体外受精-胚胎移植后妊娠早期阴道流血对妊娠结局的影响

目的 探讨体外受精-胚胎移植(IVF-ET)后妊娠早期阴道流血的发生率及其对妊娠结局的影响.方法 回顾性分析行IVF-ET或胚胎解冻-移植(F-ET)获得临床妊娠 823例患者的临床资料,分析早期阴道流血与患者年龄、不孕年限、体质量指数(BMI)、孕酮及人绒毛膜促性腺激素水平、不孕类型、流产、妊娠期并发症、早产及剖宫产率的相关性.结果 ①妊娠早期阴道流血发生率为23. 69％,多元回归分析结果显示妊娠早期阴道流血与妊娠期并发症的发生明显相关,差异有统计学意义(OR=2.90,95％ CI: 1. 85～ 4. 57,P<0.05),与流产、早产及剖宫产率无明显相关;②患者孕前BMI是影响剖宫产的独立危险因素(OR=1.09,95％ CI:1.02～1. 17,P<0.05). 结论 IVF/F-ET后妊娠早期阴道流血对妊娠结局如流产、早产率无明显影响,但与妊娠期并发症的发生密切相关.     

体重指数对不孕女性夫精宫腔内人工授精周期妊娠 结局的影响

目的:探索体重指数（BMI）对不孕女性夫精宫腔内人工授精（IUI）周期妊娠结局的影响。方法:回顾性分析2015 年1 月—2020 年6 月于天津市中心妇产科医院生殖中心施行IUI 治疗的3 707 例患者的周期资料,按照BMI 分为3 组,A 组（正常 体质量组18.5 kg/m2≤BMI＜23.0 kg/m2）、B 组（超重组23.0 kg/m2≤BMI＜25.0 kg/m2）、C 组（肥胖组BMI≥25.0 kg/m2）,比较各组间 一般资料以及妊娠结局。结果:在方案中,3 组间自然周期方案占比差异均有统计学意义（P＜0.01）,口服药物联合肌注促排药物 方案差异均有统计学意义（P＜0.01）;BMI 与活产率无关,B 组（OR=1.161,95% CI:0.861～1.565,P=0.328）以及C 组（OR＝1.003, 95% CI=0.761～1.322,P=0.948）与A 组活产率差异无统计学意义;肌注促排药物（OR＝1.425,95% CI:1.026～1.980,P=0.035） 以及口服药物联合肌注促排药物（OR=1.366,95% CI:1.038～1.796,P=0.026）是影响活产率的独立因素。肥胖（OR＝2.784,95% CI:1.471～5.267,P=0.002）以及继发性不孕（OR=3.048,95% CI=1.454～6.389,P=0.003）是早期流产的危险因素。结论:肥胖以及继 发性不孕为早期流产的危险因素,促排药物可提高不孕患者IUI 活产率。     

In vitro fertilization-embryo transfer in patients with unexplained recurrent pregnancy loss

Background:Empiric therapy for patients with unexplained recurrent pregnancy loss (URPL) is not precise. Some patients will ask for assisted reproductive technology due to secondary infertility or advanced maternal age. The clinical outcomes of URPL patients who have undergone in vitro fertilization-embryo transfer (IVF-ET) require elucidation. The IVF outcome and influencing factors of URPL patients need further study.Methods:A retrospective cohort study was designed, and 312 infertile patients with URPL who had been treated during January 2012 to December 2015 in the Reproduction Center of Peking University Third Hospital were included. By comparing clinical outcomes between these patients and those with tubal factor infertility (TFI), the factors affecting the clinical outcomes of URPL patients were analyzed.Results:The clinical pregnancy rate (35.18% vs. 34.52% in fresh ET cycles, P = 0.877; 34.48% vs. 40.27% in frozen-thawed ET cycles, P = 0.283) and live birth rate (LBR) in fresh ET cycles (27.67% vs. 26.59%, P = 0.785) were not significantly different between URPL group and TFI group. URPL group had lower LBR in frozen-thawed ET cycles than that of TFI group (23.56% vs. 33.56%, P = 0.047), but the cumulative LBRs (34.69% vs. 38.26%, P = 0.368) were not significantly different between the two groups. The increased endometrial thickness (EMT) on the human chorionic gonadotropin day (odds ratio [OR]: 0.848, 95% confidence interval [CI]: 0.748–0.962, P = 0.010) and the increased number of eggs retrieved (OR: 0.928, 95% CI: 0.887–0.970, P = 0.001) were protective factors for clinical pregnancy in stimulated cycles. The increased number of eggs retrieved (OR: 0.875, 95% CI: 0.846–0.906, P < 0.001), the increased two-pronucleus rate (OR: 0.151, 95% CI: 0.052–0.437, P < 0.001), and increased EMT (OR: 0.876, 95% CI: 0.770–0.997, P = 0.045) in ET day were protective factors for the cumulative live birth outcome.Conclusion:After matching ages, no significant differences in clinical outcomes were found between the patients with URPL and the patients with TFI. A thicker endometrium and more retrieved oocytes increase the probability of pregnancy in fresh transfer cycles, but a better normal fertilization potential will increase the possibility of a live birth.     

