Effect of Prepared Rhubarb on Insulin Resistance in Patients With Pregnancy Induced Hypertension

Objective: To investigate the effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension (PIH) and its mechanism. Methods: All the 92 patients accepted 75 g oral glucose tolerance test (OGTT) and insulin release test before and after treatment. These patients were divided into two groups (treated group and control group). Prepared rhubarb and nifedipine were given to the treated group, while nifedipine was given to the control group alone. Circulating endothelial cell (CEC), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were measured and glucose area under curve (GAUC), insulin area under curve (IAUC), insulin sensitivity index (ISI) were calculated. And 30 normal pregnant women were selected as the healthy group. Results: CEC, TNF-a, IL-6, GAUC and IAUC of PIH patients were significantly higher than those of the normal healthy group; while ISI of PIH patients was significantly lower than that of the healthy group. ISI was significantly negatively correlat     

Study on Effect of Different Dosages of Ligustrazine on Level of Plasminogen Activator Inhibitor-1 Activity in Type 2 Diabetes Mellitus Patients

Objective:To observe the effect of different dosages of ligustrazine(LG)on the level ofplasminogen activator inhibitor-1(PAI-1)activity in patients with type 2 diabetes mellitus.Methods:Ninety cases of type 2 diabetes mellitus inpatients were selected,and randomly divided into LG small dos-age group(SDG),LG large dosage group(LDG)and control group.The 120 mg LG,400 mg LG andnormal saline 250 ml were given through intravenous dripping respectively,once daily,20 days as onetreatment course. Before and after treatment,all the patients had their fasting blood taken for PAI-1 andtissue plasminogen activator(t-PA)assessment test to perform the comparative study.Results:Seventy-three out of the 90 patients completed the observation course,the PAI-1 activity of three groups aftertreatment all lowered compared with that before treatment,and the difference between groups was alsosignificant(all P<0.01).After treatment the PAI-1 level of SDG and LDG of LG were all markedly low-ered(all P<0.01),the LDG’s lowering     

Effect of Jiangtang Bushen Recipe (降糖补肾方) in Intervention Treatment of Patients with Impaired Glucose Tolerance

Objective:To evaluate the intervention effect of diet, exercise and Jiangtang Bushen Recipe (JBR, 降糖补肾方), a Chinese herbal recipe, in preventing the progress of patients with impaired glucose tolerance ( IGT ) to diabetes mellitus (DM) type 2. Methods: Fifty-one IGT patients with their diagnosis conformed to the diagnosis standard of WHO, 1999, were randomly divided into the control group (n = 26) and the TCM group (n=25). Patients in the control group attended to the educational course for DM and received dietotherapy and kinetotherapy, and to those in the TCM group, under these treatments, JBR was given additionally. Oral glucose tolerance test (OGTT), body weight index (BWI), levels of blood lipids and fasting insulin of all the patients were examined after 3 months, 6 months and 12 months of treatment. The total observation time was 1 year. Results:Except the 6 cases out of the 51 patients (11.7%), on whom the observa-tion discontinued, in the control group, as compared with before treatment, l     

Clinical Observation on 96 Cases of Primary Osteoporosis Treated with Kidney-Tonifying and Bone-Strengthening Mixture

Objective: To objectively evaluate the therapeutic effect and safety of Mixture for Nourishing Kidney and Strengthening Bone (益肾壮骨合剂). Method: Among 160 cases of osteoporosis under clinical observation,96 patients in the treatment group were treated with Mixture for Nourishing Kidney and Strengthening Bone(益肾壮骨合剂), 32 patients in the control group were given Shen Gu Capsule (肾骨胶囊) and 32 patients in the blank group were given no drug in half a year. Observation and determination were conducted on bone mineral density (BMD), clinical symptoms, bone gla protein (BGP), pyridinoline (PYD), estradiol (E2),testosterone (T), blood urea nitrogen (BUN), transaminase and routine test on blood and urine. Result: The comprehensive effect in the treatment group was remarkably superior to that in the control group. Conclusion:The safe and reliable Chinese drug can enhance BMD, promote osteogenesis and inhibit bone absorption,hence treating osteoporosis with marked effect.     

