP、2型糖尿病、骨质疏松是骨折的危险因素,而25OHD水平是骨折的保护性因素。结论对于男性骨量异常患者,需要重点关注年龄较大、β-CTX和BALP水平较高、合并慢性胃病以及2型糖尿病的患者,对这类患者应积极进行抗骨质疏松干预及治疗,以减少此类患者骨折的发生率。     

Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats

It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without exercise. Seventy-four, 8.5-month-old, intact female rats were orally treated with 0, 0.005, 0.025, 0.05, or 0.1 microg/kg alfacalcidol alone or in combination with raised cage (RC) exercise for 3 months. In vivo peripheral quantitative computerized tomography (pQCT) of the proximal tibial metaphyses (PTM) and ex vivo histomorphometric analyses of the PTM and tibial shaft (TX) were performed. Only the 0.1 microg alfacalcidol/kg dose proved to be anabolic. pQCT analysis showed that this dose increased total and cortical bone mineral content and density and trabecular bone mineral density. Histomorphometrically, it induced an anabolic response by increased trabecular mass and microarchitecture from stimulated cancellous bone and bone bouton formations, and suppressed bone resorption more than bone formation on the trabecular and endocortical surfaces, to produce a positive bone balance. A positive correlation between trabecular connectivity and bone bouton numbers occurred. These findings suggest alfacalcidol treatment augments bone mass by increased cancellous bone mass and improved trabecular architecture through its anticatabolic and anabolic properties in the intact adult female rat. Last, raised cage exercise alone or the combination of raised cage and alfacalcidol was no more effective than alfacalcidol alone.     

Health and hormonal characteristics of premenopausal women with lower bone mass

Summary A study of clinical renal and endocrinologic status was undertaken to determine whether the lowest maximal bone mass observed in premenopausal women, aged 20–40 years, was a result of undiagnosed disease or represented a continuum of measurement in young adult women. A clinical sample (n=53) was generated from an epidemiologic cross-sectional study (n=535) designed to characterize correlates of maximal bone mass. Cases were 28 premenopausal women whose femoral bone mass as in the lowest 5th percentile of the distribution, <0.75 g/cm² at the femoral neck. Controls were 25 randomly selected premenopausal women whose femoral bone mass was within 1 SD of the mean of the femoral bone mass distribution. There was no indication of increased frequency of disease among the cases as compared with the controls. No occult hypogonadism, thyrotoxicosis, hyperparathyroidism, myeloma, or renal insufficiency was observed to explain lower bone mass measurement. However, cases had significantly lower estradiol levels (75 versus 106 pg/ml,P<0.05) and higher luteinizing hormone levels (3.8 versus 3.1 mIU/ml,P<0.07) than controls. Though preliminary, these findings suggest that lower estradiol levels may contribute to significant differences in bone mass even among healthy women at the time of maximal bone accumulation.     

Forearm bone mass and biochemical markers of bone remodelling in normal Chinese women

We studied bone mineral content and density (BMC/BMD) and bone turnover markers in normal Chinese women from the age of 20 to 80 years and compared the data with those for normal women from the Western part of the world (Denmark). In all subjects (5 at each age;n=305) BMC and BMD were determined at three sites of the nondominant forearm with single X-ray absorptiometry (SXA). In addition, 10 women had five repeated measurements to determine the reproducibility of the equipment, demonstrating coefficients of variation of 1%–2% depending on the measurement site. The Chinese premenopausal women were on the average heavier (1 kg) than the postmenopausal women, but they were also taller (6 cm). The postmenopausal women had highly significantly less bone mass than the premenopausal women; 15% at the 1/4-distal site, 25% at the 8-mm-distal site, and 35% at the ultradistal site. At age 50, bone mass in Chinese women was very similar to that of a comparable group of Danish women. After age 50, bone loss accelerated and the rate of loss seemed more rapid in the Chinese than in the Danish women. Within the first 5 postmenopausal years, the most cortical part decreased by approximately 3.9%, the mixed cortical and trabecular site by 9.5%, and the mainly trabecular site by 16.2%. In the following 5 years the decreases were 6.3%, 5.5%, and 6.6%, respectively, and 5.6%, 11.3%, and 8.9% for year 11–15 after menopause. The bone decrement continued throughout the 25th year of menopause, and except for the ultradistal site, the rate of loss did not change very much. The postmenopausal women had highly significantly higher levels of all bone turnover markers than premenopausal women. The markers stayed high at all ages. We conclude that the present study gives the normal values of Chinese women's bone mass at three sites of the distal forearm. The data were collected in a way which allows them to be used as reference for normal Chinese women. The data demonstrate that women from the East and West are relatively similar in terms of bone mass.     

Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents

This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross‐sectional area (CSA), and section modulus (SM) were obtained by dual‐energy X‐ray absorptiometry. Multiple linear regression models were used to assess the PFM‐bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age‐ and gender‐specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole‐body‐less‐head BA (WB‐BA), lumbar spine BA (L₂–L₄‐BA), total‐hip BA (TH‐BA), total‐hip BMC, CSA, and SM (p < .005 for all, adjusted p < .05). Similar inverse associations were observed in females for all the preceding parameters except WB‐BA and L2–L₄‐BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM‐bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors. © 2010 American Society for Bone and Mineral Research     

体重和身高对峰值骨量的影响

本研究选用单光子吸收法测定了１３６名女性、１１８名男性而年龄在２５～３５岁的正常人前臂骨骨密度，计算出骨密度与身高、体重和体表面积的比值，并探讨了骨密度与身高、体重和体表面积的相关关系。结果显示男性峰值骨量明显高于女性，而男性峰值骨量与体重、体表面积比值则与女性无差异，其与身高比值则与女性间仍有差异；男、女峰值骨量与体重均存在线性相关关系，而与身高及体表面积则无线性相关。因此认为，男、女间体重、身高的差异决定了峰值骨量间的性别差异，且体重对峰值骨量影响较大。     

二甲双胍抑制破骨分化改善糖尿病模型鼠骨量的研究

目的 探讨二甲双胍对骨髓源性巨噬细胞(BMDM)破骨分化的影响,并观察二甲双胍对糖尿病模型鼠骨量的改善作用。方法 在体外实验中,通过梯度浓度的二甲双胍干预RANKL诱导的大鼠BMDM破骨分化,并检测破骨分化标志基因Nfatc1、Ctsk、C-fos、Traf6及相应标志蛋白的表达;在体内实验中,将24只8周龄大鼠随机分为对照组、糖尿病模型组(模型组)、糖尿病模型组+二甲双胍干预组(治疗组),每组各8只,其中对照组与模型组行生理盐水灌胃,治疗组使用二甲双胍灌胃,治疗时间为3个月,检测大鼠体重、空腹血糖,并检测各组大鼠骨量的变化。结果 在体外实验中,二甲双胍显著抑制大鼠BMDM破骨分化,并呈浓度依赖性,显著下调破骨分化标志基因Nfatc1、Ctsk、C-fos、Traf6的表达(P<0.05),显著下调破骨分化标志蛋白C-FOS、NFATC1、TRAF6、CTSK的表达;在体内实验中,模型组相比较于对照组,体重减轻、空腹血糖上升、骨量降低;治疗组相比较于模型组,体重增加、空腹血糖降低、骨量增加。结论 二甲双胍能够抑制破骨分化,在增加体重、降低空腹血糖的同时,可以减少骨表面的破骨细胞数...     

东乡族成人低骨量与肌少症相关的肌肉质量下降的相关性研究

目的 分析甘肃省东乡族成人骨量与骨骼肌量变化规律,探讨骨量降低与肌少症相关的肌肉质量下降之间的关系。方法 对甘肃省东乡族432例(男性198例,女性234例)成人骨密度、骨强度及四肢骨骼肌量进行测量及数据分析,不同年龄段多组比较采用单因素方差分析,组间两两比较采用LSD法,相关性分析采用Pearson相关分析。结果 (1)东乡族成年男性骨强度指数及骨骼肌质量指数峰值出现在40～岁、女性出现在20～岁年龄组。(2)东乡族成人不同年龄段均出现低骨量与肌少症相关的肌肉质量下降情况。(3)骨量减少会导致骨强度指数及骨骼肌质量指数降低。(4)骨量异常情况下肌少症相关的肌肉质量下降明显。(5)骨量降低与年龄、骨强度指数、骨骼肌质量指数显著相关。结论 骨量减少与肌少症相关的肌肉质量下降显著相关,骨量异常是肌少症前期发生的一个危险因素。     

Cortical versus trabecular bone mass: Influence of activity on both bone components