基于前瞻性队列研究体外受精-胚胎移植对不良妊娠结局的影响

目的：评价体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)技术本身是否会增加子代不良妊 娠结局(adverse pregnancy outcomes,APOs)的风险。方法：选择诊断为不孕症通过IVF-ET受孕的妇女为暴露组,诊断为 不孕症但通过非辅助生殖技术治疗(如促排卵或简单药物治疗)后自然怀孕的妇女作为非暴露组,建立前瞻性队列。 通过单因素分析找出两组除IVF-ET操作因素外存在差异的因素,再采用多因素logistic回归分析控制这些因素,分析 IVF-ET技术对APOs的独立作用。结果：多因素logistic回归分析显示,在控制混杂因素后,IVF-ET受孕孕妇较诊断为 不孕症但自然受孕孕妇显著增加早产(OR=1.28,95% CI：1.05~1.56)、低出生体重(OR=1.69,95% CI：1.27~2.31)、围 生期死亡(OR=5.33,95% CI：2.44~11.81)和先天畸形(OR=1.83,95% CI：1.12~2.94)的风险。结论：IVF-ET操作因素本 身可能会增加APOs的风险。     

Effect of Spermatozoa Apoptosis on the Clinical Outcomes with Human in vitro Fertilization

Objective To analyze the effect of spermatozoa apoptosis on the clinical outcomes during in vitro Fertilization (IVF-ET). Methods A prospective analysis was carried out, 519 infertile couples were divided into 3 groups according to the clinical outcomes with IVF, including pregnancy and birth (liveborn group), pregnancy but abortion (miscarriage group), failure to pregnancy (failure group). Spermatozoa collected from 519 male partners were processed through density gradient centrifugation (DGC) and swim-up and the apoptosis of the spermatozoa, in ejaculated / processed semen, were evaluated using flow cytometry by determining the levels of disruption of mitochondrial membrane potential (d-MMP) and activation of caspase-3 (CP3). Results For ejaculated semen, apoptosis was significantly different among 3 groups individually, the result was as follows: liveborn group < failure group < miscarriage group (P<0.05). For processed semen, miscarriage had the highest apoptosis level (P<0.05), and there was no significant difference between liveborn group and failure group (P>0.05). Compared with the d-MMP, the activation of CP3, either in ejaculated or processed semen, showed more powerful predictive value for miscarriage other than liveborn and failure. The cutoff value of CP3 in ejaculated semen was 42.0%, with sensitivity: 0.931, specificity: 0.804. Conclusion The level of apoptosis of spermatozoa played a strongly impact on the clinical outcomes with IVF and the activation of CP3 in ejaculated semen possessed a high predictive value for miscarriage.     

英语专业学生思辨倾向和阅读水平相关性的研究

目的 比较黄体酮2种剂型(阴道缓释凝胶与注射液)对实施基于非冻融胚胎的体外受精与胚胎移植技术(IVF-ET)孕妇的妊娠结局的影响.方法 计算机检索Cochrane Library、Embase、PubMed、Elsevier、ResearchGate、万方医学数据库、中国知网数据库、维普全文数据库,搜集关于黄体酮阴道缓释凝胶与黄体酮注射液影响IVF-ET结局的随机对照试验研究.采用Revman5.3版软件对数据进行Meta分析.结果 共纳入10项研究.所有纳入研究的患者分为阴道缓释凝胶组和肌内注射组.Meta分析结果显示,2组的临床妊娠率(RR=0.98,95％CI:0.90～1.07)、继续妊娠率(RR=0.96,95％CI:0.79～1.17)、流产率(RR=0.80,95％CI:0.59～1.10)、活产率(RR=1.13,95％CI:0.97～1.31)无统计学差别.结论 黄体酮阴道缓释凝胶和肌内注射液对采用IVF-ET妊娠结局相同.     