Effect of Shugan Jianpi Granule(舒肝健脾颗粒) on Gut Mucosal Serotonin-positive Cells in Patients with Irritable Bowel Syndrome of Stagnated Gan-qi Attacking Pi Syndrome Type

Objective:To evaluate the effect of Shugan Jianpi Granule (舒肝健脾颗粒,SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type.Methods:Twenty-four patients were randomized equally into three groups.All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day.Additionally,24 g of SJG was given three times a day to group A,and the same dosage of SJG and Smecta 15 g thrice a day was given to group B,while no additional treatment was given to the control group.The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method.Results:The number of 5-HT+C decreased after treatment in all the three groups (P＜0.05),but the decrement was more significant in the two test groups than in the control group (P＜0.05 and P＜0.01,respectively),while comparison of 5-HI+C between the two test groups showed insignificant difference (P＞0.05).Conclusion:SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type,and its effect is enhanced when used in combination with Smecta.     

Effect of Feitai Capsule(肺泰胶囊) on Quality of Life and Progression-Free Survival of Patients with Unresectable Non-Small Cell Lung Cancer

<正>Objective:To examine the effect of a Chinese medicinal herbal formula(Feitai Capsule,肺泰胶囊) on the quality of life(QOL) and progression-free survival(PFS) of patients with unresectable non-small cell lung cancer(NSCLC).Methods:Sixty-two patients were randomly divided into the treatment group(31 cases) and the control group(31 cases).For the treatment group,4 capsules(1.2 g/capsule) of Feitai Capsule were administered 3 times a day after meals for 3 weeks;then no drug was administered for 1 week.This schedule was continued for at least 3 more cycles(12 weeks totally).If there were no obvious toxic reactions,the treatment was extended.The patients were evaluated at least once every 8 weeks until progressive disease(PD). For the control group,the regular follow-up and evaluation were performed at least once every 8 weeks until PD.Clinical symptoms,objective response,physical constitution and energy,QOL,and PFS were evaluated regularly.Analysis of variance(ANOVA),a non-parametric test,and analysis of covariance were used to compare clinical features,amelioration of clinical symptoms,physical constitution and energy,and QOL.Kaplan-Meier analysis was used to compare the two-group PFS.Results:Sixty patients finished the final evaluation, with 30 patients in each group.Baseline characters between groups were not significantly different(P0.05). The control group had a 36.7%improvement in clinical symptoms,while the treatment group had a 73.3% improvement.This difference was statistically significant(Z=-2.632,P=0.008).The control group had a 26.7% improvement in the Karnofsky performance status(KPS),while the treatment group had a 53.4%improvement. This was also significantly different(Z=-2.182,P=0.029).A comparative analysis indicated a positive correlation (r=0.917,P0.001).Compared with the control group,QOL in the treatment group was significantly improved, except in the social/family condition and doctor-patient relationship indicators.The PFS of the treatment group and control group were 6.23 months and 4.67 months,respectively(P=0.048).Conclusion:Feitai Capsule,a Chinese medicinal herbal treatment could improve the QOL and extend the PFS of the unresectable NSCLC patients.     

Modified Liujunzi Decoction (六君子汤) Alleviates Chemotherapy Induced Anorexia in Advanced Non-Small Cell Lung Cancer: A Propensity Score Matched Case-Control Study

Objective: To evaluate the effect of Chinese herbal medicine formula, modified Liujunzi Decoction(六君子汤, MLJZT), for anorexia, utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer(NSCLC). Methods: The study adopted a propensity score-matched design based on a prospective database. From February 2016 to September 2017, patients with advanced NSCLC that received both cisplatin-based chemotherapy and MLJZT(IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone(control group). Changes in anorexia and weight, as well as side effects were evaluated per week within 4-cycle chemotherapy. Results: Overall, 156 patients with advanced NSCLC that had received chemotherapy from our database were identified and 53 pairs were matched successfully. In total, 48.6%(50/53) of patients in the IM group had anorexia-improvement compared to 28.3%(15/53) of patients in the control group, and a total of 39.6%(21/53) of patients in the control group had a worsening of anorexia compared to only 7.8%(8/53) of patients in the IM group(P0.01). The weight reduced significantly over time in the control group(–2.36±2.53 kg) as compared to the IM group(–0.62±3.89 kg, P0.01). CHM didn't reduce the efficacy of chemotherapy in shrinking tumor size, and didn't increase the incidence of side effects such as hematological and hepatorenal toxicity. Conclusion: MLJZT is effective and safe for alleviating anorexia in patients with NSCLC. These findings warrant the conduct of a randomized controlled trial.     