Motivated by the controversy in the literature concerning the influence of activity on bone mass and on its cortical and trabecular components, a study was made using computed peripheral tomography (Stratec XCT 900) of the total, cortical, and trabecular bone mass of the dominant and nondominant upper extremities of 50 apparently normal subjects (average age 26±6 years). No differences were observed in the trabecular bone compartment, but the cortical compartment was greater (P<0.001) in the dominant extremity. There was also a significantly greater total bone mass in the dominant extremity which we attributed to greater cortical mass (P<0.025) given the highly significant correlation (r²=0.904, P=0.0001) between total and cortical bone mass and the less significant correlation between total and trabecular bone mass (r²=0.479, P=0.0001).     

Early smoking is associated with peak bone mass and prevalent fractures in young,healthy men

Smoking is associated with lower areal bone mineral density (aBMD) and higher fracture risk, although most evidence has been derived from studies in elderly subjects. This study investigates smoking habits in relation to areal and volumetric bone parameters and fracture prevalence in young, healthy males at peak bone mass. Healthy male siblings (n = 677) at the age of peak bone mass (25 to 45 years) were recruited in a cross‐sectional population‐based study. Trabecular and cortical bone parameters of the radius and cortical bone parameters of the tibia were assessed using peripheral quantitative computed tomography (pQCT). Areal bone mass was determined using dual energy X‐ray absorptiometry (DXA). Sex steroids and bone markers were determined using immunoassays. Prevalent fractures and smoking habits were assessed using questionnaires. Self‐reported fractures were more prevalent in the current and early smokers than in the never smokers (p < .05), with a fracture prevalence odds ratio for early smokers of 1.96 (95% confidence interval 1.18–3.24) after adjustment for age, weight, educational level, and alcohol use and exclusion of childhood fractures. Current smoking was associated with a larger endosteal circumference (β = 0.027 ± 0.009, p = .016) and a decreased cortical thickness (β = ?0.034 ± 0.01, p = .020) at the tibia. In particular, early smokers (≤16 years) had a high fracture risk and lower areal BMD, together with a lower cortical bone area at the tibia and lower trabecular and cortical bone density at the radius. An interaction between free estradiol and current smoking was observed in statistical models predicting cortical area and thickness (β = 0.29 ± 0.11, p = .01). In conclusion, smoking at a young age is associated with unfavorable bone geometry and density and is associated with increased fracture prevalence, providing arguments for a disturbed acquisition of peak bone mass during puberty by smoking, possibly owing to an interaction with sex steroid action. © 2010 American Society for Bone and Mineral Research     

Overexpression of secreted frizzled‐related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects

Secreted frizzled‐related protein 1 (sFRP1) is an antagonist of Wnt signaling, an important pathway in maintaining bone homeostasis. In this study we evaluated the skeletal phenotype of mice overexpressing sFRP1 (sFRP1 Tg) and the interaction of parathyroid hormone (PTH) treatment and sFRP1 (over)expression. Bone mass and microarchitecture were measured by micro‐computed tomography (µCT). Osteoblastic and osteoclastic cell maturation and function were assessed in primary bone marrow cell cultures. Bone turnover was assessed by biochemical markers and dynamic bone histomorphometry. Real‐time PCR was used to monitor the expression of several genes that regulate osteoblast maturation and function in whole bone. We found that trabecular bone mass measurements in distal femurs and lumbar vertebral bodies were 22% and 51% lower in female and 9% and 33% lower in male sFRP1 Tg mice, respectively, compared with wild‐type (WT) controls at 3 months of age. Genes associated with osteoblast maturation and function, serum bone formation markers, and surface based bone formation were significantly decreased in sFRP1 Tg mice of both sexes. Bone resorption was similar between sFRP1 Tg and WT females and was higher in sFRP1 Tg male mice. Treatment with hPTH(1‐34) (40 µg/kg/d) for 2 weeks increased trabecular bone volume in WT mice (females: +30% to 50%; males: +35% to 150%) compared with sFRP1 Tg mice (females: +5%; males: +18% to 54%). Percentage increases in bone formation also were lower in PTH‐treated sFRP1 Tg mice compared with PTH‐treated WT mice. In conclusion, overexpression of sFRP1 inhibited bone formation as well as attenuated PTH anabolic action on bone. The gender differences in the bone phenotype of the sFRP1 Tg animal warrants further investigation. © 2010 American Society for Bone and Mineral Research     