原发不孕患者行体外受精—胚胎移植的女方病因及妊娠结局分析

目的:探讨原发不孕患者行体外受精—胚胎移植(IVF-ET)的女方病因中各因素对妊娠结局的影响。方法:回顾性分析182例因女方原因行IVF-ET的原发不孕患者,根据不孕的主要因素分为4组。输卵管因素组、排卵障碍组、子宫内膜异位症组及不明原因组。比较4组间的胚胎种植率、临床妊娠率、流产率、异位妊娠率。结果:输卵管因素组胚胎种植率较高,但与其余各组比较,差异无统计学意义(P>0.05)。输卵管因素组与排卵障碍组临床妊娠率较高,输卵管因素组临床妊娠率较其余各组差异有统计学意义(P<0.05)。输卵管因素组的异位妊娠率较高,与其他三组比较,差异有统计学意义(P<0.001)。结论:在预测IVF-ET结局中应注意输卵管因素特别是输卵管积液对妊娠结局的影响。     

子宫腺肌病合并不孕的治疗

子宫腺肌病可导致不孕和流产,可增加体外受精-胚胎移植(IVF-ET)的流产率、降低活产率和临床妊娠率,也增加产科和新生儿相关并发症。经阴道超声已成为子宫腺肌病的一线诊断方法,但需提高诊断率。子宫腺肌病合并不孕症的治疗方法包括药物、手术、介入治疗和辅助生殖助孕治疗等。一般情况下可推荐首选IVF,一般推荐GnRH-a的应用和全胚冷冻策略。针对子宫腺肌病的诊断、非IVF治疗方法的效果、GnRH-a预处理以及鲜胚、冻胚移植比较等问题仍需进行更多研究。     

体外受精-胚胎移植妊娠结局的影响因素探究

目的分析囊胚移植相关因素对体外受精-胚胎移植妊娠结局的影响。方法回顾性分析2015年7月-2020年7月期间在我院接受体外受精-胚胎移植的790例患者的临床资料,比较第5天胚胎囊胚(D5)组(n=705)和第6天胚胎囊胚(D6)组(n=85)囊胚移植的妊娠结局;依据妊娠结局分为活产组(n=322)和非活产组(n=468),多因素logistic分析体外受精-胚胎移植后活产结局的囊胚移植相关影响因素。结果 D5组囊胚移植的生化妊娠率、临床妊娠率和活产率(分别为69.93%、64.96%、41.84%)均高于D6组(50.59%、45.88%、30.59%)囊胚移植,差异有统计学意义(P<0.05);D5组和D6组囊胚移植的流产率比较差异无统计学意义。多因素logistic分析显示,年龄>35岁、不孕年限>5年、移植日内膜厚度<9 mm、滋养层细胞评级为C级、囊胚移植日为D6、多产均为体外受精-胚胎移植非活产的危险因素(P<0.05)。结论年龄、不孕年限、移植日内膜厚度、滋养层细胞评级、囊胚移植日、多产均与体外受精-胚胎移植的不良妊娠结局相关,应积极监测,采取...     

Is there A Link between Serum Thyroid Stimulating Hormone Level and the Results of in vitro Fertilization and Embryo Transfer？

Objective To analyze the clinical features and outcomes in infertile patients with different levels of thyroid stimulating hormone (TSH) undergoing IVF/ICSI, and to investigate whether inappropriate level of TSH has the adverse effect on the results of the IVF-ET. Methods A total of 389 patients undergoing IVF/ICSI from January 2009 to December 2011 were divided into 3 groups according to the basal TSH level: group A (TSH< 2.0 mIU/L), group B (TSH 2.0-4.5 mIU/L) and group C (TSH>4.5 mIU/L). Oocyte retrieved, fertilization rate, cleavage rate, available embryo rate, pregnancy rate and miscarriage rate were analyzed to explore whether serum TSH level was correlated with the results of IVF/ICSI. Results There were no differences in number of oocyte retrieved, fertilization rate, cleavage rate and available embryo rate among 3 groups (P>0.05). Clinical pregnancy rate in group B (43.0%) was significantly higher than that in group A (30.2%) and group B (23.5%), respectively (P<0.05). There were no significant differences in miscarriage rate among 3 groups. Conclusion TSH level has no effect on fertility rate or miscarriage rate in patients undergoing IVF/ICSI. Inadequacy TSH level would decrease the IVF/ICSI pregnancy rate.     