Effects of Combined Therapy of Xuezhikang Capsule(血脂康胶囊)and Valsartan on Hypertensive Left Ventricular Hypertrophy and Heart Rate Turbulence

<正>Objective:To observe the effect of combined therapy with Xuezhikang Capsule(血脂康胶囊,XZK) and Valsartan on left ventricular hypertrophy(LVH) and heart rate turbulence(HRT) in hypertensive patients. Methods:Ninety primary hypertensive patients with LVH were randomly assigned to three groups.Basic treatment,including aspirin,β-blockers,calcium antagonists,etc.were administered to all patients.Additionally, Valsartan(VS,80 mg once a day) was given to the 30 patients in the VS group.Valsartan(in the same dosage) and XZK(600 mg,twice a day) were given to the 32 patients in the Chinese medicine(CM) group,while none was given to the 28 patients in the control group.The therapeutic course lasted for 24 months.Changes in left ventricular mass index(LVMI) measured by cardiac ultrasonic indices,HRT parameters,including the original heart rate(TO) and slope coefficient(TS),systolic and diastolic blood pressures(SBP and DBP),as well as blood cholesterol level(TC) were measured before and after treatment.Results:After treatment,TO and LVMI were lowered,while TS increased in both the VS group and the CM group(P0.01),but changed insignificantly in the control group.Significant differences between the CM group and the control group were shown in terms of TO,LVMI,SBP,DBP and TS(P0.01);and between the CM group and the VS group in terms of TO,LVMI and TS(P0.01).Moreover,HRT parameters showed an evident correlation with LVMI(r=0.519-0.635,P0.01). Conclusion:Combined therapy with XZK and Valsartan can improve hypertensive LVH and HRT parameters, and lessen the damage on the autonomous nervous system.     

Qingre Quyu Granule(清热祛瘀颗粒)Stabilizes Plaques through Inhibiting the Expression of Tenascin-C in Patients with Severe Carotid Stenosis

Objective:To investigate the therapeutic effects of Qingre Quyu Granule(清热祛瘀颗粒,QQG)on the patients with severe carotid stenosis,and to explore the mechanism of it.Methods:Ninety-six patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group(n=48) and a control group(n=48) randomly using consecutively numbered envelopes.The patients in the QQG group were given QQG and Western medicine,those in the control group were given Western medicine merely,the course of treatment was 16 weeks.All patients went through endarterectomy after treatment.Plaques were subjected to the analysis of CD3,CD68,soluble intercellular adhesion molecule 1(ICAM-1),matrix metalloprotease-9(MMP-9),CD40 L,tenascin-C,and collagen content lipid content by immunohistochemistry or polarized light analysis.Results:By the end of experiment,the expressions of CD3,CD68,ICAM-1,MMP9,CD40 L and tenascin-C on the plaques were statistically significant lower in the QQG group compared with the control group(P0.01).The lipid content of the plaque was also significantly lower in the QQG group compared with the control group(P0.01).The interstitial collagen in the tissue sections of the plaques was also significantly higher in the QQG group in comparison with the control group(P0.01).Conclusion:QQG could stabilize carotid artery plaques through inhibiting pro-inflammation factors and restraining the tenascin-C and MMP9 pathway.     

Preliminary observation on treatment of patients with Japanese B encephalitis with monoclonal antibody

The monoclonat antibodies(McAbs)against Japanese B encephalitis virus for clinicaluse were prepared according to the standards of Food and Drug Administration(FDA,USA).Immediately after the diagnosis,the patients were given 10 mg of McAbs(IgG)in normal salineby intravenous drip plus intramuscular injection.The average febrifugal days of the McAb treat-ment group(55 cases),symptomatic treatment group(12 cases),ribavirin treatment group(17cases)and thymus peptides treatment group(7 cases)were 2.86,6.20,7.16 and 9.11d,respec-tively(P<0.05 or P<0.01).It is necessary to take the skin test before use of the McAbs andto give dexamethasone during the McAb treatment.     