成都地区骨峰值的研究

目的了解成都地区骨峰值（ＰＢＭ）的基本情况,为骨质疏松（ＯＰ）的防治提供依据。方法随机抽取成都地区２０～４９岁人群除外心肝肺肾、内分泌等慢性病及骨代谢疾病３６８名,进行了腰椎（Ｌ２－４）正位和髋部的双能Ｘ线骨密度（ＢＭＤ）的测量。结果２０～４９岁人群的ＢＭＤ相对稳定,男性腰椎骨峰值见于２０～２９岁,值为１．０７５±０．１１４（ｇ／ｃｍ＾２）;女性见于３０～３９岁,值为１．１０６±０．１１３（ｇ／     

骨健康基本补充剂联合运动、生活方式干预对围绝经期骨量减少的临床观察

目的研究对于围绝经期女性骨量减少的干预效果,探讨女性骨质疏松症的早期预防措施。方法对围绝经期骨量减少女性给予生活方式改变、饮食结构调整、运动训练指导及骨健康基本补充剂治疗的综合干预,比较干预前后骨密度、骨转化标志物、四肢肌肉含量的变化。结果观察组在干预后腰椎骨密度、全身肌肉含量、25-OHD3水平均有改善。结论对围绝经期骨量减少女性进行多方位的早期干预可以延缓绝经后骨质疏松症的发生发展。     

广州地区骨量峰值的调查研究

目的　研究广州城乡居民骨量峰值及其特点和影响中青年妇女骨量的因素 ,为原发骨质疏松症的诊断和预防提供有用的数据。方法　随机抽取广州地区 2 0～ 4 9岁城乡正常男女性居民 4 80人 ,先行问卷调查再进行腰椎 (L2～ 4 )正位和髋部的双能X线骨密度 (BMD)的测量。结果　男性腰椎和髋部骨量峰值 (PBM)出现在 2 0～ 2 9岁 ,L2～ 4 的PBM值为 1 14 0± 0 0 12 9(g cm2 ) ,BMD随年龄增长而下降。女性腰椎和髋部PBM出现在 30～ 39岁 (髋部的Ward’s区出现在 2 0～ 2 9岁 ) ,L2～ 4 的PBM为 1 138± 0 0 99(g cm2 ) ,男女性无显著差异。髋部PBM男性高于女性差异有显著性。 4 0～ 4 9岁不论L2～ 4 和髋部BMD女性都高于男性差异有显著性。妊娠、分娩、哺乳、避孕药、输卵管结扎术对骨量影响无显著性。结论　广州地区女性的PBM近似北京及上海地区高于成都地区。 4 0～ 4 9岁女性腰椎及髋部BMD都高于男性 ,可能与广州地区女性从事较重农业劳动有关。男性则低于沈阳、北京、上海而高于成都     

力学负荷对峰值骨量影响的初步研究

目的 人的运动器官含骨量的多少与外力有关。本实验研究了重力、肌力对骨量的影响。方法 排除了继发性骨质疏松，用DXA对男56例、女55例受试测量全身骨量，收集BMC、BMD、体重、瘦体重指标。结果 发现全身体重和瘦体重与BMC呈密切相关，与BMD的相关较弱。女性的相关强于男性，男女相同体重配对后，男性的BMC、瘦体重、握力分别大于女性3．5％、27．8％、44％。这可能是男性力学性能优于女性的重要原因，而且男性体重每大于女性1kg其BMC较女性增加0．020kg；男性瘦体重每大于女性1kg其BMC较女性增加0．008kg；体重和肌力都是决定BMC的因素，体重可能是决定BMC的重要外力。结论 应该进一步研究骨质疏松诊断中如何发挥骨力学的优越性。     