主动免疫治疗对体外受精-胚胎移植的反复性自然流产患者的临床应用价值

目的:探讨主动免疫治疗对体外受精-胚胎移植的反复性自然流产(recurrent spontaneous abortion,RSA)患者的临床应用价值?方法:分析2003年7月~2011年4月,在南京医科大学第一附属医院临床生殖科免疫治疗的42例RSA患者行IVF/ICSI治疗的62个周期?RSA患者采用淋巴细胞行主动免疫治疗,妊娠后分别采用人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)或黄体酮保胎治疗?结果:移植胚胎数目为116个,平均移植胚胎数目为(1.87 ± 0.61)个,HCG日内膜厚度为(9.08 ± 2.03)mm?成功率为64.29%(27/42),免疫妊娠成功率96.43%(27/28),胚胎种植率28.45%(33/116),生化妊娠率50.00%(31/62),临床妊娠率45.16%(28/62),流产率3.57%(1/28),活产率24.19%(15/62),剖宫产率93.33%(14/15)?结论:对于行IVF/ICSI治疗的RSA患者,主动免疫治疗可以提高患者免疫反应性,有效降低流产率,有助于妊娠成功,是一种安全简单有效的治疗方法?     

血清AMH与外源性促性腺激素剂量对夫精人工授精妊娠结局的预测效能分析

目的 探讨血清抗米勒管激素（AMH）与外源性促性腺激素（Gn）剂量对夫精人工授精（AIH）妊娠结局的预测效能。方法 回顾性分析2019年2月—2021年3月在武汉市第四医院（古田院区）行AIH治疗并有妊娠结局的143例不孕症患者的临床资料。根据妊娠结局分为妊娠成功组和妊娠失败组。比较两组患者的临床资料;采用多因素Logistic逐步回归分析行AIH治疗不孕症患者妊娠结局的影响因素;绘制受试者工作特征（ROC）曲线,以曲线下面积（AUC）分析AMH、外源性Gn剂量及两者联合对行AIH治疗的不孕症患者妊娠结局的预测效能。结果 143例不孕症患者妊娠成功率为21.68%,周期临床妊娠成功率为19.20%。妊娠失败组的年龄、不孕症病程、Gn剂量高于妊娠成功组（P <0.05）,妊娠失败组的基础促卵泡素（FSH）、AMH则低于妊娠成功组（P <0.05）。多因素Logistic逐步回归分析结果显示,年龄［O^R =2.927（95% CI：1.274,6.725）］、不孕症病程［O^R =2.878（95% CI：1.253,6.611）］、AMH［O^R =3.979（95% CI：1.732,9.141）］及Gn剂量［O^R =3.695（95% CI：1.608,8.489）］均为行AIH治疗的不孕症患者妊娠结局的影响因素（P <0.05）。ROC曲线分析结果显示,血清AMH、外源性Gn剂量及两者联合预测行AIH治疗不孕症患者妊娠结局的敏感性分别为77.42%（95% CI：0.630,0.854）、74.19%（95% CI：0.596,0.828）、70.97%（95% CI：0.579,0.815）,特异性分别为68.75%（95% CI：0.540,0.805）、74.11%（95% CI：0.601,0.852）、98.21%（95% CI：0.882,0.999）,AUC分别为0.752（95% CI：0.662,0.829）、0.763（95% CI：0.674,0.838）、0.868（95% CI：0.792,0.925）。结论 血清AMH、外源性Gn剂量及两者联合对AIH妊娠结局的预测效能较高。     

40岁以上高龄妇女获卵数对体外受精-胚胎移植助孕结局的影响

目的 探讨获卵数对40岁以上高龄不孕妇女行体外受精-胚胎移植(IVF-ET)治疗后的助孕结局的影响.方法对行IVF-ET治疗的40岁以上高龄妇女的229个移植周期的临床资料进行回顾性分析.按获卵数分为3组,A组:获卵数<5个;B组:获卵数5~9个;C组:获卵数≥10个.分析3组IVF-ET治疗的妊娠结局.结果统计229个移植周期,48个周期获临床妊娠,23个周期获活产,临床妊娠率为20.9℅,活产率为10.0℅.A、B、C组的临床妊娠率分别为15.7℅、23.0℅、22.1℅,活产率为5.9℅、12.1℅、10.6℅.结论40岁以上高龄不孕妇女IVF治疗活产率低,临床妊娠率以及活产率不随获卵数增多而增加.     