Thirty Cases of the Blood-Stasis Type Prolapse of Lumbar Intervertebral Disc Treated by Acupuncture at the Xi （cleft） Point plus Herbal Intervention Injection

Objective:To observe the clinical therapeuric effects and explore the mechanism of acupuncture at the xi (cleft)points combined witll herbal intervention injection for treatment of prolapse of the lumbar intervertebral disc with TCM symptoms and signs of blood stasis.Methods:The 60 CaSeS in this series were randomly divided into a treatment group and a control group,30 cases in each group.The patients in the treatment group were treated by acupuncture at Jiaji L4-S1,Waiqiu(GB 36),Weizhong(BL 40)and Xiaxi (GB 43)plus intervention injection of Gegensu Zhusheye(葛根素注射液 Puerarin Injectio).The patients of the control group were given the routine acupuncture combined with injection of Gegensu Zhusheye (葛根素注射液 Puerarin Injectio)into the Ashi points.The changes in interleukin-6(IL-6) and hempdynamics were observed before and after treatment in both the two groups.Resuits:The total therapeutic effect in the treatment group was obviously better(P＜0.05)and the treatment course was obviously shorter than that of the control group(P＜0.01).After the treatment,the total score,the visual analog scale(VAS)pain-evaluating score,and the score in straight-leg raising test were obviously improved in both the two groups,in which the improvement in the treatment group shown by the score in straight-leg raising test and the total score superior to that of the control group(P＜0.05).The IL-6 level,red blood cell ratio,K value of blood sedimentation equation.and whole blood high shearing specific viscosity were improved in both the two groups.but the treatment group showed better improvement than that of the control group in the red blood cell ratio,K value of blood sedimentation,and IL-6 level(P＜0.05 or P＜0.01).Conclusions:The treatment group was superior to the control group in improvement of the symptoms and signs,the daily life ability,and in pain alleviation.The mechanism is possibly related witb the improvement in the IL-6 level and hemodynamic indexes.which may promote the subsidence of inflammation of the nerve roots.     

Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer

Objective:To evaluate the efficacy and side effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer(NSCLC).Methods:Sixty-three patients with stageⅢB andⅣNSCLC hospitalized from October 2001 to October 2008 were enrolled and assigned to two groups using a randomizing digital table,with 33 patients in the treatment group and 30 in the control group. They were all treated with the Navelbine and Cisplatin(NP) chemotherapy,but to the treatment group the Chinese drugs...     

Effects of Kaixin Powder(开心散)on Melatonin Receptor Expression and ~(125)I-Mel Binding Affinity in A Rat Model of Depression

Objective:To explore the effects of Kaixin Powder(开心散,KXP) on melatonin receptor(MR)expression and ~(125)I-Mel binding affinity in a depression rat model.Methods:Seventy-two male Wistar rats were divided into six groups:a blank control group,model group,ramelteon group,KXP high-dosage group(HKXP),medium-dosage group(MKXP) and low-dosage group(LKXP).To establish the depression model,all groups except the blank control group were singly housed and exposed to chronic unpredictable mild stress.Weight gain,sucrose consumption and the open-field test were used to evaluate induction of depression.KXP at 260,130 and 65 mg/(kg·d) was also respectively administered to the rats in the HKXP,MKXP and LKXP groups for 21 days.Ramelteon[0.83 mg/(kg·d)]was given to the positive drug control group.An equivalent volume of physiological saline was given to the blank and model groups.The liquid chip method was used to measure the concentration of plasma melatonin(MT).Mel1a(MT1) and Mel1b(MT2) expression levels were determined by Western blotting.In addition,a radioactive ligand-binding assay was used to analyze the specific binding properties and dynamic characteristics between MR and ~(125)I-Mel.Results:The results of weight gain,sucrose consumption and the open-field test showed that our model successfully produced depressive symptoms and depressive-like behavior.The concentration of plasma MT in the model group decreased significantly at night but increased in the MKXP group(P0.05).The HKXP group showed significantly increased expression of MT1(P0.05);however,the expression of MT2 in all groups exhibited no significant differences(P0.05).The maximum binding capacity(B_(max)) for specific binding between MR and ~(125)I-Mel in the MKXP group was significantly higher than that in the model group(P0.05),but no significant differences were found in the equilibrium dissociation constant(K_d) of each group(P0.05).Conclusions:KXP may have a similar effect as ramelteon.KXP improved depressive-like behavior by increasing the concentration of plasma MT and MT1 expression,thereby increasing three B_(max) of MR to achieve the desired antidepressant effect.     