寰枢椎侧块关节内碎骨植骨融合术治疗寰枢椎不稳的临床疗效

【摘要】 目的：探讨寰枢椎侧块关节内碎骨植骨融合术治疗寰枢椎不稳的临床疗效。方法：对2016年1月~2019年12月在海军军医大学附属长征医院骨科行寰枢椎后路螺钉内固定植骨融合术的49例寰枢椎不稳患者进行回顾性分析。其中男性17例,女性32例;年龄8~72岁（45.2±17.1岁）。所有病例均采用寰枢椎后路椎弓根钉棒内固定技术,根据所行植骨方式不同将患者分为两组：2016年1月~2018年12月期间行寰椎后弓与枢椎椎板间结构性植骨融合术的28例患者纳入A组,男9例,女19例,年龄42.1±20.2岁;2018年1月~2019年12月期间行寰枢椎侧块关节内碎骨植骨融合术的21例患者纳入B组,男8例,女13例,年龄49.3±19.8岁。记录两手术时间、术中出血量和随访时间,比较两组患者术前和末次随访时的日本骨科协会评分（Japanese Orthopaedic Association,JOA）、颈部残疾指数（neck disability index,NDI）和颈部疼痛视觉模拟评分（visual analogue scale,VAS）,术前、术后和末次随访时在冠状位CT上测量寰枢椎侧块关节间隙的高度,观察植骨融合情况。结果：两组患者年龄、性别、疾病种类无统计学差异（P>0.05）,具可比性。两组患者均顺利完成手术,术中无椎动脉和神经损伤。A组术中出血量显著性低于B组（210.2±26.6mL vs 230.5±6.2mL,P＜0.05）,两组手术时间和随访时间无统计学差异（P>0.05）。两组患者末次随访时的JOA评分、NDI和VAS评分与术前比较均明显改善（P＜0.05）,两组间同时间点比较均无统计学差异（P>0.05）。术前两组患者的寰枢侧块关节间隙高度无显著性差异（P>0.05）;术后即刻B组侧块关节间隙高度显著性高于A组（P＜0.05）;末次随访时,两组侧块关节间隙高度均有不同程度的下降,但B组侧块关节间隙高度仍显著性高于A组（P＜0.05）。所有患者植骨均融合,两组植骨融合时间无统计学差异（P>0.05）。随访期间未出现螺钉松动、移位、断裂等并发症。结论：寰枢椎后路钉棒固定融合术中采用寰枢椎侧块关节内碎骨植骨能够实现良好的骨融合,可应用于后弓缺失等不能行寰椎后弓与枢椎椎板植骨术的患者,避免取自体髂骨植骨供骨区疼痛、感染等并发症,且能够在一定程度上维持寰枢椎的关节间隙高度,增强其稳定性。     

Impact of Glucose‐Dependent Insulinotropic Peptide on Age‐Induced Bone Loss

GIP is an important hormonal link between nutrition and bone formation. We show for the first time that BMSCs express functional GIP receptors, that expression decreases with aging, and that elevations in GIP can prevent age‐associated bone loss. Introduction : We previously showed that C57BL/6 mice lose bone mass as they age, particularly between 18 and 24 mo of age. The mechanisms involved in this age‐dependent induced bone loss are probably multifactorial, but adequate nutrition and nutritional signals seem to be important. Glucose‐dependent insulinotropic peptide (GIP) is an enteric hormone whose receptors are present in osteoblasts, and GIP is known to stimulate osteoblastic activity in vitro. In vivo, GIP‐overexpressing C57BL/6 transgenic (GIP Tg⁺) mice have increased bone mass compared with controls. Bone histomorphometric data suggest that GIP increases osteoblast number, possibly by preventing osteoblastic apoptosis. However, potential GIP effects on osteoblastic precursors, bone marrow stromal cells (BMSCs), had not previously been examined. In addition, effects of GIP on age‐induced bone loss were not known. Materials and Methods : Changes in BMD, biomechanics, biomarkers of bone turnover, and bone histology were assessed in C57BL/6 GIP Tg⁺ versus Tg^? (littermate) mice between the ages of 1 and 24 mo of age. In addition, age‐related changes in GIP receptor (GIPR) expression and GIP effects on differentiation of BMSCs were also assessed as potential causal factors in aging‐induced bone loss. Results : We report that bone mass and bone strength in GIP Tg⁺ mice did not drop in a similar age‐dependent fashion as in controls. In addition, biomarker measurements showed that GIP Tg⁺ mice had increased osteoblastic activity compared with wildtype control mice. Finally, we report for the first time that BMSCs express GIPR, that the expression decreases in an age‐dependent manner, and that stimulation of BMSCs with GIP led to increased osteoblastic differentiation. Conclusions : Our data show that elevated GIP levels prevent age‐related loss of bone mass and bone strength and suggest that age‐related decreases in GIP receptor expression in BMSCs may play a pathophysiological role in this bone loss. We conclude that elevations in GIP may be an effective countermeasure to age‐induced bone loss.