辅助生殖技术中发生枯萎卵的影响因素

目的 探究辅助生殖技术(ART)妊娠妇女中枯萎卵的发生率和影响因素.方法 回顾性分析2012年1月~2015年12月在南方医科大学南方医院生殖中心行体外受精-胚胎移植临床妊娠共2378例,包括早期胚胎停育和同期单胎活产,其中胚胎停育根据有无胎芽分为胎芽组和枯萎卵组.比较枯萎卵组、胎芽组和活产组3组间基本信息,如女方年龄、男方年龄、体质量指数(BMI)、基础窦卵泡数(AFC)、基础卵泡刺激素(bFSH)、bFSH/bLH比值、不孕年限、促性腺激素(Gn)用量及Gn天数、人绒毛膜促性腺激素(hCG)注射日雌二醇值、移植日内膜厚度、获卵数、移植优胚率、移植后10~14 d血清β-hCG值、不孕类型和流产次数,以及不同移植周期、胚胎类型、不孕因素、受精方式间枯萎卵发生率的比较.结果 枯萎卵组的双方年龄、BMI、不孕年限、不孕类型、流产次数和活产组有显著性差异;β-hCG在枯萎卵组<胎芽组<活产组(P=0.000);囊胚移植较卵裂期胚胎显著增加枯萎卵的发生率(11.6%vs 5.6%,P=0.000);3组间其他参数无统计学差异(P>0.05);经多因素Logistic回归分析,女方年龄、β-hCG和囊胚移植是枯萎卵发生的危险因素.结论 女方高龄、血清β-hCG下降和囊胚移植增加枯萎卵发生的风险,枯萎卵的发生可能和早期胚胎发育的基因印记错误有关.     

Clinical Analysis on IVF-ET Treatment of 9 Cases of Post-cesarean Section Uterine Diverticulum

Objective To evaluate the influence of uterine diverticulum patients who have a history of cesarean section on IVF-ET process and pregnancy outcome. Methods Nine patients with uterine diverticulum after cesarean were retrospectively analyzed, who have received IVF-ET treatment. Clinical pregnancy rate and embryo implantation rate were measured. Results There were 9 infertility patients in all, 7 cases with tubal factor, 2 with unexplained factor; 3 cases were associated with prolonged menstruation period, including 1 patient was misdiagnosed as dysfunctioned uterine bleeding. There were a total of 16 transplantation cycles, including14 fresh cycles and 2 thawing cycles. Each cycle had at least one high-quality embryo available for transfer. Five cases were difficult to transfer. Two were clinical pregnancie, the implantation rate was 5.13% (2/39). Conclusion In this study, 14 fresh cycles all had high-quality embryo transfer, uterine diverticulum had no effect on the development of ovums and the formation of high-quality embryos. But forming uterine diverticulum after cesarean section may lead to secondary infertility or patients with prolonged menstruation period, it also may lead it difficult to transfer during the treatment of IVF-ET and affect embryo implantation. So the patients with a history of cesarean section shall receive ultrasonic examination or hysteroscopy routinely before IVF treatment. If necessary surgical treatment is required.     

原发不孕行体外受精-胚胎移植术授精方式的探讨

目的　分析原发不孕行体外受精 胚胎移植术 (IVF ET)患者的受精及妊娠率 ,为今后同类患者选择手术方式提供参考。方法　将 14 0例原发不孕患者分为输卵管性不孕组 10 1例 ,原因不明不孕组 39例 ,行IVF ET ,比较两组间受精率、受精失败率及临床妊娠率。结果　原因不明不孕组受精率明显低于输卵管性不孕组 (P <0 0 1) ,而受精失败率明显高于后者 (P <0 0 1) ,二者临床妊娠率差异无显著性意义。结论　对原发不孕输卵管性不孕患者IVF ET可作为首选。受精率低是影响原因不明不孕的重要因素 ,施行常规体外受精和胞质内单精子注射 (ICSI)各一半的授精方式 ,是此类患者的首选。     

