Uterine Leiomyosarcoma Metastasis to the Pancreas: Report of a Case and Review of the Literature

Introduction  

Uterine leiomyosarcoma is an aggressive malignant tumor that often leads to metastatic dissemination, generally in the lungs, liver, brain, and bones. Despite the fact that pancreatic neoplasms spread easily, the pancreas is not a usual target organ from other neoplasms.     

Brain Metastasis of Cardiac Myxoma: Case Report and Review of the Literature

Summary Cardiac myxoma is the most common benign heart tumor. Cardiac myxoma can be a sporadic lesion (93% of cases) and usually occurs in women over 30 years. Complete surgical removal of the myxoma and its cardiac attachment is usually curative. The frequency of recurrences in cardiac myxomas varies between 3% for sporadic cases and 22% for cases of Carney complex. Recurrence has been related to incomplete excision, multifocality, and embolism of tumor fragments. We report a case with multiple brain metastases presumably due to tumor embolization from previously operated cardiac myxoma.     

结肠腺癌转移至牙龈1例报道及文献复习

0?引言 结肠癌是我国常见的消化道肿瘤之一,而口腔转移癌临床罕见,约占所有口腔恶性肿瘤的1％[1],可能发生在口腔软组织或颌骨.其中颌骨,尤其是下颌骨,比口腔软组织更易受累(2:1),在口腔软组织中,最常见的病变部位是牙龈(54％)[2].已有报道称牙龈癌转移来自肺、前列腺、直肠癌、肾上腺癌和乳腺等,结肠癌的牙龈转移报...     

原发性肺癌胃肠道转移2例报道并文献复习

原发性肺癌最常见的远处转移部位包括肺、肝、脑、骨、肾上腺等,胃肠道转移鲜有报道。北京大学肿瘤学院胸部肿瘤内科近期先后收治了经病理证实为原发性肺癌发生胃肠道转移的2例患者,本文将就其诊治及随访情况进行报告,并回顾国内外相关文献,以加深对肺癌少见部位转移的认识,避免漏诊和误诊。     

Endometrial Carcinoma with Cerebellar Metastasis: A Case Report and Review of the Literature

Background: Endometrial cancer is the most common malignancy involving the female genital tract in the United States. There is a paucity of reports of brain metastases in this disease, and most of these reports emphasize that this pattern of dissemination is rare. Case: We present a case of a 63-year-old woman who had high-grade endometrial carcinoma treated with surgery and radiotherapy. She had three separate episodes of relapse in the lungs, the first two relapses being treated surgically. Chemotherapy was also administered following surgery for the first relapse. The third pulmonary recurrence was treated with chemotherapy and then consolidated with thoracic radiation. Four years from the date of diagnosis, and a few weeks after completion of thoracic radiotherapy, she had evidence of a solitary cerebellar metastasis. This was treated surgically and followed by whole brain irradiation. She died 6 months after this central nervous system diagnosis with systemic dissemination of her cancer. Conclusion: The existing literature on brain metastases from endometrial cancer is reviewed together with the patterns of spread of endometrial cancer. We call attention to the unusually long course of this patient. Partially successful treatment for metastatic disease may have predisposed eventual development of brain metastases. This occurrence reinforces reports emphasizing their increasing incidence in association with endometrial cancer.     

Nasopharyngeal Carcinoma Metastasis to the Pituitary Gland: A Case Report and Literature Review

While nasopharyngeal carcinoma (NPC) commonly invades the skull base, true central nervous system metastasis is a rare phenomenon. We report a case of NPC metastasis to the pituitary gland and review the literature for similar events. Eight months after his definitive radiation therapy, our patient presented with symptoms of optic chiasm compression and panhypopituitarism. Medical imaging revealed a pituitary mass but demonstrated no evidence of skull base erosion or direct intracranial extension. Subsequent biopsy of the pituitary lesion was confirmed as NPC in origin with Epstein-Barr virus-encoded RNA in-situ hybridization studies. The patient was treated with high dose chemotherapy followed by autologous stem cell transplant, which produced short-term symptomatic relief and at least a 7 month survival.     

腰大肌旁多形性脂肪肉瘤复发伴纵隔转移1例及文献回顾

纵隔内转移性多形性脂肪肉瘤为纵隔内肿瘤的罕见病种,目前总体治疗效果欠佳.本文介绍腰大肌旁多形性脂肪肉瘤复发伴纵隔转移1例,探讨多形性脂肪肉瘤的临床特点和治疗策略.回顾性分析我院收治的1例转移性多形性脂肪肉瘤患者,基于影像学诊断与手术病理诊断,对患者进行针对性的多学科综合治疗.一名41岁女性患者,诊断腰大肌旁多形性脂肪肉瘤伴纵隔转移.经手术、靶向及化疗等多学科治疗,随访至今已65个月.对于多形性脂肪肉瘤治疗策略,应以外科完整切除为首选,术后辅助相关内科治疗,多学科综合治疗以延缓患者病情进展及复发.     

Pancreatic Resection for Metastatic Melanoma. Case Report and Review of the Literature

Introduction

Pancreatic metastasis from several malignancies are increasingly encountered in clinical practice, and the usefulness of surgical resection has been suggested for certain neoplasms. Isolated pancreatic metastasis from malignant melanoma is a rare occurrence, and the role of surgery as an adjunct to systemic therapy for melanoma metastatic to a solitary or multiple sites is still debated.