Trans-abdominal ultrasonography in diagnosis of achalasia

Objective: To assess the clinical value of trans-abdominal ultrasonography for the diagnosis of achalasia. Methods: The subjects were divided into 3 groups, with 8 patients suffering from achalasia as the patient group, 10 normal individuals and 8 patients with cardiac carcinoma as controls. Real-time trans-abdominal ultrasonography (TAUS) was employed to investigate the lower esophagus and cardia of all subjects through water provocative test, and the sonographic findings were compared. After treated by administration of drugs, pneumatic balloon dilation or intrasphincteric injection of botulinum toxin, the 8 patients with achalasia were re-examined by TAUS for longitudinal comparison. Results: (1) The normal subjects had no dilation of cardia and lower esophagus before drinking water, but their cardias opened rapidly in accordance with the drinking action to allow water enter the stomach. (2) All the patients with achalasia were found to have dilation of lower esophagus before taking water. During a 1     

Application of Aidi Injection (艾迪注射液) in the Bronchial Artery Infused Neo-Adjuvant Chemotherapy for stage ⅢA Non-small Cell Lung Cancer before surgical Operation

Objective: To study the effect of Aidi Injection (艾迪注射液,ADI) applied in the bronchial artery infused (BAI) neo-adjuvant chemotherapy for stage ⅢA non-small cell lung cancer (NSCLC) before surgical operation.Methods: The 60 patients with NSCLC stage ⅢA underwent two courses BAI chemotherapy before tumor incision were assigned to two groups,the treatment and the control groups,using a random number table,30 in each group.ADI (100 mL) was given to the patients in the treatment group by adding into 500 mL of 5% glucose injection for intravenous dripping once daily,starting from 3 days before each course of chemotherapy,and it lasted for 14 successive days,so a total of 28 days of administration was completed.The therapeutic effectiveness and the adverse reaction that occurred were observed,and the levels of T-lymphocyte subsets,natural killer cell activity,and interleukin-2 in peripheral blood were measured before and after the treatment.Results: The effective rate in the treatment group was higher than that in the control group (70.0% vs.56.7%,P0.05).Moreover,as compared with the control group,the adverse reaction that occurred in the treatment group was less and mild,especially in terms of bone marrow suppression and liver function damage (P0.05).Cellular immune function was suppressed in NSCLC patients,but after treatment,it ameliorated significantly in the treatment group,showing significant difference as compared with that in the control group (P0.05).Conclusion: ADI was an ideal auxiliary drug for the patients in stage ⅢA NSCLC received BAI neo-chemotherapy before surgical operation;it could enhance the effectiveness of chemotherapy,ameliorate the adverse reaction and elevate patients' cellular immune function;therefore,it is worthy for spreading in clinical practice.     

Clinical Observation on Treatment of Acute Myelocytic Leukemia by Supplementing Qi, Nourishing Yin and Clearing Heat Principle

Objective: To observe the clinical efficacy of TCM with supplementing Qi, nourishing Yin and clearing heat principle (SQNYCH) combined with chemotherapy in treating myelocytic leukemia. Methods: One hundred and fourteen patients were randomly divided into the treated group (n= 68) and the control group (n= 46). To the treated group, SQNYCH was applied as the basic treatment, with combined chemotherapeutic protocol, using DA, HA and IA, to induce remission, and to the M3 patients, all-trans retinoic acid and arsenic trioxide were given. As for patients in the control group, only western medicine was administered. Results: In the treated group 49 patients (72.1%) were completely remitted, 9 (13.2%) partially remitted and the total remission rate being85. 3% , which was significantly different from that in the control group. After treatment, the blood and bone marrow picture were obviously improved in both groups, but the increase of hemoglobin and platelet were better in the treated group than those in the     

Effect of diltiazem and lidocaine on arterial pressure or heart rate and the quality of extubation in patients undergoing uvulopalatopharyngoplasty

Objective：To evaluate the effect of diltiazem and lidocaine on arterial pressure or heart rate and the quality of extubation in patients undergoing uvulopalatopharyngoplasty. Methods： Sixty patients were randomly divided into 4 groups： In the control group patients were given saline; in the lidocaine group patients were given 1.0 mg/kg lidocaine ; in the diltiazem group patients were given 0. 2 mg/kg diltiazem; and in the lidocaine plus diltiazem group patients were given 1.0 mg/kg lidocaine and 0. 2 mg/kg diltiazem. These drugs were given 2 rain before tracheal extuhation. Values for SBP, DBP, and HR were recorded, on arriving at the operating room, immediately at the end of the surgery, at the time of injection of the study drugs, at tracheal extubation, at 1 min and 5 min after extubation. The quality of extubation according to the Sebel＇s grading scale were compared among the 4 groups. Results：During extubation in the control group HR, SBP and DBP increased significantly when compared to baseline levels. Both lidocaine （1.0 mg/kg） and diltiazem （0. 2 mg/kg） successfully alleviated these increases. The suppressive effect of diltiazem was greater than that of lidocaine. The combinative use of the two drugs minimized the increases. The administration of lidocaine significantly suppressed bucking or coughing compared with the other groups. Conclusions： The pressor responses and tachycardia occurring in patients with uvulopalatopharyngoplasty during emergence from anesthesia and tracheal extubation, can be easily blocked by a bolus dose of 1.0 mg/kg lidocaine, 0. 2 mg/kg diltiazem or the comhinative use of the two drugs. And the concurrent use of lidocaine and diltiazem alleviated the hemodynamic changes more obviously.     