高龄多囊卵巢综合征伴不孕患者体外受精-胚胎移植的助孕策略

多囊卵巢综合征（PCOS）是育龄期妇女最常见的内分泌及代谢紊乱性疾病之一,也是无排卵不孕最常见的原因。高龄PCOS患者具有内分泌代谢紊乱、卵母细胞及胚胎质量下降、子宫内膜容受性降低等临床特征,部分患者可通过体外受精-胚胎移植（IVF-ET）改善妊娠结局,在此过程中如何寻找合适的助孕策略仍无明确定论。笔者就高龄PCOS患者行IVF-ET治疗的研究进展进行综述,以期为临床应用提供一定思路。     

Effect of Long Protocol on the Outcome of In Vitro Fertilization-embryo Transfer in Patients with Endometriosis Compared with Prolonged Protocol

Objective To investigate the effect of different down-regulation protocol on the in vitro fertilization-embryo transfer （IVF-ET） outcomes in infertile patients with endometriosis （EMs）.Methods A retrospective case control study was performed. Totally 294 infertile patients with EMs were enrolled. And 109 patients （116 cycles） received prolongedprotocol as the control, 185 patients （193 cycles） received long protocol as case group, all followed by standard controlled ovarian hyperstimulation （COH）. Response to gonadotropins, the fertilization rate, the cleavage rate, the implantation rate, the clinical pregnancy rate and the miscarriage rate were measured and analyzed between the two groups. Results A trend toward better ovarian response was observed in long protocol group. Higher fertilization rate, lower total dose of rFSH, shorter duration of stimulation and more endometrial thickness on the day of hCG injection were observed in long protocol group compared with those of prolonged protocol group, and the difference was significant （P〈0.05）. In addition, the clinical pregnancy rate, the cleavage rate and the implantation rate also had an increase trend in long protocol group compared with those of prolonged protocol group, but without significant differences. Conclusion Long protocol regimen before IVF-ET in patients with EMs resulted in a trend toward better ovarian response and higher clinical pregnancy rates than prolonged protocol regimen did.     

不孕及反复自然流产患者小卵泡排卵的诊治意义

目的：探讨不孕及自然流产患者小卵泡排卵的临床意义及治疗方法。方法：回顾性分析103例阴道B超监测为小卵泡排卵的不孕及自然流产患者的临床特征，并给予单纯黄体支持及促排卵治疗，比较两种治疗方法的妊娠结局。结果：103例小卵泡排卵的患者中不孕患者74例，习惯性流产患者49例，其中20例同时有两种主诉。74例不孕患者中黄体功能不全的发生率为59．5％，30例（40．5％）诊断为不明原因不孕，而有自然流产史的患者黄体功能不全的发生率为58．1％（18／31）。不孕患者中46例接受54个周期的单纯黄体支持治疗，29例接受51个周期的促排卵治疗，妊娠率分别为10．9％（5／46）及31．0％（9／29），P＝0．037；活产率分别为2．2％（1／46）及27．6％（8／29），P＝0．002；自然流产发生率分别为80.0%(4/5) 及11．1％（1／9），P＝0．023。人绒毛膜促性腺激素注射日卵泡径线≥18mm组周期妊娠率为28.6%(14/49)，高于＜18mm组的6.6%(4/62),P=0.003；而纂经分别为14．3％（2／14）及75．0％（3／4），P＝0．019。结论：小卵泡排卵是引起不孕及自然流产的原因之一，只有约一半的患者表现为黄体功能不全，因此B超监测是诊断小卵泡发育的主要方法。小卵泡排卵的周期妊娠率低，自然流产率高，使用促排卵药物治疗可增加妊娠率，改善妊娠结局。     

剖宫产史对体外受精-胚胎移植治疗结局的影响

目的：探讨剖宫产史对体外受精-胚胎移植（IVF-ET）治疗结局的影响。方法：回顾性分析2019年1月至2019 年12月温州医科大学附属第二医院育英儿童医院生殖中心接受IVF-ET的患者,根据患者的分娩史分为仅有阴道分娩史组（292例）和剖宫产史组（311例）,比较2组胚胎植入成功率及治疗结局等。结果：剖宫产史组的胚胎植入成功率低于仅有阴道分娩史组（P ＜0.05）。2组间的流产率、双胎率、异位妊娠率差异无统计学意义（P ＞0.05）。2组间早产、死产、出生体质量、出生缺陷、胎盘前置和产后出血等指标差异无统计学意义（P ＞0.05）。结论：剖宫产史影响了IVF-ET再妊娠的胚胎植入成功率,但剖宫产史对患者的流产率等治疗结局无明显影响。