Case Report

We report a patient with melanoma of unknown primary site metastatic simultaneously to the lung and pancreas 3 years after axillary lymph node dissection. Distal pancreatectomy with splenectomy and video thoracoscopic assisted resection of pulmonary metastasis were performed. The postoperative course was uneventful, but 6 months after surgery, the patient experienced single pulmonary recurrence. During chemotherapy with different drugs, pulmonary lesion remained stable for 1 year, and no abdominal recurrence occurred. After then, the size of the lesion progressively increased and a second metastasis occurred in the lung. Five months later, brain metastases occurred, and the patients died 24 months after surgery. Sixteen pancreatic resections for metastatic malignant melanoma, reported with adequate clinical details, were also retrieved from the literature.

Conclusion

In spite of the very limited experience, it appears that surgical resection is only a palliative procedure, because long-term survival is a rare event. However, considering the lack of effective systemic therapy, surgery may be considered as a part of an aggressive multidisciplinary approach in selected cases with malignant melanoma metastatic to single or multiple visceral sites.     

Choroid Plexus Metastasis from Carcinoma of the Bladder: Case Report and Review of the Literature

We present here a case report of a 40-year old male with adenocarcinoma of the bladder and solitary metastasis to the choroid plexus of the right lateral ventricle. This is the first such report of such a metastasis in association with bladder carcinoma. Systemic metastases frequently occur in patients with carcinoma of the bladder but involvement of central nervous system is relatively uncommon: less than 1% of patients with carcinoma of the bladder present an intracerebral metastasis. In the majority of cases there are either multiple CNS metastases or other distant metastases. A few cases present with solitary metastases to the CNS without evidence of recurrent or disseminated disease.     

Epididymis Metastasis from Colon Carcinoma: A Case Report and a Review of the Japanese Literature

A 56-year-old Japanese man in whom a descending colon carcinomahad been resected underwent a high orchitectomy for metastaticepididymis from the colon. Metastatic carcinoma from the digestiveorgans to the spermatic cord (SC) and/or the intrascrotal contents(ISC) is rare. Fifty-four Japanese patients with metastasisfrom the digestive organs to the SC and/or the ISC were analyzed.The most frequent primary site was the stomach and the mostfrequent metastatic site was the spermatic cord. Our patientwas the first to exhibit metastasis from the colon to the epididymis.A primary site was identified in 24 patients subsequent to themetastatic tumor. Twenty patients had other organ metastatis.The prognosis for SC and/or ISC metastasis patients is poor.Our patients has survived for 18 months following his orchitectomywith no other organ metastasis (31 months after the primaryoperation). In our patient, monoclonal estrogen receptor stainingwas negative; however, further study must be undertaken.     

Endobiliary Metastasis from Rectal Cancer Mimicking Intrahepatic Cholangiocarcinoma: A Case Report and Review of Literature

Purpose

The purpose of this study is to report an unusual case of liver metastasis from carcinoma rectum, which mimicked an intrahepatic cholangiocarcinoma (ICC) radiologically and pathologically, and to review the relevant literature.

Patient

A 64-year-old gentleman was treated for carcinoma rectum in our institution with neoadjuvant chemoradiation followed by low anterior resection and adjuvant chemotherapy. Two years later, he was found to have a nodule in the left hepatic duct on imaging. He underwent left hepatectomy.

Findings

The specimen revealed a tumor in the left hepatic duct, microscopically resembling an ICC. However, immunohistochemistry (IHC) showed the tumor cells to stain positively for cytokeratin 20, but not for cytokeratin 7, thus confirming the metastatic nature of the lesion.

Conclusion

Endobiliary metastasis from colorectal cancer can mimic ICC, and IHC studies may be needed to differentiate the two. Identifying endobiliary metastasis can have therapeutic and prognostic implications.     

Intrathoracic Endotracheal Metastasis from Nasopharyngeal Carcinoma: A First Case Report and Review of the Literature

Intrathoracic endotracheal metastasis from a very distant site is extremely rare. We report the first case of such a disease in a 68-year-old man with nasopharyngeal carcinoma who presented with a cough and hemoptysis 34 months after finishing radiotherapy. Prior to tracheal metastasis, he developed a solitary metastasis in the lung and underwent chemotherapy followed by radiotherapy. Computed tomography showed the presence of an enlarged lymph node in the para-aortic arch. Fiberoptic bronchoscopy revealed an endotracheal tumor 1 cm above the carina. Histological and immunohistochemical analyses confirmed its nasopharyngeal origin. He was treated with conventional radiotherapy and three-dimensional conformal radiotherapy; complete tumor remission was achieved. He died of nonmalignant disease with no signs of tumor recurrence 2 years after treatment completion. Radiotherapy may be an appropriate management approach to achieve long-term tumor control for this disease.Key Words: Metastatic disease, Endotracheal malignancy, Nasopharyngeal carcinoma, Radiotherapy     

Misdiagnosis of Left Supraclavicular Lymph Node Metastasis of Prostate Carcinoma： One Case Report and Literatures Review

China is a country with a low morbidity of prostate carcinoma.The in-cidence of prostate carcinoma in China iS 1.6/l 00.000.which iS muchlower than the rate in the United States.i…e ll 9.9/1 00.000[1].     

下腔静脉平滑肌肉瘤的诊治

Leiomyosarcoma of inferior vena cave (IVC) is an extremely rare primary malignant tumor, no more than 200cases of leiomyosarcoma of IVC were reported in publications as single case or as small series up to date^[1]. In this report, 7 cases of primary leiomyosarcoma of IVC were presented. The diagnosis and treatment of leiomyosarcoma of IVC were also reviewed.