米诺地尔酊联合氦氖激光治疗脂溢性脱发的效果观察

目的:观察米诺地尔酊联合氦氖激光治疗脂溢性脱发的效果观察分析.方法:将在2019年4日—2020年4月时期收治以脂溢性脱发为诊断的患者总计60例,采取随机数字法分成对照组(30例)与实验组(30例),其中对照组患者以氦氖激光治疗,而实验组患者则采取米诺地尔酊联合氦氖激光治疗.对照两组患者治疗前、后临床症状评分,临床治疗...     

中药治疗脂溢性脱发的药理及实验模型研究概述

脂溢性脱发为皮肤科的多发病与难治性疾病之一,中药因其多成分、多靶点、协同作用等阻断未知的疾病途径,达到较好的治疗效果,并逐渐成为科研领域的研究热点.本文综述了中药治疗脂溢性脱发的药理与实验模型研究进展,为进一步深入研究提供思路与线索.     

脂溢性脱发的中医治疗

脂溢性脱发是皮肤科疑难病之一,采用中医辨证治疗本病,有一定疗效,给大家介绍几个本科室使用有效的方子,分外服和内服。——外用方——去脂生发酊组方:仙鹤草、明矾、苦参、川椒各10克,侧     

生发软膏治疗脂溢性脱发的临床研究

目的对生发软膏用于治疗脂溢性脱发的临床疗效进行评价。方法将皮肤科门诊86例脂溢性脱发患者,随机分为治疗组和对照组,观察患者头部患病皮肤油腻性、瘙痒、脱发的程度以及新发生长情况,进行疗效评价。结果治疗组有效率为90．7％,对照组有效率为72．1％,两组有效率比较差异有统计学意义（P〈0．05）。结论生发软膏在设定的剂量和使用方法下外用,治疗脂溢性脱发疗效满意。     

脂溢性脱发的生活调理

一旦出现脱发,不必紧张,可以在皮肤科就诊以寻找原因,必要时做一些血液检查,排除其他疾病,如内分泌疾病引起的脱发。     

中西医结合治疗脂溢性脱发124例疗效分析

我科自2006年12月至2008年2月，应用纯中药配制的“生发酊”外用涂剂，结合口服生尔发治疗124例脂溢性脱发患者，取得了明显的防脱发和生发、去屑止痒、消除油腻等功效，并与单纯使用生尔发治疗的患者进行对照，前者效果满意，现总结如下。     

米诺地尔洗剂与非那雄胺合用治疗雄激素性脱发的临床疗效观察

目的探讨2%米诺地尔洗剂与非那雄胺合用治疗雄激素性脱发的临床疗效.方法选用因脱发到本院皮肤科就诊经诊断为雄激素性脱发的男性患者307例,分为三组,分别采用非那雄胺、2%米诺地尔洗剂、2%米诺地尔洗剂与非那雄胺合用治疗,疗程12～18个月,并作疗效对比.结果联合用药治疗组有效率高、显效快,经统计学处理有显著性差异(P＜0.05).结论2%米诺地尔洗剂与非那雄胺合用治疗男性雄激素性脱发安全有效,有临床推广价值.     

Androgenetic alopecia; drug safety and therapeutic strategies

Introduction: Androgenetic alopecia (AGA) is a benign condition with variable psychosocial impact, with some individuals adapting well while others needing therapeutic support. Although 5α-reductase inhibitors like finasteride and dutasteride have proven effective in ameliorating AGA, their use/selection is currently a subject of debate.

Areas covered: Treatment of AGA with 5α-reductase inhibitors lead to variable adverse effects and relatively unstable results (therapeutic efficacy ending with treatment cessation), so the choice of optimal therapy is not straightforward. This paper presents a general perspective regarding AGA based on studies listed in PubMed, to better understand/appreciate the opportunity for long term use of medication for a biological condition having non-life threatening implications. Studies focussed on adverse effects suggest that finasteride should be used with caution in AGA, due to considerable and persistent side effects induced in some men. In contrast, efficacy data indicate that dutasteride (a stronger inhibitor) presents superior therapeutic results compared to finasteride.

Expert opinion: This paper argues that finasteride should be preferred to dutasteride in the treatment of AGA. Thus, finasteride preserves important physiological roles of dihydrotestosterone (unrelated to AGA) and, in addition, its adverse effects seem to be (at least in part) predictable.     

脱发发病机理与防治药物新进展

近年由于细胞分子生物学的发展 ,两类常见脱发病—斑秃和脂溢性脱发的病理病因和治疗药物有重大进展。斑秃的发病与免疫、细胞因子、神经内分泌有关 ,局部免疫治疗和应用免疫抑制剂FK5 0 6是治疗斑秃较为理想的方法。脂溢性脱发受遗传和雄激素双重影响 ,5 α还原酶抑制剂和米诺地尔是目前较好的治疗药物。中医从整体出发 ,分析脱发的病理病机 ,开发出一系列有效的治疗方剂。采用中西医结合治疗脱发具有广阔前景     

Treatment strategies for alopecia

Background: Hair loss is a very common complaint and dermatologists should be able to make the correct diagnosis of different types of alopecia and choose the best therapeutic strategy according to patients' and doctors' expectations. Objective: To review treatment of the most common forms of hair loss. Methods: Literature review and expert opinion. Conclusion: There is good evidence based information for the treatment of androgenetic alopecia. There are very few randomized good quality studies and no information about long-term results for most of the available treatments for alopecia areata and cicatricial alopecias. Treatment of alopecia areata and cicatricial alopecias is, therefore, selected in the absence of precise information on the expected outcome and treatment failure is common.     