Effect of Shengmal Powder(生脉散) on Symptoms and Markers of Inflammatory Damage of Patients with Acute Viral Myocarditis

Objective: To evaluate the efficacy of Sheng-mai Power (SMP) in treating acute viral myocarditis. Methods: 102 patients with acute viral myocarditis were randomized to SMS group (n = 52) and placebo control group (n = 50 ). Semiquantitative integral methods were taken to observe changes of clinical symptoms such as dyspnea, palpitation and chest pain after 4 weeks of treatment, simultaneously EKG, 24h Holter, concentration of serum cardiac troponin-I, cardiac troponin T and neutralizing antibody test to the Coxsackie B virus were determined. Results: Dyspnea improved much more obvious in SMP group than in the placebo     

Psychological Distress,Social Support and Medication Adherence in Patients with Ischemic Stroke in the Mainland of China

Stroke research and rehabilitation have traditionally focused on the physical and functional impact of a stroke. Less attention has been given to the psychosocial factors associated with this chronic condition. By the few studies that have specifically focused on psychosocial factors in the context of stroke, poststroke depression is demonstrated to significantly influence stroke outcomes. Associations of stroke with psychological symptoms other than depression have rarely been evaluated. This study was aimed to investigate the changes of psychological stress, social support and medication adherence in patients with ischemic stroke in the mainland of China. In this study, 90 patients with hemiplegia one year after first-ever middle cerebral artery infarction(stroke group) in the Zhongnan Hospital of Wuhan University from June 2008 to June 2011 were recruited for interview. Ninety age- and sex-matched normal volunteers(control group) were also examined at the same period. The psychological distress was assessed by the Symptom Checklist 90(SCL-90), the social support by the Social Support Rating Scale(SSRS), and medication adherence by Morisky’s self-reported inventory, respectively. Group differences were analyzed using unpaired-t test and chi-squared test. The results showed that total mean scores of the SCL-90 in the stroke group were higher than those in the control group(P<0.01). Except two dimensions, paranoid ideation and psychoticism, mean scores of the rest dimensions(including somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, and phobic anxiety) of SCL-90 were significantly higher in the stroke group than those in the control group(P<0.05, or P<0.01). The objective support, subjective support, support availability and total social support scores in the stroke group were significantly higher than those in the control group(P<0.05, or P<0.01). Those in the “SCL-90 total scores >150 group” were significantly higher than in the “SCL-90 total scores <100 group” and the “SCL-90 total scores between 100 to 150 group”(P<0.05, or P<0.01). Those in the “SCL-90 total scores between 100 to 150 group” were significantly higher than in the “SCL-90 total scores <100 group”(P<0.05). In 90 patients with ischemic stroke, 26(28.89%) patients obtained high medication adherence, 47(52.22%) patients medium medication adherence, and 17(18.89%) patients low medication adherence, respectively. Among these stroke patients, there were 17(50.00%) patients with high medication adherence in the “SCL-90 total scores >150 group”, 28(75.67%) patients with medium medication adherence in the “SCL-90 total scores between 100 to 150 group”, and 12(61.16%) patients with low medication adherence in the “SCL-90 total scores <100 group”, respectively. There was significant difference in the medication adherence rate among the different SCL-90 scores groups in these stroke patients(P<0.05 or P<0.01). It was led to conclude that ischemic stroke patients one year after hemiplegia have psychological distress, low level of social support and poor medication adherence in the mainland of China. Therefore, it is necessary to mobilize the government, medical institutions and various social support groups to offer psychological interventions to relieve the stress of patients with ischemic stroke, and improve their medication adherence.