米诺地尔凝胶治疗斑秃的多中心随机双盲安慰剂对照临床试验

目的 评价2.2%米诺地尔凝胶（抗斑秃药）治疗斑秃的疗效和安全性.方法 用随机双盲安慰剂对照多中心研究,选择脱发＜40%头皮面积、病程在1年以内的患者,随机进入米诺地尔凝胶试验组（66例）或凝胶基质对照组（62例）,分别给予米诺地尔凝胶或基质,每日2次,外用,共3个月.结果 在毛发开始生长时间、生长长度、脱发面积减少和综合评价,试验组均优于对照组;2组药物不良反应发生率分别为7.58%,6.45%（P＞0.05）.结论 米诺地尔凝胶治疗斑秃安全、有效.     

Experimental and early investigational drugs for androgenetic alopecia

Introduction: Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth.

Areas covered: Here we review the essential pathways of androgenetic alopecia pathogenesis and collate the current and emerging therapeutic strategies using journal publications databases and clinical trials databases to gather information about active research on new treatments.

Expert opinion: We propose that topically applied medications, or intra-dermal injected or implanted materials, are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments. Evidence in support of new treatments is limited. However, we suggest therapeutics which reverse the androgen-driven inhibition of hair follicle signaling pathways, such as prostaglandin analogs and antagonists, platelet-rich plasma (PRP), promotion of skin angiogenesis and perfusion, introduction of progenitor cells for hair regeneration, and more effective ways of transplanting hair, are the likely near future direction of androgenetic alopecia treatment development.     

克罗恩病发病机制及其药物治疗的研究进展

克罗恩病是一种病因和发病机制尚未明确的表现为慢性非特异性的肠道炎症性疾病。本文描述了目前常见诱因和发病机制对于该疾病的影响,包括地理和食物因素、肠道细胞损伤、肠道菌群失调、肠道黏膜或相关组织病理生理改变和免疫功能失调等。列举了传统药物、生物制剂和中药在疾病中应用以及近年来的治疗研究进展。     

A review of the treatment of male pattern hair loss

ABSTRACT

Introduction

Androgenetic alopecia is a common hair loss disorder affecting up to 80% of males by the age of 80. It is characterized by androgen related progressive thinning of hair in a defined pattern. It results in diminished self-esteem, reduced confidence and distress in affected men, irrespective of age or stage of baldness. An effective treatment for hair baldness is needed.     

Treatment options for alopecia: an update,looking to the future

Introduction: Hair loss is a very common complaint. The diagnosis is based on clinical, dermoscopic and pathological examination. The treatment is usually continuous and requires strong compliance.

Areas covered: This article aims to i) summarize current treatment options for the most common forms of hair loss; ii) update the literature on treatment options to emerge over the 3 years since the release of the first edition of this article in 2009; and iii) outline future strategies for treating alopecia.

Expert opinion: There is good evidence-based information for the treatment of androgenetic alopecia. There are very few good-quality randomized studies, and no information about long-term results for most of the available treatments for alopecia areata and cicatricial alopecias. Significant research success has been achieved over the past few years through i) discovering the genetic profile of alopecia areata; ii) working on follicular neogenesis in androgenetic alopecia; and iii) discovering the PPAR-γ pathway in scarring alopecia.     

Finasteride in the treatment of alopecia

Finasteride is a 5α-reductase inhibitor approved for the treatment of male pattern hair loss. Originally approved for the treatment of benign prostatic hypertrophy in 1992, its approval was expanded in 1997 to include the treatment of androgenetic alopecia (AGA) in men at a dose of 1 mg/day. Finasteride inhibits 5α-reductase, thereby prohibiting the conversion of testosterone to dihydrotestosterone (DHT), which is implicated in the development of hairless in some men. Reduction in DHT results in a significant improvement in subjective and objective assessments of hair growth and density. Finasteride is well-tolerated with a favourable adverse event history. The most common adverse events include reduced libido, decreased ejaculate volume and gynaecomastia.     

基于流感发病机制的药物研究进展

流行性感冒简称流感,经飞沫或接触在人或动物之间传播的RNA流感病毒感染所致,流感病毒在宿主体内复制扩散引发机体过度免疫反应造成一些呼吸道、消化道甚至休克等症状,其强传染性一直对公共健康构成威胁。筛选新的抗流感药物并解释其作用机制已成为当前研究的热点,本文根据流感发病机制就抗流感药物进行分类总结,归纳近现代及在未来有抗流感开发前景的中药、化药及中西药联用,以期为抗流感新药的研发提供参考依据。